This document outlines a study that used qualitative research to understand women's experiences with smoking cessation support during pregnancy in Oldham, England. The results showed conflicting influences around stopping smoking and engaging with services. Researchers then developed an evidence-based strategy to address smoking in pregnancy using a heuristic model based on the study findings. The strategy aimed to increase promotion of smoking cessation and engagement with prenatal services.
Healthcare interventions to promote and assist tobacco cessation: a review of...Georgi Daskalov
Healthcare interventions to promote and assist tobacco cessation: a review of efficacy, effectiveness and affordability for use in national guideline development
Healthcare interventions to promote and assist tobacco cessation: a review of...Georgi Daskalov
Healthcare interventions to promote and assist tobacco cessation: a review of efficacy, effectiveness and affordability for use in national guideline development
Using telehealth to accelerate biomedical HIV preventionYTH
Telemedicine is a collection of means or methods for enhancing health care, public health and health education delivery and support using telecommunications technologies. With more than 95% of adults, and 100% of young adults between the age of 18-29 owning a cell phone in the United States, a technology-based health intervention can be available to hard-to-reach populations or underserved areas.
Panelists will engage a rich dialogue and showcase innovative and effective ways to create prevention programs for HIV and STDs using the potential telehealth can offer, specifically with linking young people to HIV pre-exposure prophylaxis, or PrEP. This plenary brings together leaders in the field of HIV prevention, research and policy along with private organizations and companies that are currently active on the field of biomedical prevention.
Using telehealth to accelerate biomedical HIV preventionYTH
Telemedicine is a collection of means or methods for enhancing health care, public health and health education delivery and support using telecommunications technologies. With more than 95% of adults, and 100% of young adults between the age of 18-29 owning a cell phone in the United States, a technology-based health intervention can be available to hard-to-reach populations or underserved areas.
Panelists will engage a rich dialogue and showcase innovative and effective ways to create prevention programs for HIV and STDs using the potential telehealth can offer, specifically with linking young people to HIV pre-exposure prophylaxis, or PrEP. This plenary brings together leaders in the field of HIV prevention, research and policy along with private organizations and companies that are currently active on the field of biomedical prevention.
JSI Presentation; By Lora Shimp; April 2015. This presentation illustrates the Newborn Tracking and Monitoring of Infant Vaccination Status using My Village My Home (MVMH: Malawi). MVMH is a community based new born tracking tool to identify and track all infants in a community recording infant vaccination dates. MVMH is linked with the REC approach (4th and 5th elements) empowering community leaders and volunteers to engage with caretakers on health promotion specific to vaccinating their children, as well as, taking ownership in the success of the immunization progress.
Txt 2 Stop: Mobile Phone-Based Smoking Cessation SupportLIDC
A randomised controlled trial of mobile phone-based smoking cessation support. A presentation delivered by Cari Free, of the London School of Hygiene and Tropical Medicine, at the London International Development Centre on 9 October 2009.
Highlights of the USAID Uganda STAR-EC project. STAR-EC worked to increase access, coverage, and use of quality comprehensive TB and HIV and AIDS services in east and central Uganda. Presentation made at STAR-EC End-of-Project Conference, in Jinja, Uganda, August 2016.
As part of the 2014 European Antibiotic Awareness Day, an online pledge system was launched in the UK to increase people’s commitment to reduce Anti-microbial Resistance (AMR).The aim of this evaluation was to determine whether the Antibiotic Guardian (AG) campaign improved AMR awareness and behaviour.
Antibiotic Guardian Birmingham Workshop4 All of Us
Antibiotic resistance is one of the biggest threats facing us today!
European Antibiotic Awareness Day (EAAD) is part of the UK 5 Year Antimicrobial Resistance Strategy 2013 to 2018, which focuses on antibiotics and sets out actions to slow the development and spread of antimicrobial resistance.
This year, to run in line with EAAD; Public Health England has established the Antibiotic Guardian pledge campaign. It calls on everyone in the UK, the public and healthcare community to become antibiotics guardian by choosing one simple pledge about how they will make better use of these vital medicines.
To ensure that the information and knowledge on Antibiotic Stewardship is disseminated to those practising healthcare across the nation, a series of awareness and educational events have been developed. These educational workshop events, to be held in Leeds, Birmingham and London, will provide guidance, resources and information for practitioners on topics associated with antibiotic awareness. The events will provide an opportunity to understand how you and your organisation can support combat the global challenge faced by antibiotic resistance whilst gaining advice, support and resources to inform patients and staff.
