This document discusses the potential of embryonic stem cells and adult bone marrow stem cells for treating degenerative diseases. It notes that while embryonic stem cells show promise, their use raises ethical issues. Research indicates that adult bone marrow stem cells may have similar pluripotent properties and can migrate from the bone marrow to repair damaged tissue in the heart and brain. Studies found that the algae Aphanizomenon flos-aquae can stimulate the release and migration of stem cells from the bone marrow, suggesting its potential use for treating diseases.
Pathophysiology of TBI is complex and consists of acute and delayed injury. In the acute phase, brain tissue destroyed upon impact includes neurons, glia, and endothelial cells, the latter of which makes up the blood-brain barrier. In the delayed phase, ātoxinsā released from damaged cells set off cascades in neighboring cells eventually leading to exacerbation of primary injury. As researches further explore pathophysiology and molecular mechanisms underlying this debilitating condition, numerous potential therapeutic strategies, especially those involving stem cells, are emerging to improve recovery and possibly reverse damage. In addition to elucidating the most recent advances in the understanding of TBI pathophysiology, this review explores two primary pathways currently under investigation and are thought to yield the most viable therapeutic approach for treatment of TBI: manipulation of endogenous neural cell response and administration of exogenous stem cell therapy.
There are a lot of orthopedic conditions and injuries that presently have limited treatment options available.
Here regenerative technologies comes up as a ray of hope among surgeons for the treatment by functionally repairing the tissues and organs using growth factors, stem cells and products developed by genetic engineering with the advancement in the stem cells research field .
The purpose of this presentation is to first provide idea about the orthopedic conditions along with the therapeutic potential of stem cells to treat these diseases.
Pathophysiology of TBI is complex and consists of acute and delayed injury. In the acute phase, brain tissue destroyed upon impact includes neurons, glia, and endothelial cells, the latter of which makes up the blood-brain barrier. In the delayed phase, ātoxinsā released from damaged cells set off cascades in neighboring cells eventually leading to exacerbation of primary injury. As researches further explore pathophysiology and molecular mechanisms underlying this debilitating condition, numerous potential therapeutic strategies, especially those involving stem cells, are emerging to improve recovery and possibly reverse damage. In addition to elucidating the most recent advances in the understanding of TBI pathophysiology, this review explores two primary pathways currently under investigation and are thought to yield the most viable therapeutic approach for treatment of TBI: manipulation of endogenous neural cell response and administration of exogenous stem cell therapy.
There are a lot of orthopedic conditions and injuries that presently have limited treatment options available.
Here regenerative technologies comes up as a ray of hope among surgeons for the treatment by functionally repairing the tissues and organs using growth factors, stem cells and products developed by genetic engineering with the advancement in the stem cells research field .
The purpose of this presentation is to first provide idea about the orthopedic conditions along with the therapeutic potential of stem cells to treat these diseases.
Stem cell Therapy in Neurological diseases Ibad khan
Ā
Stem cell Therapy in Neurological diseases
difinition
mechanism
types
history
advantages or disadvantages
in this presentation all theses information include ,
CiteXplore - a more sophisticated search in the life science literatureNikolay12
Ā
A presentation that was given at the conference organised by the Post-doc society at the European Molecular Biology Laboratory - Heidelberg, October 2006.
Stem cell Therapy in Neurological diseases Ibad khan
Ā
Stem cell Therapy in Neurological diseases
difinition
mechanism
types
history
advantages or disadvantages
in this presentation all theses information include ,
CiteXplore - a more sophisticated search in the life science literatureNikolay12
Ā
A presentation that was given at the conference organised by the Post-doc society at the European Molecular Biology Laboratory - Heidelberg, October 2006.
A Brief History of Regenerative MedicineJohn Makohen
Ā
In the presentation ISREGEN outlines the history of regenerative medicine fro it's earliest days when Robert Briggs and Thomas King began cloning frogs to the present medicinal advancements in stem cell research and repair.
