The document summarizes research on using statins and ezetimibe to prevent atherosclerosis by lowering LDL levels. Clinical trials showed that while ezetimibe further lowered LDL when added to statin therapy, it did not significantly reduce atherosclerosis on its own. However, a 2011 study found that patients taking simvastatin and ezetimibe saw greater reduction in plaque volume over 2 years compared to simvastatin or ezetimibe alone. The research suggests combining statins with ezetimibe may provide benefits for preventing atherosclerosis beyond statins alone.