Sharks have a ventral mouth opening with serrated teeth that can operate simultaneously or be gradually replaced. Their gastrointestinal tract includes a stomach and spiral intestine, and they lack salivary glands but have a well-developed liver and pancreas. Sharks have 5-7 pairs of gill slits on the sides of their pharynx and large olfactory lobes and cerebellum in their brain. Their skin has sensory buttons and taste buds in their oral cavity. Sharks have two-chambered hearts and use their gills to breathe by taking in water and releasing it, exchanging oxygen and carbon dioxide in their blood which is then distributed throughout their body.