Hospital-acquired pressure injuries are a significant issue, costing $11 billion annually in the US. A fishbone diagram was used to identify multiple factors that influence pressure injury development, including patient characteristics, materials, staff, processes, environment, and methods. Evidence shows that involving patients in their own care through education on positioning, mobility, and prevention can help reduce injuries. Evaluating prevention strategies and pressure injury rates through staff meetings and assessing staging can help hospitals improve processes and decrease injuries over time.