In developing countries, around 40% of deaths are caused by infectious, parasitic, and respiratory diseases, compared to 8% in developed countries. The top causes of death in developing countries are infectious and parasitic diseases exacerbated by malnutrition. Diarrheal diseases are also widespread. However, non-communicable diseases such as heart disease, cancer, and diabetes are increasing due to changes in diet, lifestyle, and urbanization. Countries experience a double burden of disease, with communicable diseases co-existing with rising non-communicable diseases.
While the world has focused on the traditional causes of premature death in Africa – communicable diseases such as HIV, malaria and tuberculosis, malnutrition, road and other accidents and political conflicts – a column of other types of killers has been gaining ground.
These are the chronic, noncommunicable diseases (NCDs) such as cancer, heart disease, diabetes, sickle-cell disease and kidney disease, whose collective toll is rising rapidly. How aware are patients of the causes of and cures for their diseases, and how well are they served by the healthcare providers in their countries?
Pneumonia and diarrhoea: tackling the deadliest diseases for the world’s poor...UNICEF Publications
Pneumonia and diarrhoea are leading killers of the world’s youngest children, accounting for 29 per cent of deaths among children under age 5 worldwide – or more than 2 million lives lost each year. This report makes a remarkable and compelling argument for tackling pneumonia and diarrhoea, two of the leading killers of children under age five. The data in this report highlight a critically important point – children living in the poorest households are less likely than the children living in the richest households to benefit from preventive measures and, when they do become ill, to receive lifesaving treatments.
While the world has focused on the traditional causes of premature death in Africa – communicable diseases such as HIV, malaria and tuberculosis, malnutrition, road and other accidents and political conflicts – a column of other types of killers has been gaining ground.
These are the chronic, noncommunicable diseases (NCDs) such as cancer, heart disease, diabetes, sickle-cell disease and kidney disease, whose collective toll is rising rapidly. How aware are patients of the causes of and cures for their diseases, and how well are they served by the healthcare providers in their countries?
Pneumonia and diarrhoea: tackling the deadliest diseases for the world’s poor...UNICEF Publications
Pneumonia and diarrhoea are leading killers of the world’s youngest children, accounting for 29 per cent of deaths among children under age 5 worldwide – or more than 2 million lives lost each year. This report makes a remarkable and compelling argument for tackling pneumonia and diarrhoea, two of the leading killers of children under age five. The data in this report highlight a critically important point – children living in the poorest households are less likely than the children living in the richest households to benefit from preventive measures and, when they do become ill, to receive lifesaving treatments.
The research of Warwick McKibbin (Australian National University, The Brookings Institution, Centre of Excellence in Population Ageing Research) and Roshen Fernando (Australian National University, Centre of Excellence in Population Ageing Research (CEPAR))
It's up to People and Governments, to reduce pandemic mortality by 50-60%! We have kea against pandemic and its Knowledge, that Oxidative Stress is in charge of more than half deaths! Please, show this file to your Health Minister and Premier Minister. You can start fight against pandemic with NEW, cheap and affordable weapon.
For decades, it has been acknowledged by the world’s premier health authorities that amid a pandemic, the functioning of society should be maintained, and human rights upheld. Governments and health organisations have at their disposal country-specific pandemic preparedness plans, as well as the World Health Organisation pandemic guidelines, which provide a roadmap outlining how to keep society functioning, while also mitigating the impact of a disease or virus.
In 2020, SARS-CoV-2 brought an almost–instantaneous rewriting of disease management principles as countries, with few exceptions, disregarded existing pandemic plans and replaced them with policies of ‘lockdown’.
There is no evidence that lockdowns have reduced mortality from Covid-19 and research is now revealing the devastation that lockdowns are causing, particularly in the developing world. In these draconian lockdown policies, we have also seen the biggest infringement on civil liberties in democratic countries during peacetime.
