This document lists 45 publications authored by Asher Zilberstein and collaborators from 1974 to 1994. The publications investigate the mechanisms of interferon action and interferon-induced inhibition of protein synthesis. They also examine the effects of tyrosine kinase inhibitors on cell proliferation, signal transduction pathways involving growth factors and their receptors, and phosphorylation events. The list demonstrates Zilberstein's extensive research on interferons, protein kinases, and growth factor signaling over a 20 year period.
Jeffrey J. Whyte is a researcher who has published extensively on topics related to swine genetics, cloning, and using pig models for human diseases. Some of his publications include studies looking at using zinc finger nucleases and CRISPR to genetically modify pigs, producing cloned knockout pig models, and investigating cytokines and placental development in pigs. He has also researched using pig models to study cardiovascular conditions in humans.
This document lists 16 publications by Peter M. Power related to research on pilin glycosylation in Neisseria meningitidis and other gram-negative bacteria. The publications span from 2000 to 2014 and include studies characterizing the genetic basis of pilin glycosylation, the role of specific genes in the glycosylation pathway, comparative analyses of glycosylation mechanisms between bacteria, and investigations into genome diversity and phase variation.
This document lists 23 publications by Agulnick and collaborators from 1992 to 2015 related to stem cell differentiation and pancreatic endocrine cell production, tumor suppression, embryogenesis, and human herpesvirus 6. Key publications include differentiation of human embryonic stem cells to insulin-producing beta cells (2015), a scalable system for production of pancreatic progenitors from human ES cells (2012), directed differentiation of human ES cells to pancreatic endocrine cells (2007), and production of pancreatic hormone-expressing cells from human ES cells (2006).
This document contains a curriculum vitae for Melissa Inman including her publications and research papers. It lists 28 publications from 1992 to 2015 related to her research on viruses that affect animals like African horse sickness virus, bovine herpesvirus 1, herpes simplex virus, Newcastle disease virus, swine influenza virus, and avian pathogenic Escherichia coli. The publications cover topics like viral infection mechanisms, detection methods, vaccine development, and viral latency and reactivation.
This document discusses how moderate exercise affects natural killer (NK) cells through killer immunoglobulin-like receptors (KIRs). It explains that KIRs are receptors on NK cells that can be either activatory or inhibitory, and regulate NK cell cytotoxicity. Moderate exercise increases expression of the KIR2DS2 activatory receptor and KIR2DL3 inhibitory receptor on NK cells. This is mediated by increased levels of heat shock protein 70 (HSP70) from exercise, which activates a transcription factor that increases expression of these KIR genes. Upregulating these receptors promotes NK cell immune surveillance and effectiveness, demonstrating how exercise can benefit immune system function.
1. Several studies examined genes that regulate cell proliferation and differentiation in the respiratory epithelium, including Sox2 and SPDEF.
2. GATA-6 was shown to activate transcription of surfactant proteins A and TTF-1.
3. Additional research investigated the roles of surfactant proteins A and D in regulating phospholipid homeostasis and enhancing clearance of pathogens like RSV and bacteria from the lungs.
This document provides biographical and professional details about Derek J. Milner, including his education, research experience, teaching experience, awards, publications, and presentations. It outlines his educational background, including a Ph.D. in Molecular and Cellular Biology from Baylor College of Medicine and a B.S. in Biochemistry from the University of Iowa. It then details his extensive research experience in regenerative biology and tissue engineering at the University of Illinois over the past 15 years, focusing on projects involving muscle regeneration, stem cells, and animal models of bone and cartilage repair.
This document lists 48 peer-reviewed journal publications by Marinus te Pas. The publications cover a wide range of topics including: the effects of genetic variants on growth traits and meat quality in pigs; regulation of muscle development genes; associations between leptin gene polymorphisms and production traits in cattle; and molecular variation in Trypanosoma parasites. Many of the publications involve characterizing genes associated with muscle growth, fat deposition, and production traits in livestock.
Jeffrey J. Whyte is a researcher who has published extensively on topics related to swine genetics, cloning, and using pig models for human diseases. Some of his publications include studies looking at using zinc finger nucleases and CRISPR to genetically modify pigs, producing cloned knockout pig models, and investigating cytokines and placental development in pigs. He has also researched using pig models to study cardiovascular conditions in humans.
This document lists 16 publications by Peter M. Power related to research on pilin glycosylation in Neisseria meningitidis and other gram-negative bacteria. The publications span from 2000 to 2014 and include studies characterizing the genetic basis of pilin glycosylation, the role of specific genes in the glycosylation pathway, comparative analyses of glycosylation mechanisms between bacteria, and investigations into genome diversity and phase variation.
This document lists 23 publications by Agulnick and collaborators from 1992 to 2015 related to stem cell differentiation and pancreatic endocrine cell production, tumor suppression, embryogenesis, and human herpesvirus 6. Key publications include differentiation of human embryonic stem cells to insulin-producing beta cells (2015), a scalable system for production of pancreatic progenitors from human ES cells (2012), directed differentiation of human ES cells to pancreatic endocrine cells (2007), and production of pancreatic hormone-expressing cells from human ES cells (2006).
This document contains a curriculum vitae for Melissa Inman including her publications and research papers. It lists 28 publications from 1992 to 2015 related to her research on viruses that affect animals like African horse sickness virus, bovine herpesvirus 1, herpes simplex virus, Newcastle disease virus, swine influenza virus, and avian pathogenic Escherichia coli. The publications cover topics like viral infection mechanisms, detection methods, vaccine development, and viral latency and reactivation.
This document discusses how moderate exercise affects natural killer (NK) cells through killer immunoglobulin-like receptors (KIRs). It explains that KIRs are receptors on NK cells that can be either activatory or inhibitory, and regulate NK cell cytotoxicity. Moderate exercise increases expression of the KIR2DS2 activatory receptor and KIR2DL3 inhibitory receptor on NK cells. This is mediated by increased levels of heat shock protein 70 (HSP70) from exercise, which activates a transcription factor that increases expression of these KIR genes. Upregulating these receptors promotes NK cell immune surveillance and effectiveness, demonstrating how exercise can benefit immune system function.
1. Several studies examined genes that regulate cell proliferation and differentiation in the respiratory epithelium, including Sox2 and SPDEF.
2. GATA-6 was shown to activate transcription of surfactant proteins A and TTF-1.
3. Additional research investigated the roles of surfactant proteins A and D in regulating phospholipid homeostasis and enhancing clearance of pathogens like RSV and bacteria from the lungs.
This document provides biographical and professional details about Derek J. Milner, including his education, research experience, teaching experience, awards, publications, and presentations. It outlines his educational background, including a Ph.D. in Molecular and Cellular Biology from Baylor College of Medicine and a B.S. in Biochemistry from the University of Iowa. It then details his extensive research experience in regenerative biology and tissue engineering at the University of Illinois over the past 15 years, focusing on projects involving muscle regeneration, stem cells, and animal models of bone and cartilage repair.
This document lists 48 peer-reviewed journal publications by Marinus te Pas. The publications cover a wide range of topics including: the effects of genetic variants on growth traits and meat quality in pigs; regulation of muscle development genes; associations between leptin gene polymorphisms and production traits in cattle; and molecular variation in Trypanosoma parasites. Many of the publications involve characterizing genes associated with muscle growth, fat deposition, and production traits in livestock.
This document provides a publication list for Dr. Kevin D. Brown including 36 peer-reviewed publications from 1990 to 2008. The publications focus on characterizing cytoskeletal proteins, identifying their roles in cell cycle regulation and DNA damage response pathways, and investigating epigenetic silencing of tumor suppressor genes in cancer development.
Abzymes are antibodies that possess catalytic activity in addition to their ligand binding ability. They can be produced through reactive immunization techniques involving haptens that mimic transition state analogs of chemical reactions, eliciting antibodies that can catalyze those reactions. One application of abzymes is in antibody-directed enzyme prodrug therapy (ADEPT), where an abzyme like 38C2 is used to activate anti-cancer prodrugs like doxorubicin selectively near tumor cells.
The document summarizes the formal synthesis of (−)-clavosolide A, a natural product with a highly functionalized 16-membered macrocyclic structure containing 14 stereocenters. The synthesis involved initial retrosynthetic analyses, exploration of various reaction strategies reported in literature for constructing key structural motifs, and development of a revised retrosynthetic route involving D-malic acid as the starting material. Key steps included preparation of an auxiliary, aldehyde synthesis, lactone formation, and generation of the C9 diastereomeric monomer.
This document summarizes the relationship between antioxidants, telomeres, aging, and disease. It discusses how free radicals cause oxidative damage that leads to cellular aging and death. Antioxidants can neutralize free radicals and protect telomeres, the protective caps at the end of chromosomes. Shortened telomeres are associated with aging and disease as cells can no longer divide. Compounds in Moringa oleifera like vitamins A, C, E, and selenium act as antioxidants that may protect telomeres from oxidative damage and slow cellular aging.
