The document discusses how best practices for performance tuning with HTTP/1.1 may need to be re-thought with the introduction of HTTP/2. It provides an overview of how HTTP/2 addresses limitations of HTTP/1.1 like head-of-line blocking through features like multiplexing, binary framing, header compression and server push. It recommends approaches like keeping HTTP requests low and caching resources while avoiding past practices like excessive domain sharding or image sprites that are no longer needed with HTTP/2.