PANDA believes that, at this juncture, the science is quite clear on what key policy responses should be—or should have been. The cure should not be worse than the disease. It is critically important that societies are reopened, whilst protecting those who may be vulnerable to serious illness from SARS-CoV-2. Human agency must be upheld, and individuals should be empowered to make their own choices.
PANDA’s Protocol for Reopening Society builds upon existing pandemic frameworks and incorporates current scientific understanding of Covid-19, to provide a roadmap out of the damaging cycle of lockdowns.
This progress report builds on the A Promised Renewed effort that emerged from the Child Survival Call to Action, a high-level forum convened in June 2012 by the Governments of Ethiopia, India and the United States, in collaboration with UNICEF. Since June, more than half the world’s governments, and hundreds of civil society organizations and leaders of faith based groups have signed up and renewed their commitment to child survival.
Review of Recent COVID-19 Science ~ Denis G. Rancourt, PhDPandataAnalytics
Measures do not prevent deaths, transmission is not by contact, masks provide no benefit, vaccines are inherently dangerous: Review update of recent science relevant to COVID-19 policy.
Coorelation study between hdi and epidemiological transition ratio among indi...subhash chandra
The Epidemiological transition—the shift from infectious and deficiency diseases to chronic non communicable diseases—was a unidirectional process, beginning when infectious diseases were predominant and ending when non communicable diseases dominated the causes of death.
It has, however, become apparent that this transition is more complex and dynamic: the health and disease patterns of a society evolve in diverse ways as a result of demographic, socioeconomic, technological, cultural, environmental and biological changes.
It is rather a continuous transformation process, with some diseases disappearing and others appearing or re-emerging. This also indicates that such a process is not unidirectional
The research of Warwick McKibbin (Australian National University, The Brookings Institution, Centre of Excellence in Population Ageing Research) and Roshen Fernando (Australian National University, Centre of Excellence in Population Ageing Research (CEPAR))
It's up to People and Governments, to reduce pandemic mortality by 50-60%! We have kea against pandemic and its Knowledge, that Oxidative Stress is in charge of more than half deaths! Please, show this file to your Health Minister and Premier Minister. You can start fight against pandemic with NEW, cheap and affordable weapon.
For decades, it has been acknowledged by the world’s premier health authorities that amid a pandemic, the functioning of society should be maintained, and human rights upheld. Governments and health organisations have at their disposal country-specific pandemic preparedness plans, as well as the World Health Organisation pandemic guidelines, which provide a roadmap outlining how to keep society functioning, while also mitigating the impact of a disease or virus.
In 2020, SARS-CoV-2 brought an almost–instantaneous rewriting of disease management principles as countries, with few exceptions, disregarded existing pandemic plans and replaced them with policies of ‘lockdown’.
There is no evidence that lockdowns have reduced mortality from Covid-19 and research is now revealing the devastation that lockdowns are causing, particularly in the developing world. In these draconian lockdown policies, we have also seen the biggest infringement on civil liberties in democratic countries during peacetime.
PANDA believes that, at this juncture, the science is quite clear on what key policy responses should be—or should have been. The cure should not be worse than the disease. It is critically important that societies are reopened, whilst protecting those who may be vulnerable to serious illness from SARS-CoV-2. Human agency must be upheld, and individuals should be empowered to make their own choices.
PANDA’s Protocol for Reopening Society builds upon existing pandemic frameworks and incorporates current scientific understanding of Covid-19, to provide a roadmap out of the damaging cycle of lockdowns.
This progress report builds on the A Promised Renewed effort that emerged from the Child Survival Call to Action, a high-level forum convened in June 2012 by the Governments of Ethiopia, India and the United States, in collaboration with UNICEF. Since June, more than half the world’s governments, and hundreds of civil society organizations and leaders of faith based groups have signed up and renewed their commitment to child survival.
