We created the innovator in suspicious order monitoring software. Our SOMLink is backed by 16 defensible algorithms and equips companies with the necessary tools to monitor and catch all orders of interest for prescription drugs. SOMLink is a suite of tools that uses statistical analysis to comply with Federal DEA 1301.74b regulation for controlled substances. SOMLink can be installed as a software or controlled in the cloud, and installs easily on the DEA's Registrant server for maximum compliance.
Pharma Blockchain Bootcamp presented by DisruptiveRx took place on November 16, 2016 in Edison, NJ. The event is the first to exclusively address #blockchain applications within the #pharmaceutical enterprise.
The MediLedger - Blockchain solutions for Pharma companiesrobinruet
The MediLedger Project is a collaboration between Chronicled and The LinkLab, bringing together expertise in both Pharmaceutical Supply Chain and Blockchain technologies. Our intention is to advance the dialogue of a blockchain utility to enhance Pharma companies’ ability to manage their supply chains.
From Surveillance to Service Excellence - Big Data in Financial ServicesRob Rensman
Regulatory compliance has become a drain on many FS organisations’ capital investment programmes. Some of the emerging surveillance and reporting issues will likely be solved using big data technologies. It would appear beneficial if the same technologies and infrastructure could be used to solve wider business growth and performance issues. This could help jump-start some of those business improvement programmes that may have been mothballed due to lack of demonstrable ROI. This presentation focuses on the merits of creating a ubiquitous advanced analytics platform that will serve both the business and the regulator, without the need for large, upfront investment programmes.
Are SSAE 16 Data Center Problems Impacting Customers? (SlideShare)SP Home Run Inc.
http://DataCenterLeadGen.com Are SSAE 16 Data Center Problems Impacting Customers? (SlideShare). An SSAE 16 data center offers compliance to customers, but of which kind? Find out why giving the wrong assurances could be costly for all parties. Copyright (C) SP Home Run Inc. All worldwide rights reserved.
Webinar | GDPR: How Can Content Services Help You Comply?Nuxeo
The General Data Protection Regulation comes into force on May 2018 and is poised to disrupt how organizations manage and use consumer information.
Aiming at establishing trust with customers, employees and citizens and giving more control over their data, this regulation may dramatically impact the manner in which organizations capture, manage, archive, distribute, and dispose of content.
With the threat of substantial financial penalties for non-compliance (up to 20M€ or 4% annual global revenue), it’s time to act!
With a comprehensive plan in place well in advance, your organization will be able to ensure compliance with the new rules in a timely manner.
Discover :
- What is GDPR and how it will impact your organization
- The compliance checklist
- How a Content Services Platform like Nuxeo can help you comply with GDPR
Pharma Blockchain Bootcamp presented by DisruptiveRx took place on November 16, 2016 in Edison, NJ. The event is the first to exclusively address #blockchain applications within the #pharmaceutical enterprise.
The MediLedger - Blockchain solutions for Pharma companiesrobinruet
The MediLedger Project is a collaboration between Chronicled and The LinkLab, bringing together expertise in both Pharmaceutical Supply Chain and Blockchain technologies. Our intention is to advance the dialogue of a blockchain utility to enhance Pharma companies’ ability to manage their supply chains.
From Surveillance to Service Excellence - Big Data in Financial ServicesRob Rensman
Regulatory compliance has become a drain on many FS organisations’ capital investment programmes. Some of the emerging surveillance and reporting issues will likely be solved using big data technologies. It would appear beneficial if the same technologies and infrastructure could be used to solve wider business growth and performance issues. This could help jump-start some of those business improvement programmes that may have been mothballed due to lack of demonstrable ROI. This presentation focuses on the merits of creating a ubiquitous advanced analytics platform that will serve both the business and the regulator, without the need for large, upfront investment programmes.
Are SSAE 16 Data Center Problems Impacting Customers? (SlideShare)SP Home Run Inc.
http://DataCenterLeadGen.com Are SSAE 16 Data Center Problems Impacting Customers? (SlideShare). An SSAE 16 data center offers compliance to customers, but of which kind? Find out why giving the wrong assurances could be costly for all parties. Copyright (C) SP Home Run Inc. All worldwide rights reserved.
