FUNDING FOR ENVIRONMENTAL RESEARCH AND DEVELOPMENT BY THE THE NATIONAL INS...
Lehmann CV_for nomination
1. CURRICULUM VITAE
Geniece M. Lehmann
PROFESSIONAL ADDRESS:
National CenterforEnvironmental Assessment
Office of Research&Development
U.S. Environmental ProtectionAgency,B243-01
ResearchTriangle Park,NC27711
Telephone:(919) 541-2289
FAX:(919) 541-0245
Email:Lehmann.Geniece@epa.gov
EDUCATION: Major Degree Date
UniversityofRochester
Rochester,NY
Toxicology Ph.D. 2006
UniversityofRochester
Rochester,NY
Toxicology M.S. 2003
St. John FisherCollege
Rochester,NY
Biology B.A. 1998
PROFESSIONAL EXPERIENCE: Date
Toxicologist
National CenterforEnvironmental Assessment
Office of Research&Development
U.S. Environmental ProtectionAgency
ResearchTriangle Park,NC
2009-present
National ResearchService AwardFellow (HL66988)
National Heart,Lung,and BloodInstitute
Departmentof Medicine
Universityof RochesterMedical Center
Rochester,NY
2006-2009
AdjunctAssistantProfessor (OrganicChemistryLab)
ChemistryDepartment
St. JohnFisherCollege
Rochester,NY
2006-2007
TeachingAssistant(Biochemical Toxicology)
Departmentof EnvironmentalMedicine
Universityof RochesterMedical Center
Rochester,NY
2004
National ResearchService AwardFellow (ES07026)
National Institute of Environmental HealthSciences
Departmentof EnvironmentalMedicine
Universityof RochesterMedical Center
Rochester,NY
2002-2004
2. Tutor (Pharmacology)
Departmentof EnvironmentalMedicine
Universityof RochesterMedical Center
Rochester,NY
2002
TeachingAssistant(Principlesof ChemistryIandII)
ChemistryDepartment
St. JohnFisherCollege
Rochester,NY
1996-1997
Tutor (OrganicChemistryIandII)
ChemistryDepartment
St. JohnFisherCollege
Rochester,NY
1996-1997
PROFESSIONAL INTERESTS:
Human healthriskassessment,especiallyinthe areasof immunotoxicologyandchildren’shealth
PROFESSIONAL ACTIVITIES:
LeadershipRoles:
US EPA ORD/NCEA IRISAssessmentManager –PolychlorinatedBiphenyls(PCBs),2009-present
Co-Chair,Societyof Toxicologyinformational sessionentitled“Understandingthe Implicationsof
BreastfedInfantExposurestoPOPs:How CanWe Do Better?”Phoenix,AZ,2014
US EPA ORD/NCEA OrganizerandCo-Chair– ExpertWorkshoponImprovingthe RiskAssessmentof
Persistent,Bioaccumulative,andToxic(PBT) ChemicalsinBreastMilk,2011-2014
US EPA ORD/NCEA IRISAssessmentManager–Ethylbenzene,2009-2012
US EPA ORD/NCEA RTP DivisionCoordinator–RiskAssessmentTrainingandExperience Program, 2009-
2011
Briefings:
US EPA Science Advisortothe Administrator
• “IRIS Toxicological Review of PCBs:EffectsOtherThanCancer(External PeerReviewDraft)”
(5/23/2012)
US EPA SeniorPolicyCounseltothe Administrator
• “IRIS Toxicological Review of PCBs:EffectsOtherThanCancer(External PeerReviewDraft)”
(5/23/2012)
US EPA AssistantAdministrators
• “IRIS Toxicological Review of PCBs:EffectsOtherThanCancer(External PeerReviewDraft)”
(6/15/2012)
US EPA ORD AssistantAdministrator
• “NCEA PCB Activities –SummaryandIssues”(5/10/2012)
• “QuestionsandAnswersRegardingPCBs”(5/10/2012)
US EPA ORD DeputyAssistantAdministratorforscience
• “Scopingand ProblemFormulationforthe IRISToxicological Reviewof Polychlorinated
