The document discusses the goals and strategies of Quahog Life Sciences to extend human lifespan. Their goal is to delay aging processes and find solutions to diseases, physical damage, and misdiagnosis that lead to death. They propose strategies like expanding biotechnology to restore youth and health, replacing organs with artificial ones, restoring youthful blood factors, and uploading memories to new bodies. They cite evidence that other species and some human populations have lived over 120 years. Achieving their goals would require developing an artificial intelligence system to analyze the many factors influencing lifespan and health.
This document discusses genetic engineering and gene editing technologies like CRISPR-Cas9. It explores both the promise and ethical concerns of being able to directly alter genes. While gene editing could help address diseases and boost agriculture, there are risks of unintended consequences due to off-target mutations or unknown long term effects of disrupting the natural human genome. The document examines arguments on both sides and notes that while scientific research is important, manipulating human heredity remains an issue of ethics that requires careful consideration and debate.
Rotator cuff repair using a stem cell approachZakary Bondy
This presentation communicates current methods for rotator cuff repair mainly focusing on mesenchymal and tendon-derived stem cells. It looks to expand on future research in this field by communicating a future experiment to expand on current knowledge of tendon-derived stem cells.
Zebrafish are widely used as a model organism in biomedical research. They are useful for studying the toxic effects of chemicals in water and as a model for atherosclerosis and other conditions. Researchers were able to reproduce early stages of atherosclerosis by feeding zebrafish a high-cholesterol diet. This suggests zebrafish are suitable for studying inflammatory processes in early atherosclerosis development. The document also discusses using zebrafish to study angiogenesis, the effects of nicotine, and evaluating nanoparticle biodistribution and efficacy.
This document provides an overview of research on the human microbiome and the American Gut project. It includes summaries of several scientific studies that examined the microbiome in infants and its role in health conditions like diabetes. It also describes the methods and collaborators involved in the American Gut project, which aims to characterize individual microbiomes through citizen science. Videos and interactive data visualization tools related to microbiome research are referenced. Variability in sample handling and analysis methods across studies is discussed.
Zebrafish as an alternative method for determining the embryo toxicity of pla...Noor Zada
The document systematically reviews 12 articles that evaluated the toxicity of various plant products using zebrafish embryos. The plant products tested included caffeine, cannabinoids, nicotine, curcumin, resveratrol, quercetin, rutin, matrine, sophocarpine, and arecoline. The studies assessed endpoints such as mortality, developmental abnormalities, heart rate, locomotor activity, and growth. Many found similar results to mammalian studies, demonstrating zebrafish embryos can be a valid alternative model for toxicity testing of plant products.
This document discusses genetic engineering and gene editing technologies like CRISPR-Cas9. It explores both the promise and ethical concerns of being able to directly alter genes. While gene editing could help address diseases and boost agriculture, there are risks of unintended consequences due to off-target mutations or unknown long term effects of disrupting the natural human genome. The document examines arguments on both sides and notes that while scientific research is important, manipulating human heredity remains an issue of ethics that requires careful consideration and debate.
Rotator cuff repair using a stem cell approachZakary Bondy
This presentation communicates current methods for rotator cuff repair mainly focusing on mesenchymal and tendon-derived stem cells. It looks to expand on future research in this field by communicating a future experiment to expand on current knowledge of tendon-derived stem cells.
Zebrafish are widely used as a model organism in biomedical research. They are useful for studying the toxic effects of chemicals in water and as a model for atherosclerosis and other conditions. Researchers were able to reproduce early stages of atherosclerosis by feeding zebrafish a high-cholesterol diet. This suggests zebrafish are suitable for studying inflammatory processes in early atherosclerosis development. The document also discusses using zebrafish to study angiogenesis, the effects of nicotine, and evaluating nanoparticle biodistribution and efficacy.
This document provides an overview of research on the human microbiome and the American Gut project. It includes summaries of several scientific studies that examined the microbiome in infants and its role in health conditions like diabetes. It also describes the methods and collaborators involved in the American Gut project, which aims to characterize individual microbiomes through citizen science. Videos and interactive data visualization tools related to microbiome research are referenced. Variability in sample handling and analysis methods across studies is discussed.
Zebrafish as an alternative method for determining the embryo toxicity of pla...Noor Zada
The document systematically reviews 12 articles that evaluated the toxicity of various plant products using zebrafish embryos. The plant products tested included caffeine, cannabinoids, nicotine, curcumin, resveratrol, quercetin, rutin, matrine, sophocarpine, and arecoline. The studies assessed endpoints such as mortality, developmental abnormalities, heart rate, locomotor activity, and growth. Many found similar results to mammalian studies, demonstrating zebrafish embryos can be a valid alternative model for toxicity testing of plant products.
The Knockout Rat Consortium (KORC) is a group of individuals and institutions working to create genetically modified rat models using techniques like transposon-based mutagenesis and chemical mutagenesis. The KORC database currently lists over 300 rat models, including models of SCID, p53 knockout, pain (Trpc4 knockout), hydrocephalus (Myo9a knockout), and obesity (Mc4r knockout). The goal of KORC is to generate rat models with single gene disruptions for every rat gene to provide a resource for the research community.
Creating a Cyberinfrastructure for Advanced Marine Microbial Ecology Research...Larry Smarr
The document discusses the creation of the Cyberinfrastructure for Advanced Marine Microbial Ecology Research and Analysis (CAMERA) project. CAMERA aims to provide metagenomic sequencing and analysis of marine microbes at high speeds. It will include data from the Sorcerer II expedition and other projects. The document outlines how CAMERA will utilize Calit2's infrastructure including high-performance computing resources and optical networks to enable remote interactive analysis of large-scale genomic and environmental data sets.
This document discusses using knock-in mouse models to study Huntington's disease. Knock-in models insert the mutant human gene into mice, mimicking the human condition genetically. Researchers created a Hdh (CAG)150 knock-in mouse model that showed age-related neuronal pathology consistent with Huntington's, such as nuclear inclusions and vacuolated cytoplasm. This model has helped identify early pathological events and provides a tool to test therapeutic interventions for Huntington's disease.
Why Life is Difficult, and What We MIght Do About ItAnita de Waard
This document discusses connecting biological knowledge through claim-evidence networks. It outlines some of the challenges in biology like variability between specimens and gene expression changes. It then proposes that claim-evidence networks can be used to connect biological knowledge by linking experimental evidence to claims. Steps to build these networks include identifying claims in documents, structuring the evidence in databases, and automatically connecting the claims and evidence. Examples of efforts that link drug interactions to evidence and predict protein interactions across species are provided. However, it notes that more still needs to be done to fully realize this approach.
The document describes Chardon Pharma's use of zebrafish (Danio rerio) as a new model system for obtaining proof of concept (POC) for potential new drug candidates. Some key advantages of the zebrafish model include lower costs and faster timelines compared to rodent and human models. Chardon Pharma has used zebrafish models for high-throughput behavioral drug screening, target identification for Huntington's disease, studying heart regeneration, and screening compounds for osteoporosis. Characteristics like small size, low cost, genetic tractability, and organ homology to humans make zebrafish a promising new model for early-stage drug development.