This document lists 31 publications by T. Hjalt and others related to research on genetic regulation and development. The publications span from 1992 to 2010 and cover topics including identification of genetic subtypes of spinal motor neurons, regulation of gene expression by transcription factors like PITX2, and the role of genes such as Neurogenin2 in neurogenesis. Many of the publications involve identification and characterization of genes involved in development of structures like the eye, kidney, and limbs.
Ton Beniers_publicatielijst overzicht 2015Ton Beniers
This document lists publications by Beniers and others from 1987-2001 related to experimental cytokine therapy for renal cell carcinoma and Wilms' tumor. It includes 18 journal publications, 5 book chapters, and 1 PhD thesis by Beniers on experimental cytokine therapy for renal cell carcinoma. The publications examine the in vitro and in vivo effects of interferons and tumor necrosis factor on renal tumor cell lines and xenografts, and differential expression of drug resistance and heat shock proteins in histological compartments of nephroblastomas.
This document lists 42 publications by Dennis Huszar. The publications span from 1981 to 2011 and cover topics related to herpes simplex virus, retrovirus vectors, gene targeting, immunology, obesity, and small molecule inhibitors for cancer treatment. Many of the publications involve collaborations and are focused on using genetic modifications in mice to study biological processes and potential drug targets.
This document provides a summary of the professional experience and qualifications of Zoya Gluzman-Poltorak. It lists her contact information and includes a detailed list of over 30 peer-reviewed publications in scientific journals related to hematology, oncology, and radiation medicine spanning from 1997 to 2015. The publications demonstrate her expertise in areas such as hematopoietic recovery after radiation exposure, the effects of cytokines like interleukin-12, and the role of proangiogenic factors in cancer progression.
The document describes a novel three-step synthesis of the N(10)-C(17) fragment of cyclotheonamides, potent serine protease inhibitors. The key steps are:
1) A Passerini reaction between protected argininal, dipeptide isonitrile, and proline derivatives that produces adduct 13 in good yield.
2) Orthogonal deprotection of 13 leads to an O- to N-acyl migration, providing compound 14.
3) Compound 14 constitutes the desired N(10)-C(17) fragment and is produced in each step in good yield under mild conditions, representing an atom-economical synthesis.
This document provides a summary of Olivier Grenet's scientific publications, patents, and presentations. It includes 18 peer-reviewed publications, many focusing on using omics technologies like microarrays and real-time PCR to study drug-induced changes in gene expression. It also lists several patents related to predictive biomarkers for drug toxicity and clinical response. Grenet has given numerous invited talks on applying genomics and pharmacogenomics in drug development to improve safety evaluation and clinical translation.
1. This document lists original articles and book chapters published by Dr. Lee BC and collaborators related to hematopoietic stem cells and cancer.
2. The publications span from 1988 to 2017 and cover topics such as the role of specific genes and receptors in regulating hematopoietic stem cells and their response to stressors like radiation.
3. Many of the articles examine how the bone marrow microenvironment influences hematopoietic stem cells through factors secreted by other cell types.
This document lists publications and abstracts by David C. Fritzinger Ph.D. relating to research on cobra venom factor (CVF) and its role in activating the complement system. It includes 23 peer-reviewed publications from 1994-2015 describing molecular cloning and structure-function analysis of CVF and development of humanized CVF proteins for therapeutic complement depletion. It also lists 25 conference abstracts from 2009-2016 presenting research on using humanized CVF to deplete complement in preclinical disease models and potential therapies.
Cellulose biosynthesis in seed plants involves rosette structures containing cellulose synthases located in the plasma membrane. Cellulose microfibrils are synthesized from the donor molecule UDP-glucose and deposited following the direction of underlying microtubules. While isolated plant membranes can synthesize callose when incubated with UDP-glucose, providing sucrose to intact cotton fibers results in the majority of the product being cellulose, suggesting sucrose synthase forms a complex channeling carbon from sucrose to UDP-glucose for cellulose synthesis. Bacteria like Gluconacetobacter xylinus are also able to synthesize cellulose extracellularly and have provided insights into the cellulose synthesis process.
This document summarizes research on the subcellular distribution of the RNA-splicing factor NeuN/Fox-3 in Alzheimer's disease. The study found that in control brains, Fox-3 was largely nuclear, but in Alzheimer's brains it exhibited increased cytoplasmic localization. This may be due to alternative splicing of Fox-3 isoforms with different nuclear localization signals. The results suggest that stress factors in Alzheimer's disease may affect the subcellular distribution of Fox-3 and disrupt its RNA-splicing activity, contributing to disease pathogenesis.
Prevalence of Gene Polymorphisms in Intervertebral Disc Degenerative Diseasesijtsrd
Intervertebral disc diseases is otherwise known as breakdown of one or more discs that separate the bone of the spine, Which cause pain in the back, neck as well as frequent pain in legs and arms. The general role of intervertebral discs is to provide the cushioning between vertebrae and absorb the pressure that is exerted on the spine. Generally low back pain LBP is considered as common disorder from disc degenerative diseases. The main reason of the LBP is due to contribution of intervertebral disc diseases and combination of genetic and environmental factors. Most of these factor identified , But some of these remain unidentified. However recent researches identified that variations in several genes may influence the risc of intervertebral disc diseases . Most of the variations associated with genes related with immune function leads to increase risk of intervertebral disc diseases . Most of these genes plays a vital role in immune response like inflammation and water loss dehydration of the discs, Which causes their degeneration. This review focuses on the evidence of genetic disposition, the genes or biological processes that are implicated, and the need to consolidate resources and clarify phenotype definition to take advantage of the new technologies in genetic analysis to enhance our understanding of this condition. Mr. C. Marimuthu | Dr. V. Pushpa Rani | Dr. V. Judia Harriet Sumathy "Prevalence of Gene Polymorphisms in Intervertebral Disc Degenerative Diseases" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-2 , February 2019, URL: https://www.ijtsrd.com/papers/ijtsrd19153.pdf
Paper URL: https://www.ijtsrd.com/biological-science/molecular-biology/19153/prevalence-of-gene-polymorphisms-in-intervertebral-disc-degenerative-diseases/mr-c-marimuthu
Kevin Hugins research paper.
Meriam-Webster defines endocrinology as “a branch of medicine concerned with the structure, function, and disorders of the endocrine glands.” When considering the human endocrine system, most people think of endocrine glands such as the hypothalamus, pituitary, gonads, adrenals, and pancreas. No one would deny that hormones released from endocrine glands have a powerful effect on cell function throughout the human body. A relatively new field of study called Microbial Endocrinology suggests that the interactions and effects of the human endocrine system involve more organisms than just the human.
Curriculum -Vitae of Dr. Ramesh Kumar _updated 9-9-15Ramesh Kumar
This curriculum vitae summarizes the educational and professional experience of Ramesh Kumar. He holds a Ph.D in Life Sciences from Jawaharlal Nehru University in New Delhi, India. He has held post-doctoral research positions at Umea University in Sweden and currently at the Oklahoma Medical Research Foundation in the United States. His research has focused on the pathogenesis of systemic lupus erythematosus and the roles of BANK1 and BLK genes in modulating TLR signaling and the development of autoimmunity. He has published 13 papers and has presented his research at several scientific conferences.
Role of genetics in periodontal diseasesAnushri Gupta
Terminologies in Genetics
Genetic study design
genetic syndrome and disease associated with periodontal diseases, heretibility of periodontal disease, gene library, gene therapy
OUR SERVICES:
Ticketing (domestic, regional and international).
Worldwide travel insurance for corporate and group travel .
Hotel reservations.
Airport transfers .
Car rental/car hire
Safaris /tour packages/excursions
Mountain climbing
Sports and cultural safaris/tours
Conference/seminar organization and facilitation
Visa application and processing
Incentive travel
Meet and assist
Overseas tour packages
Team building organization and facilitation
Seasonal and end year retreats
Student packages
Bus/shuttle and train ticketing
This document provides a publication list for Dr. Kevin D. Brown including 36 peer-reviewed publications from 1990 to 2008. The publications focus on characterizing cytoskeletal proteins, identifying their roles in cell cycle regulation and DNA damage response pathways, and investigating epigenetic silencing of tumor suppressor genes in cancer development.
Abzymes are antibodies that possess catalytic activity in addition to their ligand binding ability. They can be produced through reactive immunization techniques involving haptens that mimic transition state analogs of chemical reactions, eliciting antibodies that can catalyze those reactions. One application of abzymes is in antibody-directed enzyme prodrug therapy (ADEPT), where an abzyme like 38C2 is used to activate anti-cancer prodrugs like doxorubicin selectively near tumor cells.