Biphenyls(PCBs):EffectsOtherThanCancer”(6/25/2015)
3. • “IRIS Toxicological Review of PCBs:EffectsOtherThanCancer(External PeerReviewDraft)”
(5/23/2012)
• “NCEA PCB Activities –SummaryandIssues”(5/10/2012)
• “QuestionsandAnswersRegardingPCBs”(5/10/2012)
US EPA IRISAgency Reviewers
• “Scopingand ProblemFormulationforthe Toxicological Review of PolychlorinatedBiphenyls
(PCBs):EffectsOtherThanCancer”(3/18/2015)
• “IRIS Toxicological Review of PCBs:EffectsOtherThanCancer(AgencyReview Draft)”
(6/29/2011)
US EPA IRISInteragencyScience Consultation
• “IRIS Toxicological Review of PCBs:EffectsOtherThanCancer(InteragencyReviewDraft)”
(1/26/2012)
US Departmentof Health& Human ServicesAgencies
• “IRIS Toxicological Review of PCBs:EffectsOtherThan Cancer(External PeerReviewDraft)”
(6/13/2012)
US EPA IRISPublicScience Meeting
• “Scopingand ProblemFormulationforthe IRISToxicological Reviewof Polychlorinated
Biphenyls(PCBs):EffectsOtherThanCancer”(6/17/2015 – 6/18/2015)
ContractingOfficer’sTechnicalRepresentative:
• “Preparationof Evidence Tablesforthe IRISDraftToxicological Reviewof Polychlorinated
Biphenyls(PCBs):EffectsOtherThanCancer(CASNO.1336-36-3)”, #EP-C-14-001-WA 15 (budget
$369,000), 2013-present
• “Developmentof MaterialsforaWorkshopon ApproachestoImprovingthe RiskAssessmentof
Persistent,BioaccumulativeandToxicChemicalsinBreastMilk”,#EP-C-09-009-WA 62 (budget
$258,000), 2011-2013
• “Preparationof the IRISDraft Toxicological Reviewof PolychlorinatedBiphenyls(PCBs):Effects
OtherThan Cancer(CASNo. 1336-36-3)”, #EP-C-09-009-WA 100 (budget$277,000), 2013
• “External LetterPeerReviewof a2005 report entitled‘Benchmarkdose analysisfor
PolychlorinatedBiphenyls(PCBs)’performedbyLouise Ryan(Departmentof Biostatistics,
Harvard School of PublicHealth) undercontractfor U.S.Environmental ProtectionAgency’s
(EPA) National CenterforEnvironmentalAssessment(NCEA)”,#EP-C-07-024/025-TO137
(budget$7,000), 2011
• “Preparationof IRISDocumentsforPolychlorinatedbiphenyls(PCBs) (1336-36-3)”,#EP-C-09-
009-WA 21 (budget$105,000), 2009-2010
Committee and WorkgroupMembership:
US EPA ORD/NCEA LeaningIRISDraftDevelopmentImplementationTeam, 2015-present
US EPA OW/OSTWorkgroup to Pursue PCB CongenerTestingMethodforWastewaterAnalysis,2015-
present
US EPA ORD/NCEA IRISGeneral Toxicology,Immunotoxicology,andCancerDisciplinaryWorkgroup,
2013-present
US EPA ORD/NCEA ComprehensiveEnvironmental AssessmentWorkgroup,2012-2015
SuperfundResearchProgramResearchtoRiskAssessmentInitiative,2012-2014
4. US EPA ORD/NCEA Exposure-Response ArrayWorkgroup,2010-2011
US EPA ORD/NCEA IRISToxicological ReviewTeams:
• Hexabromocyclododecane (HBCD),2014 – present
• InorganicArsenic,2015
• Ethyl TertiaryButyl Ether (ETBE),2013
• Formaldehyde–Inhalation,2013
US EPA ORD/NCEA PPRTV ReviewPanels:
2009 – Dichlorodifluoromethane
2009 – Ethoxyethanolacetate
2009 – Diethylene glycolmonoethylether
2009 – Toluene-2,5-diamine &compounds
2010 – 2,4,6-Trichloroaniline&2,4,6-Trichloroaniline Hydrochloride
2010 – Trimethyl Phosphate
2010 – Acetophenone
2010 – BoronTrichloride
2010 – o-Chlorotoluene
2010 – 2,4-Methylaniline
2010 – Fluorobenzene