This project report summarizes research on organ-on-a-chip technology for drug development. Organ-on-a-chip devices mimic human organs using microfluidic cell culture chips containing living cells on a small scale. Lung, heart, liver and other organ chips have been developed. The goal is a "human on a chip" with multiple organ systems to better model drug efficacy and toxicity before human trials. This technology could reduce animal testing while providing more accurate models for drug development. However, challenges remain in fully integrating multiple organ systems on a single device.
This document summarizes a thesis that developed a database comparing gene expression data from axolotl and zebrafish limb regeneration studies. The thesis used a "Rosetta stone" approach to identify 78 axolotl genes that matched human genes and had homologous zebrafish genes. These genes were organized based on gene ontologies, functions during regeneration, and expression changes with TCDD exposure. Key findings included roles for ribosomal proteins, mitochondria, neurite regeneration, extracellular matrix proteins, and genes related to cell differentiation, apoptosis and maintenance.
Organ printing using 3D bioprinting technology has the potential to help address the shortage of donor organs by creating organs for transplantation. 3D bioprinting involves layering living cells onto biological scaffolds using various methods like inkjet printing, laser printing, or extrusion-based printing. Researchers have started to experiment with bioprinting simple organs like bladders and kidney structures, and more complex organs may be possible in the future. This could significantly increase the supply of organs available for transplant and potentially save many lives currently on waiting lists.
The robotic implant is designed to induce lengthening of tubular organs like the esophagus and intestines through computer-controlled application of traction forces. Testing in swine demonstrated the applied forces can induce cell proliferation and lengthening of the esophagus without reducing diameter, allowing normal eating. The implant establishes that precise, controlled lengthening can be achieved while maintaining organ geometry, exploiting mechanostimulation to regenerate tissue without traditional engineering challenges.
What's In a Genotype?: An Ontological Characterization for the Integration of...mhb120
This document discusses challenges in integrating genetic variation data and summarizes efforts by the Monarch Initiative to address these challenges. Specifically, it discusses (1) reconciling genetic variation data associated with different levels (e.g. allele, gene), (2) integrating non-genomic forms of variation, and (3) creating semantic links to related biological data. The Monarch Initiative is developing the GENO ontology and using it in their data integration pipeline to standardize genetic variation data and infer new genotype-phenotype associations.
The document discusses the Human Genome Project, which had goals of identifying all 30,000 human genes, determining the sequence of the 3 billion base pairs that make up human DNA, storing this information in databases, and improving data analysis tools. By sequencing factories generating 1000 nucleotides per second, the project was completed ahead of schedule. The project revealed that humans have fewer genes than expected, 99.9% of bases are identical between humans, and 50% or more of the genome consists of "junk DNA" with unknown functions.
Medical biotechnology scope & current applications.pptx bioNehaK23
Ms. Neha discusses four key areas of medical biotechnology:
1) Monoclonal antibodies which are clones of antibody-producing cells that can be "trained" to target cancer cells.
2) Bioprocessing which uses bacteria or viruses genetically modified to mass produce human proteins like insulin.
3) Stem cells which can potentially become any cell type and are being tested to treat conditions like heart attacks by replacing damaged tissue.
4) Tissue engineering to create human tissues externally for replacement, with successes in skin, cartilage and bone marrow reconstruction.
Using Supercomputers and Supernetworks to Explore the Ocean of LifeLarry Smarr
The document summarizes Dr. Larry Smarr's presentation about the CAMERA project, which uses supercomputers and networks to explore microbial genomic data from ocean samples. The CAMERA infrastructure provides researchers worldwide with access to over 1 billion base pairs of metagenomic sequence data through an online portal. Analysis of this data has expanded knowledge of microbial biodiversity and gene families, providing insights into evolution and relationships between microbes and human health.
Knockout mouse model of Pompe Disease(Group 8)Sindu09
1. Researchers generated a knockout mouse model of Pompe disease by disrupting the murine acid α-glucosidase gene (Gaa). Mice with this gene knockout (Gaa-/-) lacked acid α-glucosidase and accumulated glycogen in their lysosomes, mimicking the disease.
2. Comparison of different mouse models found that disruption of exon 13 represented the infantile form, while disruption of exon 6 represented both infantile and adult forms, showing varying degrees of weakness and glycogen storage.
3. Future research includes developing new recombinant enzymes and investigating alternative treatment approaches, such as suppressing the starch binding domain-containing protein 1 gene along with acid α-glucosidase.
Martin Pera stem cells and the future of medicineigorod
This document discusses stem cell research and regenerative medicine. It begins by defining regenerative medicine and stem cells. It describes different types of stem cells including tissue stem cells and embryonic stem cells. It discusses some clinical uses of tissue stem cells and limitations. It then covers the discovery of human embryonic stem cells in 1998 and their potential uses and challenges. The rest of the document discusses various stem cell research projects at USC including using stem cells to study disease, induced pluripotent stem cells, and stem cell-based therapies for conditions like macular degeneration and HIV/AIDS.
Human organoid are miniature sized, self-organized structures, that are derived from stem cells or tissues in culture. The progress, potential, limitations and challenges are discussed.
The document summarizes several genome and brain mapping projects that followed the completion of the Human Genome Project in 2003. It describes the objectives and outcomes of the HapMap Project, ENCODE Project, Human Proteome Project, European Commission's Human Brain Project, and U.S. Brain Mapping Project. All of these projects aimed to further understand the human genome and proteome, characterize gene functions, and map the structure and diseases of the human brain. The research generated vast amounts of freely available data and furthered knowledge in human biology, disease research, and brain-inspired technologies.
Discuss an example of knockout mouse model used for disease modelling (Metast...SaniikaRenganadan
Title: Discuss an example of knockout mouse model used for disease modelling
Disease: Metastatic Bladder Cancer
Module: Gene and Tissue Culture Technology
This document provides an overview of the field of bioinformatics. It discusses that bioinformatics is the analysis of biological information using computers and statistical techniques, and involves organizing, storing, analyzing and visualizing genomic data. It also discusses various databases used in bioinformatics, including nucleotide sequence databases like GenBank, protein sequence databases like Swiss-Prot, structure databases like PDB, and species-oriented databases. Examples of analyzing genomic sequences, predicting protein structures, and correlating gene expression and disease are also provided.
