T2DM AF GORD Cholecystectomy 5 years ago Brian is transferred to the neurological ward. On assessment he has a GCS of 13, left sided hemiplaegia, expressive dysphasia, dysphagia & blurred vision in his left eye. He is scheduled to see the speech pathologist and the physiotherapist later today. After a week of therapy Brian is ready to be discharged to rehab. He still has some residual dysphasia, but the dysphagia and blurred vision have largely resolved. He still has significant weakness on his left side. The doctors have ordered the following medications for discharge: Apixaban 5 mg PO daily Digoxin 125 mcg PO daily Simvastatin 40 mg PO daily Ezetimibe 10 mg PO daily Perindopril 2 mg PO daily Amlodipine 10 mg PO daily Assignment Instructions 2000 words (+/- 10%) 35% 1. Identify the most likely type and cause (what you think is the main risk factor) of Brian’s CVA • Your answer must include a rationale for this selection and explain how and why this cause can lead to a CVA from a pathophysiological perspective. • Include in your answer the pathophysiology of Brian’s CVA. • In other words, discuss the pathogenesis of the most likely cause and how it can lead to CVA. Consider his past medical history. 20% 2. Identify two (2) other risk factors that Brian has for CVA • For each of these risk factors explain how & why they can increase the risk of & lead to CVA. 3. Select two (2) signs and/or symptoms that Brian had as a result of his CVA • For each sign/symptom explain how & why it can occur after a CVA, again from a pathophysiological perspective. 35% 4. Select three (3) of Brian’s medications and explain why each of the three (3) medications was ordered for Brian • Your discussion should include the pharmacodynamics and pharmacokinetics of each medication, including relevant adverse effects and contraindications. 5. Each of Brian’s discharge medications is to be administered orally. This means they will all undergo the first pass effect. Explain what first pass is and the implications this has for a drug’s bioavailability. This is a case study, not a general discussion of CVA. It is important that only information relevant to the specific case be discussed in this assignment. Information that is not directly relevant to the case study should not be included. The assignment is not an essay, i.e. it does not require an introduction or conclusion. However, it must be written in accordance with academic conventions, i.e. full sentences, not dot points. Headings can be used to organise your assignment and please ensure appropriate use of paragraphs. All claims or assertions must be supported with evidence form the literature, using APA6 referencing guidelines. Help with Academic Writing For assistance with assignment writing, you are encouraged to make a time for an appointment with the Student Learning You can also submit a request for assistance through Studiosity. Benefits of this are the ability to: 1. Upload .