This document discusses spleen ultrasonography, including common indications such as splenomegaly, suspected malignancy, or liver disease. It describes the preparation, positioning, and sonographic appearance of a normal spleen during the procedure. The patient should fast for several hours beforehand and lie supine or on their right side. A normal spleen has a uniform, homogenous echo pattern that is slightly less echogenic than the liver but more echogenic than kidney tissue, with a smooth outer convexity and possibly indented inner margin.