This newsletter provides information on recent literature in breast cancer and other oncology fields, upcoming conferences, and a discussion forum for specialists. It includes summaries of 10 recent papers on topics like triple negative breast cancer treatment and outcomes of tamoxifen therapy. The editor announces a new online community for specialists called Senology.org - International Senologic and Oncologic Scientific Community within Doctorsbook.com.

1. Senology Newsletter file:///C:/Documents and Settings/utente/Desktop/Newsl_Apr2011.htm
Senology.org - Newsletter
International Senologic and Oncologic Scientific Community
"Connecting specialists worldwide"
Editor-in-chief: Gian Paolo Andreoletti, MD
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Literature Selection
Geffen DB et al.: "The impact of the 21-gene recurrence score assay on decision making about
adjuvant chemotherapy in early-stage estrogen-receptor-positive breast cancer in an oncology
practice with a unified treatment policy", Ann Oncol. 2011 Mar 1. [Epub ahead of print]
Blixt O et al.: "Autoantibodies to aberrantly glycosylated MUC1 in early stage breast cancer are
associated with a better prognosis", Breast Cancer Res. 2011 Mar 8;13(2):R25. [Epub ahead of print]
Luo J et al.: "Association of active and passive smoking with risk of breast cancer among
postmenopausal women: a prospective cohort study", BMJ. 2011 Mar 1;342:d1016. doi:
10.1136/bmj.d1016
Rosato V et al.: "Metabolic syndrome and the risk of breast cancer in postmenopausal women", Ann
Oncol. 2011 Mar 17. [Epub ahead of print]
Kalinyak JE et al.: "PET-Guided Breast Biopsy", Breast J. 2011 Mar;17(2):143-51
Keam B et al.: "Ki-67 can be used for further classification of triple negative breast cancer into two
subtypes with different response and prognosis", Breast Cancer Res. 2011 Mar 2;13(2):R22. [Epub
ahead of print]
Conklin MW et al.: "Aligned collagen is a prognostic signature for survival in human breast
carcinoma", Am J Pathol. 2011 Mar;178(3):1221-32
Fakkert IE et al.: "Breast cancer screening in BRCA1 and BRCA2 mutation carriers after risk
reducing salpingo-oophorectomy", Breast Cancer Res Treat. 2011 Mar 4. [Epub ahead of print]
Hackshaw A et al.: "Long-Term Benefits of 5 Years of Tamoxifen: 10-Year Follow-Up of a Large
Randomized Trial in Women at Least 50 Years of Age With Early Breast Cancer", J Clin Oncol. 2011
Mar 21. [Epub ahead of print]
Noah Vanhoucke J et al.: "Cost-effectiveness of chemoprevention of breast cancer using tamoxifen
in a postmenopausal US population", Cancer. 2011 Mar 14. doi: 10.1002/cncr.25926. [Epub ahead of
print]
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Goyal S et al.: "Ductal carcinoma in situ treated with breast-conserving surgery and accelerated
partial breast irradiation: Comparison of the Mammosite registry trial with intergroup study E5194",
Cancer. 2011 Mar 15;117(6):1149-55
Comment
"Strategies for the management of triple negative breast cancer", Hiroshi Yagata, Department of
Breast Surgical Oncology, St. Luke's International Hospital, Tokyo, Japan
"Triple negative breast cancer (TNBC) is a minor subtype and has distinctive aspect of clinical behavior.
TNBC often shows rapid and expanding growth pattern, unlike luminal type. Chemotherapy is the only
method as systemic therapy and shows remarkable effect with relatively high probability; to the contrary,
some of TNBCs show overt progression in a short period during chemotherapy and develop early recurrence
with short survival. Various molecular targeting therapies are developing, but do not reach our daily practice.