In these slides, I briefly outline how the Internet is changing healthcare by empowering the consumer and the e-patient. We look at data and examples from the USA and Europe, and consider the impact of ratings websites, online health records, and the way in which doctors are responding to the e-patient.
Using telehealth to accelerate biomedical HIV preventionYTH
Telemedicine is a collection of means or methods for enhancing health care, public health and health education delivery and support using telecommunications technologies. With more than 95% of adults, and 100% of young adults between the age of 18-29 owning a cell phone in the United States, a technology-based health intervention can be available to hard-to-reach populations or underserved areas.
Panelists will engage a rich dialogue and showcase innovative and effective ways to create prevention programs for HIV and STDs using the potential telehealth can offer, specifically with linking young people to HIV pre-exposure prophylaxis, or PrEP. This plenary brings together leaders in the field of HIV prevention, research and policy along with private organizations and companies that are currently active on the field of biomedical prevention.
Using telehealth to accelerate biomedical HIV preventionYTH
Telemedicine is a collection of means or methods for enhancing health care, public health and health education delivery and support using telecommunications technologies. With more than 95% of adults, and 100% of young adults between the age of 18-29 owning a cell phone in the United States, a technology-based health intervention can be available to hard-to-reach populations or underserved areas.
Panelists will engage a rich dialogue and showcase innovative and effective ways to create prevention programs for HIV and STDs using the potential telehealth can offer, specifically with linking young people to HIV pre-exposure prophylaxis, or PrEP. This plenary brings together leaders in the field of HIV prevention, research and policy along with private organizations and companies that are currently active on the field of biomedical prevention.
JSI Presentation; By Lora Shimp; April 2015. This presentation illustrates the Newborn Tracking and Monitoring of Infant Vaccination Status using My Village My Home (MVMH: Malawi). MVMH is a community based new born tracking tool to identify and track all infants in a community recording infant vaccination dates. MVMH is linked with the REC approach (4th and 5th elements) empowering community leaders and volunteers to engage with caretakers on health promotion specific to vaccinating their children, as well as, taking ownership in the success of the immunization progress.
Txt 2 Stop: Mobile Phone-Based Smoking Cessation SupportLIDC
A randomised controlled trial of mobile phone-based smoking cessation support. A presentation delivered by Cari Free, of the London School of Hygiene and Tropical Medicine, at the London International Development Centre on 9 October 2009.
Highlights of the USAID Uganda STAR-EC project. STAR-EC worked to increase access, coverage, and use of quality comprehensive TB and HIV and AIDS services in east and central Uganda. Presentation made at STAR-EC End-of-Project Conference, in Jinja, Uganda, August 2016.
As part of the 2014 European Antibiotic Awareness Day, an online pledge system was launched in the UK to increase people’s commitment to reduce Anti-microbial Resistance (AMR).The aim of this evaluation was to determine whether the Antibiotic Guardian (AG) campaign improved AMR awareness and behaviour.
Antibiotic Guardian Birmingham Workshop4 All of Us
Antibiotic resistance is one of the biggest threats facing us today!
European Antibiotic Awareness Day (EAAD) is part of the UK 5 Year Antimicrobial Resistance Strategy 2013 to 2018, which focuses on antibiotics and sets out actions to slow the development and spread of antimicrobial resistance.
This year, to run in line with EAAD; Public Health England has established the Antibiotic Guardian pledge campaign. It calls on everyone in the UK, the public and healthcare community to become antibiotics guardian by choosing one simple pledge about how they will make better use of these vital medicines.
To ensure that the information and knowledge on Antibiotic Stewardship is disseminated to those practising healthcare across the nation, a series of awareness and educational events have been developed. These educational workshop events, to be held in Leeds, Birmingham and London, will provide guidance, resources and information for practitioners on topics associated with antibiotic awareness. The events will provide an opportunity to understand how you and your organisation can support combat the global challenge faced by antibiotic resistance whilst gaining advice, support and resources to inform patients and staff.
In these slides, I briefly outline how the Internet is changing healthcare by empowering the consumer and the e-patient. We look at data and examples from the USA and Europe, and consider the impact of ratings websites, online health records, and the way in which doctors are responding to the e-patient.
