Michael Reuman is a Ph.D. who has published numerous papers and presentations in organic chemistry and drug development. Some of his publications focus on developing synthesis methods for potential drug candidates that target conditions like cancer, bacterial infections, and inflammation. He has also received several patents related to drug synthesis and development work.

1. MICHAEL REUMAN, Ph.D.
PUBLICATIONS:
M. Reuman, S. Beish, J. Davis, M. J. Batchelor, M. C. Hutchings, D. F. C. Moffat, P. J. Connolly,
and R. K. Russell “Scalable Synthesis of the VEGF-R2 Kinase Inhibitor JNJ-17029259 Using
Ultrasound-Mediated Addition of MeLi-CeCl3 to a Nitrile” J. Org. Chem., 2008, 73, 1121.
M. Reuman, Z. Hu, G.-H. Kuo, X. Li, R. K. Russell, L. Shen, S. Youells, and Y. Zhang “Synthesis
of a 5-((Aryloxy)methyl)-3-(4-(trifluoromethyl)phenyl)[1,2,4]thiadiazole Derivative: A Promising
PPARα,δ Agonist” Organic Process Research & Development, 2007, 11, 1010.
L. Shen, Y. Zhang, A. Wang, E. Sieber-McMaster, X. Chen, P. Pelton, J. Z. Xu, M. Yang, P. Zhu,
L. Zhou, M. Reuman, Z. Hu, R. Russell, A. C. Gibbs, H. Ross, K. Demarest, W. V. Murray, and
G.-H. Kuo “Synthesis and identification of [1,2,4]thiadiazole-derivatives as a new series of potent
and orally active peroxisome proliferators-activated receptors  and  dual agonists” J. Med.
Chem., 2007, 50, 3954.
X. Li, M. Reuman, R. K. Russell, S. Youells, S. Beish, Z. Hu, S. Branum, N. Jain, Z. Sui
“Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 2.
Process Improvement for Scale-Up Of 2,5,8-Substituted 11,12-Dihydro-5H-6,13-dioxabenzo-
[3,4]cyclohepta[1,2-a]naphthalene Derivatives” Organic Process Research & Development,
2007, 11, 731.
T. V. Hughes, S. L. Emanuel, A. K. Beck, S. K. Wetter, P. J. Connolly, K. Prabha, M. Reuman, J.
Seraj, A. R. Fuentes-Pesquera, R. H. Gruninger, S. A. Middleton, R. Lin, J. M. Davis, and D. F. C.
Moffat “4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological
evaluation” Bioorg. Med. Chem. Lett., 2007, 17, 3266.
X. Li, M. Reuman, R. K. Russell, R. Adams, R. Ma, S. Beish, S. Branum, S. Youells, N. Jain, R.
Kanojia, and Z. Sui “Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor
Modulators. Part 1. Process Development for Scale-up of 2,5,8-Substituted 5,11-Dihydro
chromeno[4,3-c]chromene Derivatives” Organic Process Research & Development, 2007, 11,
414.
X. Li, M. Reuman, and R. K. Russell “Direct Conversion of Substituted Pyrrole-2-Carboxylic Acid
Methyl Esters to their 2-Carbonitrile Analogs” Heterocycles, 2006, 70, 201.
J. Bullington, D. Argentieri, K. Averill, D. Carter, D. Cavender, B. Fahmy, X. Fan, D. Hall, G.
Heintzelman, P. Jackson, W.-P. Leung, X. Li, P. Ling, G. Olini, T. Razler, M. Reuman, K. Rupert,
R. Russell, J. Siekierka, S. Wadsworth, R. Wolff, B. Xiang, and Y.-M. Zhang “Inhibitors of
Unactivated p38 MAP Kinase” Bioorg. Med. Chem. Lett., 2006, 16, 6102
N. Chen, N. Jain, J. Xu, M. Reuman, X. Li, R. K. Russell, and Z. Sui, “Synthesis of Novel
Tetracyclic Chromenes through Carbanion Chemistry of 4-Methyl Coumarins” Tetrahedron Lett.,
2006, 47, 5909.
S. Emanuel, R. H. Gruninger, A. Fuentes-Pesquera, P. J. Connolly, J. A. Seamon, S. Hazel, R.
Tominovich, B. Hollister, C. Napier, M. R. D’Andrea, M. Reuman, G. Bignan, R. Tuman, D.
Johnson, D. Moffat, M. Batchelor, A. Foley, J. O’Connell, R. Allen, M. Perry, L. Jolliffe, and S. A.
Middleton “A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor Potentiates the
Activity of the Conventional Chemotherapeutic Agents Paclitaxel and Doxorubicin in Tumor
Xenograft Models” Mol. Pharmacol., 2004, 66, 635.

