This document provides a list of 57 articles and reviews published by François Meurens and colleagues. The articles are ranked based on their H index (Scopus) and journal impact factor. The articles cover a range of topics related to immunology, microbiology, and infectious diseases, with a focus on using the pig as a model for human diseases. Many of the articles examine innate and adaptive immune responses in pigs to pathogens like influenza virus, Salmonella, and E. histolytica.
This document provides biographical and professional information about Xingdong Yang. It includes his education, research experiences, publications, technical skills, patents, and grant writing experience. The key points are:
- Xingdong Yang received his Ph.D. in Virology and Immunology from Virginia-Maryland College of Veterinary Medicine. He is currently a postdoctoral research fellow at Cleveland Clinic.
- His research focuses on developing adoptive immunotherapy for cancer using IL9-producing NK cells and stem cell-like NK cells.
- He has over 15 peer-reviewed publications related to his work studying viral pathogenesis and immune responses using neonatal gnotobiotic pig models.
- He has experience in vi
This document lists Petra Roubos' publications, including 10 full papers published in peer-reviewed journals on topics related to microbiology and intestinal health. It also lists 7 conference papers presented between 2013-2015 related to microbiota, intestinal barrier function, and diarrhea in pigs. The list covers publications in book chapters and as lead author and co-author.
Teshome Yehualaeshet has expertise in microbiology, molecular biology, food safety, and cell biology. He is an Associate Professor at Tuskegee University who conducts research on antibiotic resistance, detection of foodborne and infectious pathogens, and use of plant extracts to modify antibiotic resistance. He has over 20 peer-reviewed publications and has mentored many students in microbiology research.
1) The document discusses how immune disorders like type 1 diabetes, asthma, and multiple sclerosis have increased in developed countries due to decreased exposure to microorganisms like helminth worms.
2) It explores the coevolutionary history between helminths and vertebrates, noting that helminths elicit a Th2 immune response that evolved to regulate the immune system but may now contribute to immune disorders.
3) Several studies are cited showing that exposure to helminths or their antigens can reduce symptoms of asthma, type 1 diabetes, multiple sclerosis, and intestinal inflammation by inducing regulatory cytokines and cells. This supports the possibility of using helminths or their molecules to treat immune disorders.
Mueller U.G., Ishak H., Lee J.C., Sen R., and Gutell R.R. (2010).
Placement of attine ant-associated Pseudonocardia in a global phylogeny (Pseudonocardiaceae, Actinomycetales): a test of two symbiont-association models.
Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 98(2):195-212.
This curriculum vitae summarizes Giovanni Salvatori's work experience and qualifications. He has over 20 years of experience leading research and development projects in immunology and biotechnology at Sigma-Tau SpA. His roles have included managing R&D from basic research through clinical trials, supervising staff, and coordinating process development activities. He holds a degree in Biological Sciences and a PhD in Cytology and Morphogenetic Science. He is fluent in English and has expertise evaluating applications for the European Commission Framework Programs.
Methicillin Resistant Staphylococcus aureus (MRSA) is a bacterium that is resistant to many antibiotics and causes difficult-to-treat infections. MRSA was first identified in the 1960s after methicillin was introduced. It has since spread worldwide and is a major public health concern. MRSA infections present with symptoms like skin abscesses or boils and can become life-threatening. Diagnosis involves culturing samples from infected sites and testing bacterial growth with antibiotics. Treatment options are limited since MRSA is resistant to many drugs.
This document lists publications by J. Bernardy including books, journal publications, speeches at international conferences, conference abstracts and posters. It provides a comprehensive list of over 50 publications spanning 2011-2005 on topics related to pig health, vaccination, immune response and the use of probiotics and yeast. The publications appear in scientific journals, books and the proceedings of numerous international pig health and veterinary conferences.
This document provides biographical and professional information about Xingdong Yang. It includes his education, research experiences, publications, technical skills, patents, and grant writing experience. The key points are:
- Xingdong Yang received his Ph.D. in Virology and Immunology from Virginia-Maryland College of Veterinary Medicine. He is currently a postdoctoral research fellow at Cleveland Clinic.
- His research focuses on developing adoptive immunotherapy for cancer using IL9-producing NK cells and stem cell-like NK cells.
- He has over 15 peer-reviewed publications related to his work studying viral pathogenesis and immune responses using neonatal gnotobiotic pig models.
- He has experience in vi
This document lists Petra Roubos' publications, including 10 full papers published in peer-reviewed journals on topics related to microbiology and intestinal health. It also lists 7 conference papers presented between 2013-2015 related to microbiota, intestinal barrier function, and diarrhea in pigs. The list covers publications in book chapters and as lead author and co-author.