Review of Recent COVID-19 Science ~ Denis G. Rancourt, PhDPandataAnalytics
Measures do not prevent deaths, transmission is not by contact, masks provide no benefit, vaccines are inherently dangerous: Review update of recent science relevant to COVID-19 policy.
Coorelation study between hdi and epidemiological transition ratio among indi...subhash chandra
The Epidemiological transition—the shift from infectious and deficiency diseases to chronic non communicable diseases—was a unidirectional process, beginning when infectious diseases were predominant and ending when non communicable diseases dominated the causes of death.
It has, however, become apparent that this transition is more complex and dynamic: the health and disease patterns of a society evolve in diverse ways as a result of demographic, socioeconomic, technological, cultural, environmental and biological changes.
It is rather a continuous transformation process, with some diseases disappearing and others appearing or re-emerging. This also indicates that such a process is not unidirectional
Health Problems in India by Preeti ThakurSMVDCoN ,J&K
India has huge burden of Health problems .In India health problems are discussed under six major headings as commonly seen in the country.
1.Communicable Disease Problem
2. Non-Communicable disease problem
3.Nutritional problem
4.Environmental sanitation problem
5.Medical care problem
6.Population problem
GLOBAL HEALTH AND DISEASEChapter 2Chapter 2 OverviewIMatthewTennant613
GLOBAL HEALTH AND DISEASE
Chapter 2
Chapter 2: Overview
Introduction
Burden of Disease
Non communicable Disease
Infectious Disease
The Future of Infectious Disease
Public Health and Healthcare Strategies
Conclusion
Introduction
Development and management
Understanding the environmental or national context
Social and cultural beliefs
The physical environment
The political climate
3
3
Introduction
Understanding the environmental or national context
Economic development
Social structures
Types of diseases present in the population
4
4
Introduction
Influence of population health needs
Distribution of medical resources
Provision of health services
5
5
Introduction
Demands on healthcare systems
Disease prevention
Primary treatment
Secondary treatment
Tertiary treatment
6
6
Introduction
Integration of the healthcare system with public health system
Public health system responsibilities
7
7
Burden of Disease
Measurement of disease
Prevalence
Incidence
Disease specific mortality
Case fatality rate
Mortality rates
8
8
Burden of Disease
Reporting the burden of disease
Disability-adjusted life years (DALY)
Quality-adjusted life years (QALY)
Health expectancy
Healthy life years
Application of cost-benefit analyses
9
9
Burden of Disease
Effect of measurement on appropriation of health resources
Difficulties with collecting health statistics
10
10
Noncommunicable Disease
Heart disease
Cerebrovascular disease
Respiratory infections
HIVAIDS
Chronic pulmonary disease
Perinatal conditions
Diarrheal disease
Tuberculosis
Malaria
Respiratory tract cancers
Top 10 leading causes of death
Noncommunicable Disease
Emergence of noncommunicable disease
Heart disease
Stroke
Cancer
12
12
Noncommunicable Diseases
Emergence of noncommunicable disease
Chronic respiratory disease
Mental illness
Diabetes
13
13
Noncommunicable Disease
Increasing impact on worldwide mortality
Differences between communicable and noncommunicable disease
World Health Organization projection
14
14
Noncommunicable Disease
Risk factors for noncommunicable disease
Lifestyle
Environment
Top ten leading causes of death worldwide
15
15
Noncommunicable Disease
Cardiovascular disease
Forms of disease
Atherosclerotic disease
Non-atherosclerotic disease
16
16
Noncommunicable Disease
Cardiovascular diseases Types
Coronary Artery Disease
Heart Attack
Congenital Heart Disease
Aneurysm
Heart Failure
High Blood Pressure
Stroke
Arrhythmias
17
17
Noncommunicable Disease
Cancer
Risk factors
Preventable risk factors
18
18
Noncommunicable Disease
Factors Known To Increase Cancer Risk
Age: can take decades to develop
Lifestyle: Certain lifestyle choices
Family history: 10% due to inherited condition
Health conditions: Some chronic health conditions can increase risks
Noncommunicable Disease
Factors Known To Increase Cancer Risk
Environment: may contain harmful chemicals
Globalization:
Rising consumption of tobacc ...