The document summarizes the formal synthesis of (−)-clavosolide A, a natural product with a highly functionalized 16-membered macrocyclic structure containing 14 stereocenters. The synthesis involved initial retrosynthetic analyses, exploration of various reaction strategies reported in literature for constructing key structural motifs, and development of a revised retrosynthetic route involving D-malic acid as the starting material. Key steps included preparation of an auxiliary, aldehyde synthesis, lactone formation, and generation of the C9 diastereomeric monomer.
This document summarizes the relationship between antioxidants, telomeres, aging, and disease. It discusses how free radicals cause oxidative damage that leads to cellular aging and death. Antioxidants can neutralize free radicals and protect telomeres, the protective caps at the end of chromosomes. Shortened telomeres are associated with aging and disease as cells can no longer divide. Compounds in Moringa oleifera like vitamins A, C, E, and selenium act as antioxidants that may protect telomeres from oxidative damage and slow cellular aging.
This document lists 31 publications by T. Hjalt and others related to research on genetic regulation and development. The publications span from 1992 to 2010 and cover topics including identification of genetic subtypes of spinal motor neurons, regulation of gene expression by transcription factors like PITX2, and the role of genes such as Neurogenin2 in neurogenesis. Many of the publications involve identification and characterization of genes involved in development of structures like the eye, kidney, and limbs.
Ton Beniers_publicatielijst overzicht 2015Ton Beniers
This document lists publications by Beniers and others from 1987-2001 related to experimental cytokine therapy for renal cell carcinoma and Wilms' tumor. It includes 18 journal publications, 5 book chapters, and 1 PhD thesis by Beniers on experimental cytokine therapy for renal cell carcinoma. The publications examine the in vitro and in vivo effects of interferons and tumor necrosis factor on renal tumor cell lines and xenografts, and differential expression of drug resistance and heat shock proteins in histological compartments of nephroblastomas.
This document lists 42 publications by Dennis Huszar. The publications span from 1981 to 2011 and cover topics related to herpes simplex virus, retrovirus vectors, gene targeting, immunology, obesity, and small molecule inhibitors for cancer treatment. Many of the publications involve collaborations and are focused on using genetic modifications in mice to study biological processes and potential drug targets.
This document provides a summary of the professional experience and qualifications of Zoya Gluzman-Poltorak. It lists her contact information and includes a detailed list of over 30 peer-reviewed publications in scientific journals related to hematology, oncology, and radiation medicine spanning from 1997 to 2015. The publications demonstrate her expertise in areas such as hematopoietic recovery after radiation exposure, the effects of cytokines like interleukin-12, and the role of proangiogenic factors in cancer progression.
The document describes a novel three-step synthesis of the N(10)-C(17) fragment of cyclotheonamides, potent serine protease inhibitors. The key steps are:
1) A Passerini reaction between protected argininal, dipeptide isonitrile, and proline derivatives that produces adduct 13 in good yield.
2) Orthogonal deprotection of 13 leads to an O- to N-acyl migration, providing compound 14.
3) Compound 14 constitutes the desired N(10)-C(17) fragment and is produced in each step in good yield under mild conditions, representing an atom-economical synthesis.
This document provides a summary of Olivier Grenet's scientific publications, patents, and presentations. It includes 18 peer-reviewed publications, many focusing on using omics technologies like microarrays and real-time PCR to study drug-induced changes in gene expression. It also lists several patents related to predictive biomarkers for drug toxicity and clinical response. Grenet has given numerous invited talks on applying genomics and pharmacogenomics in drug development to improve safety evaluation and clinical translation.
1. This document lists original articles and book chapters published by Dr. Lee BC and collaborators related to hematopoietic stem cells and cancer.
2. The publications span from 1988 to 2017 and cover topics such as the role of specific genes and receptors in regulating hematopoietic stem cells and their response to stressors like radiation.
3. Many of the articles examine how the bone marrow microenvironment influences hematopoietic stem cells through factors secreted by other cell types.
This document lists publications and abstracts by David C. Fritzinger Ph.D. relating to research on cobra venom factor (CVF) and its role in activating the complement system. It includes 23 peer-reviewed publications from 1994-2015 describing molecular cloning and structure-function analysis of CVF and development of humanized CVF proteins for therapeutic complement depletion. It also lists 25 conference abstracts from 2009-2016 presenting research on using humanized CVF to deplete complement in preclinical disease models and potential therapies.
Cellulose biosynthesis in seed plants involves rosette structures containing cellulose synthases located in the plasma membrane. Cellulose microfibrils are synthesized from the donor molecule UDP-glucose and deposited following the direction of underlying microtubules. While isolated plant membranes can synthesize callose when incubated with UDP-glucose, providing sucrose to intact cotton fibers results in the majority of the product being cellulose, suggesting sucrose synthase forms a complex channeling carbon from sucrose to UDP-glucose for cellulose synthesis. Bacteria like Gluconacetobacter xylinus are also able to synthesize cellulose extracellularly and have provided insights into the cellulose synthesis process.
This document summarizes research on the subcellular distribution of the RNA-splicing factor NeuN/Fox-3 in Alzheimer's disease. The study found that in control brains, Fox-3 was largely nuclear, but in Alzheimer's brains it exhibited increased cytoplasmic localization. This may be due to alternative splicing of Fox-3 isoforms with different nuclear localization signals. The results suggest that stress factors in Alzheimer's disease may affect the subcellular distribution of Fox-3 and disrupt its RNA-splicing activity, contributing to disease pathogenesis.
Prevalence of Gene Polymorphisms in Intervertebral Disc Degenerative Diseasesijtsrd
Intervertebral disc diseases is otherwise known as breakdown of one or more discs that separate the bone of the spine, Which cause pain in the back, neck as well as frequent pain in legs and arms. The general role of intervertebral discs is to provide the cushioning between vertebrae and absorb the pressure that is exerted on the spine. Generally low back pain LBP is considered as common disorder from disc degenerative diseases. The main reason of the LBP is due to contribution of intervertebral disc diseases and combination of genetic and environmental factors. Most of these factor identified , But some of these remain unidentified. However recent researches identified that variations in several genes may influence the risc of intervertebral disc diseases . Most of the variations associated with genes related with immune function leads to increase risk of intervertebral disc diseases . Most of these genes plays a vital role in immune response like inflammation and water loss dehydration of the discs, Which causes their degeneration. This review focuses on the evidence of genetic disposition, the genes or biological processes that are implicated, and the need to consolidate resources and clarify phenotype definition to take advantage of the new technologies in genetic analysis to enhance our understanding of this condition. Mr. C. Marimuthu | Dr. V. Pushpa Rani | Dr. V. Judia Harriet Sumathy "Prevalence of Gene Polymorphisms in Intervertebral Disc Degenerative Diseases" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-2 , February 2019, URL: https://www.ijtsrd.com/papers/ijtsrd19153.pdf
Paper URL: https://www.ijtsrd.com/biological-science/molecular-biology/19153/prevalence-of-gene-polymorphisms-in-intervertebral-disc-degenerative-diseases/mr-c-marimuthu
Kevin Hugins research paper.
Meriam-Webster defines endocrinology as “a branch of medicine concerned with the structure, function, and disorders of the endocrine glands.” When considering the human endocrine system, most people think of endocrine glands such as the hypothalamus, pituitary, gonads, adrenals, and pancreas. No one would deny that hormones released from endocrine glands have a powerful effect on cell function throughout the human body. A relatively new field of study called Microbial Endocrinology suggests that the interactions and effects of the human endocrine system involve more organisms than just the human.
Curriculum -Vitae of Dr. Ramesh Kumar _updated 9-9-15Ramesh Kumar
This curriculum vitae summarizes the educational and professional experience of Ramesh Kumar. He holds a Ph.D in Life Sciences from Jawaharlal Nehru University in New Delhi, India. He has held post-doctoral research positions at Umea University in Sweden and currently at the Oklahoma Medical Research Foundation in the United States. His research has focused on the pathogenesis of systemic lupus erythematosus and the roles of BANK1 and BLK genes in modulating TLR signaling and the development of autoimmunity. He has published 13 papers and has presented his research at several scientific conferences.
Role of genetics in periodontal diseasesAnushri Gupta
Terminologies in Genetics
Genetic study design
genetic syndrome and disease associated with periodontal diseases, heretibility of periodontal disease, gene library, gene therapy
OUR SERVICES:
Ticketing (domestic, regional and international).
Worldwide travel insurance for corporate and group travel .
Hotel reservations.
Airport transfers .