So we tried to explore effective ways of treatment for TNBC from both previous reports and our experiences
in the literature. We need to consider effective treatment strategy for TNBC, including local therapy as well
as systemic therapy with special care"
(Comment on: Yagata H et al.: "Current strategy for triple-negative breast cancer: appropriate
combination of surgery, radiation, and chemotherapy", Breast Cancer. 2011 Feb 3. [Epub ahead of
print])
Calendar of Events
Gene profiling in Clinical Oncology, Viareggio, Italy, April 8-9, 2011
IMPAKT Breast Cancer Conference, May 5-7, 2011, Brussels, Belgium
12th Greek National Congress of Mastology with international participation, May 6-8, 2011, Kalamata,
Greece
6th World Conference on Breast Cancer, June 7 -11, 2011, Hamilton, Ontario, Canada
13th Milan Breast Cancer Conference, June 22-24, 2011, Milan Italy
AORTIC (African Organisation for Research and Training in Cancer) - 8th International Conference,
November 28 - December 2, 2011, Cairo, Egypt
Literature Selection
Hsiao W et al.: "Successful Treatment of Postchemotherapy Azoospermia With Microsurgical
Testicular Sperm Extraction: The Weill Cornell Experience", J Clin Oncol. 2011 Mar 14. [Epub ahead
of print]
Chamie K et al.: "Secondary malignancies among nonseminomatous germ cell tumor cancer
survivors", Cancer. 2011 Mar 15. doi: 10.1002/cncr.26038. [Epub ahead of print]
Kim HS et al.: "A natural history of weight change in men with prostate cancer on androgen-
deprivation therapy (ADT): results from the Shared Equal Access Regional Cancer Hospital
(SEARCH) database", BJU Int. 2011 Mar;107(6):924-928
Kollmeier MA et al.: "Improved biochemical outcomes with statin use in patients with high-risk
localized prostate cancer treated with radiotherapy", Int J Radiat Oncol Biol Phys. 2011 Mar
1;79(3):713-8
Lu L et al.: "Long-term overweight and weight gain in early adulthood in association with risk of
endometrial cancer", Int J Cancer. 2011 Mar 8. doi: 10.1002/ijc.26046. [Epub ahead of print]
Green DM et al.: "Decreased fertility among female childhood cancer survivors who received 22-27
Gy hypothalamic/pituitary irradiation: a report from the Childhood Cancer Survivor Study", Fertil
Steril. 2011 Mar 2. [Epub ahead of print]
Chan AT et al.: "Inflammatory markers are associated with risk of colorectal cancer and
chemopreventive response to anti-inflammatory drugs", Gastroenterology. 2011
Mar;140(3):799-808.e2
van Hooft JE et al.: "Colonic stenting versus emergency surgery for acute left-sided malignant
colonic obstruction: a multicentre randomised trial", Lancet Oncol. 2011 Mar 11. [Epub ahead of
print]
Pickhardt PJ et al.: "Colorectal Cancer: CT Colonography and Colonoscopy for Detection--
Systematic Review and Meta-Analysis", Radiology. 2011 Mar 17. [Epub ahead of print]
Kang SY et al.: "Helicobacter pylori infection as an independent prognostic factor for locally
advanced gastric cancer patients treated with adjuvant chemotherapy after curative resection", Int J
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Cancer. 2011 Mar 21. doi: 10.1002/ijc.26081. [Epub ahead of print]
Gapstur SM et al.: "Association of alcohol intake with pancreatic cancer mortality in never smokers",
Arch Intern Med. 2011 Mar 14;171(5):444-51
Koshy M et al.: "Impact of Neoadjuvant Radiation on Survival in Stage III Non-Small-Cell Lung
Cancer", Int J Radiat Oncol Biol Phys. 2011 Apr 1;79(5):1388-94
Guglielmelli T et al.: "Previous thalidomide therapy may not affect lenalidomide response and
outcome in relapse or refractory multiple myeloma patients", Eur J Cancer. 2011 Apr:47(8):414-18
Gambacorti-Passerini C et al.: "Multicenter Independent Assessment of Outcomes in Chronic
Myeloid Leukemia Patients Treated With Imatinib", J Natl Cancer Inst. 2011 Mar 21. [Epub ahead of
print]
Discussions
"What do you think about NICE clinical guideline for colonoscopic surveillance to prevent colorectal
cancer in people with ulcerative colitis, Crohn's disease or adenomas?" - Share your opinion on LinkedIn®
Fragments of History
In the 19th century, the German scientist Rudolf Virchow (1821-1902), often called the "founder of cellular
pathology", provided the scientific basis for the modern cytological research and pathologic study of cancer
Literature Selection
Fife S et al.: "Metoclopramide to augment lactation, does it work? A randomized trial", J Matern Fetal
Neonatal Med. 2011 Mar 17. [Epub ahead of print]
Senology.org opened an on line community (Senology.org - International Senologic and Oncologic Scientific
Community) within the Doctorsbook.com platform, which will allow you to remain in touch and communicate with
colleagues. Join us and receive the weekly oncological Doctorsbook Newsletter!
Stay informed....
Recent Advances in Clinical Medicine
Poordad F et al.: "Boceprevir for untreated chronic HCV genotype 1 infection", N Engl J Med. 2011 Mar
31;364(13):1195-206
Bacon BR et al.: "Boceprevir for previously treated chronic HCV genotype 1 infection", N Engl J Med.
2011 Mar 31;364(13):1207-1
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