This document discusses Teledyne Brown Engineering's space systems department and achievements. It summarizes Teledyne's history in supporting NASA missions dating back to the 1950s. It outlines Teledyne's current work on the International Space Station, including operating the Microgravity Science Glovebox and Life Science Glovebox payloads, and developing and integrating science experiments. One highlighted experiment is a 2019 tissue engineering experiment to observe protein fibril formation under shear forces. The document also mentions Teledyne's work on future vehicles like Dream Chaser and the Deep Space Gateway.
Mike Suffredini, Manager, ISS Program Office, NASA Johnson Space Center: "The Next Decade of ISS and Beyond." Presented at the 2013 International Space Station Research and Development Conference, http://www.astronautical.org/issrdc/2013.
Mike Suffredini, Manager, ISS Program Office, NASA Johnson Space Center: "The Next Decade of ISS and Beyond." Presented at the 2013 International Space Station Research and Development Conference, http://www.astronautical.org/issrdc/2013.
The Large Interferometer For Exoplanets (LIFE): the science of characterising...Advanced-Concepts-Team
Studying the atmospheres of a statistically significant number of rocky, terrestrial exoplanets - including the search for habitable and potentially inhabited planets - is one of the major goals of exoplanetary science and possibly the most challenging question in 21st century astrophysics. However, despite being at the top of the agenda of all major space agencies and ground-based observatories, none of the currently planned projects or missions worldwide has the technical capabilities to achieve this goal. In this talk we present new results from the LIFE Mission initiative, which addresses this issue by investigating the scientific potential of a mid infrared nulling interferometer observatory. Here we will focus on the mission's yield estimates, our simulator software as well as various exemplary science cases such as observing Earth- and Venus-twins or searching for phosphine in exoplanetary atmospheres.
Optimising the use of Ground Penetrating Radar(GPR) for quality control of Pa...Himanshu Rao
Its a new Emerging way in India as well as worldwide used for quality check of pavemnents as its a non-destructive test and reliable too. it make use of Radar Technology.
Three or Four Archival Odysseys, Cybernetics, and the Root Cause of System Fa...Mark Custer
Three or Four Odysseys, Cybernetics, and the Root Cause of System Failure: from the French Revolution to the planet Mars. How can archival metadata standards and related tools make the work of both archivists and researchers more efficient?
Artificial intelligence (AI) is experiencing steadily growing interest over the recent years. For good reason, since these innovative algorithms and methods, such as machine learning and deep neural networks, in which knowledge is acquired and applied based on data, enable the automation of a wide range of processes and quickly deliver precise results. AI is also getting more and more popular in the space sector. The Institute of Space Technology & Space Applications (ISTA) at the Universität der Bundeswehr in Munich is conducting research around AI for space operations, science, and technology. An overview of activities and current developments towards fault management, autonomous collision avoidance, autonomous landing, as well as radio science at ISTA will be presented.
The Large Interferometer For Exoplanets (LIFE): the science of characterising...Advanced-Concepts-Team
Studying the atmospheres of a statistically significant number of rocky, terrestrial exoplanets - including the search for habitable and potentially inhabited planets - is one of the major goals of exoplanetary science and possibly the most challenging question in 21st century astrophysics. However, despite being at the top of the agenda of all major space agencies and ground-based observatories, none of the currently planned projects or missions worldwide has the technical capabilities to achieve this goal. In this talk we present new results from the LIFE Mission initiative, which addresses this issue by investigating the scientific potential of a mid infrared nulling interferometer observatory. Here we will focus on the mission's yield estimates, our simulator software as well as various exemplary science cases such as observing Earth- and Venus-twins or searching for phosphine in exoplanetary atmospheres.
Optimising the use of Ground Penetrating Radar(GPR) for quality control of Pa...Himanshu Rao
Its a new Emerging way in India as well as worldwide used for quality check of pavemnents as its a non-destructive test and reliable too. it make use of Radar Technology.
Three or Four Archival Odysseys, Cybernetics, and the Root Cause of System Fa...Mark Custer
Three or Four Odysseys, Cybernetics, and the Root Cause of System Failure: from the French Revolution to the planet Mars. How can archival metadata standards and related tools make the work of both archivists and researchers more efficient?
