This newsletter from Senology.org provides information on recent developments in breast cancer research and treatment. It includes summaries of 8 recent studies on topics such as the association between night work and breast cancer risk, the effect of adjuvant ultrasound screening, and the use of tumor markers to detect circulating tumor cells. It also lists upcoming conferences, and references a comment discussing further classification of triple negative breast cancer using the Ki-67 marker.

1. Senology Newsletter http://www.senology.org/newsletter/Newsl_May2011.htm
Senology.org - Newsletter
International Senologic and Oncologic Scientific Community
"Connecting specialists worldwide"
Editor-in-chief: Gian Paolo Andreoletti, MD
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Literature Selection
Lie JA et al.: "Night Work and Breast Cancer Risk Among Norwegian Nurses: Assessment by
Different Exposure Metrics", Am J Epidemiol. 2011 Apr 7. [Epub ahead of print]
Ganz PA et al.: "Examining the influence of beta blockers and ACE inhibitors on the risk for breast
cancer recurrence: results from the LACE cohort", Breast Cancer Res Treat. 2011 Apr 11. [Epub
ahead of print]
Corsetti V et al.: "Evidence of the effect of adjunct ultrasound screening in women with
mammography negative dense breasts: Interval breast cancers at 1year follow-up", Eur J Cancer.
2011 May:47(7): 1021-6
Tokudome N et al.: "Detection of circulating tumor cells in peripheral blood of heavily treated
metastatic breast cancer patients", Breast Cancer. 2011 Apr 5. [Epub ahead of print]
Cuzick J et al.: "Tamoxifen-Induced Reduction in Mammographic Density and Breast Cancer Risk
Reduction: A Nested Case-Control Study", J Natl Cancer Inst. 2011 Apr 11. [Epub ahead of print]
Gentilini O et al.: "Sentinel Lymph Node Biopsy in Multicentric Breast Cancer: Five-Year Results in a
Large Series from a Single Institution", Ann Surg Oncol. 2011 Apr 9. [Epub ahead of print]
Wagner JL et al.: "Delays in Primary Surgical Treatment Are Not Associated with Significant Tumor
Size Progression in Breast Cancer Patients", Ann Surg. 2011 Apr 13. [Epub ahead of print]
Barok M et al.: "Trastuzumab-DM1 causes tumor growth inhibition by mitotic catastrophe in
trastuzumab-resistant breast cancer cells in vivo", Breast Cancer Res. 2011 Apr 21;13(2):R46. [Epub
ahead of print]
Catanzaro JM and al.: "Elevated Expression of Squamous Cell Carcinoma Antigen (SCCA) Is
Associated with Human Breast Carcinoma",PLoS One. 2011 Apr 19;6(4):e19096
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2. Senology Newsletter http://www.senology.org/newsletter/Newsl_May2011.htm
Comment
"Ki-67 for further classification of triple negative breast cancer", Bhumsuk Keam, Department of
Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
"Triple negative breast cancer (TNBC) demonstrates poor prognosis because of aggressive tumor biology
and lack of targeted agents. TNBC with high Ki-67 was associated with a more aggressive clinical feature
despite a higher pCR rate. Ki-67 can be used for further classification of TNBC into two subtypes with
different prognosis. Our report suggests that TNBC with residual disease and high Ki-67 expression should
be a candidate for additional postoperative treatment such as platinum-based chemotherapy, or clinical trials
specifically testing novel therapies in order to improve the outcome for this high-risk group of patients. In
addition, TNBC with high Ki-67 should be followed-up more frequently within 3 years to guard for any
recurrence"
(Comment on: Keam B et al.: "Ki-67 can be used for further classification of triple negative breast
cancer into two subtypes with different response and prognosis", Breast Cancer Res. 2011 Mar
2;13(2):R22. [Epub ahead of print])
Healthcare Companies News
Genomic Health Announces Launch of NCI RxPONDER Trial Utilizing Oncotype DX® in Women with
Node-Positive Breast Cancer - Media Release - www.GenomicHealth.com
Fragments of History
In 1874 the British surgeon and pathologist James Paget makes a brief report describing changes on the
nipple that precede the manifestation of breast cancer (Paget’s disease of the nipple)
Calendar of Events
IMPAKT Breast Cancer Conference, May 5-7, 2011, Brussels, Belgium
6th World Conference on Breast Cancer, June 7 -11, 2011, Hamilton, Ontario, Canada
13th Milan Breast Cancer Conference, June 22-24, 2011, Milan Italy
1st International Michelangelo Conference, June 30 - July 1, Milan, Italy
Breast Cancer Symposium 2011, September 8-10, 2011, San Francisco, California
7th Meet the Professor. Modena International Breast Cancer Conference (MIBCC)
October 5-7, 2011, Modena, Italy
1st Advanced Breast Cancer International Consensus Conference, November 3-5, 2011, Lisbon,
Portugal
AORTIC (African Organisation for Research and Training in Cancer) - 8th International Conference,
November 28 - December 2, 2011, Cairo, Egypt
Literature Selection
Cruz FM et al.: "Gabapentin for the prevention of chemotherapy- induced nausea and vomiting: a
pilot study", Support Care Cancer. 2011 Apr 5. [Epub ahead of print]
Schutze M et al.: "Alcohol attributable burden of incidence of cancer in eight European countries
based on results from prospective cohort study", BMJ. 2011 Apr 7;342:d1584. doi: 10.1136/bmj.d1584
Ballester M et al.: "Detection rate and diagnostic accuracy of sentinel-node biopsy in early stage
endometrial cancer: a prospective multicentre study (SENTI-ENDO)", Lancet Oncol. 2011 Apr 11.
