This ppt discusses pharmacological actions, toxic effects and clinical applications of corticosteroids. It also mentions precations to be taken while using steroids
an overall overview in corticosteroids and its application in oral and maxillofacial diagnostic medicine and pathology drawing to the conclusions of the limitations and drawbacks of these medicines. i have also included the precautions to be taken in dental therapeutic procedures fo
Presentation for Medical undergraduates for teaching pharmacology. It deals with Physiology of steroid hormones and their action along with agents which are used therapeutically with their action, adverse effects and therapeutic uses.
This ppt discusses pharmacological actions, toxic effects and clinical applications of corticosteroids. It also mentions precations to be taken while using steroids
an overall overview in corticosteroids and its application in oral and maxillofacial diagnostic medicine and pathology drawing to the conclusions of the limitations and drawbacks of these medicines. i have also included the precautions to be taken in dental therapeutic procedures fo
Presentation for Medical undergraduates for teaching pharmacology. It deals with Physiology of steroid hormones and their action along with agents which are used therapeutically with their action, adverse effects and therapeutic uses.
Betnovate (Betamethasone Valerate Cream) is a potent topical corticosteroid indicated for adults, elderly and children over 1 year for the relief of the inflammatory and pruritic manifestations of steroid responsive dermatoses. The indications include Atopic dermatitis (including infantile atopic dermatitis), Nummular dermatitis (discoid eczema), Prurigo nodularis, Psoriasis (excluding widespread plaque psoriasis), Lichen simplex chronicus (neurodermatitis) and lichen planus, Seborrhoeic dermatitis, Irritant or allergic contact dermatitis, Discoid lupus erythematosus, Adjunct to systemic steroid therapy in generalised erythroderma and Insect bite reactions.
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Metoclopramide Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Metoclopramide Dosage & Rx Info | Metoclopramide Uses, Side Effects -: Indications, Side Effects, Warnings, Metoclopramide - Drug Information - Taj Pharma, Metoclopramide dose Taj pharmaceuticals Metoclopramide interactions, Taj Pharmaceutical Metoclopramide contraindications, Metoclopramide price, Metoclopramide Taj Pharma Metoclopramide Hydrochloride 10 mg tablets SMPC- Taj Pharma . Stay connected to all updated on Metoclopramide Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Betnovate (Betamethasone Valerate Cream) is a potent topical corticosteroid indicated for adults, elderly and children over 1 year for the relief of the inflammatory and pruritic manifestations of steroid responsive dermatoses. The indications include Atopic dermatitis (including infantile atopic dermatitis), Nummular dermatitis (discoid eczema), Prurigo nodularis, Psoriasis (excluding widespread plaque psoriasis), Lichen simplex chronicus (neurodermatitis) and lichen planus, Seborrhoeic dermatitis, Irritant or allergic contact dermatitis, Discoid lupus erythematosus, Adjunct to systemic steroid therapy in generalised erythroderma and Insect bite reactions.
Metoclopramide hydrochloride 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Metoclopramide Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Metoclopramide Dosage & Rx Info | Metoclopramide Uses, Side Effects -: Indications, Side Effects, Warnings, Metoclopramide - Drug Information - Taj Pharma, Metoclopramide dose Taj pharmaceuticals Metoclopramide interactions, Taj Pharmaceutical Metoclopramide contraindications, Metoclopramide price, Metoclopramide Taj Pharma Metoclopramide Hydrochloride 10 mg tablets SMPC- Taj Pharma . Stay connected to all updated on Metoclopramide Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Drugs used in urinary inconsistancy or scanty of urine, that promote urine formation and increases urine output are explained in the ppt by Dr. Mrunal Akre
This word document deals with summarized drug profile of cotrimoxazole. Important pharmacological headings, along with important counselling tips and drug catchpoints have also been elucidated.
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Pharmacotherapy of Bronchial Asthma Dr. Prerana.pptxDr Prerana Kadam
Bronchial asthma is an inflammatory airway disease associated with increased hyperresponsiveness of airway, increased airway obstruction, wheezing, rapid respiration, dyspnea and cough.
Pharmacotherapy of this conditions is directed towards two major goals:
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Methylprednisolone Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Methylprednisolone Dosage & Rx Info | Methylprednisolone Uses, Side Effects -: Indications, Side Effects, Warnings, Methylprednisolone - Drug Information - Taj Pharma, Methylprednisolone dose Taj pharmaceuticals Methylprednisolone interactions, Taj Pharmaceutical Methylprednisolone contraindications, Methylprednisolone price, Methylprednisolone Taj Pharma Methylprednisolone Tablets 4 mg SMPC- Taj Pharma . Stay connected to all updated on Methylprednisolone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Narrated Business Proposal for the Philadelphia Eaglescamrynascott12
Slide 1:
Welcome, and thank you for joining me today. We will explore a strategic proposal to enhance parking and traffic management at Lincoln Financial Field, aiming to improve the overall fan experience and operational efficiency. This comprehensive plan addresses existing challenges and leverages innovative solutions to create a smoother and more enjoyable experience for our fans.
Slide 2:
Picture this: It’s a crisp fall afternoon, driving towards Lincoln Financial Field. The atmosphere is electric—tailgaters grilling, fans in Eagles jerseys creating a sea of green and white. The air buzzes with camaraderie and anticipation. You park, join the throng, and make your way to your seat. The stadium roars as the Eagles take the field, sending chills down your spine. Each play is a thrilling dance of strategy and skill. This is what being an Eagles fan is all about—the joy, the pride, and the shared experience.