ScanScan 1Scan 2Scan 3Scan 4Scan 5Scan 6Scan 7Scan 8Scan 9Scan 10Scan 11Scan 12Scan 13
Chapter 13 Global Health Challenges
MANY INDIVIDUALS AND NONGOVERNMENTAL ORGANIZATIONS (NGOS) HELP FIGHT GLOBAL DISEASE. The Bill and Melinda Gates Foundation plays a key role in the war against malaria, AIDS, and other diseases. Melinda and Bill Gates met with doctors and patients at the Manhica Research Center and Hospital in an area of Mozambique heavily affected by malaria.
Learning Objectives
1. 13.1Recall the causes and effects of noncommunicable diseases
2. 13.2Evaluate the role of global travel and trade in facilitating the globalization of infectious diseases
3. 13.3Outline the three developments that gave rise to the concept of human security
4. 13.4Describe the three epidemiologic transitions to better understand contemporary concerns about infectious diseases
5. 13.5Report the cause, spread, effects, and control measures of influenza and avian flu
6. 13.6Report the cause, spread, effects, and control measures of malaria
7. 13.7Recognize the causes and preventive measures of HIV
8. 13.8Report the origin, spread, effects, and control measures of SARS
9. 13.9Report the origin, spread, effects, and control measures of Ebola
10. 13.10Outline role of the WHO in preventing the spread of infectious diseases
Noncommunicable diseases (NCDs) such as heart disease, cancer, diabetes, chronic respiratory disease, and mental illness in general and Alzheimer’s disease in particular are the leading causes of death and disability globally. Long associated with affluent Western standards of living, NCDs are now a global problem. While rich countries are better equipped to deal with chronic diseases, they are far more deadly in poor countries. Growing numbers of old people and the spread of middle-class lifestyles make NCDs more prevalent than infectious diseases. Globalization also contributes to the growth of NCDs by helping expand the global middle class and by promoting fast foods, sugary drinks, alcohol, smoking, processed foods, and sedentary lifestyles. A major global health threat that undermines efforts to cure diseases is the emergence of germs that are resistant to antibiotics. This is due mainly to the excessive use of antibiotics in medicine and agriculture.
Infectious diseases are intertwined with numerous global issues and are inseparable from political, economic, and cultural components of globalization. Ethnic conflicts make populations vulnerable to infectious diseases. Fighting contributes to the collapse of public services, which means that many people die from what would ordinarily be treatable diseases, such as diarrhea and respiratory infections. Conflicts also create refugees, overcrowding, and unsanitary conditions, thereby creating environments conducive to the spread of infectious diseases.
Environmental degradation and deforestation expose humans to a variety of infectious diseases. They also contribute to global warming and flooding,.
ScanScan 1Scan 2Scan 3Scan 4Scan 5Scan 6Scan 7Scan 8Scan 9Scan 10Scan 11Scan 12Scan 13
Chapter 13 Global Health Challenges
MANY INDIVIDUALS AND NONGOVERNMENTAL ORGANIZATIONS (NGOS) HELP FIGHT GLOBAL DISEASE. The Bill and Melinda Gates Foundation plays a key role in the war against malaria, AIDS, and other diseases. Melinda and Bill Gates met with doctors and patients at the Manhica Research Center and Hospital in an area of Mozambique heavily affected by malaria.
