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                                      SALES PROJECTION
                                    FOR POPULATIONAL AND
                                   PRENATAL SURVEILLANCE




                                                           1
INTRODUCTION
          BIO-OXFORD is a Brazilian company that has been working in the area of Health
          for the last 15 years and one of its main products is the “Child-foot Test”. Today,
          this product has been spread all over Brazil and it is being applied to 90% of the new-
          born babies.

          Based on the same technology of child-foot test, Bio-Oxford has developed other
          kinds of tests by also using philter paper for blood collection, so it is sufficient to
          make a small punch on a finger to detect the following diseases:

                            SYPHILIS
                            HIV
                            HEPATITIS B and C
                            TOXOPLASMOSIS
                            RUBEOLA
                            HTLV 1+2
                            CHAGAS
                            CYTOMEGALOVIRUS

The advantages of this methodology are innumerable but we can emphasize the
following ones:

     ● The use of philter paper makes easier the access to remote places and offers a better
       quality of diagnosis.

     ● It makes easier the surveillance and control of diseases of populational health programs
       that are usually made by serologic methods. In addition, blood collection on philter
       paper is a cheaper method, fit for collecting, stocking, transporting, handling and
       keeping samples of blood for long periods, with the same safety and reliability of sero-
       plasma samples.

     ● Important information: the conveyance of samples is made under environmental
       temperature and they may be stocked until 90 days without any necessity of ice or any
       other refrigeration, so the postage is the better means of transportation because the
       sample collected on philter paper is not considered a biologic material. This is certainly
       the way of reaching the population of low revenue.




                                                                                                    2
ISSUES


1. Negotiations performed in 2010

2. Projects under way

3. Proposals to foreign countries




                                    3
1. NEGOTIATIONS PERFORMED IN 2011



a) Study On Parturients Surveillance
  Project of the Ministry of Health affording, for the first time, blood collection on philter
  paper in 250 maternity wards of Brazil:
  ● 45.000 tests HIV...........................sale concluded
  ● 45.000 tests for Hepatitis B.......... on course
  ● 45.000 tests for Hepatitis C.......... on course




b) INDAIATUBA  

PRENATAL: 24.000 tests
This sale has been made through a Bid won by Bio-Oxford. Notice that in spite of being a
small city, we could realize how important is this segment and how positive will be the sale
Promotion, even in small cities all over Brazil.




c)  PARAÍBA  

   PRENATAL: 960.000 tests (on course) .

   Paraiba is a small State in which we sold 960.000 tests through a Bid.




                                                                                                 4
2. PROJECTS UNDER WAY



    a) State of São Paulo

We have proposed to benefit all the population, either in prenatal tests and in populational tests. The decision
has been to start by a “pilot project” and subsequently to implant the overall project, little by little.

Prenatal:                5.964.540 tests
Populational:           69.246.868 tests



    b) Federal District (GFD)


  Our proposal in the Federal District is being analysed for a positive implantation.   

Pré- Natal:     60.000 tests
Populational: 1.662.422 tests




    c) R E N A F I L T R O

Project of the Ministry of Health, viewing the creation of a centralized network of diagnosis in philter paper.
A network would be settled in each one of the five macro regions of the country and the blood collection will
be decentralized to all the municipalities of Brazil.
.




                                                                                                                   5
d)   C N B B 
Project in partnership with the Ministry of Health, viewing to attain the same population targetted by Renafiltro
through an implantation in three phases (initially at the North, Northeast and Center-West) and little by little
reaching all the further Brazilian municipalities.




       e) The Brazilian Army

This Project views to carry out tests for HIV, SYPHILIS, HCV and HBsAg to all the effective 3 forces:
Army, Airforce, Navy, attaining also their families and all the retired militaries.

Estimated Population : Militaries and civil persons : 315.000 people
                      Their Families: 945.000 people
                      Total: 1.260.000 people

Patients attained: 1.260.000 people

For the time being we have two Proposals :
One from the Health Department of the Army
One from the Health Department of the Navy
The intention is to attain also the civil population assisted by the Army.
Example: rivers inhabitants of Amazone and Pantanal
Assisted Population: more than 1.000.000 people

The implantation of this Project has to be made by stages , taking into account the social conditions, and the
logistics needed for such a magnitude of event attaining all the national territory and requiring considerable
financial resources.
.




    f)  F U N A S A 

This Project views to attain all the Brazilian Indian population estimated to be of 460.000 people
Target : 300.000 people between 16 to 59 years of age
Project’s total Patients: 300.000 people




                                                                                                                    6
g) MINISTRY OF JUSTICE ‐ PENITENTIARY


The Project is for medical surveillance of prisoners (prisons, jails, police stations jails) and refers to the 4 kinds
of diagnosis.
Target : 480.000 people


Note: our sales in Brazil are almost exclusive to governmental entities.