Slide 3:
But now, the day is marred by frustration. The excitement wanes as you struggle to find a parking spot. The congestion is overwhelming, and tempers flare. The delays mean you miss the pre-game excitement, the tailgate camaraderie, and even the opening kick-off. After the game, the joy of victory or the shared solace of defeat is overshadowed by the stress of navigating out of the parking lot. The gridlock, honking horns, and endless waiting drain the energy and joy from what should have been an unforgettable experience.
Our proposal aims to eliminate these frustrations, ensuring that from arrival to departure, your experience is extraordinary. Efficient parking and smooth traffic flow are key to maintaining the high spirits and excitement that make game days special.
Slide 4:
The Philadelphia Eagles are not just a premier NFL team; they are an integral part of the community, hosting games, concerts, and various events at Lincoln Financial Field. Our state-of-the-art stadium is designed to provide a world-class experience for every attendee. Whether it's the thrill of game day, the excitement of a live concert, or the camaraderie of community events, we pride ourselves on delivering a fan-first experience and maintaining operational excellence across all our activities. Our commitment to our fans and community is unwavering, and we continuously strive to enhance every aspect of their experience, ensuring they leave with unforgettable memories.
Slide 5:
Recent trends show an increasing demand for efficient event logistics. Our customer feedback has consistently highlighted frustrations with parking and traffic. Surveys indicate that a significant number of fans are dissatisfied with the current parking situation. Comparisons with other venues like Citizens Bank Park and Wells Fargo Center reveal that we lag in terms of parking efficiency and convenience. These insights underscore the urgent need for innovation to meet and exceed fan expectations.
Slide 6:
As we delve into the intricacies of our operations, one glaring issue emer
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2. Steroids - Introduction
Three classes,
• Glucocorticoids – The daily secretion of cortisol
is about 20 mg/ day with diurnal variation, peaks
during early morning hrs, lowest during late
evening hrs. Also exert feedback inhibition on
HPA axis, maximal inhibition during late evening
hours
• Mineralocorticoids – for salt & water balance
• Sex steroids – for reproductive function
4. Example 1
• Methylprednisolone 4 mg / Prednisolone
4 mg / Dexamethasone 0.5 –1.0 – 2 mg
three times daily for treating an episode
of Asthma exacerbation / attack of Gouty
arthritis.
Why Irrational – Inadequate
Immunosupression & risk of HPA axis
suppression
5. Example 2
• IV Hydrocortisone 100 – 200 mg every 6
hourly / IV Methyl prednisolone 40 – 125
mg every 8 hourly for status asthmaticus
(even included in some guidelines)
Why Irrational –Risk of salt & water
retention ( greater with hydrocortisone) &
risk of HPA axis suppression
6. Steroids – Classification
(on the basis of biological half lives)
Short acting
8-12 hrs
Cortisone
Hydrocortisone (Cortisol)
Intermediate acting
12-36 hrs
Fludrocortisone
Prednisone
Prednisolone
Methylprednisolone
Long acting
36-72 hrs
Triamcinolone
Dexamethasone
Betamethasone
8. Glucocorticoids - Indications
• As hormone replacement therapy – in
deficiency syndromes like Addisonian
states ( physiological replacement doses)
• For HPA axis suppression, in Congenital
Adrenal Hyperplasia (physiological doses
are sufficient)
• Anti Inflammatory activity /
Immunosuppressive action (5- 20 times of
physiological doses)
10. Glucocorticoid – Preferred ones
Gluco- Mine
ralo-
Preferred indication
Short
acting
Cortisol 1 1 For deficiency syndromes.
Cortisone 0.8 0.8
Inter-
mediate
Prednisone 4 0.8 For immunosupression
Prednisolone 4 0.8
Methylprednisolone 5 0.5
Long
acting
Dexamethasone 25 0 For HPA axis suppression, no
risk of salt & water retention.
Betamethasone 25 0
11. Glucocorticoids – Dosing regimen
Preferred indication Dosing regimen
Cortisol For deficiency
syndromes.
10 mg PO, at 8 AM & 2
PM
Cortisone
Prednisone For immunosupression,
minimal risk of HPA
axis suppression.
20 mg & upwards, at 8 AM
daily/ on alternate days
Prednisolone
Methylprednisolone
Dexamethasone For HPA axis
suppression, no risk of
salt & water retention.
1-2 mg at bed time
Betamethasone
12. Rational use…. Example 1
Methylprednisolone 4 mg / Prednisolone 4 mg /
Dexamethasone 0.5 – 2 mg three times daily for
treating an episode of Asthma exacerbation / attack of
Gouty arthritis.
The rational regimen for treating an episode
of Asthma exacerbation / attack of Gouty
arthritis - Methylprednisolone 16 - 32 mg
/ Prednisolone 20 - 60 mg once daily / on
alternate days, repeated at 8 AM in the
morning.
13. Rational use….. Example 2
IV Hydrocortisone 100 – 200 mg every 6 hourly /
IV Methyl prednisolone 40 – 125 mg every 8
hourly for status asthmaticus (even included in
some guidelines)
The rational regimen for status asthmaticus
– IV Methylprednisolone 125 – 1000mg
stat followed by oral regimen stated
above (example 1), once the condition
settles down.
14. Benefit of RUD - Glucocorticoids
Better immunosupression in patients with Br
Asthma / RA / without any HPA axis
inhibition
Adequate inhibition of HPA axis in patients
with Congenital Adrenal Hyperplasia,
without salt & water overloading.
15. Thank you, wish to have your
views & comments.
Based on Goodman & Lawrence.