Learning Objectives
1. 13.1Recall the causes and effects of noncommunicable diseases
2. 13.2Evaluate the role of global travel and trade in facilitating the globalization of infectious diseases
3. 13.3Outline the three developments that gave rise to the concept of human security
4. 13.4Describe the three epidemiologic transitions to better understand contemporary concerns about infectious diseases
5. 13.5Report the cause, spread, effects, and control measures of influenza and avian flu
6. 13.6Report the cause, spread, effects, and control measures of malaria
7. 13.7Recognize the causes and preventive measures of HIV
8. 13.8Report the origin, spread, effects, and control measures of SARS
9. 13.9Report the origin, spread, effects, and control measures of Ebola
10. 13.10Outline role of the WHO in preventing the spread of infectious diseases
Noncommunicable diseases (NCDs) such as heart disease, cancer, diabetes, chronic respiratory disease, and mental illness in general and Alzheimer’s disease in particular are the leading causes of death and disability globally. Long associated with affluent Western standards of living, NCDs are now a global problem. While rich countries are better equipped to deal with chronic diseases, they are far more deadly in poor countries. Growing numbers of old people and the spread of middle-class lifestyles make NCDs more prevalent than infectious diseases. Globalization also contributes to the growth of NCDs by helping expand the global middle class and by promoting fast foods, sugary drinks, alcohol, smoking, processed foods, and sedentary lifestyles. A major global health threat that undermines efforts to cure diseases is the emergence of germs that are resistant to antibiotics. This is due mainly to the excessive use of antibiotics in medicine and agriculture.
Infectious diseases are intertwined with numerous global issues and are inseparable from political, economic, and cultural components of globalization. Ethnic conflicts make populations vulnerable to infectious diseases. Fighting contributes to the collapse of public services, which means that many people die from what would ordinarily be treatable diseases, such as diarrhea and respiratory infections. Conflicts also create refugees, overcrowding, and unsanitary conditions, thereby creating environments conducive to the spread of infectious diseases.
Environmental degradation and deforestation expose humans to a variety of infectious diseases. They also contribute to global warming and flooding,.
Article Type: Editorial
Title: Changing and Challenging Scenario of Burden of Disease
Year: 2022; Volume: 2; Issue: 1; Page No: 3 – 4
Author: Dr. P.K. Govindarajan
10.55349/ijmsnr.20222134
Affiliation: Professor, Department of Community Medicine, Vinayaka Missions Medical College and Hospital, Karaikal, Puducherry (UT), India.
Email ID: drpkgr@gmail.com
Article Summary:
Submitted : 15-February-2022
Revised : 27-February-2022
Accepted : 15-March-2022
Published : 31-March-2022
Chapter TwoHealth Determinants, Measurements, and Trends.docxtiffanyd4
Chapter Two
Health Determinants, Measurements, and Trends
Overview
What are the determinants of health?
What are the most important health indicators and key terms related to measuring health status and the burden of disease?
What are the leading causes of death and the burden of disease in low-, middle-, and high-income countries?
What are the demographic and epidemiological transitions?
The Importance of Measuring Health Status
In order to address global health issues, we must understand:
The factors that influence health status most
The indicators used to measure health status
The key trends in health status that have occurred historically
Determinants of Health
The interconnected factors that determine an individual’s health status
Determinants include personal and inborn features, socioeconomic status, culture, environment, educational attainment, health behaviors, childhood development, access to care, and government policy
Increasing attention is being paid to the social determinants of health
Key Health Indicators
Health status indicators are useful for:
Finding which diseases people suffer from
Determining the extent to which the disease causes death or disability
Carrying out disease surveillance
To perform these functions, it is important to use a consistent set of indicators in order to make comparisons
Key Health Indicators
Key Health Indicators
Key Health Indicators
Key Health Indicators
Key Health Indicators
Key Health Indicators
Key Health Indicators
Terms
Morbidity—sickness or any departure, subjective or objective, from a psychological or physiological state of well-being
Mortality—death
Disability—temporary or long-term reduction in a person’s capacity to function
13
Key Health Indicators
Terms
Prevalence—number of people suffering from a certain health condition over a specified period
Incidence—the rate at which new cases of a disease occur in a population
14
Key Health Indicators
Communicable diseases—illnesses caused by a particular infectious agent that spreads directly or indirectly from people to people, animals to people, or people to animals; also called infectious diseases
Noncommunicable diseases—illnesses not spread by an infectious agent
Injuries—include road traffic injuries, falls, self-inflicted injuries, and violence, among other things
Vital Registration
Vital registration systems record births, deaths, and causes of death
An accurate system is key to having quality data on a population
Many low- and middle-income countries lack a vital registration system
Often there are cultural barriers to timely vital registration
Vital Registration
Measuring the Burden of Disease
Health-Adjusted Life Expectancy (HALE)
Summarizes expected number of years to be lived in what might be termed the equivalent of good health
A health-expectancy measure
To calculate HALE: the years of ill health are weighted according to severity and subtracted from overall life e.