Car rental/car hire
Safaris /tour packages/excursions
Mountain climbing
Sports and cultural safaris/tours
Conference/seminar organization and facilitation
Visa application and processing
Incentive travel
Meet and assist
Overseas tour packages
Team building organization and facilitation
Seasonal and end year retreats
Student packages
Bus/shuttle and train ticketing
Impacts of agricultural development projects on gender relations in farming h...futureagricultures
The document presents findings from a case study analyzing the impacts of agricultural development projects on gender relations in farming households in Blantyre rural, Malawi. It finds that while both the Agriculture Sector Wide Approach Program (ASWAP) and Irrigation, Rural Livelihoods and Agricultural Development Project (IRLADP) mention supporting women farmers, only ASWAP clearly articulated gender mainstreaming strategies and guidelines and had impacts such as improving women's participation in decision making, control over resources, and work responsibilities. The study recommends that to effectively mainstream gender, future project documents must clearly outline gender implementation plans and monitor impacts on local gender relations.
Is it worth it just to lower my rate by a half of percentClint Hammond
This document discusses whether refinancing a mortgage is worth it for a small interest rate reduction. It argues that the common rule of thumb that a refinance is only worthwhile if the rate is reduced by 2% or more is flawed because it does not consider transaction costs or the homeowner's goals. The document presents examples showing that a refinance could make sense even with a 1% rate reduction if the costs can be recouped quickly. It also argues that concerns about restarting a 30-year term are misplaced, as the homeowner maintains full control over extra payments to pay off the loan early.
The document contains a listening exercise with words in English that have similar pronunciations but different meanings. It provides examples of word pairs like "ill" and "eel", "where" and "whale", "sore" and "sour", "they are" and "there are", and "grass" and "glass" to demonstrate minimal pairs. Students are instructed to listen to the pronunciation on an audio track and write down the number associated with each word they hear.
This document provides notes for online students about quantitative data analysis and SPSS. It discusses that the lecture series will cover basic ideas in quantitative data analysis. It notes that many different statistical software programs are available but that the course will use SPSS because it is easy to use and popular for statistical analysis.
IS IT WORTH IT JUST TO LOWER MY RATE BY A HALF OF PERCENTClint Hammond
This document discusses whether refinancing a mortgage is worth it for a small interest rate reduction. It argues that the common rule of thumb that a refinance is only worthwhile if the rate is reduced by 2% or more is misleading, as it does not consider transaction costs or the homeowner's goals. The document presents examples showing that a refinance could make sense even with a 1% rate reduction, and outlines different options for utilizing the savings, such as paying off the loan faster or investing the difference.
This document summarizes a presentation about Jews and comics given by Dr. Arlene B. Holtz on August 31, 2011. It discusses how many pioneering comic book characters were created by Jewish writers and artists and explores some of the Jewish themes and identities reflected in characters like Superman, Batman, Captain America, and The Thing. It also highlights some comics like Hate from the 1950s that addressed issues like anti-Semitism and Art Spiegelman's Pulitzer Prize-winning graphic novel Maus about the Holocaust.
Edison Research conducted a study on mothers' media habits called "Moms And Media 2011". The study found that mothers spend more time online daily than the general population, with over 2.5 hours a day on average. It also found that mothers are highly active on Facebook, with 62% having a profile, and that smartphone ownership among mothers has increased significantly in recent years. The report provides a comparison of mothers' media behaviors to fathers and the general population, with a focus on what makes mothers unique in both online and offline media consumption.
This document provides information for parents about the first grade program at Cradlerock Elementary School. It includes details about:
- A typical school day schedule including times for language arts, math, recess, and related arts.
- Homework policies which include spelling and math homework assigned Monday through Thursday to be checked by teachers.
- What students will learn throughout the year, including subjects like reading, writing, math, science, and social studies.
- Grading, grouping, and communication policies to keep parents informed about student progress.
El documento resume actualizaciones recientes en el aeropuerto de Congonhas en São Paulo, Brasil, incluyendo: 1) cambios en las distancias declaradas de las pistas, 2) cierres temporales de pistas, 3) rutas preferenciales alternativas debido al uso de áreas, y 4) nuevas aproximaciones RNAV.
SafePeak - How to manually configure SafePeak ClusterVladi Vexler
This document provides instructions for manually configuring a SafePeak active-passive cluster by installing SafePeak on two servers in single mode, installing the Windows NLB feature, configuring NLB on both servers with a virtual IP address, and configuring SafePeak MySQL databases and licenses on each server to enable synchronization and failover functionality.
Hussain Qureshi has created a photo album documenting his travels over the past year. The album contains landscapes, portraits, and candid shots from his trips to India, Thailand, and Australia. It aims to capture the beauty and diversity of the places he visited through his lens.
This document appears to be a slide presentation with 6 slides. It includes navigation buttons like "next", "back", and a button to go "home". The final slide is labeled "Slide 6" and there is an additional word in another language at the end that may indicate the end of the presentation.
This curriculum vitae summarizes the professional experience and qualifications of Michael John Dewey. It lists his education, including a Ph.D. in Microbiology from the University of Pennsylvania in 1973. It details his professional roles, such as Instructor at Colorado State University since 2007 and various director positions. It also provides a selection of his 75 publications in peer-reviewed journals on topics related to genetics and microbiology research.
This document lists 41 publications authored or co-authored by Himadri Samanta from 1977 to 2007. The publications cover research conducted by Samanta and collaborators on topics including thymineless death in Escherichia coli, radiation response of thymine starved bacteria, interferon action and the enzymology of interferon pathways, expression of hepatitis B virus antigens, characterization of recombinant enzymes expressed in cell lines, analysis of drug-resistant HIV strains, and discovery of new classes of HIV integrase inhibitors.
This curriculum vitae summarizes the career of Ethan Royal Signer, PhD. He has had a long career as a consultant for non-profit foundations focused on neurodegenerative diseases from 2016-2018. Prior to that, he was a senior scientific advisor for similar foundations from 2006-2016 and founding managing director from 2001-2006. Academically, he was a professor of biology emeritus at MIT from 1997 until retiring. He has authored over 50 publications in peer-reviewed journals focused on genetics and genetic engineering in plants, bacteria, and viruses.
Xiumei Cao is a Chinese scientist currently working as an associate professor in Shanghai Jiaotong University. She has a Ph.D. in Biological Regulation from the Weizmann Institute of Science in Israel and extensive experience in immunology and cancer research. Her work has focused on the regulation of signaling pathways like TLR, TNF, and Sonic Hedgehog that are important in innate immunity and cancer. She has published numerous papers investigating the roles of various molecules in these pathways.
- Molecular and cellular biologist with extensive experience in oncology research including target validation, biomarker discovery, drug mechanism, immunology, and translational research.
- Experienced project leader able to effectively manage collaborative projects and communicate across teams.
- Background includes positions at Pharmacyclics, Inc., Stanford University, and MD Anderson Cancer Center investigating various areas of cancer research including B cell lymphomas, acute myeloid leukemias, biomarkers, drug combinations, and tumor microenvironment.
James J. Campbell has had an extensive career in immunology research. He is currently a Senior Director at ChemoCentryx, where he leads pre-clinical research teams investigating drug mechanisms of action. Previously, he was a Principal Investigator and Professor at Harvard Medical School, where he managed an immunology lab and published over 60 peer-reviewed papers. He has received many awards and honors for his research and expertise in T cell biology, chemokines, and skin and intestinal immunity.
This document lists the presentations, publications, and other work of E. Meierhenry. It includes over 30 publications, many in peer-reviewed journals, on topics related to toxicology pathology in animals. The publications span from the 1970s to planned 2018 publication and cover a wide range of topics including neurotoxicity, carcinogenicity, hepatic pathology, and more.
Myofibroblasts are specialized cells that play an important role in wound healing, fibrosis, and tissue remodeling. They have characteristics of both fibroblasts and smooth muscle cells. Myofibroblasts secrete growth factors, cytokines, and extracellular matrix proteins that promote wound contraction, tissue repair, and the formation of new tissue. They are formed through the differentiation of various cell types and help regulate inflammation and the proliferation of epithelial, vascular and other cells through paracrine signaling. Myofibroblasts are vital for normal tissue development and wound healing but excessive accumulation can lead to fibrosis.
Article critiques ( Min 1500 words) Styles of leadership. .docxdavezstarr61655
Article critiques :( Min 1500 words)
Styles of leadership.
Note :-( Rules for submission) The structure includes:
• Title – informs us it is a review
• Informative Abstract – informs us this is a meta-analysis (novel analysis in a novel context of previously published data)
• Introduction
• Body – Material & Methods, Results (including the use of tables and figures to display novel findings), Discussion
• Conclusion – a listing of novel findings of the meta-analysis
• References – organized alphabetically
1. Abstract On your abstract page, center the word “Abstract” at the top of the page without any additional formatting.
On the next line, write a concise summary of your critique. This should be a brief summary about the article and your critique. Examples of points to make in this paragraph include objectively analyzing the article and evaluating its contributions to learning. This paragraph should be between 150 to 250 words.
