The Great Schism between the Catholic Church in Rome and Eastern Orthodox Church in Constantinople occurred in 1054 due to various theological and political disputes. Key issues included whether the Holy Spirit proceeds from the Father alone or the Father and Son, the authority of the Pope versus patriarchs, and the use of icons. Excommunications were exchanged between Pope Leo IX and Patriarch Michael Cerularius, formally dividing the churches. While reunification efforts continue, theological and structural differences remain unresolved.