Webinar | GDPR: How Can Content Services Help You Comply?Nuxeo
The General Data Protection Regulation comes into force on May 2018 and is poised to disrupt how organizations manage and use consumer information.
Aiming at establishing trust with customers, employees and citizens and giving more control over their data, this regulation may dramatically impact the manner in which organizations capture, manage, archive, distribute, and dispose of content.
With the threat of substantial financial penalties for non-compliance (up to 20M€ or 4% annual global revenue), it’s time to act!
With a comprehensive plan in place well in advance, your organization will be able to ensure compliance with the new rules in a timely manner.
Discover :
- What is GDPR and how it will impact your organization
- The compliance checklist
- How a Content Services Platform like Nuxeo can help you comply with GDPR
Managing The Risk of Open Payments - Validate Spend Report Before CMS Submissionqordata
This presentation is meant to help you understand how you, as a pharmaceutical company, can protect yourself from risks of audit and fines even before you submit your final report to CMS.
By passively analyzing your wire data, ExtraHop provides deep visibility into HL7 messages, Citrix performance, EHR behavior, ICD-10 conversion, and more.
Proactive monitoring and remediation
Optimization and continuous improvement
Pervasive security monitoring and compliance
Clinical and operations analytics
Getting IDMP Ready via Modern Product Data ManagementCognizant
For life sciences and pharma companies, compliance with the identification of medicinal products (IDMP) mandate is best achieved by building on an existing IDMP-compliant data management platform that can integrate all product master data.
Watch here: https://bit.ly/2D1fqB6
Today’s evolving data landscape has spawned new business challenges that require innovative solutions. These challenges include:
- Strategic decision-making, which relies on multiple perspectives such as social and economic factors that require combining internal and external data.
- Accounting for the increased volume and structural complexity of today’s data, and increased frequency required in delivering data assets.
- Coping with data silos that house data that must be combined and provisioned to support decision-making.
- Exposing purpose-built analytics, such as supply chain, for consumption in order to expedite decision-making.
Attend this session to learn how Data as a Service, fueled by data virtualization, overcomes these common challenges from the three dimensions of:
- Provisioning information-rich external data assets,
- Connecting data silos, and
- Enabling pre-built and packaged analytics.
Enterprise Data World Webinar: Mastering & Referencing Data for the EnterpriseDATAVERSITY
Developing and implementing a master record and reference data through a best practice approach and lessons learned for your organization’s data business needs. The ability to leverage the immense data available across an organization has become paramount for continued growth and success. Companies need accessible and reliable information to make more informed and effective business decisions across channels while continuing to provide quality service to their customers. Many companies recognize the need to develop a Master Data Program, as part of an overall Data Strategy initiative, to consistently manage the quality, data interoperability, accessibility, and availability of core data (e.g., customer, product). Determining where to start, finding business opportunities, defining what master data management means in your organization, and addressing the cultural and political realities are all critical to make your master data program successful and valuable. This seminar will present real world approaches used for successfully implementing a Master Data Domain and program from several organization cases including Walgreens.
TrustArc Webinar - Unlock the Power of AI-Driven Data DiscoveryTrustArc
Effective data discovery is crucial for maintaining compliance and mitigating risks in today's rapidly evolving privacy landscape. However, traditional manual approaches often struggle to keep pace with the growing volume and complexity of data.
Join us for an insightful webinar where industry leaders from TrustArc and Privya will share their expertise on leveraging AI-powered solutions to revolutionize data discovery.
You'll learn how to:
- Effortlessly maintain a comprehensive, up-to-date data inventory
- Harness code scanning insights to gain complete visibility into data flows leveraging the advantages of code scanning over DB scanning
- Simplify compliance by leveraging Privya's integration with TrustArc
- Implement proven strategies to mitigate third-party risks
Our panel of experts will discuss real-world case studies and share practical strategies for overcoming common data discovery challenges. They'll also explore the latest trends and innovations in AI-driven data management, and how these technologies can help organizations stay ahead of the curve in an ever-changing privacy landscape.
The Drug Quality and Security Act adds additional requirements that are causing pharmaceutical companies to adjust their serialization strategies and implementation timelines.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
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Managing The Risk of Open Payments - Validate Spend Report Before CMS Submissionqordata
This presentation is meant to help you understand how you, as a pharmaceutical company, can protect yourself from risks of audit and fines even before you submit your final report to CMS.
