This presentation explains how we intend to generate a Gene Therapy tool to cure the neurodegenerative disease Huntington’s disease (HD). Our work is aimed at the creation of Herpes Simplex Virus type1 (HSV) -based vectors as potential therapy for HD. The results of our experiments will indicate 1) which step of the synthesis pathway of the neuroprotective hormone melatonin is impaired in HD cells, and 2) if restoring, or even increasing, levels of melatonin endogenously produced in HD cell can have a neuroprotective effect.