Essays On Cancer. Cancer essays - Reliable Essay Writers That Deserve Your TrustKimberly Jabbour
Breast Cancer Information Essay Free Essay Example. Top Cancer Essay Thatsnotus. Essay on cancer pathogenesis and the 6 hallmarks of cancer PHU3111 .... cancer essay. Cancer Writing Assignment Cancer Earth amp; Life Sciences. Cancer in College Students, Essay Sample SpeedyPaper.com. Understanding Breast Cancer - Free Essay Example PapersOwl.com. Environmental Factors that Could Cause Cancer Essay Example Topics .... essay examples: Breast Cancer Essay. Introduction Cancer Today: Origins, Prevention, and Treatment The .... Inflammatory Breast Cancer Essay Example Topics and Well Written .... The dust bowl essay - Trustworthy Writing Service From Top Professionals. How the American Cancer Society Might Provide Education and Support .... Essay on Cancer Cancer Essay for Students and Children in English - A .... The Origin and Treatment of Cancer Essay Example Topics and Well .... Breast cancer college essays. Cancer essays - reportz515.web.fc2.com. Cancer. Approach for Cancer Care Essay Example Topics and Well Written Essays .... Imposing Breast Cancer Essay Thatsnotus. Topic C - Cancer Essay - Cancer is among the worlds deadliest .... Chemotherapy essay Chemotherapy Cancer. Thesis for cancer research paper. 012 Free Breast Cancer Essays Essay About Dreams Thatsnotus. Skin cancer research paper conclusion / custom essay paper writing. Scholarship essay: Cancer essay. Essay on cancer disease. Essay on Introduction and Conclusion to .... Write an essay about cancer. Essay: Cancer. 2019-01-21. Pin on cancer prevention. Cancer essays - Reliable Essay Writers That Deserve Your Trust Essays On Cancer Essays On Cancer. Cancer essays - Reliable Essay Writers That Deserve Your Trust
Stem cell research holds promise to treat many medical conditions but also faces ethical controversies. While embryonic stem cells are fully pluripotent, their use raises concerns about human embryo destruction. Alternatives like induced pluripotency and somatic cell nuclear transfer aim to achieve the benefits of embryonic stem cells without using embryos. Government policies on funding stem cell research have varied between administrations and some regulations are criticized for being hastily made and hindering scientific progress. Overall, stem cell research could help millions but also generates religious and ethical debates around topics like cloning and embryo use that societies are still grappling with.
The Knockout Rat Consortium (KORC) is a group of individuals and institutions working to create genetically modified rat models using techniques like transposon-based mutagenesis and chemical mutagenesis. The KORC database currently lists over 300 rat models, including models of SCID, p53 knockout, pain (Trpc4 knockout), hydrocephalus (Myo9a knockout), and obesity (Mc4r knockout). The goal of KORC is to generate rat models with single gene disruptions for every rat gene to provide a resource for the research community.
Creating a Cyberinfrastructure for Advanced Marine Microbial Ecology Research...Larry Smarr
The document discusses the creation of the Cyberinfrastructure for Advanced Marine Microbial Ecology Research and Analysis (CAMERA) project. CAMERA aims to provide metagenomic sequencing and analysis of marine microbes at high speeds. It will include data from the Sorcerer II expedition and other projects. The document outlines how CAMERA will utilize Calit2's infrastructure including high-performance computing resources and optical networks to enable remote interactive analysis of large-scale genomic and environmental data sets.
This document discusses using knock-in mouse models to study Huntington's disease. Knock-in models insert the mutant human gene into mice, mimicking the human condition genetically. Researchers created a Hdh (CAG)150 knock-in mouse model that showed age-related neuronal pathology consistent with Huntington's, such as nuclear inclusions and vacuolated cytoplasm. This model has helped identify early pathological events and provides a tool to test therapeutic interventions for Huntington's disease.
Why Life is Difficult, and What We MIght Do About ItAnita de Waard
This document discusses connecting biological knowledge through claim-evidence networks. It outlines some of the challenges in biology like variability between specimens and gene expression changes. It then proposes that claim-evidence networks can be used to connect biological knowledge by linking experimental evidence to claims. Steps to build these networks include identifying claims in documents, structuring the evidence in databases, and automatically connecting the claims and evidence. Examples of efforts that link drug interactions to evidence and predict protein interactions across species are provided. However, it notes that more still needs to be done to fully realize this approach.
The document describes Chardon Pharma's use of zebrafish (Danio rerio) as a new model system for obtaining proof of concept (POC) for potential new drug candidates. Some key advantages of the zebrafish model include lower costs and faster timelines compared to rodent and human models. Chardon Pharma has used zebrafish models for high-throughput behavioral drug screening, target identification for Huntington's disease, studying heart regeneration, and screening compounds for osteoporosis. Characteristics like small size, low cost, genetic tractability, and organ homology to humans make zebrafish a promising new model for early-stage drug development.
This project report summarizes research on organ-on-a-chip technology for drug development. Organ-on-a-chip devices mimic human organs using microfluidic cell culture chips containing living cells on a small scale. Lung, heart, liver and other organ chips have been developed. The goal is a "human on a chip" with multiple organ systems to better model drug efficacy and toxicity before human trials. This technology could reduce animal testing while providing more accurate models for drug development. However, challenges remain in fully integrating multiple organ systems on a single device.
This document summarizes a thesis that developed a database comparing gene expression data from axolotl and zebrafish limb regeneration studies. The thesis used a "Rosetta stone" approach to identify 78 axolotl genes that matched human genes and had homologous zebrafish genes. These genes were organized based on gene ontologies, functions during regeneration, and expression changes with TCDD exposure. Key findings included roles for ribosomal proteins, mitochondria, neurite regeneration, extracellular matrix proteins, and genes related to cell differentiation, apoptosis and maintenance.
Organ printing using 3D bioprinting technology has the potential to help address the shortage of donor organs by creating organs for transplantation. 3D bioprinting involves layering living cells onto biological scaffolds using various methods like inkjet printing, laser printing, or extrusion-based printing. Researchers have started to experiment with bioprinting simple organs like bladders and kidney structures, and more complex organs may be possible in the future. This could significantly increase the supply of organs available for transplant and potentially save many lives currently on waiting lists.
The robotic implant is designed to induce lengthening of tubular organs like the esophagus and intestines through computer-controlled application of traction forces. Testing in swine demonstrated the applied forces can induce cell proliferation and lengthening of the esophagus without reducing diameter, allowing normal eating. The implant establishes that precise, controlled lengthening can be achieved while maintaining organ geometry, exploiting mechanostimulation to regenerate tissue without traditional engineering challenges.
What's In a Genotype?: An Ontological Characterization for the Integration of...mhb120
This document discusses challenges in integrating genetic variation data and summarizes efforts by the Monarch Initiative to address these challenges. Specifically, it discusses (1) reconciling genetic variation data associated with different levels (e.g. allele, gene), (2) integrating non-genomic forms of variation, and (3) creating semantic links to related biological data. The Monarch Initiative is developing the GENO ontology and using it in their data integration pipeline to standardize genetic variation data and infer new genotype-phenotype associations.
The document discusses the Human Genome Project, which had goals of identifying all 30,000 human genes, determining the sequence of the 3 billion base pairs that make up human DNA, storing this information in databases, and improving data analysis tools. By sequencing factories generating 1000 nucleotides per second, the project was completed ahead of schedule. The project revealed that humans have fewer genes than expected, 99.9% of bases are identical between humans, and 50% or more of the genome consists of "junk DNA" with unknown functions.
Medical biotechnology scope & current applications.pptx bioNehaK23
Ms. Neha discusses four key areas of medical biotechnology:
1) Monoclonal antibodies which are clones of antibody-producing cells that can be "trained" to target cancer cells.
2) Bioprocessing which uses bacteria or viruses genetically modified to mass produce human proteins like insulin.
3) Stem cells which can potentially become any cell type and are being tested to treat conditions like heart attacks by replacing damaged tissue.
4) Tissue engineering to create human tissues externally for replacement, with successes in skin, cartilage and bone marrow reconstruction.