2010 – 2-chloroethanol
2010 – p-Toluidine
Ad hocreviewer: 2011–present
Chemical Research in Toxicology,ToxicologicalSciences,Toxicology and Applied Pharmacology,
EnvironmentalScienceand Pollution Research
Invitedreviewer(EPA Clearances): “BrominatedFlameRetardantsinHumanMilkandSerumfrom the
US EPA MAMA Study:ModeledPredictionsof InfantExposuresandConsiderationsforRisk
Assessment”(2015),“Probabilisticapproachestodose-responseanalysesinchemical risk
assessments”(2015),“Data dialogues:critical connectionsfor designingandimplementing
future nanomaterial research”(2014),“Environmental ChemicalsinBreastMilk”(2013),
“Reviewof Health-BasedReference ValuesforInhalationExposures”(2012), “Nanomaterial
Case Study:A Comparisionof MultiwalledCarbonNanotube andDecabromdiphenyl Ether
Flame-RetardantCoatingsAppliedtoUpholsteryTextiles”(2012),“BenchmarkDose Modeling
and ItsUse In RiskAssessment”(2009)
Professional Affiliations:
Societyof Toxicology,FullMember(2011-present)
Societyof Toxicology,TraineeMember(2001-2011)
SocietyforRiskAnalysis(2009-2010)
AssociationforResearchinVisionandOphthalmology(2009-2010)
PEER-REVIEWED ARTICLES
5. 1. PowersC.M., GriegerK.,Meacham C. A.,GoodingM. L.,Gift J.S., LehmannG. M., HendrenC.
O.,Davis J.M., Burgoon L. (2015). Applyingcomprehensive environmental assessmentto
researchplanningformultiwalledcarbonnanotubes:Refinementstoinformfuture stakeholder
engagement. IntegrEnviron AssessManag http://www.ncbi.nlm.nih.gov/pubmed/26011822.
2. LehmannG. M., ChristensenK.,Maddaloni M.,PhillipsL.J.(2015). Evaluatinghealthrisksfrom
inhaledpolychlorinatedbiphenyls:researchneedsforaddressinguncertainty.Environ Health
Perspect123, 109-113.
3. LehmannG. M., VernerM. A.,LuukinenB.,HenningC.,AssimonS.A.,LaKindJ.S.,McLanahan E.
D., PhillipsL.J.,DavisM. H., PowersC.M., HinesE.P., HaddadS., LongneckerM.P., PoulsenM.
T., Farrer D. G., Marchitti S. A.,Tan Y. M., SwartoutJ.C., SagivS. K.,WelshC.,Campbell J.L.Jr.,
FosterW. G., Yang R. S.,FentonS. E.,Tornero-VelezR.,FrancisB.M., Barnett J.B., El-Masri H. A.,
SimmonsJ.E. (2014). Improvingthe riskassessmentof lipophilicpersistentenvironmental
chemicalsinbreastmilk. CritRev Toxicol44, 600-17.
4. PowersC.M., Gift J., LehmannG. M. (2014). SparkingConnections:TowardBetterLinkages
BetweenResearchandHumanHealthPolicy-AnExample withMultiwalledCarbonNanotubes.
Toxicol Sci 141, 6-17.
5. KuriyanA.E., LehmannG. M., Kulkarni A.A.,WoellerC.F.,FeldonS.E.,HindmanH. B., Sime P.
J.,HuxlinK.R., PhippsR.P.(2012). ElectrophilicPPARligandsinhibitcorneal fibroblastto
myofibroblastdifferentiationinvitro:A potentiallynovel therapyforcorneal scarring. Exp Eye
Res 94, 136-45.
6. Xi X., McMillanD., LehmannG. M., Sime P.J.,LibbyR., HuxlinK.R.,FeldonS.E., PhippsR.P.
(2011). Ocularfibroblastdiversity:Implicationsforinflammationandocularwoundhealing.
InvestOphthalmolVisSci 52, 4859-65.
7. LehmannG. M., Xi X., Kulkarni A.A.,OlsenK.C.,PollockS.J.,Baglole C.J.,Gupta S.,CaseyA. E.,
HuxlinK.R.,Sime P.J., FeldonS.E.,PhippsR.P. (2011). The aryl hydrocarbonreceptorligandITE
inhibitsTGFβ1-inducedhumanmyofibroblastdifferentiation. AmJPathol178, 1556-67.
