This newsletter provides information on recent publications in breast cancer research and upcoming conferences. It includes a summary of an editorial on the prognostic value of tumor-infiltrating lymphocytes in node-positive breast cancer. Brief summaries are given of recent literature on topics like dairy intake and breast cancer recurrence, decreasing late-stage breast cancer with mammography screening, and analyzing circulating tumor DNA to monitor metastatic breast cancer. Upcoming events like conferences are also listed.

1. Senology Newsletter Page 1 of 3
Senology.org - Newsletter
International Senologic and Oncologic Scientific Community (ISOSC)
"Connecting specialists worldwide"
April 10, 2013
Editor-in-Chief: Gian Paolo Andreoletti, MD
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Literature Selection
Kroenke CH et al.: "High- and Low-Fat Dairy Intake, Recurrence, and Mortality After Breast Cancer
Diagnosis", J Natl Cancer Inst. 2013 Mar 14. [Epub ahead of print]
Foca F et al.: "Decreasing incidence of late-stage breast cancer after the introduction of organized
mammography screening in Italy", Cancer. 2013 Mar 15 [Epub ahead of print]
Dawson SJ et al.: "Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer", N Engl J
Med. 2013 Mar 13. [Epub ahead of print]
Schindlbeck C et al.: "Comparison of circulating tumor cells (CTC) in peripheral blood and
disseminated tumor cells in the bone marrow (DTC-BM) of breast cancer patients", J Cancer Res Clin
Oncol. 2013 Mar 23. [Epub ahead of print]
Harbeck N et al.: "Ten-year analysis of the prospective multicentre Chemo-N0 trial validates American
Society of Clinical Oncology (ASCO)-recommended biomarkers uPA and PAI-1 for therapy decision
making in node-negative breast cancer patients", Eur J Cancer. 2013 Mar 12 [Epub ahead of print]
Darby SC et al.: "Risk of ischemic heart disease in women after radiotherapy for breast cancer", N
Engl J Med. 2013 Mar 14;368(11):987-98
Donker M et al.: "Comparison of the sentinel node procedure between patients with multifocal and
unifocal breast cancer in the EORTC 10981-22023 AMAROS Trial: Identification rate and nodal
outcome", Eur J Cancer. 2013 Mar 19 [Epub ahead of print]
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2. Senology Newsletter Page 2 of 3
Editorial
"Prognostic and predictive value of tumor-infiltrating lymphocytes in node-positive breast cancer",
Sherene Loi, Translational Breast Cancer Genomics Lab, Division of Research, Peter MacCallum Cancer
Centre, East Melbourne, Victoria, Australia
""We and others have previously shown that an immune signal can influence prognosis and response to
treatment, particularly “immunogenic therapies” in specific breast cancer subtypes, such as those estrogen
receptor (ER)-negative and/or overexpressing the HER2/neu oncogene. To validate this further and determine
immunity could be a clinically relevant biomarker, we evaluated the association between quantity of tumor
infiltrating lymphocytes (TILs) in a breast cancer, prognosis and prediction of response to anthracyline
chemotherapy in a large clinical trial in over 2000 primary breast cancers and long term follow-up data. We
found that TILs were strongly associated with a good prognosis in the triple negative breast cancer (TNBC:
ER, PGR, and HER2-negative) subtype - even node positive TNBCs had an excellent survival if they were
observed to have high amounts of TILs at diagnosis (read more)".
