Robetta is an online web-based tool that is publicly available for protein structure prediction. It utilizes methods like comparative modeling, de novo prediction, and mutation prediction using the Rosetta software package. Users submit a protein sequence in FASTA format, and Robetta generates up to 1000 structural models and provides results through the web interface or via email, including predicted coordinates. It analyzes proteins to predict unknown structures and model protein complexes.

1. Robetta

2. Content
● Introduction
● Objectives
● Input & Output
● Methodology
● Results Analysis
● Conclusion

3. For structure
predictions of protein, Robetta
is a fully automated
tool. Features include an
interactive submission interface
that allows custom sequence
alignments for homology
modeling, constraints, local
fragments, and more.
Introduction

4. “Based on Rosetta standalone package,
Robetta is a publicly available server of
homology modeling for protein
structure determination.”

5. Objectives
Available on
Robetta is an online
web based tool that is
publicly available for
the users.
Research
Outcome
It can predict up to
1000 models, so it is
suitable fo any protein
model.
Analyzes
Utilized to predict a
protein structure (in
particular, a protein whose
structure is experimentally
unknown).

6. Input
The server requires
to upload the file
containing the
query sequence in
FASTA format.
Results for a specific job
are provided through the
web interface from the job
id listed in the queue
table. For full structure
predictions, coordinates
are also emailed to the
user.
Output
Input & Output

7. de novo
prediction
Method used for
Protein structural
model
Mutation
Predict the effects of
mutations on protein–
protein interactions
Prediction
Rosetta software
package for
protein structure
prediction.
Complexes
Model multi-chain
complexes and provides
the option for large scale
sampling.
Comparative
modeling
Method used for
Protein structural
model
Methodology
PDB100
Robetta uses the
PDB100 template
database, which is
updated weekly

8. This is how Robetta predict
the 3D structure for protein
and estimate angstroms
error along with the
positions.

9. Robetta is an Internet
service that provides
automated structure
prediction and analysis
tools that can be used to
infer protein structural
information from
genomic data.
Conclusion

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