THIS PPT GIVES ONE AN IDEA ABOUT SUBSTANCE P.NEUROTRASNMITTER

1. Substance P
Presented by
Payaam Vohra
23PCM3895

2. TYPES OF NEUROKININ
RECEPTORS
SUBSTANCE P
NK1
SUBSTANCE
P
NK2 NK3

5. Ion Channels Involved in Substance P-Mediated Nociception and
Antinociception

7.  Rheumatoid arthritis
Bipolar disorder
Epilepsy
Alzheimer disease
Cardiomyopathies
Substance P has been implicated in the pathogenesis of several
diseases :
•Emesis
•Fibromyalgia
•Eczema
•Psoriasis
•Depression
•Anxiety
•Heart failure
•Myocardial infarction
•Asthma
•Chronic bronchitis
•Inflammatory bowel diseases
•Migraine
•Osteoarthritis

8. Immune cell types SP Expression is NK1R mediated effect is SP or NK1R agonist signaling
on immune cells
Dendritic cells shown in human and mouse shown in human and mouse Potentiate immunostimulatory
function and survival of DCs, IL-
12 production and generation of
type I immunity.
Monocytes/Macrophages shown in human and mouse shown in human and mouse NK1R-T stimulation in
monocytes augments CCR5
signaling and promotes M-tropic
HIV infection. NK1R signaling
enhances IL-12 production in
macrophages.
Eosinophils shown in human and mouse not shown SP effects are NK2R mediated.
Inhibit spontaneous apoptosis of
cells in culture, exerts
chemotactic effect and causes
the release of O2
-
.
Neutrophils Shown in human and mouse shown in human and mouse Causes superoxide production,
enhances phagocytosis,
increases expression of
chemokine and chemokine
receptor.
Mast cells not shown shown in human and mouse Causes mast cell degranulation,
TNF-α and VEGF secretion.
Natural Killer Cells shown in human and mouse shown in human and mouse Increases IFN-γ production,
either inhibits or enhances NK
cell cytotoxicity under defined
set of condition.
T lymphocytes shown in human and mouse shown in human and mouse Enhances IL-2 and IFN-γ
production, promotes T cell
proliferation, generation of
memory Th17 from non-
committed memory CD4 T cells.
EXPRESSION OF SUBSTANCE P

9. Ion channels modulated by substance P.
Channel
Receptor
mechanism
Via
Experimentation
Animal
Expression Effect
TRPV1 PKCε DRG Rat ↑ Pro-nociception
L, N type calcium channel PKC DRG Rat ↑
Low threshold potassium
channel (Kv4)
DRG Rat ↓ Pro-nociception
P2X3 TG Rat ↑ Pro-nociception
GABAAR Gi/o
Spinal dorsal horn
neurons
Rat ↑ Anti-nociception
Glycine receptor Gi/o
Spinal dorsal horn
neurons
Rat ↑ Anti-nociception
M-type potassium channel Tyrosine kinase DRG Mice ↑ Anti-nociception
T-type calcium channel Gi/o DRG Rat ↓ Anti-nociception

10. Substance P degrading Enzymes

11. SUBSTANCE P IN HYPERALGESIA

12. SUBSTANCE P IN CVS

13. GI Motility online (May 2006) | doi:10.1038/gimo75
VR1 activation in nerve endings triggers the release of substance P (SP),
calcitonin gene-related-peptide (CGRP), and neurokinin A.

14. 1. Lin, J.H.; Hung, C.H.; Han, D.S.; Chen, S.T.; Lee, C.H.; Sun, W.Z.; Chen, C.C.
Sensing acidosis: Nociception or sngception? J. Biomed. Sci. 2018, 25, 85.
[Google Scholar] [CrossRef]
2. Lin, S.H.; Cheng, Y.R.; Banks, R.W.; Min, M.Y.; Bewick, G.S.; Chen, C.C.
Evidence for the involvement of ASIC3 in sensory mechanotransduction in
proprioceptors. Nat. Commun. 2016, 7, 11460. [Google Scholar] [CrossRef]
[PubMed] [Green Version]
3. Cheng, Y.R.; Jiang, B.Y.; Chen, C.C. Acid-sensing ion channels: Dual function
proteins for chemo-sensing and mechano-sensing. J. Biomed. Sci. 2018, 25,
46.
REFERENCES