Stem CellĀ ResearchStem cells are cells that can grow and differe.docxwhitneyleman54422
Ā
Stem CellĀ Research
Stem cells are cells that can grow and differentiate into other types of cells. These cells have great potential for the treatment of various disorders such as cancer or Parkinsonās disease where the body cannot regenerate healthy cells to cure the disease. Stem cell research has been going on for a long time, and there have been great breakthroughs in the research. One such breakthrough has been the use of stem cells in the rejuvenation of neural cells of monkeys suffering from Parkinsonās disease. Scientists have used induced pluripotent cells to form some types of brain cells that have been damaged by the disease. Parkinsonās disease is caused by the degeneration of specific brain cells that control motor functions and mood. Researchers have previously been able to restore motor functions in rats that have shown characteristic symptoms of Parkinsonās disease by using dopamine neurotransmitters grown from human induced pluripotent cells. In spite of this, there has not been any investigation on the long-term effects of the use of this practice on the primates.
Researchers from California have demonstrated that injecting stem cells taken from the hearts of newborn rats into older rats improved the latterās cardiovascular function and capacity.
A study done by Jun Takahashi was done to evaluate the safety and applicability of the practice in primates. Human induced pluripotent cells were used to generate dopamine neurons which were transplanted into primates that had been induced to have the Parkinsonās disease. The primates showed increasing spontaneous increase in the motor cells after transplantation and complete functioning in the midbrain. There was no long-term effect of the cells on the primates after two years since no brain tumors were observed (Sandoiu, 2017). This information is critical as it has opened a gateway to the treatment of Parkinsonās disease. The study shows that once more research is done this could be a method to treat people suffering from the disease and will help to relieve human suffering. The study has unlocked one of the many possibilities of the use of stem cell research and will, therefore, earn it more favor and support from the public.
Human neural stem cells are derived via fluorescence-activated cell sorting (FACS) from donated fetal brainĀ tissue.
A study was done on mice by Hai Nguyen, Aileen Anderson and colleagues found that mice receiving stem cells grown from human brain tissue required the depletion of some types of immune cells to improve the motor skills of the mice. The donor cells survived equally when transplanted either immediately or after a month after the injury. Their location however continuously changed and this suggested that the cells were populating the spinal cord at different times after the injury and it affected the ability of the transplants to provide functional recovery of the motor skills (Society for Neuroscience. 2017). This means that the stem cells could .
Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neu...johnohab
Ā
Here we show that conditional deletion of Pten in a subpopulation of adult neural stem cells in the subependymal zone (SEZ) leads to persistently enhanced neural stem cell self-renewal without sign of exhaustion. These Pten null SEZ-born neural stem cells and progenies can follow the endogenous migration, differentiation, and integration pathways and contribute to constitutive neurogenesis in the olfactory bulb. As a result, Pten deleted animals have increased olfactory bulb mass and enhanced olfactory function. Pten null cells in the olfactory bulb can establish normal connections with peripheral olfactory epithelium and help olfactory bulb recovery from acute damage. Following a focal stroke, Pten null progenitors give rise to greater numbers of neuroblasts that migrate to peri-infarct cortex. However, in contrast to the olfactory bulb, no significant long-term survival and integration can be observed, indicating that additional factors are necessary for long-term survival of newly born neurons after stroke. These data suggest that manipulating PTEN-controlled signaling pathways may be a useful step in facilitating endogenous neural stem/progenitor expansion for the treatment of disorders or lesions in regions associated with constitutive neurogenesis.
Neurodegenerative diseases are a group of disorders characterized by the gradual loss of structure or function of neurons in the brain or spinal cord. Some common neurodegenerative diseases include Alzheimer's disease, Parkinson's disease, and Huntington's disease.
For better view, press F5.
As we go through our lives each of us will have very different needs for our own healthcare.
Scientist's are constantly researching to make medical care treatment more personalized.
One way they are doing this is by-
Stem Cells therapy
Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.
It is also known as regenerative medicine, promotes the reparative response of diseased, dysfunctional or injured tissue using stem cells or their derivatives.
It is the next chapter of organ transplantation and uses cells instead of donor organs, which are limited in supply.
What are Stem cells?
Stem cells are called āmaster cellsā
Stem cells are cells that are undifferentiated.
What are Stem cells?
Steam cells have the potential to become all other kinds of cells in our body.
What are Stem cells?
Types of Stem cells
How stem cell therapy works?
Disease cured by stem cell therapy.
Spinal Cord Injuries
Stem cell treatment of Diabetes mellitus type 1 & 2
Stem cell treatment of Stroke
Cancer treatment
Heart damage
Baldness
Tooth implanting
Deafness and blindness
Have stem cells already been used to treat diseases?
