Three missions are proposed to achieve the grand challenge of a climate-smart, sustainable food system for a healthy Europe: 1) Improve dietary patterns and lifestyles for a 50% reduction in non-communicable diseases by 2030 while reducing environmental impact, 2) Create a resource-smart food system with 50% lower greenhouse gas emissions by 2030, and 3) Realize trust and inclusive governance for a resilient and safe food system. The document outlines 17 focus areas to achieve these missions and makes recommendations for the European Union, member states, companies, farmers, citizens, cities, and civil society to contribute to the goals.