This document discusses respiratory tract infections, including infections of the upper and lower respiratory tract. It describes common upper respiratory tract infections like the common cold, pharyngitis, laryngitis, sinusitis, and otitis media. Lower respiratory tract infections discussed include bronchitis and pneumonia. The document outlines signs and symptoms of upper and lower respiratory tract infections and describes diagnostic tests. It provides information on different classes of antibiotics like penicillin, cephalosporins, fluoroquinolones, macrolides, and tetracyclines. Specific antibiotics discussed in more depth include clarithromycin.
History of medicine, pre historic medicine, egyptian medicine, ayurveda, chinese medicine, Greek medicine, Roman medine, Medievial medicine, Future trends in medicine, medicine in 21st century, Medicine in 18th century, medicine in 19th century, Medicine in 20th century, Tech trends in medicine, Medicine pioneers, Dark age medicine, Babylonian medicine, Greek medicine, Roman medicine, Babylonian medicine, Prehistoric men believed that illness and diseases were a punishment from the Gods
First physicians were witch doctors who treated illness with ceremonies, WAY OF LIFE
Hunter Gatherers, Major Threats to Health, Egyptians believed gods, demons and spirits played a key role in causing diseases, Ancient Egyptian doctors prescribed mashed pig’s eyes blended with honey and red ochre for eye problems, The practice of medicine is very specialized among Egyptian, Each physician treats just one disease, Oldest surviving complete medical system in the World – A highlights the way of life that teaches how to maintain and protect health, Babylonians introduced the concepts of diagnosis, prognosis, physical examination and prescriptions.
Patients were treated with various therapies, While Ancient Civilizations were undoubtedly versed in the use of herbs as medicines, Extensive Written Records Appeared only During the Time of Greeks, The medical knowledge was acquired by Romans by Greek physicians who were brought into Roman empires, mostly as Slaves, Time of intellectual and societal stagnation throughout much of Europe, But the torch of academia continued to burn brightly in the Islamic world, Church taught that God sent illness & repenting would cure all evils many people at the time believed that pilgrimage would cure them
History of medicine, pre historic medicine, egyptian medicine, ayurveda, chinese medicine, Greek medicine, Roman medine, Medievial medicine, Future trends in medicine, medicine in 21st century, Medicine in 18th century, medicine in 19th century, Medicine in 20th century, Tech trends in medicine, Medicine pioneers, Dark age medicine, Babylonian medicine, Greek medicine, Roman medicine, Babylonian medicine, Prehistoric men believed that illness and diseases were a punishment from the Gods
First physicians were witch doctors who treated illness with ceremonies, WAY OF LIFE
Hunter Gatherers, Major Threats to Health, Egyptians believed gods, demons and spirits played a key role in causing diseases, Ancient Egyptian doctors prescribed mashed pig’s eyes blended with honey and red ochre for eye problems, The practice of medicine is very specialized among Egyptian, Each physician treats just one disease, Oldest surviving complete medical system in the World – A highlights the way of life that teaches how to maintain and protect health, Babylonians introduced the concepts of diagnosis, prognosis, physical examination and prescriptions.
Patients were treated with various therapies, While Ancient Civilizations were undoubtedly versed in the use of herbs as medicines, Extensive Written Records Appeared only During the Time of Greeks, The medical knowledge was acquired by Romans by Greek physicians who were brought into Roman empires, mostly as Slaves, Time of intellectual and societal stagnation throughout much of Europe, But the torch of academia continued to burn brightly in the Islamic world, Church taught that God sent illness & repenting would cure all evils many people at the time believed that pilgrimage would cure them
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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2 Case Reports of Gastric Ultrasound
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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8. Antibiotics
A chemical material produced by a microorganism, which is harmful to other
microorganisms. Antibiotics are typically developed by soil microorganisms and are
likely to be a means by which organisms regulate the growth of competing
microorganisms in complex environments, such as soil.
10. Antibiotics
Penicillin
• Inhibits cell wall mucopeptide
biosynthesis
• Not active against penicillinase-producing
bacteria containing several staphylococcal
strains
Cephalosporins
• used to manage a wide range of
infections from gram-positive and
gram-negative bacteria.
• The five generations of
cephalosporins are useful against
skin infection, resistant bacteria,
meningitis, and other infections.
Fluoroquinolone
• The fluoroquinolones are indicated for the treatment of several bacterial infections, including bacterial
bronchitis, pneumonia, sinusitis, urinary tract infections, septicemia, and intraabdominal infections,
joint and bone infections, soft tissue, and skin infections, typhoid fever, anthrax, bacterial
gastroenteritis
11. Fluoroquinolone
• The fluoroquinolones are indicated for the
treatment of several bacterial infections,
including bacterial bronchitis, pneumonia,
sinusitis, urinary tract infections,
septicemia, and intraabdominal infections,
joint and bone infections, soft tissue and
skin infections, typhoid fever, bacterial
gastroenteritis
Antibiotics
Macroloides
• Indicated for treating community acquired
bacterial pneumonia because of their action
against numerous causative organisms.
• Also used for the treatment of sexually
transmitted infections caused by Chlamydia
trachomatis. Macrolides are also used for skin
and soft tissue infections caused by
staphylococci, and Propionobacter acnes.
Tetracyclines
• Commonly been used to treat acne and lots of infection in the skin and also respiratory tract
infections, it is also known to be effective in the treatment of urinary infections.
• Since the 1950s, tetracyclines have been used in the treatment of a large spectrum of gram-positive
and gram-negative bacterial infections.
12. Indication
Alternative medication for the treatment of acute otitis media caused by H. influenzae, or S. pneumoniae in
patients with a history of type I penicillin hypersensitivity. Also for the treatment of pharyngitis and
tonsillitis caused by susceptible Streptococcus pyogenes, as well as respiratory tract infections including
acute maxillary sinusitis, acute bacterial exacerbations of chronic bronchitis, mild to moderate
community-acquired pneumonia, Legionnaires' disease, and pertussis.
Other indications :
1. include treatment of uncomplicated skin or skin structure infections, helicobacter pylori infection,
duodenal ulcer disease.
2. Clarithromycin may also decrease the incidence of cryptosporidiosis, prevent the occurence of α-
hemolytic (viridans group) streptococcal endocarditis, as well as serve as a primary prevention
for Mycobacterium avium complex (MAC) bacteremia or disseminated infections.
3. Clarithromycin is indicated in combination with vonoprazan and amoxicillin as co-packaged triple therapy
to treat Helicobacter pylori (H. pylori) infection in adults.
Clarithromycin
13. Mechanism of Action
• Inhibits the production of Glycolax by binding to 50 s unit, which helps penetrate the bacterial
cell.
• Increases activities of concomitantly used other bacterial agents.
• Stimulates phagocytic activity of leucocytes.
• Inhibits the expression of cytokines.
