Simvastatin is a lipid-lowering drug that belongs to the statin class. It works by inhibiting HMG-CoA reductase and is derived synthetically from lovastatin, which is produced by the fungus Aspergillus terreus. Simvastatin lowers LDL and triglyceride levels while raising HDL. It is used to treat high cholesterol and reduce heart disease risk. The document describes simvastatin's mechanism of action, pharmacokinetics, production method from lovastatin, side effects, and clinical uses.