Using Supercomputers and Supernetworks to Explore the Ocean of LifeLarry Smarr
The document summarizes Dr. Larry Smarr's presentation about the CAMERA project, which uses supercomputers and networks to explore microbial genomic data from ocean samples. The CAMERA infrastructure provides researchers worldwide with access to over 1 billion base pairs of metagenomic sequence data through an online portal. Analysis of this data has expanded knowledge of microbial biodiversity and gene families, providing insights into evolution and relationships between microbes and human health.
Knockout mouse model of Pompe Disease(Group 8)Sindu09
1. Researchers generated a knockout mouse model of Pompe disease by disrupting the murine acid α-glucosidase gene (Gaa). Mice with this gene knockout (Gaa-/-) lacked acid α-glucosidase and accumulated glycogen in their lysosomes, mimicking the disease.
2. Comparison of different mouse models found that disruption of exon 13 represented the infantile form, while disruption of exon 6 represented both infantile and adult forms, showing varying degrees of weakness and glycogen storage.
3. Future research includes developing new recombinant enzymes and investigating alternative treatment approaches, such as suppressing the starch binding domain-containing protein 1 gene along with acid α-glucosidase.
Martin Pera stem cells and the future of medicineigorod
This document discusses stem cell research and regenerative medicine. It begins by defining regenerative medicine and stem cells. It describes different types of stem cells including tissue stem cells and embryonic stem cells. It discusses some clinical uses of tissue stem cells and limitations. It then covers the discovery of human embryonic stem cells in 1998 and their potential uses and challenges. The rest of the document discusses various stem cell research projects at USC including using stem cells to study disease, induced pluripotent stem cells, and stem cell-based therapies for conditions like macular degeneration and HIV/AIDS.
Human organoid are miniature sized, self-organized structures, that are derived from stem cells or tissues in culture. The progress, potential, limitations and challenges are discussed.
The document summarizes several genome and brain mapping projects that followed the completion of the Human Genome Project in 2003. It describes the objectives and outcomes of the HapMap Project, ENCODE Project, Human Proteome Project, European Commission's Human Brain Project, and U.S. Brain Mapping Project. All of these projects aimed to further understand the human genome and proteome, characterize gene functions, and map the structure and diseases of the human brain. The research generated vast amounts of freely available data and furthered knowledge in human biology, disease research, and brain-inspired technologies.
Discuss an example of knockout mouse model used for disease modelling (Metast...SaniikaRenganadan
Title: Discuss an example of knockout mouse model used for disease modelling
Disease: Metastatic Bladder Cancer
Module: Gene and Tissue Culture Technology
This document provides an overview of the field of bioinformatics. It discusses that bioinformatics is the analysis of biological information using computers and statistical techniques, and involves organizing, storing, analyzing and visualizing genomic data. It also discusses various databases used in bioinformatics, including nucleotide sequence databases like GenBank, protein sequence databases like Swiss-Prot, structure databases like PDB, and species-oriented databases. Examples of analyzing genomic sequences, predicting protein structures, and correlating gene expression and disease are also provided.
Essays On Cancer. Cancer essays - Reliable Essay Writers That Deserve Your TrustKimberly Jabbour
Breast Cancer Information Essay Free Essay Example. Top Cancer Essay Thatsnotus. Essay on cancer pathogenesis and the 6 hallmarks of cancer PHU3111 .... cancer essay. Cancer Writing Assignment Cancer Earth amp; Life Sciences. Cancer in College Students, Essay Sample SpeedyPaper.com. Understanding Breast Cancer - Free Essay Example PapersOwl.com. Environmental Factors that Could Cause Cancer Essay Example Topics .... essay examples: Breast Cancer Essay. Introduction Cancer Today: Origins, Prevention, and Treatment The .... Inflammatory Breast Cancer Essay Example Topics and Well Written .... The dust bowl essay - Trustworthy Writing Service From Top Professionals. How the American Cancer Society Might Provide Education and Support .... Essay on Cancer Cancer Essay for Students and Children in English - A .... The Origin and Treatment of Cancer Essay Example Topics and Well .... Breast cancer college essays. Cancer essays - reportz515.web.fc2.com. Cancer. Approach for Cancer Care Essay Example Topics and Well Written Essays .... Imposing Breast Cancer Essay Thatsnotus. Topic C - Cancer Essay - Cancer is among the worlds deadliest .... Chemotherapy essay Chemotherapy Cancer. Thesis for cancer research paper. 012 Free Breast Cancer Essays Essay About Dreams Thatsnotus. Skin cancer research paper conclusion / custom essay paper writing. Scholarship essay: Cancer essay. Essay on cancer disease. Essay on Introduction and Conclusion to .... Write an essay about cancer. Essay: Cancer. 2019-01-21. Pin on cancer prevention. Cancer essays - Reliable Essay Writers That Deserve Your Trust Essays On Cancer Essays On Cancer. Cancer essays - Reliable Essay Writers That Deserve Your Trust
Stem cell research holds promise to treat many medical conditions but also faces ethical controversies. While embryonic stem cells are fully pluripotent, their use raises concerns about human embryo destruction. Alternatives like induced pluripotency and somatic cell nuclear transfer aim to achieve the benefits of embryonic stem cells without using embryos. Government policies on funding stem cell research have varied between administrations and some regulations are criticized for being hastily made and hindering scientific progress. Overall, stem cell research could help millions but also generates religious and ethical debates around topics like cloning and embryo use that societies are still grappling with.
The document discusses biotechnology approaches for aging, including stem cell rejuvenation by targeting sirtuins, telomerase activation to lengthen telomeres, senolytic therapies to clear senescent cells, and hydrogen therapy. Recent advancements include improved curcumin delivery for anti-aging, using lymph nodes to grow replacement organs, quantum computing for drug design, oral drugs for weight loss and neuroinflammation, immune cell therapies for cancer, wearable brain monitoring, and potential ways to repair Alzheimer's damage. The future may see prolonging ovarian function by modulating anti-Müllerian hormone levels.
1 What is the study systemGeneral information. E.g. What is a .docxhoney725342
1 What is the study system?
General information. E.g. What is a “cell line”? Include images.
1 Why would a researcher use this study system?
The particular features of this system that make it useful. E.g. cell lines allow the study of genetically identical cells in many labs
1 What type of research questions can this study system be used to help answer?
List a few examples of research questions or general areas of research that can be addressed using this system. Elaborate a little on each, so we understand what you mean.
1 How does a researcher typically use this system?
What are the logistics of it? E.g. basic information about how they culture and propagate cell lines.
1 What are the pros and cons of this study system?
List and briefly explain any drawbacks or caveats that we should be aware of, along with particular benefits E.g. mammalian cell lines need adequate facilities and resources to be propagated, but they also allow for the study of mammalian cellular systems in vitro instead of studying another eukaryote like yeast.
6.Are there alternatives or variations on this study system?
If you can’t use this particular study system, what are your options for alternatives? E.g. Use yeast as a representative of a eukaryotic cell.
1 What is a real example from primary literature of this study system being used?
Provide a brief summary of the research that used the study system of interest, including the main objective, basic methods used, the main results, and conclusions. Include an image of at least one figure or table, along with an explanation of what that figure/table illustrates. You must provide the complete citation of the paper and/or a link to the online paper.