8. LehmannG. M., WoellerC.F.,PollockS.J.,O’LoughlinC.W.,Gupta S.,FeldonS.E., PhippsR.P.
(2010). Novel anti-adipogenicactivityproducedby humanfibroblasts. AmJPhysiolCell Physiol
299, C672-81.
9. FergusonH.E., Kulkarni A., LehmannG.M., Garcia-BatesT. M., ThatcherT. H., HuxlinK.R.,
PhippsR.P.,Sime P.J. (2009). Electrophilicperoxisome proliferator-activatedreceptor-γ ligands
have potentantifibroticeffectsinhumanlungfibroblasts. AmJRespirCell Mol Biol 41, 722-30.
10. LehmannG. M., FeldonS.E., SmithT. J.,PhippsR.P. (2008). Immune mechanismsinthyroideye
disease. Thyroid 18,959-65.
11. Garcia-BatesT. M., LehmannG. M., Simpson-HaidarisP.J.,BernsteinS.H.,Sime P.J.,PhippsR.
P. (2008). Role of Peroxisome Proliferator-ActivatedReceptorGammaandIts Ligandsinthe
Treatmentof Hematological Malignancies. PPARRes 2008, 834612-30.
12. LehmannG. M., Garcia-BatesT. M., SmithT. J., FeldonS.E.,PhippsR.P. (2008). Regulationof
Lymphocyte FunctionbyPPARgamma:Relevance toThyroidEye Disease-RelatedInflammation.
PPARRes 2008, 895901-13.
13. SpinelliS.L.,O’BrienJ.J.,Bancos S., LehmannG. M., SpringerD. L., BlumbergN.,FrancisC.W.,
TaubmanM. B., PhippsR.P.(2008). The PPAR-PlateletConnection:Modulatorsof Inflammation
and Potential CardiovascularEffects. PPARRes 2008, 328172-88.
6. 14. LehmannG. M. andMcCabe M. J.(2007). Arsenite slows Sphase progressionviainhibitionof
cdc25A dual specificityphosphatasegene transcription. ToxicolSci 99, 70-8.
15. TaylorB. F., McNeelyS.C.,MillerH. L., LehmannG. M., McCabe M. J., Jr.,StatesJ. C. (2006). p53
suppressionof arsenite-inducedmitoticcatastrophe ismediatedbyp21CIP1/WAF1. J Pharmacol
Exp Ther 318, 142-51.
16. McCollum(Lehmann) G.,KengP.C.,StatesJ. C.,and McCabe M. J.(2005). Arsenite delays
progressionthrougheachcell cycle phase andinducesapoptosisfollowingG2/Marrest inU937
myeloidleukemiacells. JPharmacolExp Ther 313, 877-87.
17. McCabe M. J., WhitekusM.J., HyunJ.,EcklesK. G., McCollum(Lehmann) G.,andRosenspire A.J.
(2003). InorganicmercuryattenuatesCD95-mediatedapoptosisbyinterferingwithformationof
the deathinducingsignalingcomplex. ToxicolApplPharmacol190, 146-56.
INVITED BOOK CHAPTERS
PhippsR.P., LehmannG. M., Sime P.J.(2011). Lung fibrosis:The impactof fibroblastdiversityand
differentiation.In Proceedingsof 2009 Hales Lung Conference:clinical and pathophysiologicaspectsof
diffuseparenchymallung disease (pp.10-15). EllicottCity,MD: BioBitField.
INVITED LECTURES AND SEMINARS:
1. PCB National Meeting.August5,2015. “IRISToxicological Reviewof PCBs:EffectsOtherThan
Cancer.”Washington,DC.
2. AmericanIndustrial Hygiene Conference &Exposition.June1,2015. “EvaluatingNoncancer
HealthRisksfromInhaledPCBs.”SaltLake City,UT.
3. NIEHS SRPGrantee InformationExchange Meeting.November5,2014. “How Toxicology
ResearchIsUsed inHuman HealthRiskAssessment:StudyDesignandEvaluation.”
4. 8th International PCBWorkshop.October7,2014. “EvaluatingNoncancerHealthRisksfrom
InhaledPCBs.”WoodsHole,MA.
5. SuperfundResearchProgramRiskeLearningSeries.April 28,2014. “EvaluatingHealthRisksfrom
InhaledPCBs:ResearchNeedstoAddressUncertainty.”
