Suicide as deviance act in the society. This can be utilize especially those who take social work course as part of their subject. It discuss the stigma in the society what are the laws and programs relative to suicide.
Social phobia in Australia, treatment, Symptoms and TriggersSuzana Phillips
Discover social phobia, what it is, the treatment and emotional and behavioural symptoms. Furthermore a look into the lives of people living with the disorder and how to cope.
Social phobia in Australia, treatment, Symptoms and TriggersSuzana Phillips
Discover social phobia, what it is, the treatment and emotional and behavioural symptoms. Furthermore a look into the lives of people living with the disorder and how to cope.
Suicide Risk Assessment and Interventions - no videosKevin J. Drab
An in depth presentation of the current information known about suicide and the most effective interventions we currently have. If you are unclear about how to handle suicidal behavior or what are the more research-based approaches this PPT will be an excellent review for you. I have been training clinicians in Suicidology for over 20 years and have always stayed on top of the latest research and literature.
Social Phobia or shyness in disguise. How to differentiate shyness in social and social phobia. How does Social Phobia differ? Epidemiology of social phobia. A model of Etiology of Social Phobia.
Suicide, risk factors, assessment and methodological problemsDr. Amit Chougule
Seminar on Suicide from a psychiatric point of view
definition, global and indian epidemiology of suicide, risk assessment of suicide and methodological issues associated with risk assessment and suicide research are covered.
Suicide Risk Assessment and Interventions - no videosKevin J. Drab
An in depth presentation of the current information known about suicide and the most effective interventions we currently have. If you are unclear about how to handle suicidal behavior or what are the more research-based approaches this PPT will be an excellent review for you. I have been training clinicians in Suicidology for over 20 years and have always stayed on top of the latest research and literature.
Social Phobia or shyness in disguise. How to differentiate shyness in social and social phobia. How does Social Phobia differ? Epidemiology of social phobia. A model of Etiology of Social Phobia.
Suicide, risk factors, assessment and methodological problemsDr. Amit Chougule
Seminar on Suicide from a psychiatric point of view
definition, global and indian epidemiology of suicide, risk assessment of suicide and methodological issues associated with risk assessment and suicide research are covered.
Catching Early Signs And Symptoms Of Suicidal Behavior | Solh WellnessSolh Wellness
Suicide, a grave and deeply concerning issue, is not in itself a mental illness. Instead, it represents a distressing and potentially fatal outcome that can result from untreated or poorly managed mental disorders.
Suicide: Risk Assessment and InterventionsKevin J. Drab
Suicide: Risk Assessment and Interventions; assessing suicide; suicide; killing oneself; death by suicide; indirect suicide; dynamics of suicide; self-harm; suicide survivors; psychological autopsy; commonalities of suicide; protective factors suicide; suicide risk; suicide prevention; suicide prediction; risk factors suicide; suicide risk categories; Collaborative Assessment and Management of Suicidality (CAMS) method; Suicide Status Form (SSF); motivational interviewing and suicide; Common Errors of Suicide Interventionists; contracting for safety; completed suicide; died by suicide; suicide prevention; self injury; guns and suicide
Suicide:Risk Assessment & InterventionsKevin J. Drab
Suicide: Risk and Interventions - a review of recent advances in suicidology and the use of Jobes' CAMS approach to suicide intervention and prevention.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
3. Suicidal warning signs:
Feeling trapped – like there is no way out of a
situation.
Talking or writing about death or suicide.
Appearing depressed or sad most of the time.
Losing interest in most activities.
4. Common Characteristics of Suicide:
Stimulus - Unendurable Psychological pain
Stressor - frustrated psychological needs
Purpose - Seek solution
Action - Egression or escape
Emotions - Hopelessness and helplessness
Internal attitude - Ambivalence
Interpersonal act - Communication of intention
5. Four Types of Suicidal Behaviour
Suicide – The person intend to dies and does so
Attempted Suicide- The person intend to die, but does not
Suicidal gesture- The person has no real intention of dying
and does not
Accident- the person does not intend to die but does
6. Causes of Suicide attempts:
A. Depression
B. Bipolar disorder
C. Schizophrenia and other
psychoses
7. Depression
it is a low mood that lasts for a long time,
affecting everyday life.
Symptoms: Persistent sadness, loss of interest in
activities, loss of appetite, feelings of
worthlessness, becoming easily agitated
8. Bipolar Disorder
manic depressive illness. , is a mood
disorder with two extremes: depressed
(“low”) and manic (“high”)
Symptoms: When depressed, a person
feels persistently sad, hopeless and
lethargic, and may feel suicidal
9. Schizophrenia and other
psychoses
Characterised by distortions in thinking, perception,
emotions, language, sense of self and behaviour.
Symptoms: a person may think other people are talking
about him or her, or hear voices. The person may also
feel sad and irritable, or that he or she is constantly
being watched
10. Main brunt of Stigmatization on
how it operates
Survivor for suicide loss
These people might be family members, lovers, friends, or
anyone else who is impacted by the death of a loved one
Suicide attempt Survivor
They are often face extreme stigmatization and are not
taken seriously because they are viewed as simply “crying
wolf”.
11. Copycat Suicide
Another suicide that the person attempting
suicide knows about either from local knowledge
or due to accounts or depictions of the original
suicide on social media.
12. Copycat Suicide
Factors in suicide
Publishing the means of suicides, romanticized and
sensationalized reporting, particularly about celebrities.
Social Proof
A psychological phenomenon where people assume the
actions of others in an attempt to reflect correct behavior
for a given situation. (Cialdini)
13. Laws and Programs
R.A no. 11036 Mental Health Act
Section 21 Suicide Prevention
Mental health services shall also include mechanisms for suicide
intervention, prevention, and response strategies, with
particular attention to the concerns of the youth.
To provide assistance to individuals with mental health
conditions, especially individuals at risk of committing suicide.