                                                                                                                         7
3. PROPOSALS TO FOREIGN COUNTRIES



We believe that in Africa we have a great opportunity of introducing our technology.
Among all the African countries, we have only approached Angola and the result have
been the following:



Populational Survey: 32.800.000 tests

Prenatal Survey :     8.600.000 tests




                                                                                       8

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Sales Projection --Bio Oxford

  • 1. Authorized distribution for Ro‐Rad Laboratories SALES PROJECTION FOR POPULATIONAL AND PRENATAL SURVEILLANCE 1
  • 2. INTRODUCTION BIO-OXFORD is a Brazilian company that has been working in the area of Health for the last 15 years and one of its main products is the “Child-foot Test”. Today, this product has been spread all over Brazil and it is being applied to 90% of the new- born babies. Based on the same technology of child-foot test, Bio-Oxford has developed other kinds of tests by also using philter paper for blood collection, so it is sufficient to make a small punch on a finger to detect the following diseases: SYPHILIS HIV HEPATITIS B and C TOXOPLASMOSIS RUBEOLA HTLV 1+2 CHAGAS CYTOMEGALOVIRUS The advantages of this methodology are innumerable but we can emphasize the following ones: ● The use of philter paper makes easier the access to remote places and offers a better quality of diagnosis. ● It makes easier the surveillance and control of diseases of populational health programs that are usually made by serologic methods. In addition, blood collection on philter paper is a cheaper method, fit for collecting, stocking, transporting, handling and keeping samples of blood for long periods, with the same safety and reliability of sero- plasma samples. ● Important information: the conveyance of samples is made under environmental temperature and they may be stocked until 90 days without any necessity of ice or any other refrigeration, so the postage is the better means of transportation because the sample collected on philter paper is not considered a biologic material. This is certainly the way of reaching the population of low revenue. 2
  • 3. ISSUES 1. Negotiations performed in 2010 2. Projects under way 3. Proposals to foreign countries 3
  • 4. 1. NEGOTIATIONS PERFORMED IN 2011 a) Study On Parturients Surveillance Project of the Ministry of Health affording, for the first time, blood collection on philter paper in 250 maternity wards of Brazil: ● 45.000 tests HIV...........................sale concluded ● 45.000 tests for Hepatitis B.......... on course ● 45.000 tests for Hepatitis C.......... on course b) INDAIATUBA   PRENATAL: 24.000 tests This sale has been made through a Bid won by Bio-Oxford. Notice that in spite of being a small city, we could realize how important is this segment and how positive will be the sale Promotion, even in small cities all over Brazil. c)  PARAÍBA   PRENATAL: 960.000 tests (on course) . Paraiba is a small State in which we sold 960.000 tests through a Bid. 4
  • 5. 2. PROJECTS UNDER WAY a) State of São Paulo We have proposed to benefit all the population, either in prenatal tests and in populational tests. The decision has been to start by a “pilot project” and subsequently to implant the overall project, little by little. Prenatal: 5.964.540 tests Populational: 69.246.868 tests b) Federal District (GFD)   Our proposal in the Federal District is being analysed for a positive implantation.    Pré- Natal: 60.000 tests Populational: 1.662.422 tests c) R E N A F I L T R O Project of the Ministry of Health, viewing the creation of a centralized network of diagnosis in philter paper. A network would be settled in each one of the five macro regions of the country and the blood collection will be decentralized to all the municipalities of Brazil. . 5
  • 6. d) C N B B  Project in partnership with the Ministry of Health, viewing to attain the same population targetted by Renafiltro through an implantation in three phases (initially at the North, Northeast and Center-West) and little by little reaching all the further Brazilian municipalities. e) The Brazilian Army This Project views to carry out tests for HIV, SYPHILIS, HCV and HBsAg to all the effective 3 forces: Army, Airforce, Navy, attaining also their families and all the retired militaries. Estimated Population : Militaries and civil persons : 315.000 people Their Families: 945.000 people Total: 1.260.000 people Patients attained: 1.260.000 people For the time being we have two Proposals : One from the Health Department of the Army One from the Health Department of the Navy The intention is to attain also the civil population assisted by the Army. Example: rivers inhabitants of Amazone and Pantanal Assisted Population: more than 1.000.000 people The implantation of this Project has to be made by stages , taking into account the social conditions, and the logistics needed for such a magnitude of event attaining all the national territory and requiring considerable financial resources. . f)  F U N A S A  This Project views to attain all the Brazilian Indian population estimated to be of 460.000 people Target : 300.000 people between 16 to 59 years of age Project’s total Patients: 300.000 people 6
  • 7. g) MINISTRY OF JUSTICE ‐ PENITENTIARY The Project is for medical surveillance of prisoners (prisons, jails, police stations jails) and refers to the 4 kinds of diagnosis. Target : 480.000 people Note: our sales in Brazil are almost exclusive to governmental entities. 7
  • 8. 3. PROPOSALS TO FOREIGN COUNTRIES We believe that in Africa we have a great opportunity of introducing our technology. Among all the African countries, we have only approached Angola and the result have been the following: Populational Survey: 32.800.000 tests Prenatal Survey : 8.600.000 tests 8