Smoking is the single largest preventable cause of foetal and infant morbidity in UK including miscarriage
The baby can incur long-term disability as a result or born prematurely.
Other health related on the mother include lung cancer and heart disease
This poster was presented at the 45th Union World Conference on Lung Health in 2014. It outlines the interim findings of a study that tests behaviour change interventions aimed at lung health patients in Nepal
RESEARCH ARTICLELong term effect of primary health care.docxrgladys1
RESEARCH ARTICLE
Long term effect of primary health care
training on HIV testing: A quasi-experimental
evaluation of the Sexual Health in Practice
(SHIP) intervention
Kamla Pillay
1
, Melissa Gardner
2,3
, Allon Gould
4
, Susan Otiti
5
, Judith Mullineux
6
,
Till Bärnighausen
7,8,9,10
, Philippa Margaret Matthews
11,12*
1 Homerton Hospital, London, United Kingdom, 2 Sexual Health in Practice Community Interest Company,
London, United Kingdom, 3 Killick Street Health Centre, London, United Kingdom, 4 Whipps Cross Hospital,
London, United Kingdom, 5 Public Health, London Borough of Haringey, London, United Kingdom, 6 Sexual
Health Promotion, Birmingham, United Kingdom, 7 Africa Health Research Institute, Somkhele, South Africa,
8 Institute of Public Health, Heidelberg University, Heidelberg, Germany, 9 Infection and Population Health,
University College London, London, United Kingdom, 10 Department of Global Health and Population,
Harvard T.H. Chan School of Public Health, Boston, United States of America, 11 Division of Infection and
Immunity, University College London, London, United Kingdom, 12 Africa Health Research Institute,
Somkhele, South Africa
* [email protected]
Abstract
Background
To examine the effect of Sexual Health in Practice (SHIP) training for general practitioners
(GPs) on HIV testing rates in Haringey, a deprived area of London, UK, with a population of
over 250,000 and HIV prevalence of 0.7% (in 2014). SHIP is an educational intervention
delivering peer-developed and peer-led face-to-face training to improve quality of sexual
and reproductive health (SRH) care.
Methods
We carried out a quasi-experimental study of intervention effects across 52 GP practices
(2008–2016). We used time variation in SHIP intervention exposure for effect estimation,
controlling for practice and calendar month fixed effects in panel analysis. From 2008–2010,
baseline data were collected, and in the subsequent six-year period, 78 GPs in Haringey
(approximately 40% of all GPs) were SHIP trained. 46 Haringey practices (of 52) had at
least one trained doctor. Outcome measures were monthly HIV tests and results by practice
(obtained from the hospital laboratories).
Results
SHIP significantly increased HIV testing; for every GP trained, practice HIV testing rates
increased by 16% (testing rate ratio (TRR) 1.16, 95% confidence interval (CI) 1.05–1.28,
p value 0.004). This significant effect was demonstrated using an 8-year observation period,
PLOS ONE | https://doi.org/10.1371/journal.pone.0199891 August 1, 2018 1 / 13
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OPEN ACCESS
Citation: Pillay K, Gardner M, Gould A, Otiti S,
Mullineux J, Bärnighausen T, et al. (2018) Long
term effect of primary health care training on HIV
testing: A quasi-experimental evaluation of the
Sexual Health in Practice (SHIP) intervention. PLoS
ONE 13(8): e0199891. https://doi.org/10.1371/
journal.pone.0199891
.
Running head NURSING RESEARCH 1NURSING RESEARCH 7.docxglendar3
Running head: NURSING RESEARCH 1
NURSING RESEARCH 7
Nursing Research
Student's Name
Institutional Affiliation
Nursing research
Obesity and Weight Management Programs
Introduction to the Problem
The problem under investigation in this research is the issue of obesity and weight management. This topic was selected because it the issues is affecting many people today around the world and most significantly in the United States. Thousands of people worldwide are dying from obesity and overweight related illnesses such as diabetes, cancer, high blood pressure among many others (Obesity & weight control: Health risks, weight loss & bariatric surgery, n.d.). Therefore, it has a huge impact on the healthcare system since it has increased the problems that healthcare professionals and facilities are facing. Hospitals are now congested mainly due to diet related illnesses, obesity being at the top of the list, which causes short staffing due to the increasing patients numbers relative to providers’ numbers. The providers, especially nurses, may then suffer from burnout and thus affecting the quality of care that they provide. Several weight management programs have then been created in order to tackle the serious problem of obesity. Therefore, conducting a proper research on obesity and weight management programs is very crucial since it will help in providing in-depth understanding of the whole issue and thus useful in developing and implementing ways that can curb the problem by proper implementation of these programs. This will improve the conditions of healthcare facilities and eventually the quality of care provided.
