Screening involves testing apparently healthy individuals to detect unrecognized disease. It aims to identify disease at earlier, more treatable stages through simple, rapid and low-cost tests. An ideal screening test should accurately detect the target condition, have a high yield of positive results, and be acceptable to the population. Screening criteria include addressing an important health problem, having a recognizable pre-symptomatic stage, and providing early treatment that reduces disease burden. Evaluation of screening tests considers their sensitivity, specificity, and predictive values to determine how well results identify individuals with and without the disease. The cut-off point for positive results impacts the balance between false positives and negatives.
Hookworm is one of the most important small intestinal nematodes causing iron deficiency anemia. This PPT illustrates hookworms associated with human diseases, life cycle, pathogenesis, laboratory diagnosis, treatment and prevention of hookworm infection.
Hookworm is one of the most important small intestinal nematodes causing iron deficiency anemia. This PPT illustrates hookworms associated with human diseases, life cycle, pathogenesis, laboratory diagnosis, treatment and prevention of hookworm infection.
Leptospirosis is a worldwide public health problem. In humid tropical and subtropical areas, where most developing
countries are found, it is a greater problem than in those with a temperate climate. The magnitude of the problem in
tropical and subtropical regions can be largely attributed to climatic and environmental conditions but also to the
great likelihood of contact with a Leptospira-contaminated environment caused by, for example, local agricultural
practices and poor housing and waste disposal, all of which give rise to many sources of infection. In countries with
temperate climates, in addition to locally acquired leptospirosis, the disease may also be acquired by travellers
abroad, and particularly by those visiting the tropics.
Leptospirosis is a potentially serious but treatable disease. Its symptoms may mimic those of a number of other
unrelated infections such as influenza, meningitis, hepatitis, dengue or viral haemorrhagic fevers. Some of these
infections, in particular dengue, may give rise to large epidemics, and cases of leptospirosis that occur during such
epidemics may be overlooked. For this reason, it is important to distinguish leptospirosis from dengue and viral
haemorrhagic fevers, etc. in patients acquiring infections in countries where these diseases are endemic. At present,
this is still difficult, but new developments may reduce the technical problems in the near future. It is necessary,
therefore, to increase awareness and knowledge of leptospirosis as a public health threat.
Taking urine culture is very important in order to make right diagnosis of urinary tract infection, correct decision and make a logic follow up for children and infants
Screening is a process by which we identify the people who have the disease from those who don't have the disease by using specific tests.
It's helps in identifying the disease even before the pre symptomatic period.
It can eliminate the disease my early diagnosis or decrease the damage it causes to one person's health by early treatment .
Leptospirosis is a worldwide public health problem. In humid tropical and subtropical areas, where most developing
countries are found, it is a greater problem than in those with a temperate climate. The magnitude of the problem in
tropical and subtropical regions can be largely attributed to climatic and environmental conditions but also to the
great likelihood of contact with a Leptospira-contaminated environment caused by, for example, local agricultural
practices and poor housing and waste disposal, all of which give rise to many sources of infection. In countries with
temperate climates, in addition to locally acquired leptospirosis, the disease may also be acquired by travellers
abroad, and particularly by those visiting the tropics.
Leptospirosis is a potentially serious but treatable disease. Its symptoms may mimic those of a number of other
unrelated infections such as influenza, meningitis, hepatitis, dengue or viral haemorrhagic fevers. Some of these
infections, in particular dengue, may give rise to large epidemics, and cases of leptospirosis that occur during such
epidemics may be overlooked. For this reason, it is important to distinguish leptospirosis from dengue and viral
haemorrhagic fevers, etc. in patients acquiring infections in countries where these diseases are endemic. At present,
this is still difficult, but new developments may reduce the technical problems in the near future. It is necessary,
therefore, to increase awareness and knowledge of leptospirosis as a public health threat.
