StemFlo is a blend of nutrients shown to improve microvascular function and hemodynamics. A study investigated the effects of StemFlo consumption on fibrinolytic activity and microcirculation. In phase 1, StemFlo improved fibrinolytic parameters like maximum turbidity and lysis time in most volunteers within 2 hours. In phase 2, StemFlo reduced blood pressure in all volunteers over 4 weeks and improved microvascular function parameters in all volunteers. The study concludes that StemFlo likely improves capillary circulation and stem cell migration in most individuals.
Universal Standards for LEI and other Corporate Reference Data: Enabling risk...Paul Houle
Individual Records are supposed be updated yearly, but more than 25% of records have lapsed
LEI records must be updated sooner in response to corporate actions if the GLEIS is to be useful as golden copy reference data inside financial institutions
Needed: real-time, streaming analytics to monitor SIFI, trading and the buildup of systemic risk
LOUs publish records daily, which are concatenated by the LOUS: however, the data on organization types (Corporation, Fund, Trust, etc.), Geographic Regions, Business Registry Numbers, Hierarchy and other fields are often missing or inconsistently represented
Implementing Reference Dataand Corporate Actions in a Blockchain
Universal Standards for LEI and other Corporate Reference Data: Enabling risk...Paul Houle
Individual Records are supposed be updated yearly, but more than 25% of records have lapsed
LEI records must be updated sooner in response to corporate actions if the GLEIS is to be useful as golden copy reference data inside financial institutions
Needed: real-time, streaming analytics to monitor SIFI, trading and the buildup of systemic risk
LOUs publish records daily, which are concatenated by the LOUS: however, the data on organization types (Corporation, Fund, Trust, etc.), Geographic Regions, Business Registry Numbers, Hierarchy and other fields are often missing or inconsistently represented
Implementing Reference Dataand Corporate Actions in a Blockchain
Retrouvez dans cette présentation de Benoît Mouchard, Chef de projet / Consultant Business Intelligence chez Atol des trucs et astuces pour le développement de tableaux de bord Pentaho
AWS re:Invent 2016: Industry Opportunities for AWS Partners: Healthcare, Fina...Amazon Web Services
Take advantage of key trends in healthcare, financial services, and digital media and learn what they mean for your service offerings and technology solutions. For healthcare and life sciences, clearing the compliance hurdle and obtaining customer buy-in to bring HIPAA and GxP workloads on AWS. For financial services, automating security and fast-tracking compliance to generate more business (featuring NICE Actimize + Avoka). For media and entertainment, leading an end-to-end digital transformation story with your media customers and understanding where to apply the AWS platform, Elemental Technologies, and M&E partners to accelerate customer adoption. You gain insight into where to add value with consulting engagements and where to build managed services and SaaS offerings.
AWS re:Invent 2016: How Amazon S3 Storage Management Helps Optimize Storage a...Amazon Web Services
Customers using Amazon S3 at large scale benefit greatly from storage management features. Storage lifecycle policies help them reduce storage costs. Cross-region replication makes it easier to copy data between AWS regions for compliance or disaster recovery. Event notifications allow automatic initiation of processes on objects as they arrive, or capture information about objects and log it for security purposes. In this session, you'll learn about these features, and also several new storage management features in Amazon S3 that give users unmatched visibility into what data they are storing and how that data is being used. These new features make it simpler to analyze usage by users, apps, or organizations, to highlight anomalies, and to optimize business process workflows. They also help identify opportunities to reduce costs, improve performance, and archive infrequently used data. In addition, they can provide insight into who is accessing data stored in S3. As part of this talk, AWS customer Pinterest shows how they have been able to leverage many of the new S3 storage management features to reduce their storage costs significantly by moving a large amount of their data from S3 Standard to S3 Standard – Infrequent Access storage.
Retrouvez dans cette présentation de Benoît Mouchard, Chef de projet / Consultant Business Intelligence chez Atol des trucs et astuces pour le développement de tableaux de bord Pentaho
AWS re:Invent 2016: Industry Opportunities for AWS Partners: Healthcare, Fina...Amazon Web Services
Take advantage of key trends in healthcare, financial services, and digital media and learn what they mean for your service offerings and technology solutions. For healthcare and life sciences, clearing the compliance hurdle and obtaining customer buy-in to bring HIPAA and GxP workloads on AWS. For financial services, automating security and fast-tracking compliance to generate more business (featuring NICE Actimize + Avoka). For media and entertainment, leading an end-to-end digital transformation story with your media customers and understanding where to apply the AWS platform, Elemental Technologies, and M&E partners to accelerate customer adoption. You gain insight into where to add value with consulting engagements and where to build managed services and SaaS offerings.
