The document provides a response to an article published in The Scientist that questioned 1) the effect of endogenous stem cell release on health, 2) the efficacy of StemEnhance, and 3) the safety of StemEnhance. The response criticizes the journalism used in the article, argues that consensus has not been reached on the role of adult stem cells, cites evidence that increasing circulating stem cells can benefit health, and claims the article failed to consult experts knowledgeable about StemEnhance and presented opinions to discredit the product.
Age Reversal Update from Bill Faloon on December 15th 2020maximuspeto
Â
Bill Faloon of LifeExtension reviews several recent age-reversal topics including the remarkable effects of hyperbaric oxygen on telomere length and senescence in humans and clinical studies designed to assess age-reversal potential of multiple interventions.
CONFERENCE
ON
Multiple Hereditary Exostoses
Insights Into Pathogenesis
November 3-5, 2005
Shriners Hospital of Houston
6977 Main Street
Houston, Texas
and the
Houston Marriott Medical Center
6580 Fannin Street
Houston, Texas
Sponsored By:
The Shriners Hospital
The National Institutes of Health
American Association of Enchondroma Diseases
March of Dimes Birth Defects Foundation
The Orthopaedic Research Society
The MHE Coalition
Gene Dx, DNA Diagnostic Services
The Mizutani Foundation for Glycoscience
Organizers: Dan Wells, Ph.D., Jacqueline Hecht, Ph.D., Sarah Ziegler
Age Reversal Update from Bill Faloon on December 15th 2020maximuspeto
Â
Bill Faloon of LifeExtension reviews several recent age-reversal topics including the remarkable effects of hyperbaric oxygen on telomere length and senescence in humans and clinical studies designed to assess age-reversal potential of multiple interventions.
CONFERENCE
ON
Multiple Hereditary Exostoses
Insights Into Pathogenesis
November 3-5, 2005
Shriners Hospital of Houston
6977 Main Street
Houston, Texas
and the
Houston Marriott Medical Center
6580 Fannin Street
Houston, Texas
Sponsored By:
The Shriners Hospital
The National Institutes of Health
American Association of Enchondroma Diseases
March of Dimes Birth Defects Foundation
The Orthopaedic Research Society
The MHE Coalition
Gene Dx, DNA Diagnostic Services
The Mizutani Foundation for Glycoscience
Organizers: Dan Wells, Ph.D., Jacqueline Hecht, Ph.D., Sarah Ziegler
Embryonic stem cells â Promises and IssuesTania Jabin
Â
Introduction, Embryonic Stem Cells, Promises of Embryonic Stem cell research, Figure: The Promise of Stem Cell Research, Issues in Embryonic Stem cells - ďź New embryonic stem cell lines from frozen embryos ďź Informed consent for donation of materials for stem cell research ďź Waiver of consent ďź Consent from gamete donors ďź Confidentiality of donor information ďź Ethical concerns about oocyte donation for research (1. Medical risks of oocyte retrieval, 2. Protecting the reproductive interests of women in infertility treatment, 3. Payment to oocyte donors, 4. Informed consent for oocyte donation).
Better cell cultures lower your research costs!-A common Neuromics' theme is harnessing the power of cells. The raw cost of the cells are often the biggest consideration. We encourage our customers to focus on true costs. These include the # number of cells (how many times can they be passaged?), culture viability (how long do the cells live) and bioactivity (how closely do cultures mimic in vivo behavior?). I would like to present a publication and presentation confirms our competitiveadvantage when analyzing true costs.
Ortho: to make straight or right. The use of biologic substances to prompt, stimulate or support a âhealing eventâ within the body.The use of biologic substances to promote healing or reduce pain.The use of platelets and stem cells in treatment and management of musculoskeletal conditions
The Opposing Viewpoint of Stem CellStem cell research explores t.docxoreo10
Â
The Opposing Viewpoint of Stem Cell
Stem cell research explores the nature and growth capabilities of cells essential for ensuring replacement of cells in living organisms (Paddock, 2017). Such cells have an advantage of being manipulated to any type of cells as it is deemed necessary by the scientists based on scarcity or slow rejuvenation process of the natural cells. The general public has largely adopted a reserved approach to stem cell research and therapy despite the positive research and development showcased by leading scientists including;
¡ Jun Takahashi: he explored the safety and applicability of stem cell therapy in primates in relations to the Parkinsonâs disease, recording a major success between the interaction of human cells and animals (Sandoiu). Furthermore, no long-term negative effect was established from the treatment that saw full recovery of the primates.