Artificial intelligence (AI) is experiencing steadily growing interest over the recent years. For good reason, since these innovative algorithms and methods, such as machine learning and deep neural networks, in which knowledge is acquired and applied based on data, enable the automation of a wide range of processes and quickly deliver precise results. AI is also getting more and more popular in the space sector. The Institute of Space Technology & Space Applications (ISTA) at the Universität der Bundeswehr in Munich is conducting research around AI for space operations, science, and technology. An overview of activities and current developments towards fault management, autonomous collision avoidance, autonomous landing, as well as radio science at ISTA will be presented.
This is the presentation given at the end of the Space studies program at NASA Ames, August 2009. The ACCESS Mars project stands for Assessing Cave Capabilities and Evaluating Specific Solutions (ACCESS) Mars explores the future of robotic and human exploration missions to Mars via subsurface habitation.
Mission statement: "...to develop a mission architecture for an initial settlement on Mars by assessing the feasibility of cave habitation as an alternative to proposed surface-based solutions".
Toward a Global Interactive Earth Observing CyberinfrastructureLarry Smarr
05.01.12
Invited Talk to the 21st International Conference on Interactive Information Processing Systems (IIPS) for Meteorology, Oceanography, and Hydrology Held at the 85th AMS Annual Meeting
Title: Toward a Global Interactive Earth Observing Cyberinfrastructure
San Diego, CA
Scott Willoughby
Northrop Grumman Aerospace Systems
Vice President and JWST Program Manager
For more information, please visit: https://give.fit.edu/james-webb-space-telescope
Exploration – One Year On
19 November 2008, Pasadena California
Session 6: Exploration – One Year On
19 November 2008, Pasadena California
http://www.astronautical.org/conference/conference-2008
Reference Guide To The International Space StationSérgio Sacani
The International Space Station is a unique place – a convergence of science, technology and human innovation that demonstrates new technologies and makes research breakthroughs not possible on Earth.
It is a microgravity laboratory in which an international crew of six people live and work while traveling at a speed of five miles per second, orbiting Earth every 90 minutes.
The space station has been continuously occupied since November 2000. In that time, more than 200 people from 15 countries have visited.
Crew members spend about 35 hours each week conducting research in many disciplines to advance scientific knowledge in Earth, space, physical, and biological sciences for the benefit of people living on our home planet.
The station facilitates the growth of a robust commercial market in low-Earth orbit, operating as a national laboratory for scientific research and facilitating the development of U.S. commercial cargo and commercial crew space transportation capabilities.
More than an acre of solar arrays provide power to the station, and also make it the next brightest object in the night sky after the moon. You don’t even need a telescope to see it zoom over your house. And we’ll even send you a text message or email alert to let you know when (and where) to look up, spot the station, and wave!
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
2. Agenda
2
1. About Teledyne Brown Engineering/Space Systems Department
2. Space Systems Organization and Achievements
3. Direct Past Experiment with Tissue Engineering in Microgravity
4. Future Space Initiatives
4. Engineered Systems –
Teledyne Brown Engineering History
► Established in 1953 in Huntsville, Alabama to support Dr. Wernher
Von Braun’s Rocket Team.
► Founded Cummings Research Park, the second-largest such park in
the U.S.
► Evolved from a defense and aerospace service contractor to an
engineering and advanced manufacturing company focused on
solutions for large scale projects in challenging environments. 406/06/18
5. 1950 1960 1970 1980 1990 2000 2010 Present
Teledyne Brown Engineering History
5
Explorer
Redstone
Rocket
Apollo
Radiological
Lab Services
Chemicals
Weapons
Demilitarization
Space Shuttle
Nuclear
Waste
Containers
International
Space Station
(ISS)
Harpoon
Skylab
Space Launch
System (SLS)
Program
Multiple User
System for
Earth Sensing
(MUSES)
Hydrogen
Generators
SWCS
Hydrogen
Fuel Cells
OSF
Curiosity with
MMRTG
Ground-based
Midcourse
Defense (GMD)
JASSM
6. Teledyne Brown Engineering
Space Systems
6
► Space Flight Hardware
► Ground Support
Equipment and Propulsion
Subsystems
► Mission Planning and
Control Center Operations
► Payload Development,
Testing, Integration and
Training
7. Teledyne Brown Engineering is a Prime Contractor
Marshall Operations Service, Systems & Integration
(MOSSI)
7
► Plan science payloads, train
astronauts, and manage all
science experiments on ISS.