8.List of sources and places where we can find more information.
Background
C. elegans: A Simple Multicellular Model Organism
Scientists worldwide conduct basic research to address gaps in our knowledge in the hopes that this information can serve humanity in the future. Basic biological research seeks to answer questions of such elementary cellular and organismal activities as how cells grow, divide, die, move, store and use energy, and communicate.
Scientists use model organisms in basic research to answer these questions because model organisms offer simplified cellular systems that reproduce quickly, are easy to maintain, and are cost efficient. For example,
if a DNA mutation is known to result in a neurological disorder, more data can be generated using a model organism such as C. elegans, which reproduces and matures every 2–3 days, rather than waiting for a human child to mature and show symptoms. Commonly used basic model organisms include S. cerevisiae (yeast), C. elegans (nematode), D. melanogaster (fruit fly), and M. musculus (mouse).
Despite the seeming lack of a relationship to human beings, these model organisms have helped researchers understand the basic cellular machinery underlying a host of human pathologies such as cancer, neurological disorders, ...
The document discusses the ethics of stem cell research. It explains that stem cells can become specialized cells and have potential medical uses but obtaining embryonic stem cells requires destroying embryos, raising ethical issues. Potential solutions are debated such as only using induced stem cells, banning research, or limited embryonic stem cell use with preference for induced cells. The author's opinion is that a limited use of embryonic stem cells balanced with induced cell research allows scientific progress while addressing ethical concerns.
This document discusses cloning and its potential uses and controversies. It begins by defining DNA and RNA as the essential ingredients for life, carrying genetic information. It then defines cloning as the process of creating identical genetic copies, which occurs naturally but can also be achieved through biotechnology. The document outlines several methods of cloning, from gene cloning to somatic cell nuclear transfer. It notes cloning could allow targeted genetic manipulation and addresses both potential benefits, such as more efficient meat production, and concerns, such as the power it may one day give humanity over manipulating life. In closing, it states cloning removes uncertainty from selective breeding but that humanity is not yet ready to fully understand and utilize genetic manipulation.
The document discusses the potential benefits of stem cell research for treating diseases and addressing the organ transplant shortage. It notes that stem cells can develop into specialized cell types and have been shown to treat diseases like multiple sclerosis. While some view embryonic stem cell research as unethical, the document argues that embryos used in research are typically frozen cells from ended pregnancies that would not develop into life otherwise. It states that over 110,000 such embryos are stored in the US with no potential for life. The document concludes that these embryos should be used for potentially lifesaving research rather than being discarded.
The document discusses several biological theories of aging. The theories fall into two main categories: programmed aging theories and non-programmed aging theories. Programmed theories propose that aging is an evolved process with genetic programs that limit lifespan. Non-programmed theories propose that aging is an unavoidable byproduct with no evolutionary purpose. The document outlines several specific theories, provides examples to support each theory, and discusses implications for medicine and potential anti-aging behaviors.
- Biomedical engineering combines engineering and technology to address biological and medical problems. It has potential for remarkable medical advances but is also controversial as some see its practices as immoral.
- Both positive and negative aspects exist, such as developing new medical tools but also raising ethical concerns about playing God or using embryonic stem cells which require embryo destruction.
- Stem cell research has potential to treat many conditions but also causes moral dilemmas due to the sources of stem cells, particularly embryonic stem cells which require embryo destruction.
What You Should Know About Stem Cells EssayHaley Johnson
This document discusses embryonic stem cell research and its potential medical benefits. It explains that embryonic stem cells can differentiate into almost any cell type and thus may help treat diseases like Parkinson's, Alzheimer's, heart disease, diabetes, and more. However, embryonic stem cell research remains controversial due to ethical concerns about the destruction of embryos. The document also notes some alternatives like induced pluripotent stem cells that may avoid the ethical issues.
This document discusses several emerging medical technologies: growing organs from a patient's own cells to address organ transplant shortages and rejection issues; implanting memory chips to help with memory loss from conditions like Alzheimer's; and retinal implants to restore sight. While these technologies could help many people by prolonging lives and improving quality of life, there are also considerations around costs, impacts on population growth, and ethical issues of enhancing human abilities. Overall, medical advances hold promise but must be guided by concern for society and ensuring technologies benefit the greater good.
Monitor and Engage Clinical Trial Participants for better outcomeQuahog Life Sciences
Quahog platform provides a comprehensive solution for Clinical Trial administrators to collect and integrate data from devices, so that participant health parameters can be monitored daily and get rich insights on trial effectiveness. Monitoring in real-time can also allow them to handle adverse events more effectively
The key to longevity in trying to live with Diabetes is in precise management and that is hindered by meds with side effects or lack of awareness among patients or it could be lack of everyday patient compliance
An AI-based Decision Platform built using unified data model, incorporating systems biology topics for unit analysis using semi-supervised learning models
This document summarizes a healthcare data unification solution called Quahog's HealthDSTM. The solution aims to solve the healthcare data disconnect by aggregating and normalizing data across disparate systems to create a unified patient record. This allows for seamless access to current and historical patient information. The unified data foundation also supports analytics, workflows, and real-time monitoring to generate insights and recommendations. This assists with continuous patient care and helps streamline operational processes. The expected benefits include deeper insights for improved decision-making, faster access to real-time insights, and cost savings from reduced data storage needs and advanced automation.
Quahog Life Sciences is building an AI based Healthcare Decision System (Health DS) that promises to take the accuracy of health care decisions to a new level using machine learning and advanced analytics.
Explains how Cancer Management can be made more effective using an integrated approach. From collecting data across reports to predict tumor growth and to be able to help users manage their condition through diet or therapy, the platform can be used to constantly track and monitor outcomes.
Quahog Data Visualization is a module that allows medical enterprises like hospitals, pharmaceutical companies, and bioresearch organizations to build insights and decision dashboards from their data on a unified platform. It features data import, transformation, analysis and visualization capabilities. Pre-built models can be configured to extract behavioral patterns, perform collaborative filtering, and recognize named entities for information extraction. The platform provides flexibility in data organization and integration with other modules for runtime reporting and insights. Its advantages include time savings, inbuilt analytical models, and instant notifications.
Data Infrastructure for Real-time Analysis to provide Health InsightsQuahog Life Sciences
Illustrating how a well planned data infrastructure designed for real-time and continuous learning can have multiple advantages, facilitating better preventive strategies
The document provides an overview of solutions from Quahog Life Sciences including data management, security, analysis, visualization, and applications. The platform allows merging of multiple data sources, creation of a logical data model, and organization of patient data. Advanced encryption is used to securely share data. The platform supports machine learning using a recursive neural network and analytics models. Use cases described include pattern discovery in cancer research and influencer detection in cellular research. Visualization capabilities include interactive dashboards with multiple chart types. Additional applications include bot assistance for diabetologists and physicians.
From Natural Language to Structured Solr Queries using LLMsSease
This talk draws on experimentation to enable AI applications with Solr. One important use case is to use AI for better accessibility and discoverability of the data: while User eXperience techniques, lexical search improvements, and data harmonization can take organizations to a good level of accessibility, a structural (or “cognitive” gap) remains between the data user needs and the data producer constraints.