¡ Hai Nguyen, Aileen Anderson and colleagues: carried a similar exercise on injured mice to record tremendous success of the donor cells in a period ranging immediately after the induction process to at most one month (Society for Neuroscience. 2017).
¡ Scientists from the Cedars-Sinai Heart Institute in Los Angeles CA: highlighted the need for stem therapy in replacing aging heart muscles using rats (Paddock, 2017). The induced cells were able to grow and multiply thus repair the heart muscles of the older rats to improve the general body functioning.
Despite the breathtaking discoveries as tested and presented by these scientists, ethical concerns have prevailed to the dismay of an excited global scientistsâ fraternity. The general public is cautious in its approach to stem cell therapy from various reasons ranging from the potential to cause cancer to how the media overrates the treatment process that still has critical gaps to full implementation (Begley, 2017). There are two major concerns that arise from the Cedars-Sinai Heart Institute research as reported by Paddock. The first concern as perceived by the layman defined as the general public is the fact the findings are based on animals other than human beings. This experiment was purely run on rodent tissue thus raising a legitimate query as to the consistency if replicated in humans. The second concern arises from Paddocks admission that the scientists proposed the need for further research to determine whether the findings are only valid when the donors are young (2017).
Since the same article admits the fact modern day medicine has seen prolonged life with a possibility of the elderly to exceed the children population, such a dependency on young donors may endanger the human species in the long run.
The excitement surrounding Stem Cell Research is magnified through mainstream media that often cares about moving volumes in sales rather than realistically highlight the caution or reservations pronounced by scientists. However, Sharon Begley is exemplary in her revelation of a high-risk gap in research that li ...
Embryonic stem cells â Promises and IssuesTania Jabin
Â
Introduction, Embryonic Stem Cells, Promises of Embryonic Stem cell research, Figure: The Promise of Stem Cell Research, Issues in Embryonic Stem cells - ďź New embryonic stem cell lines from frozen embryos ďź Informed consent for donation of materials for stem cell research ďź Waiver of consent ďź Consent from gamete donors ďź Confidentiality of donor information ďź Ethical concerns about oocyte donation for research (1. Medical risks of oocyte retrieval, 2. Protecting the reproductive interests of women in infertility treatment, 3. Payment to oocyte donors, 4. Informed consent for oocyte donation).
Better cell cultures lower your research costs!-A common Neuromics' theme is harnessing the power of cells. The raw cost of the cells are often the biggest consideration. We encourage our customers to focus on true costs. These include the # number of cells (how many times can they be passaged?), culture viability (how long do the cells live) and bioactivity (how closely do cultures mimic in vivo behavior?). I would like to present a publication and presentation confirms our competitiveadvantage when analyzing true costs.
Ortho: to make straight or right. The use of biologic substances to prompt, stimulate or support a âhealing eventâ within the body.The use of biologic substances to promote healing or reduce pain.The use of platelets and stem cells in treatment and management of musculoskeletal conditions
The Opposing Viewpoint of Stem CellStem cell research explores t.docxoreo10
Â
The Opposing Viewpoint of Stem Cell
Stem cell research explores the nature and growth capabilities of cells essential for ensuring replacement of cells in living organisms (Paddock, 2017). Such cells have an advantage of being manipulated to any type of cells as it is deemed necessary by the scientists based on scarcity or slow rejuvenation process of the natural cells. The general public has largely adopted a reserved approach to stem cell research and therapy despite the positive research and development showcased by leading scientists including;
¡ Jun Takahashi: he explored the safety and applicability of stem cell therapy in primates in relations to the Parkinsonâs disease, recording a major success between the interaction of human cells and animals (Sandoiu). Furthermore, no long-term negative effect was established from the treatment that saw full recovery of the primates.