► Contract recompete combines 2
contracts, MO&I and HOSC. It will
be called Marshall Operations
Services, Systems, & Integration
(MOSSI).
► Largest contract in TBE’s history.
8. Teledyne Brown Engineering
Global Commercial Space Imaging
8
► Multi-User System for Earth Sensing
(MUSES) Platform
• Multiple payload options
► Precise Pointing of High-Resolution
Earth-Imaging Instruments
► On-Site Command and Control
Tele-Science Center
► Hyperspectral Imagery Data
DESIS Robotic Installation on MUSES Platform (August 27, 2018)
9. VEGITATI
ON
INDEX
VEGETATION
INDEX
SUSPENDED
MATTER
DISSOLVED ORGANIC
MATERIAL
► Partnered with German Space Center
(DLR),
► Operating successfully on ISS since
August 28, 2018
DESIS-30 Hyperspectral Imager
First Instrument on MUSES
► 30 meter ground sampling distance;
30 km swath; 235 spectral bands;
Visible to Near Infrared.
ACTIONABLE INTELLIGENCE
Vegetation No Vegetation
10. Microgravity Science Glovebox (MSG)
ISS Configuration
10
Command &
Monitoring
Panel Airlock
Stowage
Drawers
Utility Interface
Panel
DC Power &
Circuit
Breakers
Video System
Drawer
Gloveports
Rack Power
Distribution
Assembly
Rack Maintenance
Switch Assembly
• Delivered to ISS on STS-111 and installed June 2002. Operations started July 2002
• Enables crew interaction for setup, sample exchange, and experiment monitoring.
• Provides 2 levels of containment for safety, 1 KW power & cooling, HD video, and data
• Engineering Unit w/ PRCU used for high-fidelity Verification, Integration, Training and
Troubleshooting (4 available Units --Training Unit, Engineering Unit, Ground Unit, & Flight Unit)
• Operational Tele-science Center at TBE and local ISS POIC at MSFC
11. Life Science Glovebox (LSG)
ISS Configuration
1111
• Launched on HTV-7, September 22, 2018
• Currently Undergoing Installation and Checkout on the ISS
• TBE provided design, analysis, test, & Integration Support
12. ISS Science Payload Development/Integration &
Sustaining Support for MSG/LSG/MSRR
12
► Life Science Glovebox (LSG)
delivered to the International Space
Station (ISS) by the Japanese H-II
Transfer Vehicle (HTV), also called
Kounotori (White Stork) .
LSG
MSG
MSRR
15. Ring Sheared Drop (RSD) Experiment will
Fly on ISS in early 2019
Experiment Objective: Observe
Formation of Fibrils as Protein
Undergoes Shear Forces as Sample
Drop Spins
Magnified Imaging of Fibrils RSD – Inside MSG Work Volume
16. Future – Dream Chaser
Sierra Nevada & TBE
Dream Chaser is a reusable composite
spacecraft designed to carry from 2 to 7
people and/or cargo to orbital destinations
such as the International Space Station
20. Summary
20
Teledyne Brown Engineering has the proven experience to successfully
integrate and operate your Tissue Engineering or Mechanobiology Experiment
on ISS and other space vehicles.
We have successfully taken many payloads through the ISS Payload Safety
Review Process which is a critical skill for launch and on-orbit operations
approval.
The following contract vehicles are available now to facilitate your work:
Contract Vehicle Abbreviation Contracting Organization
Research, Engineering, and Mission
Integration Services
REMIS NASA Johnson Space Center
Engineering Solutions and
Prototyping
ESP NASA Marshall Space Flight Center
CASIS Implementation Partner Direct Contract with CASIS