The Problem
The problem is obesity and weight management programs. Obesity is a medical condition that occurs when an individual has excess body fat or weight that might have some significant effect on his or her health (Hu, 2008). On the other hand, weight management is the process of embracing long-term lifestyle modification to keep a healthy body weight on depending on the age, gender, and height of an individual. They include methods such as eating heathy food and increasing the levels of physical activity. Weight management programs are then the initiatives that are created in controlling the weight of individuals in order to control such conditions as obesity. Managing one’s weight through these programs is very important part of their health because they avoid being overweight and obese to reduce the risks of medical conditions such as heart disease, diabetes, high blood pressure and stroke. The intake of diet considered unhealthy, lack of physical exercise and practicing unhealthy lifestyles such as too much intake of alcohol, smoking may lead to increase in weight, and thus a person is considered overweight. This is when the body contains too much body fat above the required amount. Obesity then occurs after being overweight when the calorie intake of a person goes higher than the amount of energy that .
Running head NURSING RESEARCH 1NURSING RESEARCH 7.docxtodd581
Running head: NURSING RESEARCH 1
NURSING RESEARCH 7
Nursing Research
Student's Name
Institutional Affiliation
Nursing research
Obesity and Weight Management Programs
Introduction to the Problem
The problem under investigation in this research is the issue of obesity and weight management. This topic was selected because it the issues is affecting many people today around the world and most significantly in the United States. Thousands of people worldwide are dying from obesity and overweight related illnesses such as diabetes, cancer, high blood pressure among many others (Obesity & weight control: Health risks, weight loss & bariatric surgery, n.d.). Therefore, it has a huge impact on the healthcare system since it has increased the problems that healthcare professionals and facilities are facing. Hospitals are now congested mainly due to diet related illnesses, obesity being at the top of the list, which causes short staffing due to the increasing patients numbers relative to providers’ numbers. The providers, especially nurses, may then suffer from burnout and thus affecting the quality of care that they provide. Several weight management programs have then been created in order to tackle the serious problem of obesity. Therefore, conducting a proper research on obesity and weight management programs is very crucial since it will help in providing in-depth understanding of the whole issue and thus useful in developing and implementing ways that can curb the problem by proper implementation of these programs. This will improve the conditions of healthcare facilities and eventually the quality of care provided.
The Problem
The problem is obesity and weight management programs. Obesity is a medical condition that occurs when an individual has excess body fat or weight that might have some significant effect on his or her health (Hu, 2008). On the other hand, weight management is the process of embracing long-term lifestyle modification to keep a healthy body weight on depending on the age, gender, and height of an individual. They include methods such as eating heathy food and increasing the levels of physical activity. Weight management programs are then the initiatives that are created in controlling the weight of individuals in order to control such conditions as obesity. Managing one’s weight through these programs is very important part of their health because they avoid being overweight and obese to reduce the risks of medical conditions such as heart disease, diabetes, high blood pressure and stroke. The intake of diet considered unhealthy, lack of physical exercise and practicing unhealthy lifestyles such as too much intake of alcohol, smoking may lead to increase in weight, and thus a person is considered overweight. This is when the body contains too much body fat above the required amount. Obesity then occurs after being overweight when the calorie intake of a person goes higher than the amount of energy that .