Communicable Disease
Chapter 12
Chapter 12: Communicable Disease
1
The Importance of Communicable Diseases
31% of the burden of disease in low- and middle-income countries and 40% of all DALYS.
Disproportionately affect the poor.
Enormous economic consequence.
Relevance to MDGs.
Burden of communicable disease is unnecessary, many can be prevented or treated.
DiseaseMortalityHIV/AIDS1.5 millionTB1.5 millionDiarrhea800,000Malaria550,000
Communicable disease account for 31% of the disease burden in low and middle income countries. This burden is disproportionately high in Africa and in low income people. People with higher education are more likely to protect themselves from the disease in compare to low income and less educated people. The economic consequences of infectious diseases are high. In addition to the high cost of the treatment which forces people to live below the poverty level, it also has negative consequences of the economic growth of the country. This high burden of the disease in unnecessary because many of these condition could easily be prevented with low cost interventions like vaccinations.
2
Key Terms, Definitions, and Concepts
Communicable diseases are the ones that are transmitted from human to human, animal to animal, and animal to human. They could be transmitted directly such as through inhalation or indirectly through a vector like mosquito. The control of communicable disease also depends on a number of factors. Among them are vaccination, vector control, improved sanitation, chemotherapy, disease recognition and improved care seeking, and behavioral change.
3
Communicable disease- transmitted from animal to animal, animal to human, or human to human
Spread (direct and indirect) and contracted through food, water, bodily fluids, vector, inhalation, non-traumatic contact, and traumatic contact
Controlled with vaccination, mass chemotherapy, vector control, improved water and sanitation, improved care seeking and disease recognition, case management, and behavioral change
This table contains communicable disease key terms which we need to be familiar with as it relates to the discussion on communicable diseases.
4
The Burden of Communicable Diseases
31% of total deaths, 40% of total DALYs lost annually in low- and middle-income countries
Relative importance compared to non-communicable diseases and injuries varies by region (refer to slide 6-7).
South Asia and sub-Saharan Africa have highest relative burden of deaths from communicable diseases.
Relative importance of specific communicable diseases varies by age, too.
In low and middle income countries, 36% of total deaths and 40% of total DALYs lost annually because of communicable diseases.
5
Deaths from Selected Infections and Parasitic Diseases, as Percent of Total Deaths, by Region 2008
Source: http://vizhub.healthdata.org/gbd-compare/ Accessed Jan 19 2016, .
South Asia and Sub-Saharan Africa shares the highes.
Communicable Disease
Chapter 12
Chapter 12: Communicable Disease
1
The Importance of Communicable Diseases
31% of the burden of disease in low- and middle-income countries and 40% of all DALYS.
Disproportionately affect the poor.
Enormous economic consequence.
Relevance to MDGs.
Burden of communicable disease is unnecessary, many can be prevented or treated.