That is where AI – and most importantly, Natural Language Processing and Large Language Model techniques – could make a difference. This natural language, conversational engine could facilitate access and usage of the data leveraging the semantics of any data source.
The objective of the presentation is to propose a technical approach and a way forward to achieve this goal.
The key concept is to enable users to express their search queries in natural language, which the LLM then enriches, interprets, and translates into structured queries based on the Solr index’s metadata.
This approach leverages the LLM’s ability to understand the nuances of natural language and the structure of documents within Apache Solr.
The LLM acts as an intermediary agent, offering a transparent experience to users automatically and potentially uncovering relevant documents that conventional search methods might overlook. The presentation will include the results of this experimental work, lessons learned, best practices, and the scope of future work that should improve the approach and make it production-ready.
The Microsoft 365 Migration Tutorial For Beginner.pptxoperationspcvita
This presentation will help you understand the power of Microsoft 365. However, we have mentioned every productivity app included in Office 365. Additionally, we have suggested the migration situation related to Office 365 and how we can help you.
You can also read: https://www.systoolsgroup.com/updates/office-365-tenant-to-tenant-migration-step-by-step-complete-guide/
QR Secure: A Hybrid Approach Using Machine Learning and Security Validation F...AlexanderRichford
QR Secure: A Hybrid Approach Using Machine Learning and Security Validation Functions to Prevent Interaction with Malicious QR Codes.
Aim of the Study: The goal of this research was to develop a robust hybrid approach for identifying malicious and insecure URLs derived from QR codes, ensuring safe interactions.
This is achieved through:
Machine Learning Model: Predicts the likelihood of a URL being malicious.
Security Validation Functions: Ensures the derived URL has a valid certificate and proper URL format.
This innovative blend of technology aims to enhance cybersecurity measures and protect users from potential threats hidden within QR codes 🖥 🔒
This study was my first introduction to using ML which has shown me the immense potential of ML in creating more secure digital environments!
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectorsDianaGray10
Join us to learn how UiPath Apps can directly and easily interact with prebuilt connectors via Integration Service--including Salesforce, ServiceNow, Open GenAI, and more.
The best part is you can achieve this without building a custom workflow! Say goodbye to the hassle of using separate automations to call APIs. By seamlessly integrating within App Studio, you can now easily streamline your workflow, while gaining direct access to our Connector Catalog of popular applications.
We’ll discuss and demo the benefits of UiPath Apps and connectors including:
Creating a compelling user experience for any software, without the limitations of APIs.
Accelerating the app creation process, saving time and effort
Enjoying high-performance CRUD (create, read, update, delete) operations, for
seamless data management.
Speakers:
Russell Alfeche, Technology Leader, RPA at qBotic and UiPath MVP
Charlie Greenberg, host
Discover the Unseen: Tailored Recommendation of Unwatched ContentScyllaDB
The session shares how JioCinema approaches ""watch discounting."" This capability ensures that if a user watched a certain amount of a show/movie, the platform no longer recommends that particular content to the user. Flawless operation of this feature promotes the discover of new content, improving the overall user experience.
JioCinema is an Indian over-the-top media streaming service owned by Viacom18.
ScyllaDB is making a major architecture shift. We’re moving from vNode replication to tablets – fragments of tables that are distributed independently, enabling dynamic data distribution and extreme elasticity. In this keynote, ScyllaDB co-founder and CTO Avi Kivity explains the reason for this shift, provides a look at the implementation and roadmap, and shares how this shift benefits ScyllaDB users.
"Frontline Battles with DDoS: Best practices and Lessons Learned", Igor IvaniukFwdays
At this talk we will discuss DDoS protection tools and best practices, discuss network architectures and what AWS has to offer. Also, we will look into one of the largest DDoS attacks on Ukrainian infrastructure that happened in February 2022. We'll see, what techniques helped to keep the web resources available for Ukrainians and how AWS improved DDoS protection for all customers based on Ukraine experience
In our second session, we shall learn all about the main features and fundamentals of UiPath Studio that enable us to use the building blocks for any automation project.
📕 Detailed agenda:
Variables and Datatypes
Workflow Layouts
Arguments
Control Flows and Loops
Conditional Statements
💻 Extra training through UiPath Academy:
Variables, Constants, and Arguments in Studio
Control Flow in Studio
GlobalLogic Java Community Webinar #18 “How to Improve Web Application Perfor...GlobalLogic Ukraine
Під час доповіді відповімо на питання, навіщо потрібно підвищувати продуктивність аплікації і які є найефективніші способи для цього. А також поговоримо про те, що таке кеш, які його види бувають та, основне — як знайти performance bottleneck?
Відео та деталі заходу: https://bit.ly/45tILxj
"Scaling RAG Applications to serve millions of users", Kevin GoedeckeFwdays
How we managed to grow and scale a RAG application from zero to thousands of users in 7 months. Lessons from technical challenges around managing high load for LLMs, RAGs and Vector databases.
What is an RPA CoE? Session 2 – CoE RolesDianaGray10
In this session, we will review the players involved in the CoE and how each role impacts opportunities.
Topics covered:
• What roles are essential?
• What place in the automation journey does each role play?
Speaker:
Chris Bolin, Senior Intelligent Automation Architect Anika Systems
"NATO Hackathon Winner: AI-Powered Drug Search", Taras KlobaFwdays
This is a session that details how PostgreSQL's features and Azure AI Services can be effectively used to significantly enhance the search functionality in any application.
In this session, we'll share insights on how we used PostgreSQL to facilitate precise searches across multiple fields in our mobile application. The techniques include using LIKE and ILIKE operators and integrating a trigram-based search to handle potential misspellings, thereby increasing the search accuracy.
We'll also discuss how the azure_ai extension on PostgreSQL databases in Azure and Azure AI Services were utilized to create vectors from user input, a feature beneficial when users wish to find specific items based on text prompts. While our application's case study involves a drug search, the techniques and principles shared in this session can be adapted to improve search functionality in a wide range of applications. Join us to learn how PostgreSQL and Azure AI can be harnessed to enhance your application's search capability.
Dandelion Hashtable: beyond billion requests per second on a commodity serverAntonios Katsarakis
This slide deck presents DLHT, a concurrent in-memory hashtable. Despite efforts to optimize hashtables, that go as far as sacrificing core functionality, state-of-the-art designs still incur multiple memory accesses per request and block request processing in three cases. First, most hashtables block while waiting for data to be retrieved from memory. Second, open-addressing designs, which represent the current state-of-the-art, either cannot free index slots on deletes or must block all requests to do so. Third, index resizes block every request until all objects are copied to the new index. Defying folklore wisdom, DLHT forgoes open-addressing and adopts a fully-featured and memory-aware closed-addressing design based on bounded cache-line-chaining. This design offers lock-free index operations and deletes that free slots instantly, (2) completes most requests with a single memory access, (3) utilizes software prefetching to hide memory latencies, and (4) employs a novel non-blocking and parallel resizing. In a commodity server and a memory-resident workload, DLHT surpasses 1.6B requests per second and provides 3.5x (12x) the throughput of the state-of-the-art closed-addressing (open-addressing) resizable hashtable on Gets (Deletes).