Running head NURSING RESEARCH 1NURSING RESEARCH 7.docxcheryllwashburn
Running head: NURSING RESEARCH 1
NURSING RESEARCH 7
Nursing Research
Student's Name
Institutional Affiliation
Nursing research
Obesity and Weight Management Programs
Introduction to the Problem
The problem under investigation in this research is the issue of obesity and weight management. This topic was selected because it the issues is affecting many people today around the world and most significantly in the United States. Thousands of people worldwide are dying from obesity and overweight related illnesses such as diabetes, cancer, high blood pressure among many others (Obesity & weight control: Health risks, weight loss & bariatric surgery, n.d.). Therefore, it has a huge impact on the healthcare system since it has increased the problems that healthcare professionals and facilities are facing. Hospitals are now congested mainly due to diet related illnesses, obesity being at the top of the list, which causes short staffing due to the increasing patients numbers relative to providers’ numbers. The providers, especially nurses, may then suffer from burnout and thus affecting the quality of care that they provide. Several weight management programs have then been created in order to tackle the serious problem of obesity. Therefore, conducting a proper research on obesity and weight management programs is very crucial since it will help in providing in-depth understanding of the whole issue and thus useful in developing and implementing ways that can curb the problem by proper implementation of these programs. This will improve the conditions of healthcare facilities and eventually the quality of care provided.
The Problem
The problem is obesity and weight management programs. Obesity is a medical condition that occurs when an individual has excess body fat or weight that might have some significant effect on his or her health (Hu, 2008). On the other hand, weight management is the process of embracing long-term lifestyle modification to keep a healthy body weight on depending on the age, gender, and height of an individual. They include methods such as eating heathy food and increasing the levels of physical activity. Weight management programs are then the initiatives that are created in controlling the weight of individuals in order to control such conditions as obesity. Managing one’s weight through these programs is very important part of their health because they avoid being overweight and obese to reduce the risks of medical conditions such as heart disease, diabetes, high blood pressure and stroke. The intake of diet considered unhealthy, lack of physical exercise and practicing unhealthy lifestyles such as too much intake of alcohol, smoking may lead to increase in weight, and thus a person is considered overweight. This is when the body contains too much body fat above the required amount. Obesity then occurs after being overweight when the calorie intake of a person goes higher than the amount of energy that .
Budget RESEARCHBudget Template - page 1 of 2GRANT(For Internal Use.docxAASTHA76
Budget RESEARCHBudget Template - page 1 of 2GRANT(For Internal Use Only - see specific sponsoringTitle:Union County of Georgia cancer prevention programagency for the proper forms)Date:12-May-17RFA no.PI:Project Period:2017/2018Budget Period:2017-2018Year 1Field researchResearch assitants( Salaries & benefits)250,000Transport120,000Research tools( questionaires and interviews)50,000420,000Screening actvitiesLocal hospital staff service fees80,000Electricity consumed by equipment20,000Maintenace expenses40,000140,000MarketingNutrionists service fees150,000Local gym service15,000Formation of chamber fo commerce180,000Education workshops ( schools and community centers)50,000395,000
pasterme:
rate as of 7/1/05
subject to change
confirm with the SPH
Business Office
pasterme:
part-time student rate as of 7/1/04 subject to change confirm with the SPH Business Office
pasterme:
rate subject to change Please review all budgets with the SPH
Business Office.
Running head: COMMUNITY COALITION 1
COMMUNITY COALITION 3
Community Coalition
Kimberly Crawford
Kaplan University
January 8, 2018
Community Coalition
1. Choose 5 partnerships to engage and explain why you would invite each of these people//organizations to be a part of the coalition.
The creation of community health promotion and education programs takes into consideration several agencies or parties who help in the achievement of the desired health goals. Each of the partners will address its roles using different approaches depending on their area of expertise. This is an important factor to consider as different institutions address health promotion using different approaches and perspectives. The overall outcome from the contribution of every partner should be able to restore and promote the physical, emotional, spiritual, psychological, and social wellness of the community in relation to the health issue being suffered (Minelli, & Breckon, 2009). Chronic diseases are currently the leading causes of death in the community due to their complexity and the severe effects on human health. The community health promotion and education program will be provided by the ‘Health Concerns Coalition’ which will be made up of the following partners; community religious groups, Cancer Supportive Care Foundation, an association of cancer-survivor patients, nutritional organizations, and the local authority.
1. Cancer Supportive Care Foundation – This is an important part of the coalition as it will offer technical expertise in education and diagnosis of chronic diseases. The foundation team will include medical experts who will diagnose the community members of any chronic illnesses. Examinations for diseases such as breast cancer, prostate cancer, diabetes and blood pressure will be conducted by this partner as they will provide modern machines needed for the diagnosis of chronic illnesses.