2. MICHAEL REUMAN, Ph.D.
M. Reuman, S. J. Daum, B. Singh, M. P. Wentland, R. B. Perni, P. Pennock, P. M. Carabateas, M.
D. Gruett, M. T. Saindane, P. H. Dorff, S. A. Coughlin, D. M. Sedlock, J. B. Rake, and G. Y.
Lesher, "Synthesis and Antibacterial Activity of some Novel 1-Substituted
1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents" J.
Med. Chem.,1995, 38, 2531.
G. D. Diana, P. Rudewicz, D. C. Pevear, T. J. Nitz, S. C. Aldous, D. J. Aldous, D. T. Robinson, T.
Draper, F. J. Dutko, C. Aldi, G. Gendron, R. C. Oglesby, D. L. Volkots, M. Reuman, T. R. Bailey,
R. Czerniak, T. Block, R. Roland, and J. Oppermann, "Picornavirus Inhibitors: Trifluoromethyl
Substitution Provides a Global Protective Effect against Hepatic Metabolism" J. Med. Chem.,
1995, 38, 1355.
M. Reuman, J. P. Mallamo, and D. L. DeHaven-Hudkins, "Synthesis and Binding Affinity of
2,3,3a,4,9,9a-Hexahydro-9,4-(Iminomethano)-1H-benz[f]indenes. Ligands for the PCP Site of
the NMDA Receptor" Bioorg. Med. Chem. Lett., 1995, 5, 371.
M. Reuman, M. A. Eissenstat, and J. D. Weaver III, "Cyanide Mediated Decarboxylation of
1-Substituted-4-oxoquinoline and 4-oxo-1,8-naphthyridine-3-carboxylic Acids" Tetrahedron Lett.,
1994, 35, 8303.
B. Singh, E. R. Bacon, S. Robinson, R. K. Fritz, G. Y. Lesher, V. Kumar, J. A. Dority, M. Reuman,
G.-H. Kuo, M. A. Eissenstat, E. D. Pagani, D. C. Bode, R. G. Bently, M. J. Connell, L.T. Hamel,
and P. J. Silver, "Novel cAMP PDE III Inhibitors: Imidazo[4,5-b]pyridin-2(3H)-ones and
Thiazolo[4,5-b]pyridin-2(3H)-ones and Their Analogs" J. Med. Chem., 1994, 37, 248.
M. P. Wentland, G. Y. Lesher, M. Reuman, M. D. Gruett, B. Singh, S. C. Aldous, P. H. Dorff, J. B.
Rake, and S. A. Coughlin, "Mammalian Topoisomerase II Inhibitory Activity of
1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic
Acid and Related Derivatives" J. Med. Chem., 1993, 36, 2801.
M. P. Wentland, G. Y. Lesher, M. Reuman, G. M. Pilling, M. T. Saindane, R. B. Perni, M. A.
Eissenstat, J. D. Weaver III, B. Singh, J. Rake, and S. A. Coughlin, "Relationship of Structure of
Bridged (2,6-Dimethyl-4-Pyridinyl) Quinolones to Mammalian Topoisomerase II Inhibition" Bioorg.
Med. Chem. Lett., 1993, 3, 1711.
M. Reuman and G. Y. Lesher, "Antibacterial Agents, Synthetic-Quinolones" in the Kirk-Othmer:
Encyclopedia of Chemical Technology 4th Edition, J. I. Kroschwitz, Ed., John Wiley: NY, 1992,
854.
M. Reuman and A. I. Meyers, "The Synthetic Utility of Oxazolines in Aromatic Substitution"
Tetrahedron, 1985, 41, 837.
A. I. Meyers, R. J. Himmelsbach, and M. Reuman, "The Reductive Cleavage of Aryl Oxazolines to
Benzaldehydes and Substituted Toluenes" J. Org. Chem., 1983, 48, 4053.
A. I. Meyers, M. Reuman, and R. A. Gabel, "Nucleophilic Annulations of Aromatics. Novel Route
to Benzo-Fused Ring Systems via Oxazoline Activation" J. Org. Chem., 1981, 46, 783.
D. Masilamani, M. E. Reuman, and M. Rogic, "Ene-Type Reaction through the Intermediacy of the
1,4-Dipolar Ion in the Reaction of Tetracyanoethylene with Nucleophilic Double Bonds in Liquid
Sulfur Dioxide" J. Org. Chem., 1981, 46, 4602.

3. MICHAEL REUMAN, Ph.D.
L. K. Truesdale and M. E. Reuman, "Sodium Bismuthate Oxidation of Olefins" J. Org. Chem.,
1980, 45, 726.
PATENTS:
M, Reuman “Process for the Preparation of Tri-Substituted Pyridine and Tri-Substituted
Pyrimidine Derivatives useful as GDIR Agonists” US 20100113480 A1 May 2010.
