The presentation by Hannes Hapke at the Pydx Conference covers the essentials of geospatial data handling, including geocoding, serving geospatial data via APIs, and using tools like PostGIS, GDAL, and GeoDjango. It emphasizes the importance of location data and demonstrates various coding examples for geocoding addresses, generating KML files, and creating APIs with Django REST Framework. Additionally, it highlights privacy considerations and suggests useful resources for further learning in geospatial development.