¡ Hai Nguyen, Aileen Anderson and colleagues: carried a similar exercise on injured mice to record tremendous success of the donor cells in a period ranging immediately after the induction process to at most one month (Society for Neuroscience. 2017).
¡ Scientists from the Cedars-Sinai Heart Institute in Los Angeles CA: highlighted the need for stem therapy in replacing aging heart muscles using rats (Paddock, 2017). The induced cells were able to grow and multiply thus repair the heart muscles of the older rats to improve the general body functioning.
Despite the breathtaking discoveries as tested and presented by these scientists, ethical concerns have prevailed to the dismay of an excited global scientistsâ fraternity. The general public is cautious in its approach to stem cell therapy from various reasons ranging from the potential to cause cancer to how the media overrates the treatment process that still has critical gaps to full implementation (Begley, 2017). There are two major concerns that arise from the Cedars-Sinai Heart Institute research as reported by Paddock. The first concern as perceived by the layman defined as the general public is the fact the findings are based on animals other than human beings. This experiment was purely run on rodent tissue thus raising a legitimate query as to the consistency if replicated in humans. The second concern arises from Paddocks admission that the scientists proposed the need for further research to determine whether the findings are only valid when the donors are young (2017).
Since the same article admits the fact modern day medicine has seen prolonged life with a possibility of the elderly to exceed the children population, such a dependency on young donors may endanger the human species in the long run.
The excitement surrounding Stem Cell Research is magnified through mainstream media that often cares about moving volumes in sales rather than realistically highlight the caution or reservations pronounced by scientists. However, Sharon Begley is exemplary in her revelation of a high-risk gap in research that li ...
Generating a custom Ruby SDK for your web service or Rails API using Smithyg2nightmarescribd
Â
Have you ever wanted a Ruby client API to communicate with your web service? Smithy is a protocol-agnostic language for defining services and SDKs. Smithy Ruby is an implementation of Smithy that generates a Ruby SDK using a Smithy model. In this talk, we will explore Smithy and Smithy Ruby to learn how to generate custom feature-rich SDKs that can communicate with any web service, such as a Rails JSON API.
Elevating Tactical DDD Patterns Through Object CalisthenicsDorra BARTAGUIZ
Â
After immersing yourself in the blue book and its red counterpart, attending DDD-focused conferences, and applying tactical patterns, you're left with a crucial question: How do I ensure my design is effective? Tactical patterns within Domain-Driven Design (DDD) serve as guiding principles for creating clear and manageable domain models. However, achieving success with these patterns requires additional guidance. Interestingly, we've observed that a set of constraints initially designed for training purposes remarkably aligns with effective pattern implementation, offering a more âmechanicalâ approach. Let's explore together how Object Calisthenics can elevate the design of your tactical DDD patterns, offering concrete help for those venturing into DDD for the first time!
Connector Corner: Automate dynamic content and events by pushing a buttonDianaGray10
Â
Here is something new! In our next Connector Corner webinar, we will demonstrate how you can use a single workflow to:
Create a campaign using Mailchimp with merge tags/fields
Send an interactive Slack channel message (using buttons)
Have the message received by managers and peers along with a test email for review
But thereâs more:
In a second workflow supporting the same use case, youâll see:
Your campaign sent to target colleagues for approval
If the âApproveâ button is clicked, a Jira/Zendesk ticket is created for the marketing design team
Butâif the âRejectâ button is pushed, colleagues will be alerted via Slack message
Join us to learn more about this new, human-in-the-loop capability, brought to you by Integration Service connectors.
And...
Speakers:
Akshay Agnihotri, Product Manager
Charlie Greenberg, Host
Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024Tobias Schneck
Â
As AI technology is pushing into IT I was wondering myself, as an âinfrastructure container kubernetes guyâ, how get this fancy AI technology get managed from an infrastructure operational view? Is it possible to apply our lovely cloud native principals as well? What benefitâs both technologies could bring to each other?
Let me take this questions and provide you a short journey through existing deployment models and use cases for AI software. On practical examples, we discuss what cloud/on-premise strategy we may need for applying it to our own infrastructure to get it to work from an enterprise perspective. I want to give an overview about infrastructure requirements and technologies, what could be beneficial or limiting your AI use cases in an enterprise environment. An interactive Demo will give you some insides, what approaches I got already working for real.