By passively analyzing your wire data, ExtraHop provides deep visibility into HL7 messages, Citrix performance, EHR behavior, ICD-10 conversion, and more.
Proactive monitoring and remediation
Optimization and continuous improvement
Pervasive security monitoring and compliance
Clinical and operations analytics
Getting IDMP Ready via Modern Product Data ManagementCognizant
For life sciences and pharma companies, compliance with the identification of medicinal products (IDMP) mandate is best achieved by building on an existing IDMP-compliant data management platform that can integrate all product master data.
Watch here: https://bit.ly/2D1fqB6
Today’s evolving data landscape has spawned new business challenges that require innovative solutions. These challenges include:
- Strategic decision-making, which relies on multiple perspectives such as social and economic factors that require combining internal and external data.
- Accounting for the increased volume and structural complexity of today’s data, and increased frequency required in delivering data assets.
- Coping with data silos that house data that must be combined and provisioned to support decision-making.
- Exposing purpose-built analytics, such as supply chain, for consumption in order to expedite decision-making.
Attend this session to learn how Data as a Service, fueled by data virtualization, overcomes these common challenges from the three dimensions of:
- Provisioning information-rich external data assets,
- Connecting data silos, and
- Enabling pre-built and packaged analytics.
Enterprise Data World Webinar: Mastering & Referencing Data for the EnterpriseDATAVERSITY
Developing and implementing a master record and reference data through a best practice approach and lessons learned for your organization’s data business needs. The ability to leverage the immense data available across an organization has become paramount for continued growth and success. Companies need accessible and reliable information to make more informed and effective business decisions across channels while continuing to provide quality service to their customers. Many companies recognize the need to develop a Master Data Program, as part of an overall Data Strategy initiative, to consistently manage the quality, data interoperability, accessibility, and availability of core data (e.g., customer, product). Determining where to start, finding business opportunities, defining what master data management means in your organization, and addressing the cultural and political realities are all critical to make your master data program successful and valuable. This seminar will present real world approaches used for successfully implementing a Master Data Domain and program from several organization cases including Walgreens.
TrustArc Webinar - Unlock the Power of AI-Driven Data DiscoveryTrustArc
Effective data discovery is crucial for maintaining compliance and mitigating risks in today's rapidly evolving privacy landscape. However, traditional manual approaches often struggle to keep pace with the growing volume and complexity of data.
Join us for an insightful webinar where industry leaders from TrustArc and Privya will share their expertise on leveraging AI-powered solutions to revolutionize data discovery.
You'll learn how to:
- Effortlessly maintain a comprehensive, up-to-date data inventory
- Harness code scanning insights to gain complete visibility into data flows leveraging the advantages of code scanning over DB scanning
- Simplify compliance by leveraging Privya's integration with TrustArc
- Implement proven strategies to mitigate third-party risks
Our panel of experts will discuss real-world case studies and share practical strategies for overcoming common data discovery challenges. They'll also explore the latest trends and innovations in AI-driven data management, and how these technologies can help organizations stay ahead of the curve in an ever-changing privacy landscape.
The Drug Quality and Security Act adds additional requirements that are causing pharmaceutical companies to adjust their serialization strategies and implementation timelines.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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2. About Us
Founded in 1999 e-SupplyLink has been supporting the Life Sciences
Industry with innovative and efficiency-driven software solutions. In 2010
with the launch of SOMLink we presented one of the first Suspicious Order
Monitor (SOM) offerings on the market to assist our clients in complying with
the Controlled Substances Act and the DEA's “Know your customer” policy.
Other compliance solutions:
ComplyLink - B2B shipping system that bolts on to existing EDI or
Warehouse Management System.
3. McKesson fined $150M / Kaiser Permanente fined $850K (one
phamacist) / Safeway fined $3m
Over 12 million people in the US use prescription drugs for non-
medical purposes.
Approximately 15% of doctors and nurses self-medicate and
abuse prescription drugs.
There are 13,539 (1 every hour) newborns addicted to prescription
drugs each year in the US.
