This document discusses the nature of sound and how it is produced and travels. It defines sound as vibration that the human ear can detect. It explains that sound needs a medium, like air, to travel and describes how sound vibrations travel through the air to reach the ear, where they cause the eardrum and other structures to vibrate to enable hearing. It explores the characteristics of sound waves, including amplitude, which determines loudness, and frequency, which determines pitch. It also discusses sound production in humans and musical instruments. Finally, it covers noise pollution and its health impacts.
Q1 LESSON 1
YOU NOW HAVE A PRETTY GOOD POWERPOINT OF YOUR MUSIC 6. I EVEN PUT THERE THE MELC FOR WEEK 1. YOU CAN REMOVE THE LOGO AND ANYTHING THERE. DON'T FORGET TO PUT YOUR SOURCES :)
Q1 LESSON 1
YOU NOW HAVE A PRETTY GOOD POWERPOINT OF YOUR MUSIC 6. I EVEN PUT THERE THE MELC FOR WEEK 1. YOU CAN REMOVE THE LOGO AND ANYTHING THERE. DON'T FORGET TO PUT YOUR SOURCES :)
this is a notes of sound for class 8 students. this will help you to revise the chapter very quickly. recap is also included in this.
with the help of pictures you will be able to understand it quickly.
Anything that moves back and forth makes sound. Moving back and forth is called vibrating. Pluck a guitar string and watch it vibrate back and forth. The vibrations make sound waves.
Sound by gaurav Sound by gaurav Sound by gaurav ghankhedeSound by Sound by gaurav Sound by gaurav ghankhede Sound by gaurav Sound by gaurav Sound by gaurav ghankhedeSound by gaurav ghankhede
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
2. Sound is a form of energy which produces a
sensation of hearing in our ears. There are
also other forms of energy like mechanical
energy, heat energy, light energy etc.
Sound plays an important role in our life. It
helps us to communicate with one another.
We hear a variety of sounds in our
surroundings.
4. Touch the school bell when not in use. What do
you feel? Again touch it when producing sound.
Can you feel it vibrating?
The to and fro or back and forth motion of an
object is termed as Vibration.
When a tightly stretched band is plucked, it
vibrates and produces sound.
When it stops vibrating, it does not produce any
sound.
5. We see that a vibrating object produces sound.
In some cases, the vibrations are easily visible to
us.
But in most cases, their amplitude is so small
that we cannot see them. However, we can feel
them.
Many of you might have seen the manjira
(cymbals), the ghatam, and the noot (mudpots)
and the kartal.
These instruments are commonly used in many
parts of our country.
These musical instruments are simply beaten or
struck.
7. Speak loudly for a while or sing a song, or buzz
like a bee. Put your hand on your throat like this
in the picture given below.
8. In humans, the sound is produced by the
voice box or the larynx.
Put your fingers on the throat and find a
hard bump that seems to move when you
swallow.
This part of the body is known as the voice
box. It is at the upper end of the windpipe.
Two vocal cords, are stretched across the
voice box or larynx in such a way that it
leaves a narrow slit between them for the
passage of air.
10. When the lungs force air through the slit, the
vocal cords vibrate, producing sound.
Muscles attached to the vocal cords can make
the cords tight or loose.
When the vocal cords are tight and thin, the
type or quality of voice is different from that
when they are loose and thick.
The vocal cords in men are about 20mm long.
In women these are about 5mm shorter.
Children have very short vocal cords.
This is the reason why the voices of men,
women and children are different.
11. When you call up your friend who is standing at
a distance, your friend is able to hear your voice.
How does the sound travel to her?
Can you think of an explanation? Is it possible
that the decreasing amount of air in the tumbler
had something to do with decreasing loudness
of the ring?
Indeed, if you had been able to suck all the air in
the tumbler, the sound would stop completely.
12. Actually, sound needs a medium to travel.
When air has been removed completely from
a vessel, it is said that there is vacuum in the
vessel.
The sound cannot travel through vacuum.
Sound can travel through solids, gases,
liquids.
It is no so easy to hear sound in liquids. But
we can hear.
Sound can
travel through
solids.
13. The shape of the outer part of the ear is like a
funnel. When sound enters in it, it travels down
a canal at the end of which a thin membrane is
stretched tightly.
It is called the eardrum. It performs an
important function.
The eardrum is like a stretched rubber sheet.
Sound vibrations make the eardrum vibrate .
The eardrum sends vibrations to the inner ear.
From there, the signal goes to the brain. That is
how we hear.
15. We have learnt that the to and fro motion of an
object is known as vibration. This motion is also
called oscillatory motion.
We have already learnt in earlier classes about
the oscillatory motion and its time period.
The number of oscillations per second is called
the frequency of oscillation. Frequency is
expressed in hertz.