The Art of the Pitch: WordPress Relationships and SalesLaura Byrne
Â
Clients donât know what they donât know. What web solutions are right for them? How does WordPress come into the picture? How do you make sure you understand scope and timeline? What do you do if sometime changes?
All these questions and more will be explored as we talk about matching clientsâ needs with what your agency offers without pulling teeth or pulling your hair out. Practical tips, and strategies for successful relationship building that leads to closing the deal.
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
Â
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
DevOps and Testing slides at DASA ConnectKari Kakkonen
Â
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
Key Trends Shaping the Future of Infrastructure.pdfCheryl Hung
Â
Keynote at DIGIT West Expo, Glasgow on 29 May 2024.
Cheryl Hung, ochery.com
Sr Director, Infrastructure Ecosystem, Arm.
The key trends across hardware, cloud and open-source; exploring how these areas are likely to mature and develop over the short and long-term, and then considering how organisations can position themselves to adapt and thrive.
GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using Deplo...James Anderson
Â
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
Securing your Kubernetes cluster_ a step-by-step guide to success !KatiaHIMEUR1
Â
Today, after several years of existence, an extremely active community and an ultra-dynamic ecosystem, Kubernetes has established itself as the de facto standard in container orchestration. Thanks to a wide range of managed services, it has never been so easy to set up a ready-to-use Kubernetes cluster.
However, this ease of use means that the subject of security in Kubernetes is often left for later, or even neglected. This exposes companies to significant risks.
In this talk, I'll show you step-by-step how to secure your Kubernetes cluster for greater peace of mind and reliability.
Transcript: Selling digital books in 2024: Insights from industry leaders - T...BookNet Canada
Â
The publishing industry has been selling digital audiobooks and ebooks for over a decade and has found its groove. Whatâs changed? What has stayed the same? Where do we go from here? Join a group of leading sales peers from across the industry for a conversation about the lessons learned since the popularization of digital books, best practices, digital book supply chain management, and more.
Link to video recording: https://bnctechforum.ca/sessions/selling-digital-books-in-2024-insights-from-industry-leaders/
Presented by BookNet Canada on May 28, 2024, with support from the Department of Canadian Heritage.
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
Â
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...
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Reply to the scientist
1. Response to the The Scientist Article
An article was recently published by the online journal The Scientist. We deplore the low
quality of journalism used in writing this article and would like to provide further
information to interested readers on various points raised by this article.
The articles questioned 1) the effect of endogenous stem cell release on health; 2) the
efficacy of StemEnhance, and 3) the safety of StemEnhance.
Effect of endogenous stem cell release on health
The Scientist quoted a number of scientists stating that the role of adult stem cells in the
body has not reached a consensus among scientists. If a consensus had been reached the
writing of this article by The Scientist would have been obsolete. If a consensus had been
reached there would be no confrontation of ideas to talk about. As with virtually any
development in the history of science, novel ideas are at first supported by little evidence
and are opposed by those involved in more conventional thinking. With time and with
the accumulation of evidence, or lack thereof, ideas grow into a theory or disappear.
The field of adult stem cell research is vast and prolific, and the number of studies
confirming the role of adult stem cells in tissue regeneration is undeniable. Indisputable
demonstration of the role of endogenous stem cell release in health will be made in the
next few years and consensus will be reached, at least on therapeutic applications, which
have already begun. Why The Scientist decided to only report the opinions of scientists
opposing this view is a question to ask the author Kerry Grens. We deplore the
disinformation they offered their own readers. It has been solidly demonstrated that
increasing the number of circulating stem cells can lead to significant health benefits (see
references).
