8. Carbon dioxide/Bicarbonate Relationship CO 2 + H 2 O <---> H 2 CO 3 <---> H + + HCO 3 - Carbon dioxide dissolved in water readily combines with water to form carbonic acid. The carbonic acid then dissociates into the hydrogen ion and bicarbonate ion. The former reaction is catalized by and enzyme called Carbonic Anhydrase in many tissues. www.freelivedoctor.com
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10. HEMOGLOBIN/OXYGEN DISSOCIATION P O 2 of blood (mmHg) % Hemoglobin Saturation Resting P O 2 Systemic Normal P O 2 Capillaries www.freelivedoctor.com
11. Agents which shift the Hb/O Dissociation curve: The Bohr Effect www.freelivedoctor.com
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13. Agents which shift the Hb/O Dissociation curve: The Bohr Effect www.freelivedoctor.com
14. Carbon dioxide/Bicarbonate Relationship CO 2 + H 2 O <---> H 2 CO 3 <---> H + + HCO 3 - Carbon dioxide dissolved in water readily combines with water to form carbonic acid. The carbonic acid then dissociates into the hydrogen ion and bicarbonate ion. The former reaction is catalized by and enzyme called Carbonic Anhydrase in many tissues. www.freelivedoctor.com
15. Carbon Dioxide Transport in the Blood: At the tissues Tissue Cell Red Blood Cell CO 2 + H 2 O ---> H 2 CO 3 ---> H + + HCO 3 Carbonic Anhydrase + Hb --->HbH + Hb ---> HbCO 2 HbO 2 -----> Hb + O 2 www.freelivedoctor.com
16. Carbon Dioxide Transport in the Blood: At the lungs Alveolus Red Blood Cell CO 2 + H 2 O <--- H 2 CO 3 <--- H + + HCO 3 - Carbonic Anhydrase + Hb <---HbH + Hb <--- HbCO 2 HbO 2 <--- Hb + O 2 www.freelivedoctor.com
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