Its symbol is Hz. A frequency of 1 Hz is one
oscillation per second.
16. We can recognize many familiar sounds
without seeing the objects producing them.
How is it possible?
These sounds must be different to enable you
to recognize them. Have you ever thought
what factors make them different?
Amplitude and frequency are two important
properties of any sound.
Now we can differentiate sounds on the basis
of their amplitude and frequencies.
17. Activity
Take a metallic tumbler and a tablespoon. Strike
the tablespoon gently at the brim of the tumbler.
Hear the sound produced. Now bang the spoon
on the tumbler and hear the sound produced
again. Now suspend a small thermocole ball
touching the rim of the tumbler Vibrate the
tumbler by striking it. See how far the ball is
displaced. The displacement of the ball is a
measure of the amplitude of vibration of the
tumbler.
18. Now, strike the tumbler gently and then with
some force. Compare the amplitudes of
vibrations of the tumbler in the two cases.
Thermocole ball
touching the
vibrating glass
tumbler
19. Loudness of sound is proportional to the square
of the amplitude of the vibration producing the
sound.
For example, if the amplitude becomes twice,
the loudness increases by a factor of 4.
The loudness is expressed in a unit called
decibel (dB).
Normal breathing 10 dB
Soft whisper (at 5m) 30 dB
Normal conversation 60 dB
Busy traffic 70 dB
Average factory 80 dB
20. The loudness of sound depends on its amplitude.
When the amplitude of vibration is large, the sound
produced is loud.
When the amplitude is small, the sound produced
is feeble.
Compare the sound of a baby with that of an adult.
Is there any difference? Even if two sounds are
equally loud, they differ in some way.
The frequency determines the shrillness or pitch of
a sound. If the frequency of vibration is higher we
say that the sound is shrill and has a higher pitch. If
the frequency of vibration is lower, we say that the
sound has a lower pitch. For example, a drum
vibrates with a low frequency.
22. Therefore, it produces a low-pitched sound. On
the other hand, a whistle has a high frequency
and therefore, produces a sound of higher pitch.
A bird makes a high-pitched sound whereas a
lion makes a low-pitched roar. However, the roar
of a lion is very loud while the sound of the bird is
quite feeble.
Every day you hear the voices of children and
adults. Do we find any difference in their voices?
Can we say that the frequency of the voice of a
child is higher than that of an adult? Usually the
voice of a woman has a higher frequency and is
shriller than that of a man.
23. We know that we need a vibrating body for the
production of sound. Can we hear the sound of
all vibrating bodies?
The fact is that sounds of frequencies less than
about 20 vibrations per second (20 Hz) cannot
be detected by the human ear.
Such sounds are called inaudible.
On the higher side, sounds of frequencies
higher than about 20,000 vibrations per second
(20 kHz) are also not audible to the human ear.
Thus, for human ear, the range of audible
frequencies is roughly from 20 to 20,000 Hz.
24. We hear different types of sounds around us. Is
the sound always pleasing?
Does a sound sometimes cause discomfort to
you? Some sounds are pleasant to the ear,
whereas some are not. Suppose construction
work is going on in your neighborhood. Are the
sounds coming from the construction site
pleasing?
Do you enjoy the sounds produced by horns of
buses and trucks? Such unpleasant sounds are
called noise.
25. We enjoy sounds from musical instruments.
Musical sound is one which is pleasing to
the ear.
Sound produced by a harmonium is a
musical sound. The string of a sitar also
gives out a musical sound.
If the sound gets so loud will it be called
music?
No, it would known as noise.
26. You already know about air pollution. Presence
of unwanted gases and particles in air is called
air pollution.
Similarly, presence of excessive or unwanted
sounds in the environment is called noise
pollution.
Major causes of noise pollution are sounds of
vehicles, explosions including bursting of
crackers, machines, loudspeakers etc.
27. Television and transistor radio at high volumes,
some kitchen appliances, desert coolers, air
conditioners, all contribute to noise pollution.
We know that presence of excessive noise in the
surroundings may cause many health related
problems. Lack of sleep, hypertension (high
blood pressure), anxiety and many more health
disorders may be caused by noise pollution.
A person who is exposed to a loud sound
continuously may get temporary or even
permanent impairment of hearing.
28. To control noise, we must control the sources of
noise.
For this, silencing devices must be installed in air
craft engines, transport vehicles, industrial
machines and home appliances.
How can the noise pollution be controlled in a
residential area?
The noisy operations must be conducted away from
any residential area.
Noise producing industries should be set up away
from such areas. Use of automobile horns should be
minimized.
29. TV and music systems should be run at low
volumes.
Trees must be planted along the roads and around
buildings to cut down on the sounds reaching the
residents, thus reducing the harmful effects of
noise pollution.