Getting the Most Out of ScyllaDB Monitoring: ShareChat's TipsScyllaDB
ScyllaDB monitoring provides a lot of useful information. But sometimes it’s not easy to find the root of the problem if something is wrong or even estimate the remaining capacity by the load on the cluster. This talk shares our team's practical tips on: 1) How to find the root of the problem by metrics if ScyllaDB is slow 2) How to interpret the load and plan capacity for the future 3) Compaction strategies and how to choose the right one 4) Important metrics which aren’t available in the default monitoring setup.
What is an RPA CoE? Session 1 – CoE VisionDianaGray10
In the first session, we will review the organization's vision and how this has an impact on the COE Structure.
Topics covered:
• The role of a steering committee
• How do the organization’s priorities determine CoE Structure?
Speaker:
Chris Bolin, Senior Intelligent Automation Architect Anika Systems
[OReilly Superstream] Occupy the Space: A grassroots guide to engineering (an...Jason Yip
The typical problem in product engineering is not bad strategy, so much as “no strategy”. This leads to confusion, lack of motivation, and incoherent action. The next time you look for a strategy and find an empty space, instead of waiting for it to be filled, I will show you how to fill it in yourself. If you’re wrong, it forces a correction. If you’re right, it helps create focus. I’ll share how I’ve approached this in the past, both what works and lessons for what didn’t work so well.
[OReilly Superstream] Occupy the Space: A grassroots guide to engineering (an...
Role of AI in Longevity
1. QuahogLife - named after the Quahog mollusc, a hard clam
with a lifespan of 400+ years, that symbolizes our mission.
Quahog Life Sciences
2. Our Goal @ Quahog
Our goal is to extend human lifespan.
Our mission is to come up with strategies/
solutions that can
(a) Delay natural aging processes by
optimizing cellular management of
production, digestion, replication and self
repair functions within the body.
(b) Find Preventive or Remedial solutions to
every disruption(diseases) that lead to
death
(c) Find solutions to monitor and avoid the
harm of pathogens.
(d) Find solutions to prevent death from forms
of physical damage.
(e) Create systems that help assure accurate
diagnosis and prevent the loss of lives due
to misdiagnosis.
3. General Views
# Preventing death through delayed
ageing would also mean extending
healthy energetic life too
# Death is not easy to solve . That's
true if we work in silos with
disconnected knowledge. The
approach needs a change to solve the
problem
# Too many variables. We cannot fix
this problem without a artificial
intelligent machine. We need the
capability to look at the integrated
picture by processing millions of
behavioral parameters. Human brain
cannot process and hence cannot see
the answer
Different Strategies
# We can resolve complexities of aging by
expanding the biotechnology of rejuvenation,
in order to understand how to restore
functional pathways and assist the body in
self repair.
# We can solve by replacing the core
functional components (artificial organs and
tissues) to restore body functions
# Another method is to restore youthful
blood factors; by way of replacing blood or
enhancing it periodically with personalized
compounds, in order to reduce organ
workload and boost immune system
functionality.
# Uploading memories and other system
parameters to an external new body or
hardware is being proposed for the future.
#Another way is to manage health by way of
constant monitoring and maintenance.
4. Evidence that it can be achieved
Evidence of other cellular forms living longer
(a) The Turritopsis dohrnii, commonly called the Immortal Jellyfish, species is shown to be
potentially immortal. This animal perpetually avoids deterioration by reverting to an immature
polyp stage and then maturing again.
(b) Ocean Quahogs, Greenland Sharks, Bowhead whales, Galapagos Giant tortoise can live for
200 years or longer.
Evidence that humans have lived well over 120
# The Hunza people are able to live up to 145 years. This tribe was first documented by Dr.
Robert McCarrison in the publication Studies in Deficiency Disease, followed in 1961 by an article
in JAMA documenting the remarkable lifespan of the Hunza.
https://sites.psu.edu/siowfa15/2015/09/15/the-hunza-people/
Saparman Sodimejo known more commonly as Mbah Gotho (died 30 April 2017) was an
Indonesian man who unverifiably claimed to be the oldest person ever recorded lived upto 142
years. https://en.wikipedia.org/wiki/Mbah_Gotho
However, the veritably oldest human lived for 122 years and 164 days, a female, Jeanne Louise
Calment from Arles, France.
https://www.demogr.mpg.de/books/odense/6/09.htm
5. The science of Abiogenesis presents a possible explanation
Abiogenesis, or informally the origin of life, is the natural process by which life arises from
non-living matter, such as simple compounds. The transition from non-living to living entities is
not thought to have taken place in a single event, but as a gradual process of increasing
complexity that involved molecular self-replication, self-assembly, autocatalysis and cell
membranes. Although the occurrence of abiogenesis is uncontroversial among scientists, there
is no single, generally accepted model for the origin of life.
https://en.wikipedia.org/wiki/Abiogenesis
6. Atomic Aggregates to
Cellular Living Forms
If we traced back how life was even formed,
we would start to see that they were formed
by non-living matter.
A certain characteristic of specific
compounds in an environment capable of
self replication and self assembly turned into
biological forms
In other words, if we carefully recreate this
entire process, we can probably create life
artificially
Understanding creation of life is key to
maintenance and restoration. Understanding
bottom-up technologies like molecular
manufacturing might throw more light on how
its done
7. Processes that keeps life going
The perfect orchestration of multiple pathways that account to energy continuum. Below is the
Unified map of global metabolic pathways mapped by Kyoto Encyclopedia of Genes and
Genomes.
https://www.genome.jp/kegg-bin/show_pathway?map01100
8. Bottom-up on
reasons that cause
death
Reverse engineering factors that lead
to cellular death, and learning how to
overcome them, can provide the
needed insights for avoiding this
problem.
Learning to manage cellular replication
errors and/or mutations causing DNA
damage, may allow for half of the battle
to be won.The other half may involve
replenishing lost functionality
(correcting telomere length, clearing
away cellular debris, etc.) and solutions
that negate larger forms of physical
damage.
9. Telomere Shortening
Many scientific studies have shown the strong connection between short telomeres and
cellular aging. The incorrect length of telomeres is involved in all aspects of the aging process
at the cellular level. That is, correct telomere length (not too long or too short) strongly
determines cellular health and biological age (as opposed to our chronological age). Without
the protection correct telomere length provides to DNA, our cells age, and the result is an
aging body. The enzyme telomerase rebuilds shortened telomeres, which otherwise shorten
during cell division without it.
In healthy cells, the telomerase gene is only expressed by reproductive cells. Hence, when
somatic cells divide via mitosis. because telomerase is absent (the gene is not expressed),
telomeres will gradually shorten due to replication errors. As cells recursively divide, at some
point each progeny reaches the Hayflick limit (believed to be between 50-70 cell divisions). At
this limit, cells become senescent and cell division stops. However, causing telomerase to
express in somatic cells allows for their telomeres to rebuild, creating healthy cell division. By
causing telomerase expression in somatic cells, the reversal of cellular and bodily aging was
achieved in test animals by Harvard Medical School in 2010.
https://www.tasciences.com/what-
is-a-telomere/
10. On Liz Parrish, CEO of BioViva
Liz Parrish, CEO of the Seattle-based company BioViva, reversed her biological age by 20
years by undergoing telomerase induction to lengthen her telomeres. She is the first human
to undergo telomerase induction therapy. Parrish learned that her telomeres were “unusually
short for her age” (she had the telomere shortening of someone in their mid-60s, perhaps due
to the lengthy childhood illness she suffered). She was treated at 44 years of age in
September of 2015, and has steadily regained telomere length.
