A 14-year-old boy presented to the ER after an RTA with abdominal distension and tenderness, vomiting, and hematuria. Imaging showed a subcapsular renal hematoma of 150-200ml. The mechanism was blunt trauma from the RTA. Based on imaging findings, it is a Grade 3 renal injury. Evaluation includes hemodynamic stability, history, and testing for hematuria. Management is usually non-operative for Grade 1-4 injuries, with angioembolization for bleeding. Options include exploration for hemodynamic instability or high grade injuries.
Consensus on GU Trauma
Evaluation and management of renal
injuries: consensus statement of the
renal trauma subcommittee
BJU International
Volume 93 Issue 7 Page 937-954, May 2004
Consensus on GU Trauma
Evaluation and management of renal
injuries: consensus statement of the
renal trauma subcommittee
BJU International
Volume 93 Issue 7 Page 937-954, May 2004
Please find the power point on Urinary Tract Injury (Kidney Injury). I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Please find the power point on Urinary Tract Injury (Kidney Injury). I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
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Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
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Stay informed, stay safe, and get your flu shot today!
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
2. Case Scenario
14 year old boy, presented to ER department with history of RTA on 16/2/23 ( hit by bike while
crossing the road), his abdomen was distended and tender, he was having vomiting and
hematuria, after resuscitation USG done which showed sub-capsular hematoma of about 150-200
ml, Renal Tri-phasic CT scan showed.
3.
4.
5.
6.
7. Questions:
Which mechanism of injury is it?
Which type & grade of renal trauma is it?
How to evaluate?
How to manage?
What are the options to manage the patient?
8.
9.
10.
11.
12. Epidemiology:
Road Traffic accidents are major cause of long-term morbidity and mortality in developing countries.
Genitourinary Injuries accounts for 10% of all abdominal trauma.
Renal trauma accounts 5% of all trauma cases and 84% of genitourinary injuries.
Early Diagnosis is essential to prevent serious complications.
13. Signs of Renal Injury
Large Retroperitoneal Hematoma (Grey Turner’s Sign).
A palpable mass may represent a large Retroperitoneal Hematoma or urinary extravasation but if retro-
peritoneum has been torn, free blood may be noted in peritoneal cavity and no palpable mass will be
appreciated.
14. Kidney:
Microscopic / Gross Hematuria
Tenderness or ecchymosis over flanks or upper quadrant of abdomen
Diffuse abdominal tenderness on palpation (acute abdomen)
Distended abdomen with absent bowel sounds
16. Imaging:
Indications for imaging are
Visible hematuria.
Non-visible hematuria and one episode of hypotension.
A history of rapid deceleration injury and/or significant associated injuries.
Penetrating trauma.
Clinical signs suggesting renal trauma e.g. flank pain, abrasions, fractured ribs, abdominal
distension and/or a mass and tenderness.
17. Multiphase CT Scan is the imaging modality of choice in renal trauma.
Ultrasound is inferior to CT scan but can be used for follow up.
Diagnostic accuracy of MRI is similar to CT scan in renal trauma .
IVP should only be performed when CT isn’t available .
CT urography is the examination of choice when ureteral injuries are suspected.
18. Renal Trauma Classification:
Blunt trauma (80-90%)
Direct blow to the kidney (fall from ladder, direct fall onto flank)
Rapid acceleration or rapid deceleration ( RTA etc.)
A combination of above
Penetrating injury (10-20%)
Gunshot Injuries (more common)
Stab Injuries
19. Penetrating Injury is more severe and less predictable.
Bullets are mostly associated with multiple organ injuries (77%).
Penetrating Trauma anterior to anterior axillary line disrupts renal pedicle & hilum, hence more
damaging .
Penetrating Trauma posterior to anterior axillary line damages renal parenchyma .
20. AAST Renal Injury Grading Scale
American Association of Surgery for Trauma has developed this validated system which has
clinical relevance.
It helps to predict the need for any intervention.
Can predicts morbidity and mortality.
21.
22.
23. Evaluation
Assess hemodynamic stability upon admission.
Record past renal surgery, and known pre-existing renal abnormalities (ureter-o-pelvic junction
obstruction, solitary kidney, uro-lithiasis).
Test for hematuria in a patient with suspected renal injury.
24. Management
Manage stable patients with blunt renal trauma non-operatively with close monitoring and re-imaging
as required.
Manage isolated Grade 1-4 stab and low-velocity gunshot wounds in stable patients non-operatively.
25. Use selective angio-embolisation for active renal bleeding if there are no other indications for immediate
surgical exploration.
Proceed with renal exploration in the presence of:
Persistent hemodynamic instability
Grade 5 vascular or penetrating injury
Expanding or pulsatile peri-renal hematoma.
26. Repeat imaging in high-grade and penetrating injuries and in cases of fever, worsening flank pain,
or falling hematocrit.
Measure blood pressure annually to diagnose Reno-vascular hypertension.
27. The overall exploration rate for blunt trauma is low.
The goals of exploration following renal trauma are control of hemorrhage and renal salvage.
Most series recommend the trans-peritoneal approach for surgery.
Entering the retro peritoneum and leaving the confined hematoma undisturbed within the perinephric
fascia is recommended; temporarily packing the fossa tightly with laparotomy pads can salvage the
kidney in instances of intra-operative hemorrhage.
28. Access to the pedicle is obtained either through the posterior parietal peritoneum, which is incised over the
aorta, just medial to the inferior mesenteric vein or by bluntly dissecting along the plane of the psoas muscle
fascia, adjacent to the great vessels, and directly placing a vascular clamp on the hilum.
Feasibility of renal reconstruction should be judged during the operation.
The overall rate of patients who undergo a nephrectomy during exploration is approximately 30%.
Other intra-abdominal injuries also increase the likelihood of nephrectomy.
29. Mortality is associated with overall severity of the injury and not often a consequence of the renal
injury itself.
High velocity gunshot injuries make reconstruction difficult and nephrectomy is usually required.
Since nephrectomy is independently associated with increased risk of mortality in injured patients it
should be avoided when possible.
30. Renorrhaphy is the most common reconstructive technique.
Partial nephrectomy is required when non-viable tissue is detected.
Watertight closure of the collecting system is desirable, although closing the parenchyma over the injured
collecting system is acceptable.
31. The use of hemostatic agents and sealants in reconstruction is helpful. In all cases, drainage of the ipsilateral
retro-peritoneum is recommended.
The repair of vascular injuries is seldom, if ever, effective.
Repair should be attempted in patients with a solitary kidney or bilateral injuries.
Nephrectomy for main artery injury has outcomes similar to those of vascular repair and does not worsen
post-treatment renal function in the short-term. Bleeding or dissection of the main renal artery may also be
managed with a stent.