6. PCB National Meeting.June5,2012. “IRISToxicological Reviewof PCBs:EffectsOtherThan
Cancer (External PeerReviewDraft).”Washington,DC.
7. 7th International PCBWorkshop.May30, 2012. “EvaluatingNon-CancerHealthRiskfrom
InhaledPCBs:CurrentU.S.Perspectives.”Arcachon,France.
8. 7th International PCBWorkshop.May28, 2012. “EvaluatingNon-CancerHealthRiskfrom
InhaledPCBs:UncertaintiesandResearchNeeds.”Arcachon,France.
9. PCB National Meeting.June7,2011. “IRISToxicological Reviewof PCBs:EffectsOtherThan
Cancer (AgencyReviewDraft).”Washington,DC.
ABSTRACTS & POSTER PRESENTATIONS
1. AlcalaC, LaKindJS, LehmannGM, HinesE, Marchitti S,DavisM, and LorberM. The State of the
Science onEnvironmental Chemicalsin Breastmilkandthe RelationshiptoInfantHealth.
International Societyof Exposure Science AnnualMeeting.Henderson,NV.October18-22, 2015.
2. LehmannGM and SchaumJ. Assessingnon-cancerhealthriskfrominhaledPCBs.Societyof
ToxicologyAnnual Meeting.Washington,DC.March 6-10, 2011.
7. 3. LehmannGM, PollockSJ,O’LoughlinCW,FeldonSE,andPhippsRP.Thy-1+human orbital
fibroblastsproduce anovel anti-adipogenicfactor.Annual Meetingof the Associationfor
ResearchinVisionandOphthalmology.FortLauderdale,FL.April 30-May1, 2010.
4. LehmannGM, EcklesKG, Gantz MA, and McCabe MJ. Arsenite inducesSphase delayinU937
cellsviadownregulationof the cdc25A phosphatase.Societyof ToxicologyAnnualMeeting.San
Diego,CA.March 5-9, 2006.
5. LehmannGM, EcklesKG, Gantz MA, and McCabe MJ. Arsenite inducesSphase delayinU937
cellsviadownregulationof the cdc25A phosphatase.AACR-NCI-EORTCMolecularTargetsand
Cancer TherapeuticsConference.Philadelphia,PA.November14-18, 2005.
6. LehmannGM and McCabe MJ. Arsenite inhibitscell cycle progressionof U937 myeloidleukemia
cells:role of cdc25A degradation.Societyof ToxicologyAnnual Meeting.New Orleans,LA.
March 6-10, 2005.
7. McCollum(Lehmann) Gand McCabe MJ. Arsenite stimulatesapoptosisinmyeloidleukemiacells
duringG2/M phase.Miami Nature BiotechnologyWinterSymposium.Miami,FL.January31-
February4, 2004.
8. McCollum(Lehmann) Gand McCabe MJ. Arsenite stimulatesapoptosisinmyeloidleukemiacells
duringG2/M phase. Societyof ToxicologyAnnual Meeting.SaltLake City,UT.March 9-13, 2003.
9. McCollum(Lehmann) G,HyunJ, Rosenspire AJ,andMcCabe MJ. Attenuationof CD95-InducedT
Cell ApoptosisbyInorganicMercury:Effectsof Mercuryand OtherGroup IIMetals.Societyof
ToxicologyAnnual Meeting.Nashville,TN.March17-21, 2002.
ACADEMIC and SCIENTIFICHONORS:
Special AccomplishmentRecognitionandTime-offAwards(numerous>10;EPA/ORD/NCEA),2009-2015
AmnisTravel Stipend,2010
Rochester/FingerLakesEye &Tissue BankResearchGrant, 2009
Bristol MyersSquibbTravel Award,2005
Societyof ToxicologyMetalsSpecialtySectionPre-doctoral ResearchAward(FirstPlace),2005
PhRMA Predoctoral FellowshipinPharmacology/Toxicology,2004
WilliamF.NeumanAward,2004
2004 Miami Nature BiotechnologyWinterSymposium, Travel Fellowship,2004
Graduate Womenin Science Travel andConferenceAward,2003
Societyof ToxicologyGraduate StudentTravel Award,2003
Societyof ToxicologyMetalsSpecialtySectionPre-doctoral ResearchAward(SecondPlace),2003
KodakToxicologyScholar:Universityof Rochester,2001