Teshome Yehualaeshet has expertise in microbiology, molecular biology, food safety, and cell biology. He is an Associate Professor at Tuskegee University who conducts research on antibiotic resistance, detection of foodborne and infectious pathogens, and use of plant extracts to modify antibiotic resistance. He has over 20 peer-reviewed publications and has mentored many students in microbiology research.
1) The document discusses how immune disorders like type 1 diabetes, asthma, and multiple sclerosis have increased in developed countries due to decreased exposure to microorganisms like helminth worms.
2) It explores the coevolutionary history between helminths and vertebrates, noting that helminths elicit a Th2 immune response that evolved to regulate the immune system but may now contribute to immune disorders.
3) Several studies are cited showing that exposure to helminths or their antigens can reduce symptoms of asthma, type 1 diabetes, multiple sclerosis, and intestinal inflammation by inducing regulatory cytokines and cells. This supports the possibility of using helminths or their molecules to treat immune disorders.
Mueller U.G., Ishak H., Lee J.C., Sen R., and Gutell R.R. (2010).
Placement of attine ant-associated Pseudonocardia in a global phylogeny (Pseudonocardiaceae, Actinomycetales): a test of two symbiont-association models.
Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, 98(2):195-212.
This curriculum vitae summarizes Giovanni Salvatori's work experience and qualifications. He has over 20 years of experience leading research and development projects in immunology and biotechnology at Sigma-Tau SpA. His roles have included managing R&D from basic research through clinical trials, supervising staff, and coordinating process development activities. He holds a degree in Biological Sciences and a PhD in Cytology and Morphogenetic Science. He is fluent in English and has expertise evaluating applications for the European Commission Framework Programs.
Methicillin Resistant Staphylococcus aureus (MRSA) is a bacterium that is resistant to many antibiotics and causes difficult-to-treat infections. MRSA was first identified in the 1960s after methicillin was introduced. It has since spread worldwide and is a major public health concern. MRSA infections present with symptoms like skin abscesses or boils and can become life-threatening. Diagnosis involves culturing samples from infected sites and testing bacterial growth with antibiotics. Treatment options are limited since MRSA is resistant to many drugs.
This document lists publications by J. Bernardy including books, journal publications, speeches at international conferences, conference abstracts and posters. It provides a comprehensive list of over 50 publications spanning 2011-2005 on topics related to pig health, vaccination, immune response and the use of probiotics and yeast. The publications appear in scientific journals, books and the proceedings of numerous international pig health and veterinary conferences.
This document provides a bibliography of references related to Myriapoda (millipedes, centipedes, and others) of the world. The bibliography contains 103 references published between 1978 and 2002 on topics such as the taxonomy, biology, ecology, and behavior of various myriapod species around the world. Many of the references are studies conducted on myriapod populations found in locations like Brazil, India, Belgium, and other places. The references cover a range of research including karyological and meiotic studies, analyses of diets, habitat use, and phenology of different myriapod groups.
Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus fo...Trevor Kane
Staphylococcus aureus is a major bacterial pathogen capable of causing a range of infections from mild to life-threatening. The review discusses several major virulence factors produced by S. aureus including the agr quorum sensing system, α-toxin, phenol soluble modulins, protein A, Panton-Valentine leukocidin, and staphylococcal enterotoxins. Recent research into antivirulence approaches that target these factors are highlighted as a potential alternative to antibiotics for treating S. aureus infections.
estrategies infection, c. albicans and c. glabrataIPN
This document compares the infection strategies of two common pathogenic yeasts - Candida albicans and C. glabrata. While their strategies share some concepts, they differ significantly. C. albicans uses aggressive hyphal growth and host cell damage to obtain nutrients, triggering a strong inflammatory response. In contrast, C. glabrata relies on stealth, evasion and persistence without severe damage, interacting with macrophages inside non-acidified phagosomes. Both fungi are successful commensals and pathogens through independent evolutionary paths.
This document lists 27 publications by R. Meyer and various co-authors related to the detection of pathogens, genetically modified organisms, and food authenticity using polymerase chain reaction (PCR) techniques. The publications span from 1991 to 2014 and were published in international journals focused on food microbiology, chemistry, and hygiene. Many of the publications describe the development and validation of PCR-based methods for detecting specific bacteria, viruses, or genetically modified crops in foods.
Scientific publications list Armin ElbersArmin Elbers
This document provides a publication list of 41 papers authored by Armin R.W. Elbers. The publications span from 1989 to 1997 and cover topics related to pig and veterinary health including studies on pig nutrition, disease prevalence, blood profiles, and occupational health risks for veterinarians. Many of the publications involve epidemiological studies and were published in journals focused on veterinary medicine and livestock production.