2. Main Body Type your title at the top of the page without any additional formatting. Following a double space, begin writing your critique. Journal critiques analyze a variety of topics. Examples of issues you may want to include in this section include whether you found any errors of fact or interpretation, the author was objective.
Choose one of the following subjects:
1-Bureaucratic Leadership
2-Charismatic Leadership
3-Servant Leadership
4-Transactional Leadership
References
Bacco, Alessandra Di, and Grace Gill. "The Secreted Glycoprotein CREG Inhibits Cell Growth Dependent on the Mannose-6-phosphate|[sol]|insulin-like Growth Factor II Receptor." Nature News. Nature Publishing Group, 21 Aug. 2003.
Bauer, Matthias, Anne C. Hamm, Melanie Bonaus, Andrea Jacob, Jens Jaekel, Hubert Schorle, Michael J. Pankratz, and Joerg D. Katzenberger. "Starvation Response in Mouse Liver Shows Strong Correlation with Life-span-prolonging Processes." Physiological Genomics. American Physiological Society, 13 Apr. 2004.
Briers, Demarcus. "Liver: Cell Types Found in Liver Simplified." DBrierscom. N.p., 20 Sept. 2012.
Bulla, Gary A. "Selective Loss of the Hepatic Phenotype Due to the Absence of a Transcriptional Activation Pathway." Somatic Cell and Molecular Genetics, 7 Mar. 1997.
Bulla, Gary. "Extinction of Alpha1-antitrypsin Expression in Cell Hybrids Is Independent of HNF1alpha and HNF4 and Involves Both Promoter and Internal DNA Sequences." Nucleic Acids Research 27 April. 1999. 1190-197.
Bulla, Gary A., Caitlin M. Aylmer, Adele L. Dust, Jeffrey L. Kurkewich, Leon K. Mire, and Arnold B. Estanda. "Genome-wide Analysis of Hepatic Gene Silencing in Hepatoma Cell Variants." Genomics 100.3 (2012): 176-83.
Bustin, Stephens. “Absolute Quantification of mRNA Using Real-Time Reverse Transcription Polymerase Chain Reaction Assays.” Journal of Molecular Endocrinology 25 (2000): 169–193.
Castell James and Gomez-Lechon John. “Liver Cell Culture Techniques.” Methods in Molecular Biology 481 (2009): 36-46.
.
Identification of genetic regions in the yuk operon of Bacillus subtilis that are differentially required for secretion of YukE, a homolog to the virulence factor, ESXA in Mycobacterium tuberculosis
This document lists 17 publications by Megan Robinson from 1990 to 2006 related to her research on topoisomerase II and mitogen-activated protein kinases (MAPKs). Her early work studied the effects of antineoplastic drugs on topoisomerase II and how they stabilize DNA cleavage complexes. Later publications investigated the roles and regulation of MAPKs ERK2 and ERK3, including their subcellular localization and effects on neurite outgrowth and cell transformation. She also authored review articles and book chapters on topoisomerase II mechanisms and MAPK pathways.
The document lists the top 200 drugs by worldwide sales in 2013 according to data from IMS Health. The top selling drug was Adalimumab (Humira) with sales of $10.058 billion, which is a monoclonal antibody used to treat inflammatory diseases. Several other monoclonal antibodies, insulin analogues, and drugs for conditions like high cholesterol and cancer rounded out the top 20 drugs. The document provides each drug's generic name, brand name, main therapeutic class and worldwide sales.
This curriculum vitae outlines the educational and professional background of Julio A. Urbina R. He received a Licenciado in Biology from the Central University of Venezuela in 1970 and a Ph.D. in Chemistry from the Massachusetts Institute of Technology in 1975. His positions have included professorships at the University of Cincinnati and Central University of Venezuela. He has also held various research positions at the Venezuelan Institute for Scientific Research since 1991. The CV lists over 40 publications in peer-reviewed journals related to biological chemistry and parasitology research.
Johannes Vogel is a senior group leader and professor at the Institute of Veterinary Physiology at the University of Zurich. He was born in 1964 in Bonn, Germany. He received his medical degree from the University of Bonn in 1992 and has since held positions at the University of Heidelberg and University of Zurich. His research focuses on the physiological and pathophysiological roles of erythropoietin. He has authored or co-authored over 25 publications in peer-reviewed journals.
This document lists 30 publications and 6 presentations by Dr. Lin Wang related to head and neck cancer research. The publications cover topics such as increased expression of HER2/HER3 in HPV-positive head and neck squamous cell carcinoma, differential pathological significance of subcellular MDM2 expression in HNSCC, targeting of STAT3 to abrogate EGFR inhibitor resistance in cancer, and the mutational landscape of head and neck squamous cell carcinoma. The presentations were given at American Society of Nephrology conferences between 2001-2006 on topics including the role of MKK3-p38 MAPK pathways in TGF-β1 signaling and renal fibrosis.
This document lists 30 publications and 6 presentations by Dr. Lin Wang related to head and neck cancer research. The publications cover topics such as increased expression of HER2/HER3 in HPV-positive head and neck squamous cell carcinoma, differential significance of subcellular MDM2 expression in HNSCC, targeting of STAT3 to abrogate EGFR inhibitor resistance, and the mutational landscape of head and neck squamous cell carcinoma. The presentations were given at American Society of Nephrology conferences between 2001-2006 on topics including the role of MKK3-p38 MAPK pathways in mediating TGF-β1 signaling.
This document lists publications by S.G. McDowall and collaborators spanning 1990-2005. The publications relate to research on the angiotensin AT4 receptor and its role in memory enhancement, spatial learning in rats, and insulin regulation. Key findings include identifying the AT4 receptor as the enzyme insulin-regulated aminopeptidase, and studying ligands that modulate its activity.
1. PUBLICATIONS
1. J. Content, B. Lebleu, A. Zilberstein, H. Berissi and M. Revel (1974). Mechanism of the Interferon-Induced
Block of mRNA Translation in Mouse L-Cells: Reversal of the Block by Transfer RNA. FEBS Letts. 41, 125-130.
2. J. Content, B. Lebleu, U. Nudel, A. Zilberstein, H. Berissi and M. Revel (1975). Blocks in Elongation and
Initiation of Protein Synthesis Induced by Interferon Treatment in Mouse L-cells. Eur. J. Biochem. 54, 1-10.
3. A. Zilberstein, J. Content, B. Lebleu, H. Berissi, L.M. Shulman and M. Revel (1975). Mechanism of Interferon-
Induced Blocks of mRNA Translation in Mouse L-cells and its Reversal by tRNA. Isr. J. Med. Sci. 11, 1211.
4. A. Zilberstein, B. Dudlock, H. Berissi and M. Revel (1976). Control of mRNA Translation by Minor Species of
Leucyl-tRNA in Extracts from Interferon-Treated L-cells. J. Mol. Biol. 108, 43-54
5. A. Zilberstein, P. Federman, L. Shulman and M. Revel (1976). Specific Phosphorylation in vitro of a Protein
Associated with Ribosomes of Interferon-Treated Mouse L-cells. FEBS Letts. 68, 119-124.
6. A. Zilberstein, L. Shulman, B. Dudock and M. Revel (1976). Specific Control of mRNA Translation by Minor
Species of tRNA in Extracts from Interferon-Treated L-cells. Isr. J. Med. Sci. 12, 1384.
7. A. Zilberstein, A. Schmidt, A. Kimchi, L. Shulman and M. Revel (1977). Regulation of the Interferon-Induced
Protein Phosphorylation and Translational Inhibition. Isr. J. Med. Sci. 13, 941.
8. A. Kimchi, A. Zilberstein, A. Schmidt, L. Shulman, P. Federman and M. Revel (1978). Interferon-Induced
Translational Inhibitors: I. The Protein Kinase System. Isr. J. Med. Sci. 14, 183.
9. A. Zilberstein, A. Schmidt, H. Berissi, P. Federman and M. Revel (1978). Interferon-Induced Translational
Inhibitors: II. The Oligo-isoadenylate Synthetase. Isr. J. Med. Sci. 14, 184.
10. A. Zilberstein, A. Kimchi, A. Schmidt and M. Revel (1978). Isolation of two Interferon-Induced Translational
Inhibitors: A Protein Kinase and an Oligo-isoadenylate Synthetase. Proc. Natl. Acad. Sci. USA 75, 4734-4738.
11. A. Schmidt, A. Zilberstein, L. Shulman, H. Berissi, P. Federman and M. Revel (1978). Interferon Action:
Isolation of Nuclease F, a Translational Inhibitor Activated by Interferon-Induced (2’-5’) oligoisoadenylate. FEBS
Letts. 95, 257-264.