AWS re:Invent 2016: How Amazon S3 Storage Management Helps Optimize Storage a...Amazon Web Services
Customers using Amazon S3 at large scale benefit greatly from storage management features. Storage lifecycle policies help them reduce storage costs. Cross-region replication makes it easier to copy data between AWS regions for compliance or disaster recovery. Event notifications allow automatic initiation of processes on objects as they arrive, or capture information about objects and log it for security purposes. In this session, you'll learn about these features, and also several new storage management features in Amazon S3 that give users unmatched visibility into what data they are storing and how that data is being used. These new features make it simpler to analyze usage by users, apps, or organizations, to highlight anomalies, and to optimize business process workflows. They also help identify opportunities to reduce costs, improve performance, and archive infrequently used data. In addition, they can provide insight into who is accessing data stored in S3. As part of this talk, AWS customer Pinterest shows how they have been able to leverage many of the new S3 storage management features to reduce their storage costs significantly by moving a large amount of their data from S3 Standard to S3 Standard – Infrequent Access storage.
Epistemic Interaction - tuning interfaces to provide information for AI supportAlan Dix
Paper presented at SYNERGY workshop at AVI 2024, Genoa, Italy. 3rd June 2024
https://alandix.com/academic/papers/synergy2024-epistemic/
As machine learning integrates deeper into human-computer interactions, the concept of epistemic interaction emerges, aiming to refine these interactions to enhance system adaptability. This approach encourages minor, intentional adjustments in user behaviour to enrich the data available for system learning. This paper introduces epistemic interaction within the context of human-system communication, illustrating how deliberate interaction design can improve system understanding and adaptation. Through concrete examples, we demonstrate the potential of epistemic interaction to significantly advance human-computer interaction by leveraging intuitive human communication strategies to inform system design and functionality, offering a novel pathway for enriching user-system engagements.
JMeter webinar - integration with InfluxDB and GrafanaRTTS
Watch this recorded webinar about real-time monitoring of application performance. See how to integrate Apache JMeter, the open-source leader in performance testing, with InfluxDB, the open-source time-series database, and Grafana, the open-source analytics and visualization application.
In this webinar, we will review the benefits of leveraging InfluxDB and Grafana when executing load tests and demonstrate how these tools are used to visualize performance metrics.
Length: 30 minutes
Session Overview
-------------------------------------------
During this webinar, we will cover the following topics while demonstrating the integrations of JMeter, InfluxDB and Grafana:
- What out-of-the-box solutions are available for real-time monitoring JMeter tests?
- What are the benefits of integrating InfluxDB and Grafana into the load testing stack?
- Which features are provided by Grafana?
- Demonstration of InfluxDB and Grafana using a practice web application
To view the webinar recording, go to:
https://www.rttsweb.com/jmeter-integration-webinar
Key Trends Shaping the Future of Infrastructure.pdfCheryl Hung
Keynote at DIGIT West Expo, Glasgow on 29 May 2024.
Cheryl Hung, ochery.com
Sr Director, Infrastructure Ecosystem, Arm.
The key trends across hardware, cloud and open-source; exploring how these areas are likely to mature and develop over the short and long-term, and then considering how organisations can position themselves to adapt and thrive.
UiPath Test Automation using UiPath Test Suite series, part 4DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 4. In this session, we will cover Test Manager overview along with SAP heatmap.
The UiPath Test Manager overview with SAP heatmap webinar offers a concise yet comprehensive exploration of the role of a Test Manager within SAP environments, coupled with the utilization of heatmaps for effective testing strategies.
Participants will gain insights into the responsibilities, challenges, and best practices associated with test management in SAP projects. Additionally, the webinar delves into the significance of heatmaps as a visual aid for identifying testing priorities, areas of risk, and resource allocation within SAP landscapes. Through this session, attendees can expect to enhance their understanding of test management principles while learning practical approaches to optimize testing processes in SAP environments using heatmap visualization techniques
What will you get from this session?
1. Insights into SAP testing best practices
2. Heatmap utilization for testing
3. Optimization of testing processes
4. Demo
Topics covered:
Execution from the test manager
Orchestrator execution result
Defect reporting
SAP heatmap example with demo
Speaker:
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
91mobiles recently conducted a Smart TV Buyer Insights Survey in which we asked over 3,000 respondents about the TV they own, aspects they look at on a new TV, and their TV buying preferences.