This document discusses the relationships between human nutrition, the gut microbiome, and the immune system. It argues that understanding how diet influences the gut microbiome and immune system could help address global health problems like malnutrition. The marriage of metagenomic methods to study the gut microbiome and gnotobiotic methods using germ-free animals could provide insights into these relationships and help test hypotheses. Dietary patterns are changing worldwide due to various social and economic factors, and understanding how these changes impact the gut microbiome may provide clues about nutritional status and immune function.
This document discusses HIV-exposed seronegative individuals (HESNs) who remain uninfected despite repeated exposure to HIV-1. It explores both genetic and immunological factors that may contribute to their resistance. Genetically, variants of the CCR5 gene that prevent HIV from binding to immune cells, like CCR5-Δ32 in Caucasians and a G316A substitution in Southeast Asians, are common in HESNs. Immunologically, HESNs exhibit elevated expression of interferon-α which inhibits HIV replication, and their adaptive immune response is characterized by regulatory T cells and low inflammation, limiting HIV target cells. Studying these natural protection mechanisms could help develop new prevention strategies.
A pilot study on effects of vaccination on immunity of broiler chickensAlexander Decker
This document summarizes a pilot study that examined the effects of vaccination on the immunity of broiler chickens challenged with Newcastle disease virus (NDV). Twenty broiler chickens were divided into five groups, with four groups receiving different locally produced NDV vaccines and one unvaccinated control group. When challenged with NDV at five weeks old, the vaccinated groups showed no clinical signs of infection while the unvaccinated group had 100% mortality within 48 hours. This indicates that vaccination is important for preventing and controlling poultry diseases, as maternal immunity alone in young chicks is not sufficient to fight infections. Locally produced vaccines should be encouraged for small farmers to manage viral outbreaks.
The study investigated the transmission of Salmonella enterica, Cronobacter sakazakii, Escherichia coli O157:H7, and Listeria monocytogenes from adult house flies to their eggs and first filial (F1) generation adults. The researchers fed adult house flies food contaminated with low, medium, and high levels of each pathogen. They found that all pathogens were present in samples of pooled house fly eggs. Transmission was highest when adults consumed medium bacterial loads. Cronobacter sakazakii was most likely to be transmitted to eggs. S. enterica and C. sakazakii were transmitted to F1 adults and more likely to be found on their surfaces than in their guts
PTG-E Congress 2008 Microbe Hunters GI Lecturemarlicz
The document discusses the human gut microbiome and its relationship to health and disease. It references studies showing that the gut microbiome can influence obesity, metabolic disorders, and inflammatory diseases. Probiotics, prebiotics, and genetically engineered bacteria are mentioned as potential therapies for manipulating the gut microbiome to treat various conditions like inflammatory bowel disease.
Depopulation options as welfare indicator for layer systemsHarm Kiezebrink
Egg production systems have become subject to heightened levels of scrutiny. Multiple factors such as disease, skeletal and foot health, pest and parasite load, behavior, stress, affective states, nutrition, and genetics influence the level of welfare hens experience. Although the need to evaluate the influence of these factors on welfare is recognized, research is still in the early stages.
In this paper conventional cages are compared to furnished cages, non-cage systems, and outdoor systems. Specific attributes of each system are shown to affect welfare, and systems that have similar attributes are affected similarly.
Environments such as conventional cages, which limit movement, can lead to osteoporosis, but environments that have increased complexity, such as non-cage systems, expose hens to an increased incidence of bone fractures.
Less is understood about the stress that each system imposes on the hen, but it appears that each system has its unique challenges. Selective breeding for desired traits such as improved bone strength and decreased feather pecking and cannibalism may help to improve welfare.
It appears that no single housing system is ideal from a hen welfare perspective. Although environmental complexity increases behavioral opportunities, it also introduces difficulties in terms of disease and pest control.
One specific circumstance has not been taken into consideration in this paper: how to depopulate the hens in case of an outbreak situation. Emergency control is not an economic parameter to choose a specific production system, but comparing a production system with or without cages, it is clear that it is much easier to depopulate chickens in a system without cages. Without a proper technique to cull the animals in a animal welfare friendly way and to transport the carcasses out of the house mechanically, the chickens are killed and transported manually.
This is not only increasing the risks for humans to get infected, it also influences the risks that animals suffer unnecessary during depopulation. Handling animals during outbreak situations is mostly done by inexperienced responders who have little to no knowledge about animal welfare. Veterinary authorities in charge of the response activities have issues like effectiveness and efficiency to consider.
How to depopulate the chickens in an outbreak situation is an important welfare indicator and the producer of these systems need to be kept responsible for the technical solution.
