Some of the biggest issues at the center of analyzing large amounts of data are query flexibility, latency, and fault tolerance. Modern technologies that build upon the success of “big data” platforms, such as Apache Hadoop, have made it possible to spread the load of data analysis to commodity machines, but these analyses can still take hours to run and do not respond well to rapidly-changing data sets. A new generation of data processing platforms -- which we call “stream architectures” -- have converted data sources into streams of data that can be processed and analyzed in real-time. This has led to the development of various distributed real-time computation frameworks (e.g. Apache Storm) and multi-consumer data integration technologies (e.g. Apache Kafka). Together, they offer a way to do predictable computation on real-time data streams. In this talk, we will give an overview of these technologies and how they fit into the Python ecosystem. This will include a discussion of current open source interoperability options with Python, and how to combine real-time computation with batch logic written for Hadoop. We will also discuss Kafka and Storm's alternatives, current industry usage, and some real-world examples of how these technologies are being used in production by Parse.ly today.