[Epub ahead of print]
Tranah GJ et al.: "Cigarette, cigar and pipe smoking, passive smoke exposure, and risk of
pancreatic cancer: a population-based study in the San Francisco Bay Area", BMC Cancer. 2011 Apr
15;11(1):138. [Epub ahead of print]
Ludwig E et al.: "Feasibility and Yield of Screening in Relatives From Familial Pancreatic Cancer
Families", Am J Gastroenterol. 2011 Apr 5. [Epub ahead of print]
Kyriazanos ID et al.: "Extra-mammary Paget's disease of the perianal region: A review of the
literature emphasizing the operative management technique", Surg Oncol. 2011 Jun;20(2):e61-71
Farwell WR et al.: "Statins and Prostate Cancer Diagnosis and Grade in a Veterans Population", J
Natl Cancer Inst. 2011 Apr 15. [Epub ahead of print]
Olofsson SE et al.:"Population-Based Study of Treatment Guided by Tumor Marker Decline in
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3. Senology Newsletter http://www.senology.org/newsletter/Newsl_May2011.htm
Patients With Metastatic Nonseminomatous Germ Cell Tumor: A Report From the Swedish-
Norwegian Testicular Cancer Group", J Clin Oncol. 2011 Apr 11. [Epub ahead of print]
Tsivian M et al.: "Cigarette Smoking Is Associated With Advanced Renal Cell Carcinoma", J Clin
Oncol. 2011 Apr 18. [Epub ahead of print]
Discussions
Cantero-Munoz P et al.: "Efficacy and safety of intraoperative radiotherapy in colorectal cancer: A
systematic review", Cancer Lett. 2011 Apr [Epub ahead of print]
"What do you think about intraoperative radiotherapy (IORT) in the treatment of
cancer?" - Share your opinion on LinkedIn®. Read a comment from Michael Baum,
University College London, London, UK
Sandblom G et al.: "Randomised prostate cancer screening trial: 20 year follow-up", BMJ. 2011
342:d1539. doi: 10.1136/bmj.d1539
"Is PSA screening test really useful?" - Share your opinion on LinkedIn®
"PSA Test: Who, When, Why" - MD Anderson Cancer Center video on
YouTube®
Literature Selection
Jacoby VL et al.: "Oophorectomy vs Ovarian Conservation With Hysterectomy: Cardiovascular
Disease, Hip Fracture, and Cancer in the Women's Health Initiative Observational Study", Arch Intern
Med. 2011 Apr 25;171(8):760-8
Osler M et al.: "Body mass and risk of complications after hysterectomy on benign indications",
Hum Reprod. 2011 Apr 5. [Epub ahead of print]
LaCroix AZ et al.: "Health outcomes after stopping conjugated equine estrogens among
postmenopausal women with prior hysterectomy: a randomized controlled trial", JAMA. 2011 Apr
6;305(13):1305-14
Stay informed....
Recent Advances in Clinical Medicine
McCormack FX et al.: "Efficacy and safety of sirolimus in lymphangioleiomyomatosis", N Engl J Med.
2011 Apr 28;364(17):1595-606
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