12. Y. Chernajovsky, A. Kimchi, A. Schmidt, A. Zilberstein and M. Revel (1979). Differential Effects of Two
Interferon-Induced Translational Inhibitors on Initiation of Protein Synthesis. Eur. J. Biochem. 96, 35-41.
13. A. Kimchi, A. Zilberstein, A. Schmidt, L. Shulman and M. Revel (1979). The Interferon-Induced Protein Kinase
PK-i from Mouse-L Cells. J. Biol. Chem. 254, 9846-9853.
14. R. Kaempfer, R. Israeli, H. Rosen, S. Knoller, A. Zilberstein, A. Schmidt and M. Revel (1979). Reversal of the
Interferon-Induced Block of Protein Synthesis by Purified Preparations of Eucaryotic Initiation Factor 2. Virology
99, 170-173.
15. H.F. Lodish, A. Zilberstein, G.J.A.M. Strous and M. Porter (1980). Processing and Maturation of the Vesicular
Stomatitis Virus Glycoprotein. Eur. J. Cell Biol. 22, 789-790.
16. A. Zilberstein, M.D., Snider, M. Porter and H.F. Lodish (1980). Mutants of Vesicular Stomatitis Virus Blocked at
Different States in Maturation of the Viral Glycoprotein. Cell 21, 417-427.
17. Y. Mory, J. Ben-Barak, D. Segev, B. Cohen, D. Novick, D.G. Fischer, M. Rubinstein, S. Kargman, A. Zilberstein,
M. Vigneron and M. Revel (1986). Efficient Constitutive Production of Human IFN-γ in Chinese Hamster Ovary
Cells. DNA 5, 181-193.
18. P.B. Sehgal, A. Zilberstein, R. Ruggieri, L.T. May, A. Ferguson-Smith, D.L. Slate, M. Revel and F.H. Ruddle
(1986). Human Chromasome 7 Carries the Beta2 Interferon Gene. Proc. Natl. Acad. Sci. USA 83, 5219-5222.
19. A. Zilberstein, R. Ruggieri, J.H. Korn and M. Revel (1986). Structure and Expression of cDNA and Genes for
Human Interferon-Beta2. A Distinct Species Inducible by Growth-Stimulatory Cytokines. EMBO J. 5, 2529-2537.
20. M. Revel, A. Zilberstein, R. Ruggieri, M. Rubinstein and L. Chen (1987). Autocrine Interferons and Interferon
β-2. J. Interferon Res. 7, 529-536.
21. J.H. Korn, Y. Mory, A. Zilberstein, H. Holtmann, M. Revel and D. Wallach (1988). Cloning of Genomic DNA for
Tumor Necrosis Factor and Efficient Expression in CHO cells. Lymphokine Res. 7, 349-358.
22. L. Chen, Y. Mory, A. Zilberstein and M. Revel (1988). Growth Inhibition of Human Breast Carcinoma and
Leukemia/Lymphoma Cell Lines by Recombinant IFN-β2. Proc. Natl. Acad. Sci. USA 85, 8037-8041.
23. J. Sanceau, R. Falcoff, A. Zilberstein, F. Beranger, J. Lebeau, M. Revel and C. Vaquero (1988). Interferon-β2
(BSF-2) mRNA is Expressed in Human Monocytes. J. Interferon Res. 8, 473-481.
24. B. Margolis, S.-G. Rhee, S. Felder, M. Mervic, R.M. Lyall, A. Levitzki, Ullrich, A. Zilberstein and J. Schlessinger
(1989). EGF Induces Tyrosine Phosphorylation of Phospholipase C-II: A Potential Mechanism for EGF-
Receptor Signalling. Cell 57, 1101-1107.
2. PAGE 2 OF 6 ASHER ZILBERSTEIN, PHD
610-804-2343, azilberstein@yahoo.com
25. R.M. Lyall, A. Zilberstein, A. Gazit, C. Gilon, A. Levitzki and J. Schlessinger (1989). Tyrphostins Inhibit EGF-
Receptor Tyrosine Kinase Activity in Living Cells and EGF-Stimulated Cell Proliferation. J. Biol. Chem. 264,
14503-14509.
26. J.R. Downing, B.L. Margolis, A. Zilberstein, R.A. Ashmun, A. Ullrich, C.J. Sherr and J. Schlessinger (1989).
Phospholipase C-γ, A Substrate for PDGF Receptor Kinase, is not Phosphorylated on Tyrosine During the
Mitogenic Response to CSF-1. EMBO J. 8, 3345-3350.
27. R. Hazan, B. Margolis, M. Dombalagian, A. Ullrich, A. Zilberstein, and J. Schlessinger (1990). Identification of
Autophosphorylation Sites of HER2/neu. Cell Growth and Differentiation 1, 3-7.
28. B. Margolis, F. Bellot, A.M. Honegger, A. Ullrich, J. Schlessinger, and Zilberstein (1990). Tyrosine Kinase
Activity is Essential for the Association of Phospholipase-C-γ with the Epidermal Growth Factor Receptor. Mol.
Cell. Biol. 10, 435-441.
29. B. Margolis, A. Zilberstein, C. Franks, A. Ullrich, S. Felder, S. Kremer, K. Skorecki, S.-G. Rhee and J.
Schlessinger (1990). Effect of Phospholipase C-γ Overexpression on PDGF-Induced Second Messengers and
Mitogenesis. Science 248, 607-610.
30. W.H. Burgess, C.A. Dionne, J. Kaplow, R. Mudd, R. Friesel, A. Zilberstein, J. Schlessinger and M. Jaye (1990).
Characterization and cDNA Cloning of Phospholipase C-γ, a Major Substrate for HBGF-1 (acidic FGF)-Activated
Tyrosine Kinase. Mol. Cell. Biol. 10, 4770-4777.
31. B. Margolis, N. Li, A. Koch, M. Mohammadi, D.R. Hurwitz, A. Zilberstein, Ullrich, T. Pawson and J. Schlessinger
(1990). The Tyrosine Phosphorylated Carboxyterminus of the EGF-Receptor is a Binding Site for GAP and
PLC-γ. EMBO J. 9, 4375-4380.
32. C.-Y.J. Hsu, D.R. Hurwitz, M. Mervic and A. Zilberstein (1991). Autophosphorylation of the Intracellular Domain
of the EGF-Receptor Results in Different Effects on its Tyrosine Kinase Activity with Various Peptide Substrates.
J. Biol. Chem. 266, 603-608.
33. H. App, R. Hazan, A. Zilberstein, A. Ullrich, J. Schlessinger and U. Rapp (1991). EGF Stimulates Association
and Kinase Activity of Raf-1 with the EGF Receptor. Mol. Cell Biol. 11, 913-919.
34. G.E. Bilder, J.A. Krawiec, K. McVety, A. Gazit, C. Gilon, R. Lyall, Zilberstein, A. Levitzki, M.H. Perrone and A.B.
Schreiber (1991). Tyrphostins Inhibit PDGF-Induced DNA Synthesis and Associated Early Events in Smooth
Muscle Cells. Amer. J. Physiol. 260, 721-730.
35. H.K. Kim, J.W. Kim, A. Zilberstein, B. Margolis, J.G. Kim, J. Schlessinger and S.G. Rhee (1991). PDGF
Stimulation of Inositol Phospholipid Hydrolysis Requires PLC-γ1 Phosphorylation on Tyrosine Residues 783 and
1254. Cell 65, 435-441.
36. T. Yoneda, R.M. Lyall, M.M. Alsina, P.E. Persons, A.P. Spada, A. Levitzki, Zilberstein and G.R. Mundy (1991).
The Antiproliferative Effects of Tyrosine Kinase Inhibitors on a Human Squamous Cell Carcinoma In Vitro and in
Nude Mice. Cancer Res. 51, 4430-4435.
37. S.M. Thomas, M. Hayes, G. D’Arcangelo, R.C. Armstrong, B.E. Meyer, Zilberstein, J.S. Brugge and S.
Halegoua (1991). Induction of Neurite Outgrowth by v-src Mimics Critical Aspects of Nerve Growth Factor-
Induced Differentiation. Mol. Cell Biol. 11, 4739-4750.
38. C.-Y.J. Hsu, P.E. Persons, A.P. Spada, R..A. Bednar, A. Levitzki and Zilberstein (1991). Kinetic Analysis of the
Inhibition of the EGF Receptor Tyrosine Kinase by Lavendustin-A and its Analogue. J. Biol. Chem. 266,
21105-21112.
3. PAGE 3 OF 6 ASHER ZILBERSTEIN, PHD
610-804-2343, azilberstein@yahoo.com
39. K.-T. Yu, R. Lyall, N. Jariwala, A. Zilberstein and J. Haimovich (1991). Antigen and Ionophore-Induced Signal
Transduction in Rat Basophilic Leukemia Cells Involves Protein Tyrosine Phosphorylation. J. Biol. Chem. 266,
22564-22568.