DiseaseMortalityHIV/AIDS1.5 millionTB1.5 millionDiarrhea800,000Malaria550,000
Communicable disease account for 31% of the disease burden in low and middle income countries. This burden is disproportionately high in Africa and in low income people. People with higher education are more likely to protect themselves from the disease in compare to low income and less educated people. The economic consequences of infectious diseases are high. In addition to the high cost of the treatment which forces people to live below the poverty level, it also has negative consequences of the economic growth of the country. This high burden of the disease in unnecessary because many of these condition could easily be prevented with low cost interventions like vaccinations.
2
Key Terms, Definitions, and Concepts
Communicable diseases are the ones that are transmitted from human to human, animal to animal, and animal to human. They could be transmitted directly such as through inhalation or indirectly through a vector like mosquito. The control of communicable disease also depends on a number of factors. Among them are vaccination, vector control, improved sanitation, chemotherapy, disease recognition and improved care seeking, and behavioral change.
3
Communicable disease- transmitted from animal to animal, animal to human, or human to human
Spread (direct and indirect) and contracted through food, water, bodily fluids, vector, inhalation, non-traumatic contact, and traumatic contact
Controlled with vaccination, mass chemotherapy, vector control, improved water and sanitation, improved care seeking and disease recognition, case management, and behavioral change
This table contains communicable disease key terms which we need to be familiar with as it relates to the discussion on communicable diseases.
4
The Burden of Communicable Diseases
31% of total deaths, 40% of total DALYs lost annually in low- and middle-income countries
Relative importance compared to non-communicable diseases and injuries varies by region (refer to slide 6-7).
South Asia and sub-Saharan Africa have highest relative burden of deaths from communicable diseases.
Relative importance of specific communicable diseases varies by age, too.
In low and middle income countries, 36% of total deaths and 40% of total DALYs lost annually because of communicable diseases.
5
Deaths from Selected Infections and Parasitic Diseases, as Percent of Total Deaths, by Region 2008
Source: http://vizhub.healthdata.org/gbd-compare/ Accessed Jan 19 2016, .
South Asia and Sub-Saharan Africa shares the highes.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
Follow us on: Pinterest
Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
3. IN A TYPICAL DEVELOPING COUNTRY ABOUT 40%OF DEATH ARE FROM INFECTIOUS ,PARASITE,AND RESPIRATORY DISEASES COMPARED WITH ABOUT 8%IN DEVELOPED COUNTRIESIN INDIA ,AS IN OTHER DEVEOPING COUNTRIES ,MOST DEATH RESULT FROM INFECTIOUS AND PARASITE DISEASE,ABETTED BY MALNUTRITION.-> DIARRHOEAL DISEASES ARE WIDESPREAD.-> CHOLERA HAS SHOWN DECLINE TREND.Non communicable diseases (NCD) are the major health burden in the industrialized countries, and are increasing rapidly in the developing countries owing to demographic transitions and changing lifestyles among the people.
14. DISEASE PATTERN The rapidity of the changes in developing countries is such that a double burden of disease may often exist. Hunger and malnutrition It includes death, disability, stunted mental and physical growth, and as a result, retarded national socioeconomic development. Some 60% of the 10.9 million deaths each year among children aged under five years in the developing world are associated with malnutrition. Traditional diets and lifestyles are changing, thus food insecurity and undernutrition persist along with chronic diseases. The epidemic of obesity exists along with heart disease, hypertension, stroke, and diabetes. Increasing prevalence of obesity indicates that physical inactivity is an increasing problem .
15. On a global basis, 60 % of the burden of chronic diseases will occur in developing countries, and by 2020, 70% of deaths will occur due to diabetes. Cardiovascular diseases are even now more numerous in India and China than in all the economically developed countries in the world put together. As for obesity, current prevalence has reached unprecedented levels, and is increasing at a substantial rate annually. The public health implications of this phenomenon are staggering, and already becoming apparent.