Ethical Consideration of Stem Cell Therapy
As the research method mainly focused on Embryonic Stem Cells, which involves taking tissue from an aborted embryo to get proper material to study. This is typically done just days after conception or between the 5th and 9th week.
Since then, researchers have moved on to more ethical study methods, such as Induced Pluripotent Stem Cells (iPS). iPS is artificially derived from a non-pluripotent cell, such as adult somatic cells.
Nowadays stem cell treatment has been spreaded throughout the world. It has also been grown commercially in developed countries.
It is thought that one day it may be the major key to treat various diseases.
Using stem cells to conduct medical research and treat disease is acceptable?
Donāt know
No
Yes
Do you approve of the extraction of stem cells from human embryos for medical research?
Donāt know
No
Yes
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Ā
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Ā
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
Ā
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
Elevating Tactical DDD Patterns Through Object CalisthenicsDorra BARTAGUIZ
Ā
After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more āmechanicalā approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
DevOps and Testing slides at DASA ConnectKari Kakkonen
Ā
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Ā
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
Participants will gain insights into the responsibilities, challenges, and best practices associated with test management in SAP projects. Additionally, the webinar delves into the significance of heatmaps as a visual aid for identifying testing priorities, areas of risk, and resource allocation within SAP landscapes. Through this session, attendees can expect to enhance their understanding of test management principles while learning practical approaches to optimize testing processes in SAP environments using heatmap visualization techniques
What will you get from this session?
1. Insights into SAP testing best practices
2. Heatmap utilization for testing
3. Optimization of testing processes
4. Demo
Topics covered:
Execution from the test manager
Orchestrator execution result
Defect reporting
SAP heatmap example with demo
Speaker:
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
Ā
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
Connector Corner: Automate dynamic content and events by pushing a buttonDianaGray10
Ā
Here is something new! In our next Connector Corner webinar, we will demonstrate how you can use a single workflow to:
Create a campaign using Mailchimp with merge tags/fields
Send an interactive Slack channel message (using buttons)
Have the message received by managers and peers along with a test email for review
But thereās more:
In a second workflow supporting the same use case, youāll see:
Your campaign sent to target colleagues for approval
If the āApproveā button is clicked, a Jira/Zendesk ticket is created for the marketing design team
Butāif the āRejectā button is pushed, colleagues will be alerted via Slack message
Join us to learn more about this new, human-in-the-loop capability, brought to you by Integration Service connectors.
And...
Speakers:
Akshay Agnihotri, Product Manager
Charlie Greenberg, Host
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
Ā
91mobiles recently conducted a Smart TV Buyer Insights Survey in which we asked over 3,000 respondents about the TV they own, aspects they look at on a new TV, and their TV buying preferences.
Key Trends Shaping the Future of Infrastructure.pdfCheryl Hung
Ā
Keynote at DIGIT West Expo, Glasgow on 29 May 2024.
Cheryl Hung, ochery.com
Sr Director, Infrastructure Ecosystem, Arm.
The key trends across hardware, cloud and open-source; exploring how these areas are likely to mature and develop over the short and long-term, and then considering how organisations can position themselves to adapt and thrive.
Assuring Contact Center Experiences for Your Customers With ThousandEyes
Ā
Stem cell primordial_food_excerpt
1. AFA Stimulates Stem Cell Mobilization
(Excerpt from Primordial Food Aphanizomenon flos-aquae: A wild blue green alga with
unique health properties, by Christian Drapeau, MSc.)
Spurred by political considerations, much attention has
recently been brought to the issue of using embryonic stem cells for
research purposes and for the development of treatments for various
diseases.
Embryonic stem cells (ESC) are cells harvested from embryos that
have nearly unlimited capacity to regenerate and become any kind of
cell in the body. In the embryo, they are the initial precursors of all
the cells destined to become the brain, heart, muscles, skin, bones,
etc. When transplanted into an adult, embryonic stem cells have the
ability to heal and repair any organ in which they are transplanted,
providing an extremely useful tool for the treatment of various
degenerative diseases. Treatment with embryonic stem cells has
either been shown or is suspected to improve various degenerative
diseases such as Parkinsonās diseases, diabetes, heart disease, as well
as degeneration of the nervous system.