40. D.C. Renard, M.M. Bolton, S.G. Rhee, B.L. Margolis, A. Zilberstein, J. Schlessinger and A.P. Thomas (1992).
Modified Kinetics of Platelet-Derived Growth Factor-Induced Ca2+ Increased in NIH 3T3 Cells Overexpressing
Phospholipase C-γ1. Biochem. J. 281, 775-784.
41. C.-Y.J. Hsu, M.V. Jacoski, M.P. Maguire, A.P. Spada and A. Zilberstein. 1992. Inhibition Kinetics and
Selectivity of the Tyrosine Kinase Inhibitor Erbstatin and a Pyridone-Based Analogue. Biochem. Pharmacol. 43,
2471-2477.
42. K.B. Reddy, G.L. Mangold, A.K. Tandon, T. Yoneda, G.R. Mundy, A Zilberstein and C.K. Osborne. 1992.
Inhibition of Breast Cancer Cell Growth In Vitro by a Tyrosine Kinase Inhibitor. Cancer Res. 52, 3636-3641.
43. M.P. Maguire, K.R. Sheets, K. McVety, A.P. Spada and A. Zilberstein. 1994. A New Series of PDGF Receptor
Tyrosine Kinase Inhibitors: 3-Substituted Quinoline Derivatives. J. Med. Chem. 37, 2129-2137.
44. K.-T. Yu, G. Nuss, R. Boyce, N. Jariwala, G. Owens, A. Pennetti, W. Chan, D.-C. Zhang, M.N. Chang and A.
Zilberstein. 1994. Inhibition of IL-1 Release from Human Monocytes and Suppression of Streptococcal Cell
Wall and Adjuvant-Induced Arthritis in Rats by an Extract of Tripterygium Wilfordii Hook. General Pharmacology
25, 1115-1122.
45. D.A. Vardy, C. Kari, G.S. Lazarus, P. Jensen, A. Zilberstein, G.D. Plowman and U. Rodeck. 1995. Induction of
an EGF Receptor Dependent Autocrine Loop in Human Keratinocytes by Insulin/IGF-1. J. Cell. Physiol. 163,
257-265.
46. W. Xian, K. Kiguchi, A. Imamoto, T. Rupp, A. Zilberstein and J. DiGiovanni. 1995. Activation of the Epidermal
Growth Factor Receptor by Skin Tumor Promoters and Skin Tumors from SENCAR Mice. Cell Growth and
Differentiation 6, 1447-1455.
47. M.R. Myers, N.N. Setzer, A.P. Spada, A.L. Zulli, J.-Y. Hsu, A. Zilberstein, S.E. Johnson, L.E. Hook and M.V.
Jacoski. 1997. The Preparation and SAR of 4-(Anilino), 4-(Phenoxy) and 4-(Thiophenoxy)-Quinazolines:
Inhibitors of p56lck and EGF-R Tyrosine Kinase Activity. Bioorganic and Med. Chem. Lett., 7, 417-420.
48. M.R. Myers, N.N. Setzer, A.P. Spada, P.E. Persons, C.Q. Ly, M.P. Maguire, A.L. Zulli, D.L. Cheney, A.
Zilberstein, S.E. Johnson, C.F. Franks and A.J. Mitchell. 1997. The Synthesis and SAR of New 4-(N-Alkyl-N-
Phenyl)Amino-6,7-Dimethoxyquinazolines and 4-(N-Alkyl-N-Phenyl)Amino-Pyrazolo[3,4-d]Pyrmidines, Inhibitors
of CSF-1R Tyrosine Kinase Activity. Bioorganic and Med. Chem. Lett., 7, 421-424.
49. J. Regan, D. McGarry, J. Bruno, D. Green, J. Newman, C.-Y. Hsu, J. Kline, J. Barton, J. Travis, Y.M. Choi, F.
Volz, H. Pauls, R. Harrison, A. Zilberstein, S.A. Ben-Sasson and M. Chang. 1997. Anionic- and Lipophilic-
Mediated Surface Binding Inhibitors of Human Leukocyte Elastase. J. Med. Chem. 40, 3408-3422.
50. F.-C. Huang, W.-K. Chan, K.J. Moriarty, D.-C. Zhang, M.N. Chang, W. He, K.-T. Yu and A. Zilberstein. 1998.
Novel Cytokine Release Inhibitors. Part I: Triterpenes. Bioorganic and Med. Chem. Lett., 8, 1883-1886.
51. W. He, F.-C. Huang, A. Gavai, W.-K. Chan, G. Amato, K.-T. Yu and Zilberstein. 1998. Novel Cytokine Release
Inhibitors. Part III: Truncated Analogs of Tripterine. Bioorganic and Med. Chem. Lett., 8, 3659-3664.
52. W. He, A. Gavai, F.-C. Huang, J. Regan, B. Hanney, G. Poli, J. Bruno, W.-K. Chan, S.W. Djuric, K.-T. Yu and A.
Zilberstein. 1999. Novel Cytokine Release Inhibitors. Part IV: Analogs of Podocarpic Acid. Bioorganic and
Med. Chem. Lett., 9, 469-474.
53. L. Hamel, M. Kenney, Z. Jayyosi, A. Ardati, K. Clark, A. Spada, A. Zilberstein, M. Perrone, J. Kaplow, L. Merkel
and C. Rojas. 2000. Induction of Heat Shock Protein 70 by Herbimycin A and Cyclopentenone Prostaglandins
in Smooth Muscle Cells. Cell Stress and Chaperons. 5, 121-131.
54. H. Zhu, S. McElwee-Witmer, M. Perrone, K. L. Clark and A. Zilberstein. 2000. Phenylephrine Protects
Neonatal Rat Cardiomyocytes from Hypoxia and Serum Deprivation-Induced Apoptosis. Cell Death and
Differentiation. 7, 773 – 784.
55. C. C. W. Arendt, G. Tang and A. Zilberstein. 2003. Vector Systems for the Delivery of small interfering RNAs:
Managing the RISC. ChemBioChem.,4, 1129 – 1136.
56. F. Long, H. Liu, C. Hahn, P. Sumazin, M.Q. Zhang and A. Zilberstein. 2004. Genome-Wide Prediction and
Analysis of Function-specific Transcription Factor Binding Sites, In Silico Biology, 4, 33.
57. H. Liu, L. Li, A. Zilberstein and C. Hahn. 2004.
Segmental Duplication Containing Tandem Repeated Genes Encoding Putative Deubiqitinating Enzymes.
4. PAGE 4 OF 6 ASHER ZILBERSTEIN, PHD
610-804-2343, azilberstein@yahoo.com
IEEE Computational Systems Bioinformatics Proceedings, pg. 31-39.
58. H. Liu, N. Ge, K. Yu, D. Krolikowski, A. Zilberstein and C. S. Hahn. 2004. Prediction of IFN-γ Regulated Gene
Transcription. In silico Biology 4: 0041.
59. W. Cao, C. Epstein, H. Liu, C. DeLoughery, N. Ge, J. Lin, R. Diao, H. Cao, F. Long, X. Zhang, Y. Chen, P.S.
Wright, S. Busch, M. Wenk, K. Wong, A.G. Saltzman, Z. Tang, L. Liu and A. Zilberstein. 2004. Comparing Gene
Discovery from Affymetrix GeneChip Microarrays and Clontech PCR-Select cDNA Subtraction: a Case Study.
BioMed Central Genomics, 5, 26.
60. W. Cao, Y. Chen, S. Alkan, A. Subramaniam, F. Long, H. Liu, R. Diao, T. Delohery, J. McCormick, R. Chen,
D. Ni, P. S. Wright, X. Zhang, S. Busch and Zilberstein. Human T Helper (Th) Cell Lineage Commitment is not
Directly Linked to the Secretion of IFN-γ or IL-4 : Characterization of The Cells Isolated by FACS based on IFN-γ
and IL-4 Secretion. 2005. Eur. J. Immunol. 35, 2709-2717.
5. PAGE 5 OF 6 ASHER ZILBERSTEIN, PHD
610-804-2343, azilberstein@yahoo.com
BOOK CHAPTERS
1. M. Revel, J. Content, A. Zilberstein, H. Berissi, B. Lebleu, E. Falcoff and R. Falcoff (1975). Mechanism of the
Interferon-Induced Block of mRNA Translation in Mouse L-cells. In: Effects of Interferon on Cells, Viruses and
the Immune System, pp. 523-547 (A. Geraldes, ed.) Academic Press, NY.
2. M. Revel, J. Content, A. Zilberstein, B. Lebleu, E. Falcoff and R. Falcoff (1975). Mechanism of Interferon-
Induced Blocks of mRNA Translation. In: Perspectives in Virology, Vol. IX, pp. 233-248, Academic Press, NY.