16. DOUBLE BURDEN OF DISEASE The rapidity of the changes in developing countries is such that a double burden of disease may often exist. Hunger and malnutrition It includes death, disability, stunted mental and physical growth, and as a result, retarded national socioeconomic development. Some 60% of the 10.9 million deaths each year among children aged under five years in the developing world are associated with malnutrition. Traditional diets and lifestyles are changing, thus food insecurity and undernutrition persist along with chronic diseases. The epidemic of obesity exists along with heart disease, hypertension, stroke, and diabetes. Increasing prevalence of obesity indicates that physical inactivity is an increasing problem .
17. DISEASE TRENDS IN INDIA Initial burden -> infectious diseases, maternal and child mortality. Present status -> non communicable diseases, injuries and geriatric problems.
18. Communicable diseases pattern in India : Small pox and guinea worm are eradicated. Yaws and plague are under control. Cholera : 1,76,307 with 86,997 death in 1950 now total cases are 5,000 and mortality is also low. Tuberculosis is not controled because of poor management, unavailability of drugs and incomplete treatment. AIDS /HIV increases from the past one and half decade.
19. Non communicable disease pattern in India : As a result of industrilization , socio economic development, urbanization and changing life styles, India is facing growing burden of Non communicable diseases. 32% of deaths are due to NCDs. 13% due to cardiovascular diseases. 8.7% injuries. 6.7% chronic respiratory diseases 3.4% cancer 0.2% diabetes 10 – 15% hypertension
25. Communicable Disease Control, Global and Local: Methods Immunization (measles and many more) Chemotherapy (STD’s, TB) Water, sanitation & washing (many) Vector control (malaria, yellow fever etc.) Education/behaviour change (HIV etc. etc.) Regulatory measures (pasteurization, quarantine etc.) **Socioeconomic development
26.
27. Appreciation of the distribution of various representative communicable diseases
28. An introduction to the principles and practice of communicable disease control
29. An introduction to the idea that International Health can be fascinating and rewarding
30.
31. Total disease burden in 2004 amounts to 5.7 million DALYs in men and 4.2 million DALYs in women were a little higher than those in 1999.
32. The proportion of burden from premature deaths in 2004 decreased among men, from 75% to 69% and from 65% to 62% among women, indicating increasing proportion of non fatality conditions for which people lived in disabilities.
33. HIV/AIDS burden considerably reduced from 32.3 to 21.1 DALYS per 1,000 population in men but moderately reduced in women (12.2 to 9.3). This indicates second wave of epidemic spread by sexual relation with long-term female partners.
34.
35. Disease trend in china The ageing of the population is the major force driving the epidemic of chronic diseases is estimated 80% of total deaths.
36. COMMUNICABLE DISEASES HIV/ AIDS epidemic in china. Due to high prevalence of homosexuality, unsafe sex ,infected blood donation. According to WHO avian influenza is a challenge for a country in recent years. WHO global targets for detecting and treating TB cases. But still TB is common in china.
37. Non-Communicable diseases It is expected that there will 200% increase in cardio vascular diseases by 2040 due to increase in ageing population. Due changing lifestyle obesity, hypertension and diabetes are fast emerging major non communicable diseases. Due to ageing Alzheimer is emerging as prominent chronic diseases. Due to excess use of tobacco chronic respiratory disease and cancer are emerging as a major problem in china.
39. Ranking of Communicable Diseases By DALYs Disease ConditionDisease Burden HIV-AIDS 84.5 million Neglected Tropical Diseases 56.6 million Malaria 46.5 million Tuberculosis 34.7 million Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Ehrlich Sachs S, Sachs JD PLoS Medicine 2006; 3: e102
40. The Neglected Tropical Diseases: Humanity’s Ancient Diseases of Stigma and Poverty 13 Parasitic and Bacterial Infections Rural Areas of Low-Income Countries Poverty-Promoting Conditions Child Development & Education Pregnancy Worker Productivity Burdened humanity for centuries “The Biblical Diseases” Disabling and deforming Associated with intense stigma Leprosy Lymphatic Filariasis Guinea Worm River Blindness