Knowledge of the potential of embryonic stem cells in treating
various health conditions emerged in the 1960s and gained
significant momentum in the 1980s. However, research involving
ESC received significant opposition over the years because of the
obvious ethical nature of harvesting cells from live human embryos
and because of the door it opens to research involving genetic
manipulation of humans. However, as an alternative to this ethical
dilemma, much evidence has accumulated over the past few years
indicating that adult bone marrow stem cells might have pluripotent
properties similar to ESC, leading to the hypothesis that stimulation
of in situ release of bone marrow stem cells could constitute an
effective treatment for various degenerative diseases.82
For example, Goodell 83 recently described how bone-
et al
marrow stem cells can migrate from the bone marrow to the heart
and contribute to cardiac muscle repair and the formation of new
blood vessels after ischemic injury (cardiac arrest).
2. In brief, highly purified bone marrow stem cells were genetically
modified to produce a fluorescent protein. The miceās innate stem
cells were killed through irradiation. Then the genetically modified
stem cells were transplanted into their bone marrow, leaving the
fluorescent bone marrow stem cells as the sole source of available
stem cells. Cardiac arrest was subsequently triggered in the mice by
coronary artery occlusion.
A few weeks later, the engrafted fluorescent stem cells had
differentiated into cardiac muscle and endothelial cells, which
contributed to the formation of functional cardiac tissue, as well as
new blood vessels.
Similar migration of bone marrow stem cells and subsequent
regeneration of tissue was also suspected to take place in the brain.
In a double-blind study including 40 patients suffering from
Parkinsonās disease, injection of embryonic stem cells derived from
seven- to eight-week-old embryos slowed the progression of the
diseases in all of the 20 patients.84 Likewise, there is evidence
indicating that stem cells could reverse symptoms of Alzheimerās
disease.85
Studies were therefore conducted to investigate whether stem
cells injected intravascularly or endogenously released from the bone
marrow could cross the blood-brain barrier, migrate, then
differentiate into brain cells. Bone marrow stem cells, along with
monocytes and macrophages, were shown to have the ability to cross
the blood-brain barrier and reach the brain.86-89
Intravascular delivery of genetically marked adult mouse bone
marrow stem cells into lethally irradiated normal adult mice led to
the development in the central nervous system of donor-derived cells
having neuronal properties (neuronal phenotypes).90 After eight to
twelve weeks, it was estimated that about 0.2 to 0.3 percent of the
total number of neurons were derived from the bone marrow. The
authors wrote, āOur results clearly show that adult cells from the
marrow can gain access to the adult brain and assume characteristics
of central nervous system neurons.ā90
Similarly, Mezey et al88 showed that in a strain of mice incapable
of developing cells of the myeloid and lymphoid lineages,
3. transplanted adult bone marrow stem cells migrated into the brain
and differentiated into cells that expressed neuron-specific antigens.
Between 2.3 and 4.6 percent of all neurons were donor-derived.
Some neurons were observed with axonic projections and apparent
dendritic trees. The authors suggested that bone marrow stem cells
might naturally migrate into certain regions of the brain and give rise
to a variety of neural cell types, thus implying a greater potential for
regeneration of the central nervous system than had been
traditionally expected.88
Based on information produced by various scientific teams,
Jensen et al82 recently proposed the Stem Cell Theory of Healing,
Regeneration and Repair (Figure 5 on previous page). This
breakthrough theory suggests that bone marrow stem cells leave the
bone marrow and travel throughout the body, providing for healing
and regeneration of damaged organs during the entire lifetime of an
individual. In other words, adult bone marrow stem cells may be one
of the natural mechanisms that the human body utilizes for healing,
regeneration and repair.
According to this theory, there is no need to harvest embryonic
stem cells, manipulate them, then reinject them into individuals.
Regeneration can take place simply by stimulating the release of
stem cells from the bone marrow and stimulating their migration
into tissues. The task is therefore simply to find natural compounds
able to stimulate stem cell release and migration. Such compounds
could be used for the daily enhancement of the bodyās natural
mechanism of healing and regeneration.
The only such natural compound known to date is AFA, which
has been recently shown to stimulate stem cell release and migration.
Based on this information, a patent has been filed regarding the use
of AFA for the treatment of Parkinsonās disease, Alzheimerās
disease, diabetes, multiple sclerosis, cardiac arrest recovery, and
regeneration.