The document proposes a simulation design for blood cell separation using molecular dynamics. It discusses previous works on blood separation techniques and molecular dynamics simulations. The proposed design uses normal and drag forces calculated through molecular dynamics and the Euler algorithm to simulate cell movement. Experimental validation is still needed to tune the system and determine the fluid flow velocity profile in complex channel geometries like junctions. The source code for the simulation is available online.
An elegant and rich premier global platform for the International Conference on Healthcare and Clinical Gerontology (ICHCG) that uniquely describes the Academic research and development across globe.
Get conference alerts on upcoming conferences, meetings, seminars, workshops and other associated events in Sleep Disorders sector in 2019/2020. AllConferenceAlert, trusted conference listing platform for academicians, industries & conference organizers, offers you complete details such as conference name, date, venue, organizer details, conference agenda & call to submit research papers at one place.
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An elegant and rich premier global platform for the International Conference on Healthcare and Clinical Gerontology (ICHCG) that uniquely describes the Academic research and development across globe.
Get conference alerts on upcoming conferences, meetings, seminars, workshops and other associated events in Sleep Disorders sector in 2019/2020. AllConferenceAlert, trusted conference listing platform for academicians, industries & conference organizers, offers you complete details such as conference name, date, venue, organizer details, conference agenda & call to submit research papers at one place.
You can further segregate all conferences and scientific events in Sleep Disorders by country, state, city, month & dates too. With more than 100,000 registered subscribers, AllConferenceAlert is the ultimate platform for PHD students, research scholars, researchers, academic professionals and industry peers to find relevant conferences/events important to them.
Find detailed list of recent & upcoming international conferences, events, seminars, webinars, and workshops in Skin Conditions & Beauty in 2019/2020, only on ICA.
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Find detailed list of recent & upcoming international conferences, events, seminars, webinars, and workshops in First Aid & Emergencies in 2019/2020, only on ICA.
We are the biggest conference listing platforms with conference registered across 150+ academic studies in more than 170 countries worldwide.
ConferenceAlerts.org has helped many organizers to promote their upcoming conferences and workshops by targeting the most relevant audience. Likewise, our email alerts have made it easier for many students, academicians and professionals to keep track of upcoming conferences across different regions and industries.
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All Conference Alert is one of the most trusted online company that provides all the updated information regarding the conferences going on in India or across the globe. Our dedicated team helps event organizers to make their conferences easy to organize. We list all international and national conferences worldwide form the genuine organizers every day.
All Conference Alert is one of the most trusted online company which provides the updated information regarding the conferences going on in India or across the globe. Our dedicated team helps event organizers to make their conferences easy to organize.
Construction of Maximum Tortuosity of Single Fluid Path in Grid-based 2-d Sys...Sparisoma Viridi
Tortuosity of 2-d and 3-d small system are constructed using grid based system. Thermodynamics postulate shows that possiblility of a microstate with tortuous channel is very small, in order of 10^{-17}. This means other mechanism is required why nature can provide some structures.
Get all conference alerts on upcoming conferences, meetings, seminars, workshops and other associated events in Eye Health sector in 2019/2020.
AllConferenceAlert, trusted conference listing platform for academicians, industries & conference organizers, offers you complete details such as conference name, date, venue, organizer details, conference agenda & call to submit research papers at one place.
Diffusion Simulation with JS: Writing Your Own ABM CodeSparisoma Viridi
Slide for Workshop on Biophysics, Room D, 10.00-12.00, Friday, 9 August 2019 in 17th SEACOMP 2019 & 3rd PIT-FMB 2019, 8-10 August 2019, Badung, Indonesia
Find detailed list of recent & upcoming international conferences, events, seminars, webinars, and workshops in Skin Conditions & Beauty in 2019/2020, only on ICA.
We are the biggest conference listing platforms with conference registered across 150+ academic studies in more than 170 countries worldwide.
Join our list on 100,000 registered conference subscribers to get free conference alerts in your email for your choice of conferences worldwide.
Find detailed list of recent & upcoming international conferences, events, seminars, webinars, and workshops in First Aid & Emergencies in 2019/2020, only on ICA.
We are the biggest conference listing platforms with conference registered across 150+ academic studies in more than 170 countries worldwide.
ConferenceAlerts.org has helped many organizers to promote their upcoming conferences and workshops by targeting the most relevant audience. Likewise, our email alerts have made it easier for many students, academicians and professionals to keep track of upcoming conferences across different regions and industries.
Join ConferenceAlerts.org to promote or track upcoming conferences by using conference alerts as an innovative tool. Upcoming Conferences on Culture are listed below.
All Conference Alert is one of the most trusted online company that provides all the updated information regarding the conferences going on in India or across the globe. Our dedicated team helps event organizers to make their conferences easy to organize. We list all international and national conferences worldwide form the genuine organizers every day.
