When the Heart BD2K grant was originally written. We proposed to build something called “Big Data World” to help advance citizen science, scientific crowdsourcing and science education – especially in bioinformatics. This past year, this idea has become Science Game Lab ( https://sciencegamelab.org ) . A collaboration between the Su laboratory at Scripps Research, Playmatics LLC, and recently the creators of WikiPathways.
2. Outline
• Why?
• Goals of SGL
• Current state
• Partnership with Wikipathways
• Next steps
3. Problems
500000
600000
700000
800000
900000
1000000 Render knowledge contained in
more than 1 million articles per
year computable.
Design RNA molecules
Fold proteins
Align multiple DNA sequences
Map connectivity of neurons in
the brain
Improve science education…
… more
4. Each of these problems can benefit
from “Human Computation”
Render knowledge contained in
more than 1 million articles per
year computable.
Design RNA molecules
Fold proteins
Align multiple DNA sequences
Map connectivity of neurons in
the brain
Improve science education…
Get manypeople working on a problem together
….
7. 150 billion human
hours per year
McGonigal J. Reality is broken : why games make us better and how they can change the world.
New York: Penguin Press; 2011.
0
2E+10
4E+10
6E+10
8E+10
1E+11
1.2E+11
1.4E+11
1.6E+11
empire state
building
one year of solitaire one year of games
7M 9B 150B
9. Learning Science with Games
• Many of the more successful games in the
previous slide are now ubiquitous in educational
settings. e.g. Foldit for teaching 3d protein
structure and prediction.
• Many games also built with the specific goal of
education.
http://tinyurl.com/ismbgames
10. Games can be used to teach
Stegman, Melanie. "Immune Attack players perform better on a test of
cellular immunology and self confidence than their classmates who play a
control video game." Faraday Discuss 169 (2014): 1-20.
Immune Attack
http://ImmuneDefenseGame.com
• High school
students
• First person
shooter game
• Significantly
improves
understanding of
concepts in
immunology
12. Use of games/gamification in education
and research
Expressivity: Depth of learning, problems solved
Fun
Benefits: recruiting,
engagement
Rosalind.info
CACAO
Gamified: badges,
leaderboards, levels
Lecture course:
Typically no
game elements
Classroom,
Work…
The Cure
Foldit
Phylo
Max5
Game: you “play it”,
learning more implicit,
purposes aside from
education
Genes in Space
EteRNA
Holy Grail
?
Cost $$
Cost $$
13. Games are not cheap
• Basically no tradition of open source code in
the game industry
• Bioinformatics postdocs generally know
nothing about graphic design, Web design,
mobile application development…
• Without truly great games, it is very hard to
gather and keep attention focused for long.
14. Science Game Lab
• Provides a mechanism for pooling limited
resources:
– Developers – lower the barrier to entry
• Reduce amount of code needed
• Make it easier to attract players, students
– Players
• Make it easier to find games, move from one game to
related games
• establish a unified identity as a citizen scientist gamer
15. What is Science Game Lab?
Science Game Lab (SGL) is a
centralized online location for scientists
and the general population to come
together for the purposes of advancing
Citizen Science -- specifically through
games, activities & community.
→ Science Game Lab ←
www.ScienceGameLab.org
● Open Source Tools
● Developer APIs
● Badges
● Leaderboards
● Community Features
16. Much more than a Portal for finding
games (but is that too)
MOLT
The Cure
19. Connecting Gamers & Citizen
Scientists to Research Worldwide
www.ScienceGameLab.org
Players get to access a growing catalogue of research-driven Citizen Science
projects that all contribute to a central player score & identity.
For Players & Citizen Scientists Around the World
● Take part in a variety of Citizen Sciences games and
activities
● Grow and build an online Ranking across all games
● Get access to a central online profile, leaderboards,
message boards and more.
● Access games related to a variety of scientific fields.
● Be part of something that will potentially change the world.
20.
21. Home (try at own risk..) sciencegamelab.org/beta.php
More games…
Site Wide
High Score
games
Achievements
Help
Profile
33. How did that work?
• Game developer builds game or series of tasks
they want player to perform
• Game developer uses SGL developer tools to
bind events in the game to triggers that send
information to SGL.
• SGL tracks user behavior across games,
providing in-game and site-wide rewards.
34. Developers
1. Create an account on SGL
2. Request developer access (currently by email..)
3. Build game
4. Go to developer portal and configure SGL-
specific game events
1. reward points
2. group into quests
3. assign badges
More information at:
http://tinyurl.com/sgldev
41. WikiPathways... in Science GAME lab ?
“…. it addresses our greatest challenge of
convincing people they are qualified and skilled
enough to contribute to the knowledge
base. And… we also want to make it fun!” --
Alex Pico, WikiPathways
45. Wikipathways uses for SGL
• Now: As a framework for recruiting and training
new users
– “transform their User Manuals and training videos
into interactive content that can plug into SGL.
Through SGL they can turn this content into quests,
friendly competitions and achievements.”
• Future: As a crowdsourcing system for
accomplishing streams of curation tasks related
to pathway construction.
48. Many Thanks To
• Sara Santini
• John Szeder
• Patrick Mooney
• Melanie Stegman
• Margaret Wallace
• Nicholas Fortugno
• Alex Pico
• Anders Riutta
• Kristina Hanspers
• Ginger Tsueng
• Andrew Su
Contact
bgood@scripps.edu
@bgood on twitter
This work was supported by the US National Institute of Health
(grants GM089820 and U54GM114833) and by the Scripps
Translational Science Institute with an NIH-NCATS Clinical and
Translational Science Award (CTSA; 5 UL1 TR001114).
With ideas and support from:
Jérôme Waldispühl,
Antoine Taly, Dan Maclean, Jesse Himmelstein
Editor's Notes
When the Heart BD2K grant was originally written. We proposed to build something called “Big Data World” to help advance citizen science, scientific crowdsourcing and science education – especially in bioinformatics. This past year, this idea has become Science Game Lab. A collaboration between the Su laboratory at Scripps Research, Playmatics LLC, and recently the creators of WikiPathways.
Why? What is the problem?
crowdsourcing, education
Isolated attempts, a scattered landscape
Games, wikis, and more in bioinformatics
Towards unification
Science Game Center
Goals of SGL
audience, mechanism
Current state
Partnership with Wikipathways
Next steps
how many hours in a year
[[possible segue]]
The group developing WikiPathways is also interested in extracting useful biomedical knowledge from the literature. Their focus, however, is on published figures of pathway diagrams.
WikiPathways is a database of pathway models that can be used to perform data integration, analysis and visualization [[stuff on the right side]]. The content for these models typically comes from researchers’ own work or it’s extracted from the literature and published figures [[stuff on left side]].
Unlike traditional databases, WikiPathways is a wiki (like Wikipedia) and has put the tools for pathway modeling into the hands of the public. This approach has been working well as you can see from this growth curve relative to one of the most popular pathway databases (KEGG). But, there is still a long way to go… [[click]]
And this is just to get the most basic coverage of human genes involved in pathways. Where is this content going to come from?...
Well, thousands of pathway figures are indexed by PubMed Central each year. And based on initial image processing on a sample of 4000 of these figures, the majority of the content has yet to be captured by any pathway database. This information is essentially trapped in image files, inaccessible to data analysis.
One way they are approaching this problem at WikiPathways is to pre-process the images to make “starter” pathway models, which can then be refined by editors and curators. They are going to need to recruit hundreds, if not thousands, of contributors with at least some basic level of pathway biology knowledge.