2. Community religious groups – Community religious groups ca ...
Pushing it up the Agenda: Promoting the Importance of Physical Activity amongst Pregnant Women by Smith R Examines in Physical Medicine and Rehabilitation
A study on drug utilisation evaluation of Bronchodilators using defined daily...Dr. Afreen Nasir
Conference proceeding: Nasir A. A study on drug utilisation evaluation of Bronchodilators using a defined daily dose method. Pharmacy Education Journal [Internet]. 2023 Aug;23(5):23–24. Available from: https://doi.org/10.46542/pe.2023.235.138
NOTES FOR TWO MORE RESEARCH ARTICLES1The Effe.docxkendalfarrier
NOTES FOR TWO MORE RESEARCH ARTICLES 1
The Effects of Smoking on Lung Cancer Rates among Adults in New York
Pulla Rao Uppatala
MSc in Computer Science, King Graduate School
KG 604: Graduate Research & Critical Analysis
Dr. Aditi Puri
14 Nov 2022
New Research Article 1
Who: The assessment of cost-utility analysis of lung cancer screening and the paybacks on integrating smoking cessation interventions was performed by Villanti et al.
Why: This study aimed to assess whether LDCT screening for lung cancer among commercially insured individuals between 50 and 64 years at high risk for this disorder is turning out to be cost-effective. The authors also strived to quantify the extra payback of integrating smoking cessation solutions within lung cancer screening programs.
When: The authors analyzed their study in 2012 assuming that all existing smokers and half of the prior smoker population aged between 50 and 64 years were eligible for screening, with the minimum being set at least thirty packs –years of smoking.
Where: The researchers used data from National Health Interview Survey on cigarette smoking conditions for individuals between 45 and 64 years who were making 30% of active smokers across the United States at the time. The cancer treatment costs were acquired from New York's taxpayer database, which provided information including physician, hospital, drug and ancillary costs eligible for insurer reimbursement.
How: The authors used qualitative research methods to build up on the prior simulation model to determine the utility cost of yearly, recurring LDCT screenings for the last 15 years within an assumed high-risk population of 18 million adults aged between 50 and 64 years. It specifically involved those who have consumed over 30 packs within their smoking history. The authors' findings indicate that the recurring yearly lung cancer screening within the high-risk population has been effective. Providing smoking cessation strategies within the yearly screening program has increased the cost-effectiveness of the disorder by between 40 and 45%.
New Research Article 2
Who: The study on Using a smoking cessation quitline to promote lung cancer screening was performed by Sharma et al.
Why: The goal of their study was to compare two alternatives to dispense information concerning lung cancer screening. This included a quitline, a mailed brochure pinned with in-depth messaging facilitated by a quitline coach. Therefore, the authors focused on assessing the strategy that will be effective and have a significant impact on the participants searching for information about lung cancer screening. The authors thus hypothesized that the individuals who received the brochure would repo.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
1. Developing Evidence based Strategy to tackle Smoking in Pregnancy using views of Service Users Research(Need to increase sizeof top left quadranti.e. promote stop smoking and increase engagement with service) Strategy (Operationaldetails developed from stakeholder views)
2. Women’s Experience of Smoking Cessation Support during Pregnancy A Modi,1 L Wilkins,1 B Hanratty2 1. NHS Oldham 2. University of Liverpool a.modi@nhs.net
3. Qualitative research was carried outto assess the experiences of women who smoked during pregnancy of the stop smoking support in Oldham Results showed there were conflicting influences around stopping smoking and engaging with services The slide shows how original research can be used to develop a strategy to address smoking in pregnancy Clear focussed message
4. The heuristic model on the left, shows the findings of the research representing conflicting influences This suggests that promoting stopping smoking and engaging with pregnant women who smoke would reduce the proportion of women who smoke one needs to make the upper left quadrant larger This was used to develop the strategy as shown in the chart on the right of the slide Pleasing to the eye
5. The research report was sponsored by the Primary Care Trust to develop their strategy to address smoking in pregnancy The report was disseminated and presented to the various stakeholders The resultant strategy was evidence based and centred around the service user Potential to aid decision making
6. Qualitatively assess the population's heath needs allows development of effective action Assess the evidence relating to the effectiveness of health interventions, programmes and services, and apply this to improve services Influence the development of policies Public Health Research Public Health competencies