Recombinant human erythropoietin was developed to treat anemia. It was first isolated from urine in 1977 and its gene was cloned in 1985, allowing industrial production. This paved the way for FDA approval in 1989 for use in chronic renal patients on dialysis to increase red blood cell production. It is now used to treat anemia associated with renal failure, cancer, prematurity, and HIV. It can also support erythropoiesis after chemotherapy or transplants and increase hemoglobin levels before surgery or for athletes. Current research continues to explore new applications of recombinant human erythropoietin.