Taking urine culture is very important in order to make right diagnosis of urinary tract infection, correct decision and make a logic follow up for children and infants
Screening is a process by which we identify the people who have the disease from those who don't have the disease by using specific tests.
It's helps in identifying the disease even before the pre symptomatic period.
It can eliminate the disease my early diagnosis or decrease the damage it causes to one person's health by early treatment .
This presentation has been prepared to highlight the most important points about screening.
It builds on previous -even little-knowledge about screening in biomedical sciences.
screening is defined as the presumptive identification of unrecognized disease or defect by the application of tests, examinations, or other procedures which can be applied rapidly to sort out those who probably have a disease from those who probably do not.
screening does not diagnose a disease but it is done to separate persons who has high probability of developing diseases during the study from apparently well person
Specificity is the ability of a test to give a negative finding when the tested person is truly free of the disease under study. i.e true negative
Sensitivity is the ability of a test to give a positive finding when the tested person truly has the disease under the study. i.e true positive
Diseased individuals with positive screening test are True positive TP
Healthy individual with positive screening test are False positive FP
Diseased individuals with negative findings are False negative FN
Healthy individual with negative screening test are True negative TN
An ideally screening test have few false positives and false negatives as possible
Mass screening: This involves screening of a whole population
Multiple or multiphasic screening: Involves the use of a variety of tests on the same occasion for the same condition
Targeted screening: Involves screening of groups with specific exposures
Case-finding or opportunistic screening: Screening of patients visiting a health care delivery point for some other purpose
Ideally we need this test to identify correctly those with the disease under investigation and to exclude this from all non diseased
The test should give
Diagnostic, screening tests, differences and applications and their characteristics, four pillars of screening tests, sensitivity, specificity, predictive values and accuracy
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Surgical Site Infections, pathophysiology, and prevention.pptx
screening.pptx
1. SCREENING OF A DISEASE
Dr Jazeela Mohamed Siddique
Senior Resident
Department of Community Medicine
2. Definition
• The search for unrecognized disease or defect
• By means of rapidly applied tests, examinations or
other procedures
• In apparently healthy individuals
INTRODUCTION
4. PREVENTION AND
NATURAL HISTORY OF
DISEASE
Biological
onset of
disease
Symptoms
appear
Pre-clinical phase
Diagnosis Therapy
begins
Clinical phase
outcome
Promoting
health and
primary
prevention
Tertiary
prevention
Rehabilitation,
support
Potential improvement by
screening
Secondary
prevention
Screening and
early detection
5. Flow chart for Screening
Apparently Healthy
Screening
Probably have disease Probably do not have
disease
Diagnostic Test
Diseased Not Diseased Periodic Screening 5
6. SCREENING TEST DIAGNOSTIC TEST
Apparently healthy Indications or sick
Applied to groups Applied to single patients all diseases
are considered
Test results are arbitrary and final Diagnosis not final but modified; sum
of all evidence.
Based on one cut-off point Based on evaluation of number of
symptoms, signs and lab findings
Less accurate More accurate
Less expensive More expensive
Not a basis for treatment Used as a basis for treatment
The initiative comes from the
investigator or agency providing care
The initiative comes from a patient
with a complaint
7. Concept of lead time
Disease onset
detection
First
possible
point
Final critical
diagnosis OUTCOME
Usual time of
diagnosis
Screening time
Lead time
A
B
7
A - usual outcome of the disease
B - advantage gained by early detection of the disease
B-A - benefit by the screening programme.