(Commentary on: Loi S et al.: "Prognostic and Predictive Value of Tumor-Infiltrating Lymphocytes in a
Phase III Randomized Adjuvant Breast Cancer Trial in Node-Positive Breast Cancer Comparing the
Addition of Docetaxel to Doxorubicin With Doxorubicin-Based Chemotherapy: BIG 02-98", J Clin
Oncol. 2013 Jan 22. [Epub ahead of print])
Questions and Answers
Breast Surgery Workshop Summary - The Center for Natural Breast Reconstruction, Mount Pleasant, SC,
USA
Fragments of History
1976 - Gianni Bonadonna (Milan, Italy): "Our data indicate that patients with potentially curable breast cancer
and with positive axillary lymph nodes at the time of mastectomy show a statistically significant reduction in
recurrence rate during the first 27 months after radical mastectomy when treated with cyclic prolonged
combination chemotherapy. At present, the advantage of CMF appears statistically evident in all subgroups of
patients" (Bonadonna G et al.: "Combination chemotherapy as an adjuvant treatment in operable breast
cancer ", N Engl J Med. 1976 Feb 19;294(8):405-10)
Calendar of Events
5th IMPAKT Breast Cancer Conference, May 2-4, 2013, Brussels, Belgium
Precision Medicines in Breast Cancer, May 9-10, 2013, London, UK
15th Milan Breast Cancer Conference, June 20-21, 2013, Milan, Italy
3rd World Congress on Cancer Science & Therapy, October 21-23, 2013, San Francisco, CA, USA - in
partnership with Senology
9th Meet the Professor. Advanced International Breast Cancer Conference (AIBCC), November 11-13,
Padova, Italy - under the Patronage of Senology
Update in Breast Imaging, 22-23 November, Ostend, Belgium
HEALTHCARE INDUSTRY NEWS
Bracco receives MHRA approval for expanded labeling of MultiHance
(gadobenate dimeglumine) in magnetic resonance imaging of the breast
Press release - Milan (Italy), March 11, 2013 - " Bracco receives MHRA approval for
expanded labeling of gadobenate dimeglumine in Magnetic Resonance Imaging of
the breast. - MultiHance, the highest relaxivity contrast agent for MRI of the central
nervous system, is now approved for breast MRI " (read more)
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3. Senology Newsletter Page 3 of 3
Literature Selection
Rasmussn-Torvik LJ et al.: "Ideal Cardiovascular Health is Inversely Associated with Incident Cancer:
The Atherosclerosis Risk in Communities Study", Circulation. 2013 Mar 18. [Epub ahead of print]
Neef HP et al.: "Outcome after repeat resection of liver metastases from colorectal cancer", Int J
Colorectal Dis. 2013 Mar 7. [Epub ahead of print]
Park JH et al.: "The beneficial effect of palliative resection in metastatic colorectal cancer", Br J
Cancer. 2013 Mar 12 [Epub ahead of print]
Verhoven B et al.: "Ki-67 Is an Independent Predictor of Metastasis and Cause-Specific Mortality for
Prostate Cancer Patients Treated on Radiation Therapy Oncology Group (RTOG) 94-08", Int J Radiat
Oncol Biol Phys. 2013 Mar 5 [Epub ahead of print]
Bomers JG et al.: "MR Imaging-guided Focal Cryoablation in Patients with Recurrent Prostate
Cancer", Radiology 2013 Mar 22 [Epub ahead of print]
Mukozu T et al.: "Serum VEGF as a Tumor Marker in Patients with HCV-related Liver Cirrhosis and
Hepatocellular Carcinoma", Anticancer Res. 2013 Mar;33(3):1013-21
Yeon JS et al.: "Thyroid Nodules with Initially Nondiagnostic Cytologic Results: The Role of Core-
Needle Biopsy", Radiology 2013 Mar 22 [Epub ahead of print]
Discussion
"Intermittent versus continuous androgen deprivation in prostate cancer " - Share your opinion on
LinkedIn
Questions and Answers
Kidney Cancer Workshop Summary - with Robert Figlin, Cedars-Sinai’s Samuel Oschin Comprehensive
Cancer Institute, Los Angeles, CA, USA
Lung Cancer Workshop Summary - with Joel Neal, Stanford University, Stanford, CA, USA
Radiation Oncology Workshop Summary - with Matt Katz, Radiation Oncology Associates, Londonderry,
NH, USA
Melanoma Workshop Summary - with Alan Spatz, McGill University, Montréal, QC, Canada
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