All Conference Alert is one of the most trusted online company which provides the updated information regarding the conferences going on in India or across the globe. Our dedicated team helps event organizers to make their conferences easy to organize.
Construction of Maximum Tortuosity of Single Fluid Path in Grid-based 2-d Sys...Sparisoma Viridi
Tortuosity of 2-d and 3-d small system are constructed using grid based system. Thermodynamics postulate shows that possiblility of a microstate with tortuous channel is very small, in order of 10^{-17}. This means other mechanism is required why nature can provide some structures.
Get all conference alerts on upcoming conferences, meetings, seminars, workshops and other associated events in Eye Health sector in 2019/2020.
AllConferenceAlert, trusted conference listing platform for academicians, industries & conference organizers, offers you complete details such as conference name, date, venue, organizer details, conference agenda & call to submit research papers at one place.
Diffusion Simulation with JS: Writing Your Own ABM CodeSparisoma Viridi
Slide for Workshop on Biophysics, Room D, 10.00-12.00, Friday, 9 August 2019 in 17th SEACOMP 2019 & 3rd PIT-FMB 2019, 8-10 August 2019, Badung, Indonesia
Simulation of cell budding & binary fission:A preliminary study using molecu...Sparisoma Viridi
International Conference and School on Physics in Medicine and Biosystems, to be held virtual on Zoom from 6 to 8 November 2020, IPB University, Bogor, Indonesia, url https://www.icspmb.org/
In-House Training Online Penyusunan Jurnal Sains, SEAMEO QITEP in Science (SEAQIS), Bandung, Indonesia, 14-16 April 2020, url https://doi.org/10.5281/zenodo.3751238
Resume beberapa hal yang dapat menyebabkan perubahan fasa pada gelombang sebagai persiapan untuk fenomena gelombang stastioner, interferensi dua sumber, interferensi lapisan tipis, pelayangan, dan lainnya
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A Strategic Approach: GenAI in EducationPeter Windle
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This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
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An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
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The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
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The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
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Simulation of Blood Cell Separation System Based on Inertia and Elasticity using Molecular Dynamics Method (a simulation design)
1. 17th SEACOMP 2019
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8-10 August 2019, Badung, Indonesia 1
Simulation of Blood Cell Separation
System Based on Inertia and Elasticity
using Molecular Dynamics Method
(a simulation design)
S. Viridi1
, F. Haryanto1
, Isa Anshori2
1
Department of Physics, Institut Teknologi Bandung, Bandung 40132 Indonesia
2
Department of Biomedical Engineering, Institut Teknologi Bandung, Bandung 40132
Indonesia
v201890809_3
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Outline
• Introduction
• Previous works
• Molecular dynamics
• Proposed simulation design
• Summaries
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Introduction
4. Blood seperation: MOFF & DEP
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H.-S. Moon, K. Kwon, S.-I. Kim, H. Han, J. Sohn, S. Lee, H.-I. Jung Lab. Chip 11 1118-1125 (2011), url
https://doi.org/10.1039/C0LC00345J
CTCs (circulating tumor cells), multi-orifice flow fractination, dielectroporesis
Human breast cancer cells
5. Blood seperation: PFF
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M. Pødenphant, N. Ashley, K. Koprowska, K. U. Mir, M. Zalkovskij, B. Bilenberg, W. Bodmer, A. Kristensen, R. Marie,
Lab. Chip 15 4598-4606 (2015), url https://doi.org/10.1039/C5LC01014D
Pinched flow fractination
Critical
diameter
6. Blood seperation: μChannel (PDMS)
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J. K. S. Tan, S.-Y. Park, H. L. Leo, S. Kim, IEEE Trans. Biomed. Circuits Syst. 11 1431-1437 (2017), url
https://doi.org/10.1109/TBCAS.2017.2748232
Polydimethylsiloxane
WBC, RBC
7. WBC capture and release: 2LHPM
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Javier Alejandro Hernández-Castro, Kebin Li, Jamal Daoud, David Juncker, Teodor Veres, "Two-level submicron high
porosity membranes (2LHPM) for the capture and release of white blood cells (WBCs)", Lab. Chip. 19 589-597 (2019),
url https://doi.org/10.1039/C8LC01256C
Two-level submicron high porosity membranes
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Previous works
9. Clogging: Initial model
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8-10 August 2019, Badung, Indonesia 9
L. Haris, S. Viridi, S. N. Khotimah, "Formulasi Interaksi antara Eritrosit dan Trombosit dalam Peristiwa Penyumbatan
Pembuluh Kapiler pada Kasus Malaria Serebral Menggunakan Metoda Dinamika Molekular", Prosiding Simposium
Nasional Inovasi Pembelajaran dan Sains 2012 (SNIPS 2012), Eds. F. D. E. Latief et al., Bandung, Indonesia, 7-8 Juni
2012, pp. 88-91.
