Human hehehrhjjdjyldyodyldyodtisydgxgxtddydtskstdoydoydotdoydkydlyddydydylyoyddkrs is a good twits do d d sytkyxx up with a different one who is really well and has an easy to use for her and a very well done and a very useful one and a good friend of mine who is very keen to help me in a better way in the meantime I will have her own a home and will home next weekend with her and her husband in the afternoon and Sunday afternoon for a dinner few days back and y a few beers and some of the other people we had were a bit more relaxed than we were and the fact we had a birthday party on Friday evening at least a few couple drinks with the kids but we did a few friends with her friends last night as they all were friends with her friends and family who friends and friends who were friends and loved friends with their parents who are in really great good school with their children in school who are in school now with their children so we can get a little bit out of her right away from but she has
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5cl-adba precursor (semi finished )
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ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
Skeletalmuscles.pptx
1. 1) Describe the distinguishing characteristics
of the different muscle tissues
2) Discuss the organization of skeletal muscle
3) Explain the micro-anatomy of a skeletal
muscle fiber
4) Describe the fascicle arrangement in
different types of muscle
5) Review general muscle terminology
Ch 9: Skeletal Muscle Tissue
and Organization
main objectives:
2. Muscle tissue vs. Muscle as an organ
One of the 4
primary tissue
types
How many
subtypes?
Made up of _____
tissue types.
> 700 skeletal
muscles
Word roots:
sarco
mys
3. Function of Skeletal Muscles
1. Skeletal movement
2. Posture and body position
3. Support of soft tissues
4. Guarding of entrances & exits
5. Maintenance of body temperature
5. Epi-, Peri-, and Endomysium
Are interwoven - Go over into tendon
Distinguish between:
Tendon
Aponeurosis
Ligament
Function:
Protection
Blood supply
Innervation
Fig 9-1
6. Nerve and Blood Vessel Supply
Skeletal muscles are rich in nerves
and blood vessels
Chemical communication at Synapsis
(neuromuscular junction)
Synaptic terminal of axon meets motor end
plate of muscle cell
Coiled capillaries are able to adapt to
changes in length of muscle fiber
Fig 9-2
7. Microanatomy of Skeletal Muscle Fibers
Some vocabulary:
Skeletal muscle fiber or
myofiber
Sarcolemma
Sarcoplasm
Sarcoplasmic reticulum
Myofibril
Myofilaments
Fig 9-3
9. Sarcomeres
Thick and Thin Filaments are organized in
repeating functional units = ______
Each myofibril has linear arrangement of
~ 10,000 sarcomers
Banded appearance (striation) due to arrangement
of thick and thin filaments
Interaction of thick and thin filaments
responsible for skeletal muscle fiber contraction
13. Some Myoblasts do not fuse satelite cells in endomysium
regeneration of muscle
Development of Myofibers from
Myoblasts
14. Motor Units
= All muscle fibers that are controlled by a
single motor neuron
The lower the ratio of muscle fibers to neurons,
the more precise the movement can be!
Few cases 1: 1 relationship. Where?
Most cases: many muscle fibers (up to
2,000) : 1 motor neuron. Where? Fig 9-12
15. Muscle Control
Muscle tone = Resting tension of skeletal
muscles (continuous contraction of some motor units to
maintain some muscle tension)
Recruitment or Multiple motor unit
summation
Maximal tension production: ?
16. Muscle Hypertrophy vs. Atrophy
Hypertrophy due to anaerobic exercise
Leads to increased muscle size - how?
Atrophy if supply of myofilaments exceeds
demand. Muscle fibers become smaller and
weaker.
Eventual death of muscle fibers is irreversible!
Importance of Physical Therapy
17. Three Types of Muscle Fibers
1) Fast (or White) Fibers
Fast contraction after nervous stimulation
Large diameter
large glycogen reserve
few mitochondria
densely packed myofibrils
Fatigue fast due to mainly anaerobic
respiration
18. 2) Slow (or Red) Fibers
Slower but continuous contraction for
extended periods
Smaller diameter (~ half)
contain myoglobin
more capillaries
more mitochondria
Do not fatigue as fast due to ?
Fig 9-13
19. 3) Intermediate Fibers
Have attributes inbetween fast and slow
types
Most skeletal muscles contain mixture of
fiber types. Proportion of fast to slow depends
on ___________?
One motor unit only contains one fiber type
Eye, hand: ____ fibers dominate
Back, calf: ____ fibers dominate
20. Organization of Skeletal Muscle Fibers
Effect of individual muscle contraction
determined by:
1. arrangement of muscle fibers
2. way of attachment to skeletal system
Bundles of muscle fibers =
Muscle fibers within 1 fascicle are parallel
4 types of fascicle organization
28. Grouping of Muscles according to
Primary Action
Agonist = Prime Mover
Antagonist (action opposes agonist)
Synergists = Assistants of prime mover
29. Naming of skeletal Muscles
Orientation of fibers
Size & shape
Location
Action
Origin & / or insertion
Specific features
Use muscle name to help identify its location,
appearance and function!