definition: It a type of a tablet that dissolve, sprays or film that is used by placing the drug under the tongue, and it is absorbed and dissolved into the blood stream through the mucous membrane. it is considered to be absorbed very fast into the circulation, as it doesn’t pass through the digestive system and the area under the tongue is rich with tiny blood capillaries. Sublingual is used in such cases as : - Patient that cannot swallow drugs - Drugs that should be absorbed quickly into the circulation - Drugs that the digestion would decrease there effect. advantages & disadvantages active ingredients market production conclusion: Overall, sublingual have a lot of advantages as it is very rapid and potent, the disadvantages is that it may interferes with food and drinking, not used with unconscious patient. There are many API of the sublingual tablets such as Buprenorphine HCL, Isosorbide dinitrate, and Hyoscyamine sulphate, etc . there are many international and national drugs used as sublingual such as saphris, abstral, isodril and nervidox, etc .