The graph shows her status in 2018. Her telomeres increased in length from 7.33kb in 2016
to 8.12kb in 2018, amounting to two decades of cellular rejuvenation so far. Tests show that,
with a single telomerase induction treatment, her telomere length is now (in 2018) normal for
her biological age.
https://bioviva-science.com/blog/new-telomere-length-results-a-2018-update-by-liz-parrish/
11. Understanding the complex science of creation,
degradation, maintenance, and restoration requires much
more analytical power than the human brain is capable
of. What is required is a deep learning machine that can
learn across all variables to understand the intricate
balance of homeostasis.
Beyond Human Analytical Capability
Solving problems of ill health and aging are
12. With so many parameters influencing one another, it is extremely hard for humans to
manually analyze data in order to deduce accurate insights. We currently find numerous
analytical systems and machine learning platforms working to help healthcare workers
analyze and automate decision-making. Two shortcuts prevent the achievement of true
accuracy.
The need for Artificial Intelligence
13. 1. The Data Structure:
Since healthcare data is stored in silos, users are developing heuristic data
models.This might temporarily solve a few sets of problems. Designing the data
structure requires thorough understanding of domain knowledge. The most efficient
approach is to create a bottom-up unified structure that can analyze all associated
dimensions, which would mean working on a designed experiment rather than relying
on random observation. In a designed experiment, we can ensure that every
confounding parameter is incorporated, thereby achieving accuracy
2. The Learning Network:
Popular machine learning (ML) models, which were primarily developed for image
recognition, are good for providing learning visuals, too. This helps with learning
cellular structure from visuals provided by scanned reports. It might be required that
the functional behavior of the cell or compounds be learned, which require us to
incorporate temporal models like recurrent neural network (RNN). We will require a
hybrid model to understand the structural as well as the functional changes in order to
analyze both spatial and temporal variables, in order to cause the machine to learn
from the accurate extraction of features.
The need for Artificial Intelligence
14. The Data Structure
The Quahog Platform proposes a
unified hierarchical data model
designed to encompass
underlying pathways, in order to
learn the outputs (diseases)
caused by pathway dysfunction.
By using a cell-centric model, we
have mapped the pathways
within the cell to understand any
and all disruptions that result in
the various functions of a
particular cell. Rolling up these
cellular functions help us in
analyzing the aggregated
disruption (diseases) and the
external effects of the disruption
(symptoms).
15. Incorporating capabilities to run spatiotemporal
analysis
The model defined helps extraction and organization as per the hierarchical structure, which
makes it ideal for back propagation through structure (Recursive Neural Network). The
relationship between nodes depicts the spatial arrangement, and the time series arrangement of
a particular node, with its associate (Veer, associate variable?) helps In analyzing the node
changes over a period of time. This is depicted through time association between the node and
the associated variable.
16. Creating a system for continuous learning
Using the network model, the platform has two networks that work like Generative and
Adversarial (GAN), wherein data collected from patients generates based on the new
parameters collected, which is compared with the Adversarial Network (the expert system) to
learn of deviations. This allows the machine is learn from every bit of new data collected, and
update the pattern database and confirm facts whenever a certain threshold is met.
17. Developing such a holistic decision-making system can have a wide range of applications,
spanning prevention, diagnosis, prediction, and remedial solutions that will help correct
health disruptions. Wellness contributes to longevity.
AI Decision System and Longevity
18. Delivering intelligence to users for better
preventive care
The Quahog Platform can help patients connect their device data, lab reports, prescription and
other data to a centralized module and then receive alerts and recommendations to prevent
early stage health disruptions. Preventive recommendations, in the form of diet, drug, exercise,
therapy, etc., can be delivered based on the combined data analysis.
19. Extending intelligence right up to automating
repair
The Quahog Platform can help patient care users monitor, diagnose and correct health
problems by delivering intelligence based on the integration of data from various devices, in
order to provide real-time monitoring of the effects of the treatment and recovery process.
20. Extending intelligence to all kind of medical quests
Comprehensively extending intelligence to a multiplicity of medical quests. N-dimensional
analysis allows various emerging health fields to determine the different probabilities
associated within their data-sets, including:
• Drug Personalization based on individual
patient variables
• Diet Personalization based on individual
patient variables
• Drug Personalization variables can be
further delivered by 3D printing and
pelletizing a wide range of drugs for oral
consumption
• Structural learning can assist when
surgeries are needed, and these trained
sets can be readily used to improve the
outcome of precision robotic surgeries
• Holistic Analysis can help cell researchers
machine learn both structural and
functional behavior
• Learning structural and functional behavior
can be extended to understand cellular
behavior in cryoenvironments, too
21. Extending intelligence to organ regeneration
efforts
Be it growing organs from stem
cells or creating artificial 3D printed
tissue, the knowledge of structural
dynamics and its chemical behavior
is critical for understanding
acceptance or rejection of
components placed within our body.
Better understanding cause and
effect requires 360 degree analysis,
to ensure that implants are risk free
and will survive without negative
side effects.
The behavior of the transplanted
organ can be predicted using the
learning model of the Platform.
22. Extending intelligence to better understand
cryopreservation
In addition, researchers are
working on ways to reduce the
toxicity of the cryoprotectants used
to vitrify water, allowing for organ
banking for later transplantation.
Alcor is optimistic that the toxicity
that occurs with vitrification will be
reversible with future molecular
repair technologies.
https://alcor.org/Library/html/vitrification.html
Sometimes, such as during sudden serious injuries, there is little time to act. Cascading effects
can quickly cause death. This is when cryogenics may present the best hope. The nonprofit
Alcor Life Extension Foundation works to preserve patients immediately upon death, with the
hope of repairing all damages in the future to bring them back to a healthy life.
A challenge lies in keeping the cellular structure and their functions intact at the low
temperatures used. It becomes extremely important to understand long-term cellular parameters
at this temperature, and understand the possible pathways that must be addressed in a
sequential manner to predict cellular survival and restoration potential.
23. Extending intelligence to understand revival
processes
http://www.bbc.com/future/story/20140704-i-bring-the-dead-back-to-life
Samuel A. Tisherman, of the University of Maryland, College Park, has demonstrated a method
that may be useful for preventing death in trauma patients. When perfected, the method can put
those who could not be saved and expired from trauma, such as heart attack or a severe wound,
into ‘suspended animation’ for hours at a time. The procedure, so far tested on animals, involves
draining the body of blood and cooling it more than 20° C below normal body temperature.
Much pre-clinical work must be
done to show the efficacy of this
method, and machine learning
can afford a better understanding
of the various chemical reactions
that take place in the body, and
help resolve the various risks and
other problems involved with the
procedure.