In 2009, Medicaid paid over $720M to cover the cost of treating
these drug-addicted babies.
It is estimated that opioid analgesic abuse results in over $72
billion in medical costs each year.
`
The Drug Abuse Problem
4. Who must comply with 21 CFR 1301.74b?
DEA Registrant Manufacturers, Distributors, Importers
& Exporters of any Controlled Substance (1301.11a)
“The registrant shall design and operate a system to
disclose to the registrant suspicious orders of
controlled substances.”
Suspicious Orders are described as “deviating substantially in
size, frequency, or pattern.”
Suspicious Order Monitoring
5. What is SOMLink?
SOMLink is a suite of tools that uses statistical analytics
that comply with the DEA 21 CFR 1301.74b regulations
which are designed to alert and flag suspicious orders
that flow through your order management system.
SOMLink also acts as a historical repository of your
investigative actions on orders of interest. This data is
easily accessible to defend against an DEA audit.
6. About SOMLink
⦿ Commercially available since 2010
⦿ Oversight from current DEA consultants and
statistical analysts.
⦿ Embedded Statistical and Comparative Engine.
⦿ NDC - Drug Family cross reference
⦿ Repository for recording investigation notes
⦿ Thresholds
● Analysis and loading of data - “Know your Customer “
⦿ Customizable
● Integration
● Extendable and scalable
● Comparison of pharmacies of similar size and volume in similar
geographic locations
● Affordable
7. SOMLink Environment
⦿Systems / Platforms
● Linux, Windows Servers, Series I*
● SQL Server, Oracle*,
⦿Order Management Integration
○ SAP
○ JD Edwards
○ Ross ERP
○ Others
8. SOMLink Features
⦿Available as software (behind firewall) or in the
Cloud
⦿Easy to use Dashboard
● Administrative Level
● Ability to address outstanding “Orders of Interest” quickly and
efficiently.
⦿Integration
● Database, XML, Web Service, Text Files.
● SSIS, Altova and others.
⦿Deployment
● Behind client's firewall: Secure, data stays in client’s control.
⦿Reporting
● XSLT Reporting
● Altova Stylevision
⦿Multi-Company / Multi-division support
9. SOMLink Performance
Please Note:
SOMLink performance varies depending on the following:
● Available Hardware
● How many validation tests are turned on
● Configuration settings, i.e. Peer Review, Threshold
● Total Number of Orders
● Total Number of Order Lines
Configurations
Total Number of Analytical Tests - 6
Thresholds : ON
Total Number of Orders : 665,696
Total Number of Order Lines : 13,986,273
Average Lines per order : 27.8
Platform
Windows 2008 Server
SQL 2008 R2 Standard Edition
Machine: Dual quad-Xeon (E5520, 2.27GHz), 24 Gigs of
RAM
Web Server: OC4J
10. SOMLink Audit Support
⦿Historical Repository - One place to go
● Notes - cannot be deleted once entered
● Attachments
○ emails
○ internal docs
○ correspondence with customer
⦿Historical Repository access
● Dashboard Search
○ Order
○ Customer/ DEA Registrant
○ Date
● Report engine - Altova XSLT Report Writer
11. Additional DEA/SOM Services
⦿ SOM Onsite Assessment
⦿ Pharmacy Site Reviews- Onsite or Longitude
⦿ SOP Review & Comment
⦿ Training
⦿ New Account Investigations
⦿ Best Industry Practices- “Know your customer”
12. Summary
⦿ Balanced oversight and support from both a
regulatory (current DEA consultants) and a
operational (statistical analysts) perspective.
⦿ Available in software or in the Cloud
⦿ Embedded Statistical and Comparative Engine.
⦿ NDC - Drug Family cross reference
⦿ Repository for recording investigation notes
⦿ Thresholds
● Analysis and loading of data - “Know your Customer “
⦿ Customizable
● Integration
● Extendable and scalable
● Affordable
⦿ Personalized Customer Service- Team execution to
insure efficiency and timely delivery
13. SOMLink
Suspicious Order Monitoring Solution
Questions / Next Steps
Call or email us to get started with e-SupplyLink
(231) 933-7212 or sales@e-supplylink.com
Todd LaBonte, CEO, Solution Architect
