STAT 3 protein plays a role in cross-talk between immune cells and keratinocytes in psoriasis. STAT3 is activated by cytokines and growth factors and activates transcription of target genes. In psoriasis, dendritic cells and T cells are activated, forming an immunological synapse that triggers keratinocyte proliferation, altered differentiation, and angiogenesis through cytokine and chemokine release. Plasmacytoid dendritic cells accumulate in pre-psoriatic skin and secrete interferon-α early in disease formation, triggering autoimmune inflammation and psoriasis development.

1. STAT 3 Protein & Immuno Competent Cells Cross Talks in Psoriasis M.YOUSRY ABDEL-MAWLA,MD Zagazig Faculty of Medicine,Egypt .

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54. Roles of IL-23 on T Helper 17 cells in Chronic Inflammation in Psoriasis Adapted from Iwakura & Ishigame, J Clin Invest 116:1218-1222 (2006) Dendritic cell Macrophage IL-23 IL-12 Th1 Th17 IFN  IL-1, IL-6 TNF Inflammatory response Endothelial cells Stromal cells Epithelial cells Fibroblasts Macrophage IL-17, IL-6 IL-1 IL-6 IL-8 TNF IL-12R IL-23R IL-23R

57. Toll like Receptor (TLR) in Th17 -mediated Autoimmune Inflammation ( Goriely S, Neurath M, Goldman M, Nature Rev Immunol 2007 ) IL-23 IL-12 IL-27 TLR3 TLR2 Th1 Th1 Th17 IFN-  Autoimmune Inflammation polyI : C PGN IFN- 

69. A Tender Piece of Information

71. Studies on Stat 3 in Psoriasis

72. Stat 3 in Psoriasis

76. Manipulation of Psorasis

78. Therapeutic Targets in Psoriasis As a T Helper 17 Cell-Mediated Disease

79. Anti TNF approved for psoriasis treatment JEADV 2010, 24 (Suppl. 5), 2–24

86. Current Rheumatology Reports 2007 , 9:461–467

89. Future Psoriasis Therapy ( Wippel-Slupetzky&Stingl Curr Probl Dermatol., 2009, 38, : 172–189 )

90. Future Psoriasis Therapy ( Wippel-Slupetzky&Stingl Curr Probl Dermatol., 2009, 38, : 172–189 )

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