Antioxidants protect the body from oxidative damage caused by free radicals, which are harmful molecules that can destabilize other molecules. The document discusses various types of antioxidants, including vitamins and enzymatic antioxidants like superoxide dismutase and glutathione peroxidase, and their mechanisms of action. It emphasizes the relationship between antioxidants and NADPH, highlighting the importance of glutathione as a master antioxidant in managing oxidative stress.

1. Relationship between
Antioxidant and NADPH
Prepared by: Mahmoud Abdullah Sabry
Supervisor : Dr / Amany Ahmed

2. what is meant by Antioxidant ?
 Antioxidants protect the body from damage caused by harmful molecules called free radical
.
 Or is a molecule that inhibits the oxidation of other molecule

3. Free radical

4. Antioxidant system in our body
•Ascorbate. (vit C )
•Vit E
Enzymatic
•SOD
•GPx
Non
enzymatic

5. The Enzymatic antioxidant
SOD(superoxide dismutase(
GPx (selenium-dependent
glutathione peroxidas(
Catalase

6. Several way of antioxidant to work
• They reduced the
energy of the free
radical
Step 1
• They give up some of their
electron for it.s use
thereby causing the radical
more stable
Step 2

7. The relation between Antioxidant and NADPH

8. The relation between Antioxidant and NADPH

9. The relation between Antioxidant and NADPH

10. Important notes
Glutathione (The master antioxidant)
the oxidased form of GSH is called GSSG
Hydrogen peroxide: is one of a family of reactive oxygen species (ROS) that are
formed from the partial reduction of molecular oxygen

11. Free radical causes oxidative Stress
Oxidative stress reflects an imbalance between the systemic manifestation of reactive
oxygen species and a biological system's ability to readily detoxify the reactive
intermediates

12. Dangerous of oxidative stress
can be
summarized as
follow :

13. Example:

14. Finally