PHP Frameworks: I want to break free (IPC Berlin 2024)Ralf Eggert
In this presentation, we examine the challenges and limitations of relying too heavily on PHP frameworks in web development. We discuss the history of PHP and its frameworks to understand how this dependence has evolved. The focus will be on providing concrete tips and strategies to reduce reliance on these frameworks, based on real-world examples and practical considerations. The goal is to equip developers with the skills and knowledge to create more flexible and future-proof web applications. We'll explore the importance of maintaining autonomy in a rapidly changing tech landscape and how to make informed decisions in PHP development.
This talk is aimed at encouraging a more independent approach to using PHP frameworks, moving towards a more flexible and future-proof approach to PHP development.
Connector Corner: Automate dynamic content and events by pushing a buttonDianaGray10
Here is something new! In our next Connector Corner webinar, we will demonstrate how you can use a single workflow to:
Create a campaign using Mailchimp with merge tags/fields
Send an interactive Slack channel message (using buttons)
Have the message received by managers and peers along with a test email for review
But there’s more:
In a second workflow supporting the same use case, you’ll see:
Your campaign sent to target colleagues for approval
If the “Approve” button is clicked, a Jira/Zendesk ticket is created for the marketing design team
But—if the “Reject” button is pushed, colleagues will be alerted via Slack message
Join us to learn more about this new, human-in-the-loop capability, brought to you by Integration Service connectors.
And...
Speakers:
Akshay Agnihotri, Product Manager
Charlie Greenberg, Host
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
Builder.ai Founder Sachin Dev Duggal's Strategic Approach to Create an Innova...Ramesh Iyer
In today's fast-changing business world, Companies that adapt and embrace new ideas often need help to keep up with the competition. However, fostering a culture of innovation takes much work. It takes vision, leadership and willingness to take risks in the right proportion. Sachin Dev Duggal, co-founder of Builder.ai, has perfected the art of this balance, creating a company culture where creativity and growth are nurtured at each stage.
GDG Cloud Southlake #33: Boule & Rebala: Effective AppSec in SDLC using Deplo...James Anderson
Effective Application Security in Software Delivery lifecycle using Deployment Firewall and DBOM
The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
LF Energy Webinar: Electrical Grid Modelling and Simulation Through PowSyBl -...DanBrown980551
Do you want to learn how to model and simulate an electrical network from scratch in under an hour?
Then welcome to this PowSyBl workshop, hosted by Rte, the French Transmission System Operator (TSO)!
During the webinar, you will discover the PowSyBl ecosystem as well as handle and study an electrical network through an interactive Python notebook.
PowSyBl is an open source project hosted by LF Energy, which offers a comprehensive set of features for electrical grid modelling and simulation. Among other advanced features, PowSyBl provides:
- A fully editable and extendable library for grid component modelling;
- Visualization tools to display your network;
- Grid simulation tools, such as power flows, security analyses (with or without remedial actions) and sensitivity analyses;
The framework is mostly written in Java, with a Python binding so that Python developers can access PowSyBl functionalities as well.
What you will learn during the webinar:
- For beginners: discover PowSyBl's functionalities through a quick general presentation and the notebook, without needing any expert coding skills;
- For advanced developers: master the skills to efficiently apply PowSyBl functionalities to your real-world scenarios.
Essentials of Automations: Optimizing FME Workflows with ParametersSafe Software
Are you looking to streamline your workflows and boost your projects’ efficiency? Do you find yourself searching for ways to add flexibility and control over your FME workflows? If so, you’re in the right place.
Join us for an insightful dive into the world of FME parameters, a critical element in optimizing workflow efficiency. This webinar marks the beginning of our three-part “Essentials of Automation” series. This first webinar is designed to equip you with the knowledge and skills to utilize parameters effectively: enhancing the flexibility, maintainability, and user control of your FME projects.
Here’s what you’ll gain:
- Essentials of FME Parameters: Understand the pivotal role of parameters, including Reader/Writer, Transformer, User, and FME Flow categories. Discover how they are the key to unlocking automation and optimization within your workflows.
- Practical Applications in FME Form: Delve into key user parameter types including choice, connections, and file URLs. Allow users to control how a workflow runs, making your workflows more reusable. Learn to import values and deliver the best user experience for your workflows while enhancing accuracy.
- Optimization Strategies in FME Flow: Explore the creation and strategic deployment of parameters in FME Flow, including the use of deployment and geometry parameters, to maximize workflow efficiency.
- Pro Tips for Success: Gain insights on parameterizing connections and leveraging new features like Conditional Visibility for clarity and simplicity.
We’ll wrap up with a glimpse into future webinars, followed by a Q&A session to address your specific questions surrounding this topic.
Don’t miss this opportunity to elevate your FME expertise and drive your projects to new heights of efficiency.