3. M. Revel, J. Content, A. Zilberstein, U. Nudel, H. Berissi and B. Dudock (1975). Control of mRNA Translation
by Specific tRNAs in Extracts from Interferon-Treated Mouse Cells. In: In Vitro Transcription and Translation of
Viral Genomes. INSERM 47, 397-406.
4. M. Revel, E. Gilboa, A. Kimchi, A. Schmidt, L. Shulman, E. Yakobson and A. Zilberstein (1977). Proceedings of
the 11th FEBS Meeting, Copenhagen, Vol. 43, pp. 47-58, Pergamon Press, Oxford.
5. M. Revel, A. Schmidt, L. Shulman, A. Zilberstein and A. Kimchi (1978). The Regulation of Protein Synthesis by
Interferon. Proceedings of the 12th FEBS Meeting. Dresden, Vol. 51, pp. 415-426, Pergamon Press, Oxford.
6. M. Revel, A. Kimchi, A. Schmidt, L. Shulman and A. Zilberstein (1979). The Interferon System: Studies on the
Molecular Mechanism of Interferon Action. In: The Molecular Biology of Picornaviruses, pp. 239-253 (R. Perez-
Bercoff, ed.), Plenum Publishing Co.
7. H.F. Lodish, A. Zilberstein, G.J.A.M. Strous, M. Porter and M. Boucher (1980). Synthesis and Maturation of the
Vesicular Stomatitis Virus Glycoprotein. In: Biosynthesis, Modification and Processing of Cellular and Viral
Polyproteins, pp. 111-125 (G. Koch and D. Richter, eds.), Academic Press, NY.
8. H.F. Lodish, A. Zilberstein and M. Porter (1981). Synthesis and Assembly of Vesicular Stomatitis Virus and
Sindbis Virus Glycoproteins. In: Perspectives in Virology, Vol. XI, pp. 31-55 (M. Pollard, ed.), Alan R. Liss, Inc.
NY.
9. H.F. Lodish, W.A. Braell, A.L. Schwartz, G.J.A.M. Strous and A. Zilberstein (1981). Synthesis and Assembly of
Membrane and Organelle Proteins. In: Membrane Research, Classic Origins and Current Concepts. (Dedicated
to J.F. Danielli) International Reviews of Cytology, Supplement 12, pp. 247-307
(A.L. Muggleton-Harris, ed).
10. H.F. Lodish, A. Zilberstein and M. Porter (1981). Synthesis and Assembly of Transmembrane Viral and Cellular
Glycoproteins. In: Methods in Cell Biology, Vol. 23. Basic Mechanisms of Cellular Secretion, pp. 5-25.
Academic Press, NY.
11. A. Zilberstein and H.F. Lodish (1981). Synthesis and Assembly of the Vesicular Stomatitis Virus Glycoprotein
and Related Glycoproteins. In: Membranes and Transport: Vol. 1, pp. 219-236 (A. Martonosi, ed.). Plenum
Press, NY.
12. A. Zilberstein, M.D. Snider and H.F. Lodish (1982). Synthesis and Assembly of the Vesicular Stomatitis Virus
Glycoprotein. Cold Spring Harbor Symposia on Quant. Biol., Vol. 46, pp. 785-795.
13. Y. Mory, S.I. Feinstein, Y. Chernajovsky, U. Nir, A. Zilberstein and M. Revel (1981). Studies on New IFN-β
Genes in Human Cells. Proceedings of the 2nd Annual International Congress for Interferon Research.
14. A. Zilberstein, R. Ruggieri and M. Revel (1985). Human Interferon-β2: Is it an Interferon Inducer? In: the
Interferon System, Serono Symposia, Vol. 24, pp. 73-83. (G.B. Rossi and E. Dianzani, eds.) Raven Press, New
York.
15. M. Revel, R. Ruggieri and A. Zilberstein (1986). Expression of Human IFN-β2 Genes in Rodent Cells. In: The
Biology of the Interferon System 1985, pp. 207-216. (H. Schellekens and W.E. Stewart II, eds.) Elsevier Press,
Amsterdam.
16. A. Zilberstein, A. Nissim, R. Ruggieri, L. Shulman, L. Chen and M. Revel (1986). The Mode of Action of Human
Interferon-β2. In: The Biology of the Interferon System 1985, pp. 119-124. (H. Schellekens and W.E. Stewart II,
eds.) Elsevier Press, Amsterdam.
17. A. Zilberstein, R. Ruggieri, J.H. Korn, L. Chen, Y. Mory, J. Chebath, L. Shulman and M. Revel (1987).
Biological Activities of Human Interferon-β2 Produced by cDNA Expression in Hamster Cells and Possible
Autocrine Functions of this Cytokine-Induced IFN. In: The Biology of the Interferon System 1986, pp. 165-171 (K.
Cantel and H. Schellekens, eds.).
18. J. Sanceau, R. Falcoff, A. Zilberstein, F. Beranger and C. Vaquero (1987). Interferon Beta-2 is Constitutively
Expressed in Human Monocytes. In: The Biology of the Interferon System 1986, pp. 153-158 (K. Cantell and
H. Schellekens, eds.).
6. PAGE 6 OF 6 ASHER ZILBERSTEIN, PHD
610-804-2343, azilberstein@yahoo.com
19. M. Revel, A. Zilberstein, R. Ruggieri, L. Chen, Y. Mory, M. Rubinstein and R. Michalevicz 1988a). Human IFN-
beta-2: a Cytokine with Multiple Functions in Infections and Inflammation. In: Monokines and Other Non-
Lymphocytic Cytokines, Progress in Leukocyte Biology. Vol. 8, pp. 21-27 (M.C. Powanda et al. eds.). A.R. Liss.
NY.
20. M. Revel, A. Zilberstein, R. Ruggieri, L. Chen, Y. Mory, M. Rubinstein and R. Michalevicz (1988b). Human IFN-
Beta-2: A Multifunctional Cytokine. In: Tumor Necrosis Factor, Cachetin and Related Cytokines, pp. 252-258
(H. Kirchner, B. Bonavida and L. Old, eds.). S. Karger, Basel.
21. M. Revel, L. Chen, Y. Mory, A. Zilberstein and R. Michalevicz (1989). Interferon-Type and Other Activities of
IFN-β-2/BSF-2/HSF. In: Advances in Immunopharmacology. Vol. 4, pp. 175-183. (J.W. Hadden et al. eds.)
Pergamon Press.
22. M. Revel, A. Zilberstein, L. hen, Y. Gothelf, I. Barash, D. Novick, M. Rubinstein and R. Michalevicz (1989).
Biological Activities of Recombinant Human IFN-β-2/IL-6 (E. coli). In: Regulation of the Acute Phase and
Immune Responses: Interleukin-6. Annals of the New York Academy of Sciences, Vol. 557, pp. 144-156 (P.B.
Sehgal, G. Grieninger and G. Tosato eds.).
GRANTED PATENTS (SELECTED)
1. Tyrosine Kinase Inhibitor Composition for Treating Bone Disease and Inflammation - Contains Compounds
Having Bis Ring System Comprising Aryl Ring and Aryl-, Carbocyclic- or Heterocyclic- Ring.
2. Chin-Yi Jenny Hsu, Susan Johnson, Martin Maguire, Michael R. Myers, Paul E. Persons, Alfred Spada and
Asher Zilberstein. U.S. Patent No. 5,480,883; Issued Apr. 19, 1994.
3. Aryl and Heteroaryl Quinazoline Compounds which Inhibit CSF-1 Receptor Tyrosine Kinase.
Michael R. Myers, Alfred P. Spada, Martin Maguire, Paul E. Persons, Asher Zilberstein, Chin-Yi Jenny Hsu and
Susan E. Johnson. U.S. Patent No. 5,714,493; Issued Feb. 3, 1998.
4. New Composition Containing Human Interferon - beta 2A for Treating Inflammation and Acute Phase Response.
Michel Revel and Asher Zilberstein. European Patent No. 536520; Issued Apr. 14, 1993.
5. Highly Purified Human Interferon Preparation - by Genetic Engineering of Bacterial Strain with Cloned Interferon
DNA. Michel Revel, P. Tiollais and Asher Zilberstein. U.S. Patent No. 5,468,607; Issued Jan. 21, 1995.
6. A DNA Sequence Encoding Active Interferon - beta 2A - Used in the Production of the Protein for the Treatment
of Cancer, by Inhibition of Fibroblast Proliferation. Michel Revel and Asher Zilberstein. European Patent No.
645452; Issued March 29, 1995.
7. Recombinant Human Interferon - beta 2A and beta 2B - Useful for Inflammation, Acute Phase Response or
Regulation of Cell Proliferation. Michel Revel, Asher Zilberstein and P. Tiollais. U.S. Patent No. 5,510,472;
Issued Apr. 23, 1