For example a pertinent quote would have been that of Dr. Prentice from Georgetown
University, â[Adult stem cells] have significant capabilities for growth, repair, and
regeneration of damaged cells and tissues in the body, akin to a built-in repair kit or
maintenance crew that only needs activation and stimulation to accomplish repair of
damage. [âŚ] direct stimulation of endogenous stem cells within a tissue may be the
easiest, safest, and most efficient way to stimulate tissue regeneration." (Prentice, 2003)
The efficacy of StemEnhance
The Scientist quoted, among others, Dr. William Frishman from the New York Medical
College in Valhalla as saying, "I would look at this with great, great, great skepticism." It
is unfortunate that The Scientist has put respectable scientists in the position of
expressing an opinion on a product about which they have no knowledge. Why is The
Scientist seeking the opinion of scientists having no knowledge of StemEnhance rather
than scientists having a first hand experience of its clinical use?
2. Before bringing StemEnhance to the marketplace, STEMTech HealthSciences sought the
opinions of experts in the field of stem cell research. We requested opinions on two
specific issues: 1) the role of stem cells in the human body, and 2) the effect of
StemEnhance on stem cells. These scientists did not answer a few questions during a
phone interview; they reviewed the entire scientific literature for relevant studies that
they analyzed in great details. They also reviewed our data and the records of our studies
and laboratory work. They concluded that adult stem cells indeed constituted the natural
renewal system of the body, that more stem cells in the blood indeed supports health.
They further supported the conclusion from the available data that StemEnhance supports
the natural release of stem cells from the bone marrow in safe manner. Independent
clinical research on StemEnhance validating the efficacy of our product has recently been
accepted for publication in a scientific journal.
We could have provided all this information, had the author Kerry Grens asked. Instead,
she chose to offer her readers the opinion of Stephen Barrett at the MLM-Watch, a man
who lost his medical license and whose âtestimony should be accorded little, if any,
credibilityâ, as stated in writing by a Judge of the Superior Court of California. She also
presented as pertinent the opinion of Dale Peterson of the Wellness Clubs of America, a
man who sells dietary supplements on his website and is eager to bring down other
successful providers in order to boost his own sales. We will let the reader draw his own
conclusion as to the professionalism of the journalism offered by The Scientist.
The safety of StemEnhance
Likewise when considering the safety of StemEnhance, the author Kerry Grens elected to
seek the advice of scientists who had no knowledge of the data of StemEnhance. It is
obvious that any respectable scientist who does not have knowledge about a specific
product or plant will err by answering on the cautious side. It seems rather obvious that if
one wants to get a relevant answer about a product one should seek the opinion of
scientists having knowledge and experience with that product. We could have given
Grens the reference of many doctors and clinicians using StemEnhance in their practice.
Furthermore, had she asked STEMTech, we could have provided a copy of a study
showing that consumption of the human equivalent of up to 400 capsules a day led to no
signs of toxicity in mice, including no sign of cancer. Aside from that study, the simple
fact that the raw material from which StemEnhance is made has been safely consumed by
consumers for over 20 years, attests to the safety of StemEnhance.
The Scientist biased approach is indirectly made obvious by the quoted response of
William Frishman from the New York Medical College in Valhalla. Frishman is quoted
saying, âHere [with StemEnhance] you're giving a general stem cell booster. Some
people might have occult malignancies and all of a sudden you're giving them a stem cell
booster." Frishman cannot be blamed for expressing his view, but had he any knowledge
of the mechanism of action of StemEnhance he would have known that it is not a
3. âgeneral stem cell boosterâ but simply a stem cell mobilizer, which has nothing to do
with the stimulation of occult malignancies.
Finally, the author mischaracterized our approach regarding the FDA and clinical trials.
StemEnhance is a dietary supplement and STEMTech HealthSciences has absolutely no
concern about any revocation of its status as a dietary supplement. In order to ensure
long-term supply to the thousands of people who enjoy the health benefits of
StemEnhance, STEMTech HealthSciences has adopted the position of complying in a
very strict and conservative manner with the Dietary Supplement Health and Education
Act of 1994 (DSHEA), the law regulating dietary supplements. The company makes
absolutely no claims about its product beyond the âstructure and functionâ claims
allowed by DSHEA. Our products simply support the natural release of adult stem cells.
We actively monitor the individuals who distribute our product to ensure compliance
with applicable law. If we find anyone making improper claims about our product, we
move swiftly to correct them, and repeat offenders are forced to terminate their
relationship with us.
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