10. Clogging: All spheres
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L. Haris, S. Viridi, S. N. Khotimah, F. Haryanto, "Two-Dimensional Coulomb Model of Capillary Vessel in the Case of
Cerebral Malaria using Molecular Dynamics", Proceedings of the 12th Asia-Oceania Congress of Medical Physics
(AOCMP) and the 10th South-East Asian Congress of Medical Physics (SEACOMP), Eds. A. Krisanachinda et al.,
Chiang Mai, Thailand, 11-14 December 2012, pp. 170-172.
11. Clogging: Orientation
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L. Haris, S. N. Khotimah, F. Haryanto, S. Viridi, "Physics Modeling for Medical Purposes: Molecular Dynamics
Simulation on Malaria-Infected Blood Flow in 2-D Channel", Prosiding Simposium Nasional Inovasi dan Pembelajaran
Sains 2013 (SNIPS 2013), Eds. A. Purqon et al., Bandung, Indonesia, 3-4 Juli 2013, pp. 142-145.
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L. Haris, S. N. Khotimah, F. Haryanto, S. Viridi, "Molecular Dynamics Simulation of Soft Grains: Malaria-Infected Red
Blood Cells Motion within Obstructed 2-D Capillary Vessel", in Symposium on Biomathematics-2013, edited by H.
Arimura et al., AIP Conference Proceedings 1587, American Institute of Physics, Melville, NY, 2014, pp. 43-46., urll
https://dx.doi.org/10.1063/1.4866530
Clogging: Position, orientation, charge
13. Single RBC
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Ismi Yasifa, Sparisoma Viridi, "Pemodelan Dua Dimensi Deformabilitas Sel Darah Merah berbasis Granular", Prosiding
Simposium Nasional Inovasi dan Pembelajaran Sains 2018 (SNIPS 2018), Eds. G. Hikmawan et al., Bandung,
Indonesia, 9-10 Juli 2018, pp. 86-91.
Variation of
spring initial
length ≠
stable
structure
14. Collision of two RBCs
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Sparisoma Viridi and Ismi Yasifa, "Simulation of two red blood cells (RBC) collision based on granular model: case of
one-dimensional collision", Journal of Physics: Conference Series 1248 (1), 012083 (2019),url
https://doi.org/10.1088/1742-6596/1248/1/012083
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Molecular dynamics
16. • Normal force: Collision between (sperical) cell
where ξij is overlab between two spheres
Considered forces
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.
ijijNijijNij rrkN
ξγξ −=
( )ijjiij rRR −+= ,0minξ
17. • Drag force: Motion of cells due to fluid flow
Considered forces (cont.)
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.
( )ififi vvRD
−−= πη6
iv
fv
18. • Sum of forces at time t
• Acceleration at time t
Newton’s second law of motion
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.
( )∑∑ =
−+=
N
j
ijijNDF i
1
1 δ
∑= F
m
a
i
1
19. Euler algorithm
• Velocity at time t + Δt
• Position at time t + Δt
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( ) ( ) tatvttv ∆+=∆+
( ) ( ) tvtrttr ∆+=∆+
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Proposed simulation
design
21. • It alows the use of previous formulation of
normal force
Channel wall builts from spheres
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` `
` `
`
.
22. A (minor) problem
• Proposed approach requires flow velocity
profile, which is only known mathematically
for fully developed flow between two parallel
plates or in a cylindrical channel
which known as Poiseuille flow
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url http://brennen.caltech.edu/fluidbook/basicfluiddynamics/Navierstokesexactsolutions/poiseuilleflow.pdf [20190809]
( ) ( )22
4
1
rR
dz
dp
ruz −
−=
η
23. Fluid flow velocity profile
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url https://www.engineersedge.com/fluid_flow/flow_velocity_profiles.htm [20190809]
24. Developing velocity profile
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url https://www.theseus.fi/bitstream/handle/10024/106991/Acharya_Saroj.pdf?sequence=1&isAllowed=y [20190809]
25. Fluid flow velocity profile of a junction
• There is no analytical solution, it seems com-
plicated: phase φ, junction angle α, radius ρ
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X. Li, S. Wang, "Flow field and pressure loss analysis of junction and its structure optimization of aircraft hydraulic pipe
system", Chinese Journal of Aeronautics[], vol. 26, no. 4, pp. 1080–1092, Aug 2013 url
https://doi.org/10.1016/j.cja.2013.04.004
26. Suggestion
• Is there any suggested solution?
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28. Summaries
• Simulation design for blood cell separation
based on inertial and elasticity using mole-
cular dynamics method implementing Euler
algorithm in JavaScript has been proposed
• Experiment confirmation is required for
tuning the system and also for the fluid flow v
profile
• Source is avalable at
https://github.com/dudung/butiran.js17th SEACOMP 2019
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29. 17th SEACOMP 2019
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https://osf.io/tg79j/