This study aimed to assess the relationship between nurse unit managers' motivation and their performance management in three hospitals in Makkah, Saudi Arabia. A sample of 60 nurse unit managers completed questionnaires assessing their motivation and performance management. The results found a highly statistically significant correlation between motivation and performance management. Motivation was also found to significantly differ between the hospitals. The study concluded that motivation through factors like drive, control, relationships, challenges and rewards can effectively motivate nurse unit managers and positively impact their performance management.