8. USES OF SCREENING
CASE DETECTION Prescriptive screening
People are screened for their own
benefit.(cancer, DM, HTN)
CONTROL OF DISEASE Prospective screening
People are screened for the benefit of
others.(HIV,STD)
RESEARCH to know the natural history
of disease
EDUCATION public awareness
9. TYPES OF SCREENING
1. Mass screening
2. High risk or selective screening
3. Multiphasic screening
10. Mass screening
• Screening of whole population
• Irrespective of risk of
contracting the disease
• Eg: visual defects in school
children
• Indiscriminate mass screening
not useful unless backed up by
a suitable treatment
High risk screening
• screening of selected high-risk
groups in the population
• Eg: screening for HIV in risk
groups
• Effective and economical use
of resources
TYPES OF SCREENING
11. •Two or more screening tests in combination to a large no of
people at one time
• Eg: Chemical and hematological tests on blood and urine
specimens, LFT, audiometry, and measurement of visual acuity
Multiphasic screening
12. CRITERIA FOR SCREENING
• Disease to be screened
• Screening test
– Acceptability
– Repeatability
– Validity
– Yield
– simplicity, safety, rapidity, ease of administration
and cost
13. • Important health problem high prevalence
• Recognizable latent or early asymptomatic stage
• Natural history of the condition should be known
• Test that can detect the disease prior to onset of signs &
symptoms
• Facilities to confirm diagnosis
DISEASE TO BE SCREENED - CRITERIA
14. • Effective treatment should be there
• There should be an agreed-on policy concerning whom to treat
as patients
• Evidence that early detection & treatment reduces morbidity
& mortality
• Expected benefits greater than risk and cost of screening
DISEASE TO BE SCREENED - CRITERIA
16. 2. REPEATABILITY/ RELIABILITY/ PRECISION/
REPRODUCIBILITY
• The test must give consistent results when repeated more
than once on the same individual or material, under the same
conditions.
• Depends on 3 major factors:
➢ Observer variation.
➢ Biological variation
➢ Errors relating to technical methods.
17. 3.VALIDITY (ACCURACY)
• The term validity refers to what
extent the test accurately
measures which it purports to
measure.
• Ability of the test to distinguish
those who have the disease
from those who do not.
• Two components - Specificity
and sensitivity
18. 4. YIELD
It is the amount of previously unrecognized disease that is
diagnosed as a result of screening effort.
Yield depends up on :
▪ sensitivity
▪ specificity
▪ prevalence of the disease
▪ community participation
▪ availability of medical care
19. EVALUATION OF A SCREENING TEST
Screening test
results
Cancer Diagnosis(Sx biopsy) Total
Diseased Not diseased
Positive(FNAC) a (14)
( true positive)
b(8)
(false positive)
a + b (22)
Negative(FNAC) c (1)
(False negative )
d (91)
( true negative)
c + d (92)
Total a + c(15) b + d (99) a+b+c+d (114)
20. 1. Sensitivity
• It is defined as the proportion of the diseased people who
were correctly identified as positive by the test.
TP/ TP+FN = a/ a+c x100 = 14/ 14+1 x100 = 93%
• For the FNAC test,93% of all the patients with breast cancer
had positive test results
EVALUATION OF A SCREENING TEST
21. 2. Specificity
• It is defined as the proportion of non diseased people who are
correctly identified as negative by the test.
TN/TN+FP = d / d+b x100 = 91/91+8 x 100 =92%
• If the test is highly specific ,a positive test result should
strongly suggest the presence of the disease of interest.
22. 3. Positive Predictive value
• The "predictive value of a positive test" indicates the
probability that a patient with a positive test result has, in
fact, the disease in question.
PPV = TP/TP+FP X 100 =a / a+b x 100 =
14/ 14+8 x100= 64%
23. 4. Negative Predictive value
• The "predictive value of a negative test" indicates the
probability that a patient with a negative test result doesn't
have disease in question.
• NPV= TN /TN+FN x100 = d / d+c x100 =91/91+1x100=99%
24. 5. Percentage of false positives
• Means that patients who do not have the disease are told
that they have the disease.
• FP/ FP + TN *100
= b/ b+ d *100
= 8 / 8+91x100 =8%
25. 6. Percentage of false negatives
• Means that patients who actually have the disease are told
that they do not have the disease.
• FN/ TP + FN *100
= c/ a+ c *100
= 1/1+14 x100 = 6.6%