1. StemFlo™ improves vascular functions and hemodynamics
Introduction
The microvasculature (microscopic blood vessels) consists of small arterioles carrying the blood away from the heart to the tissues and venules carrying the blood
away from the tissues back to the heart. Between arterioles and venules are the capillaries where O2 and CO2 exchange take place, as well as nutrient delivery.
A portion of the capillary referred to as the post-capillary venule is a highly significant site for
cellular migration from blood into tissue. It is at the level of the post-capillary venule that stem
cells can migrate out of the blood into tissues. Therefore, it has been suggested that blocking of
capillaries, which hinders blood flow to the post-capillary venules, may reduce migration of stem
cells into tissue. If this hypothesis is correct, then it follows that the removal of obstructions in the
microvascular system, particularly the capillaries, may facilitate stem cell migration into tissues.
Certain nutritional and nutraceutical interventions were shown to support improvement of
peripheral vascular function. For example, a fibrinolytic enzyme extracted from the fermented soy
cheese ‘Natto’, called Nattokinase, was shown to increase plasma fibrinolytic activity of the blood
and to promote lysis of blood clot after induced thrombosis. Consumption of Nattokinase prior to
long-haul flights (7-8 hours) was shown to prevent venous thrombosis in humans, as well as edema.
Similar effects have been reported with other fibrinolytic enzymes such as Serrapeptase extracted
from the enterobacteria Serratia E15.
Antioxidant nutrition can also improve micro-circulation. Transformation of fibrinogen into fibrin
involves activation of sialidase enzyme by reactive oxygen species. Once activated, sialidase would
mesh can be triggered through the so-called Bradford-Allen Coagulation Pathway. This pathway
Figure 1
cleave sialic caps on fibrinogen disulfide bridges, triggering the agglomeration of fibrin monomers into fibrin mesh. Antioxidant supplementation has also been
shown to indirectly favor vascular improvement due to a reduction of inflammatory conditions.
Therefore optimal blood circulation in the microvasculature, which is essential for optimal migration of stem cells into tissues, can be achieved by:
• Digesting fibrin mesh in the blood by consumption of fibrinolytic enzymes such as Nattokinase and Serrapeptase, and
• Reducing oxidative stress and inflammation by antioxidant nutrition, which prevents the formation of fibrin mesh.
StemFlo™, a blend of Nattokinase, Serrapeptase, and antioxidant nutrition including berry extracts, mangosteen, curcumin, and cat’s claw was investigated to see
if consumption of this product could lead to any measurable improvements in vascular function and hemodynamics.
Methods & Results
In brief, the study was comprised of two independent phases using a total of 19 volunteers. The first phase was a short-term study that investigated the fibrinolytic
capacity of blood samples obtained immediately before and within 2 hours after consumption of StemFlo. The second phase was a long-term investigation (4
weeks) of the effect of StemFlo on microvascular functions.
PHASE 1
The short-term phase was carried using 12 volunteers. Blood samples taken before (T0) as well as 1 hour (T1) and 2 hours (T2) after consumption of StemFlo.
Blood samples were prepared and then pipetted into a pre-warmed 96-well U-bottom plate where blood clots were induced by the addition of CaCl2. The plate was
placed in a pre-warmed 37°C microplate optical reader, where the turbidity caused by the formed clot was read at 405nm. Lysis of the clot by fibrinolytic enzymes
present in the plasma was followed by measuring the turbidity of the sample over the next 29 hours, with readings every 7 minutes.
2. We examined four different parameters, as described in the below:
• Maximum turbidity;
• Time to maximum turbidity (TM);
• Slope during optimal clot lysis;
• Lysis Time, i.e. the time to reach a plateau with no further clot lysis.
Maximum
Turbidity
Slope
Time
to
Max
Lysis
Time
Maximum Turbidity: Maximum turbidity is the time point at which the clot reaches
its most dense state, causing the highest turbidity and absorbance
to baseline (T0). This being said, it
is important to mention that in cases of very low baseline fibrinolytic activity, the formation of larger clots may lead to
reading. If StemFlo results in an improved fibrinolytic capacity of the blood, then the Maximum Turbidity readings at T1 and T2 would be reduced compared
reduced turbidity, as smaller clots agglomerate into larger clots. Eight of the 12 volunteers showed a reduction in clot formation after consuming StemFlo. Of
these, seven showed improved fibrinolytic capacity already after one hour.
Time to Max: Time to Max is the amount of time it takes to reach maximum turbidity, and consequently the time it takes before initiation of fibrinolysis.
