This document discusses the factors that cause spoilage in perishable foods. It outlines three main classes of foods based on their susceptibility to spoilage: non-perishable, semi-perishable, and perishable. The main causes of spoilage are biological factors like microbes and enzymes, and biochemical factors like the food's characteristics and storage conditions. Microbial spoilage can be caused by bacteria, yeasts, molds, insects, parasites, and rodents. The optimal conditions for microbial growth like temperature, oxygen levels, moisture, and duration of storage are described. Mechanical damage during handling can also introduce points of entry for microbes.