A. Choudhury and M. Reuman “Process for the Preparation of Tri-Substituted Pyridine and
Tri-Substituted Pyrimidine Derivatives useful as GDIR Agonists” US 20100113479 A1 May 2010.
M. Reuman, R. Faessler, A. Roessler, K. Sorgi, X. Li, and J. Grimm “One-Pot
Condensation-Reduction Methods for Preparing Substituted Allylic Alcohols” US 20080009628
A1 Jan 2008, WO 2008005670 A2 Jan 2008
D. J. Aldous, T. R. Bailey, G. D. Diana, G.-H. Kuo, T. J. Nitz, and M. Reuman, "Substituted
Quinoline Derivatives Useful as Antipiconaviral Agents" US 5,523,312, June 1996, US 5,514,692,
May 1996, WO1996009822 A1 April 1996.
G. Y. Lesher, B. Singh, M. Reuman, and S. J. Daum, "Pyridinyl-Quinoline Compounds, their
Preparation and Use", US 5,169,853, December 1992. European Patent EP 417,669 A2, March
1991
G. Y. Lesher, B. Singh, and M. Reuman, "Pyridinyl-Quinoline Compounds, their Preparation and
Use", US 5,075,319, December 1991.
G. Y. Lesher, B. Singh, and M. Reuman, "4-Oxo-3-quinolinecarboxylic acids Useful as
Antibacterial Agents and Preparation thereof", EP 309,789, April 1989.
PRESENTATIONS:
Z. Hu, U. Maharoof, J. Travins, M. Reuman, R. Russell, and R. Galemmo “Improved Synthesis of
Indane-Fused Pyrazole Compound: An Anti-Proliferative Agent for the Treatment of Solid
Tumors” 40th National Organic Chemistry Symposium, Duke University, Durham, NC, May 2007
M. Reuman, J. P. Mallamo, W. G. Earley, and D. L. DeHaven-Hudkins "Synthesis and Binding
Affinity of 2,3,3a,4,9,9a-Hexahydro-9,4-(Iminomethano)-1H-benz[f]indenes. Ligands for the PCP
Site of the NMDA Receptor" Winter Conference on Bioorganic and Medicinal Chemistry, January
1995, Steamboat Springs, CO.
M. Reuman, M. Eissenstat, and J. Weaver "Cyanide Mediated Decarboxylation of Substituted
4-Oxo-3-quinolinecarboxylic acids" Gordon Research Conference on Organic Reactions and
Processes, July 1992.
M. P. Wentland, G. Y. Lesher, M. Reuman, M. D. Gruett, B. Singh, S. C. Aldous, P. H. Dorff, J. B.
Rake, and S. A. Coughlin, "Relationship of Mammalian Topoisomerase II Inhibitory Potency to the
structure of 6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid derivatives", Proc. Am.
Assoc. Cancer Res., March 1992, Abstract No. 2577, 431.
S. A. Coughlin, D. W. Danz, R. G. Robinson, K. M. Klingbell, M. P. Wentland, G. Y. Lesher, M.
Reuman, and J. B. Rake, "Dramatic Divergence in Structure Activity Requirement for
Topoisomerase II Inhibition by Quinolones", Proc. Am. Assoc. Cancer Res., March 1992, Abstract
No. 2576, 431.

4. MICHAEL REUMAN, Ph.D.
M. P. Wentland, G. Y. Lesher, M. Reuman, G. M. Pilling, M. T. Saindane, R. B. Perni, M. A.
Eissenstat, J. D. Weaver, J. B. Rake, and S. A. Coughlin, "Mammalian Topoisomerase Inhibitory
Activity of 1,8-bridged-7-(2,6-dimethyl(4-pyridinyl))-3-quinolinecarboxylic acids", Proc. Am.
Assoc. Cancer Res., May 1991, Abstract No. 14317, 336.
D. M. Deuel, D. M. Sedlock, G. Y. Lesher, S. J. Daum, M. P. Wentland, M. Reuman, M. A.
McKinlay, and J. B. Rake, "In Vitro Antibacterial Activity of a New Dimethylpyridinyl Quinolone,
Win 57273, against Clinical Pathogens", 29th Interscience Conference on Antimicrobial Agents
and Chemotherapy; Houston, TX, September, 1989, No. 1194.
M. Reuman, S. J. Daum, B. Singh, S. A. Coughlin, D. M. Sedlock, J. B. Rake, and G. Y. Lesher,
"Synthesis and Antibacterial Activity of Some Novel 1-Substituted
7-Pyridinyl-1,4-Dihydro-4-Oxoquinoline-3-Carboxylic Acids", 29th Interscience Conference on
Antimicrobial Agents and Chemotherapy; Houston, TX, September, 1989, No. 1193.