If StemFlo consumption increases the fibrinolytic capacity, blood samples taken after consumption should show a reduced TM. Nine of the 12 volunteers
showed an improved fibrinolytic capacity, as seen by a reduced Time to Max.
Slope: Slope was determined by linear regression analysis on the area of the curve defined by the estimated Time to Max data point and the estimated
Lysis Time point. If a volunteer did not have a clearly identifiable Lysis Time, the slope was estimated on the curve to the right of Time to Max, based upon
which linear regression analysis was performed. Based on the slope analysis, 100 % of the volunteers showed improved fibrinolytic capacity after StemFlo
consumption. Five volunteers showed the most improvement at T1, while seven volunteers showed the most improvement at T2.
Lysis Time: The Lysis Time is the amount of time it takes to dissolve an artificially made clot. Lysis Time can be determined as the start of a plateau phase
after a significant drop from the Maximum Turbidity. Nine of the 12 volunteers showed improved (i.e. shorter) Lysis Times after consumption of StemFlo.
While six volunteers showed maximum improvement at 1 hour after consumption, 3 volunteers showed greatest improvement at 2 hours after consumption.
the effect of stress from a blood draw on the readings. Eight of the 12 volunteers showed lower systolic blood pressure 2
The blood pressure and heart rate of all volunteers were taken before and after the study. These readings were taken prior to the first blood draw and prior
hours after StemFlo consumption.
Overall average change in systolic blood pressure in all volunteers was -4%.
to the last blood draw, to minimize
PHASE 2
microvascular function. Ankle-brachial index was determined using Laser Doppler and
was used to quantified Post Occlusive Reactive Hyperemia (PORH),
Seven volunteers with some minor vascular problems (varicose veins, circulatory complaints) were recruited. Vascular assessment was performed at study
start, and after 2 and 4 weeks of StemFlo consumption, and involved measurement of blood pressure, ankle-brachial index (bilateral), and assessment of
while assessment of microvascular function was made through the measurement of transcutaneous oxygen pressure (tcpO2).
3. Blood pressure
Consumption of StemFlo over a period of 4 weeks led to healthier blood pressure in all volunteers, as shown by a reduced systolic pressure. Overall, average
change in systolic blood pressure after 4 weeks was -7%.
Post Occlusive Reactive Hyperemia (PORH)
PORH is a test whereby a limb, arm or leg, is deprived of oxygen for four minute using a pressure cuff, and then fluctuations in blood flow is quantified
immediately after releasing the pressure cuff. Laser Doppler data is analyzed using a PORH analysis software (PeriFlux 5000, PeriMed, Stockholm, Sweden).
The vascular system is subject to many types of immediate physiological regulation to maintain relatively constant blood pressure, temperature, oxygen
supply, and blood perfusion. The health of the microvasculature can be assessed by looking at a number of parameters. Time to recovery (TR) is the time it
takes for blood flow to reach baseline level after the occlusion is released. Time to half before hyperemia (TH1) is the time it takes after the release of the
occlusion for perfusion to reach the midpoint between no-flow and peak flow. Time to Max (TM) is the time it takes after the release of the occlusion for
perfusion to reach peak flow. Time to half after hyperemia (TH2) is the time it takes after the release of the occlusion, post-hyperemia, for perfusion to reach
the midpoint between peak flow and baseline.
Consumption of StemFlo over a period of 4 weeks led to improvements in microvascular functions in all volunteers. Improvements in TM and TH2 were seen
in all volunteers with decrease of 31% and 40%, respectively. Improvements in TR and TH1 were seen in some of the volunteers.
Discussion
StemFlo is a combination of fibrinolytic enzymes and antioxidant nutrition aimed at improving blood circulation in small capillaries. Improvement in fibrinolytic
activity of the plasma was shown to be significant in all participants when measured 1 and 2 hours after consumption. Reducing the presence of fibrin in the
blood, which increases the volume of the overall blood vasculature by providing greater access to capillaries, would be expected to reduce overall blood pressure. As
expected, blood pressure was reduced (-4%) in half of the participants 2 hours after consumption and in all participants (-7%) after 4 weeks of daily consumption.
In this study, actual circulation in small capillaries was assessed using post Occlusion Reactive Hyperemia (PORH). Using this method, two of the four parameters
measured (TM and TH2) were improved in all participants whereas the other two parameters were improved in only half the participants.
Overall, consumption of StemFlo led to improvements of at least one parameter in every participant and of most parameters in nearly half of the participants.
Therefore, we can conclude that consumption of StemFlo is likely to improve capillary circulation in most individuals, supporting the migration of stem cells into
tissues, as well as the delivery of nutrients and oxygen throughout the body.