Harm Kiezebrink
Research Fellow Queensland University /
CEO AVT Europe AB
AVT Applied Veterinary Technologies Europe AB
Address details: c/o INTRED, Södra Hamnen 2,
45142 Uddevalla, Sweden
Phone: +44 7452 272 358
E-mail: harm.kie@gmail.com
Preparedness, Prediction and Prevention of Emerging Zoonotic Viruses with Pan...Global Risk Forum GRFDavos
Presentation at 3rd GRF One Health Summit 2015
The One Health Approach for Communicable Diseases
Sylvie VAN DER WERF, Institut Pasteur, France, on behalf of the PREDEMICS consortium
This document summarizes a study on the effect of Clostridium difficile experimental infection on the health of weaned rabbits. Thirty rabbits were divided into three groups, with two groups infected with C. difficile either subcutaneously or orally. The orally infected group showed signs of diarrhea and bloat, while no signs were seen in the subcutaneous group. No mortalities occurred. At the end of the study, the orally infected rabbits showed liver and kidney enlargement and congestion as well as mild enteritis. The C. difficile was re-isolated from infected rabbits. The study found that C. difficile can negatively impact the health of weaned rabbits.
This study investigated antibiotic resistance in urinary tract E. coli isolates from hospitalized patients in India. Urine samples were collected from 73 patients with urinary tract infections and E. coli was isolated from 35 samples (48%). The E. coli isolates showed high resistance to novobiocin, vancomycin, and co-trimaxazole. 80% of isolates were biofilm producers, with over 50% producing strong biofilms. 51% of isolates were beta-lactamase producers. The results indicate that biofilm-producing E. coli strains with beta-lactamase activity exhibited the highest antibiotic resistance.
Mold and cystic fibrosis : what can we learn from studying fungal microbiota ?Laurence Delhaes
This document discusses studying the fungal microbiota (mycobiota) in the lungs of cystic fibrosis (CF) patients. It begins by providing background on human microbial diversity and the emerging importance of studying the lung mycobiota. The authors aim to characterize the lung mycobiota in CF patients using deep sequencing techniques and analyze how the mycobiota relates to clinical status and bacterial composition. Preliminary results on 36 sputum samples from CF patients with and without pulmonary exacerbation show no association between common fungi like Aspergillus fumigatus and exacerbation. Principal component analysis of bacterial and fungal genera indicates some correlations and lack of correlation between certain microorganisms. Further statistical analysis is ongoing.
What can we learn from studying fungal microbiotaLaurence Delhaes
The document discusses analyzing the fungal microbiota (mycobiota) in the lungs of cystic fibrosis (CF) patients. It summarizes a study that used high-throughput sequencing to analyze sputum samples from CF patients. The study found greater fungal diversity than previous culture-based methods, identifying 24 fungal genera including Aspergillus. Preliminary results showed associations between decreased fungal diversity and poorer clinical outcomes in CF patients. Larger studies are still needed to better understand the role of the lung mycobiota in CF exacerbations and how it interacts with bacterial communities and clinical status.
This document discusses antimicrobial resistance mechanisms in Staphylococcus aureus, specifically methicillin-resistant S. aureus (MRSA). MRSA infections are now responsible for more deaths per year in the US than HIV and add billions to healthcare costs worldwide. MRSA strains have developed diverse genetic elements that confer resistance to multiple antimicrobials like methicillin, aminoglycosides, erythromycin, and tetracycline. Certain MRSA strains are also resistant to additional drugs including fluoroquinolones. Effective antimicrobial therapy is threatened as S. aureus continues developing resistance.
Increase your Understanding of the Pathogenesis of Gluten Spectrum DisordersCell Science Systems
Recently, researchers at Harvard University, Alessio Fasano et. al., and the National Institutes of Health (laboratories of immunology and cellular and molecular biology), reported real-time microscopic observations of gluten-induced neutrophil activation.
According to authors, " To what extent neutrophil function adds to, or protects against, gluten intolerance is currently under vigorous investigation."
This presentation will shed light on this question. It will also review the Fasano study and examine the role of neutrophil function in multiple disease conditions, as well as explore how neutrophil function may also play a dual role in protecting the body from the untoward effects of dietary and environmental agents.
This document reviews the role of the protozoan Toxoplasma gondii in manipulating host behavior. T. gondii can infect many warm-blooded animals and is able to alter host behavior in ways that may benefit transmission to feline hosts. The document introduces the concept of a "T. gondii-rat manipulation-schizophrenia model" to study how rodent behavior changes during infection could provide insights into behavioral changes in humans, including potential links to schizophrenia. It discusses evidence that T. gondii infection is associated with increased dopamine levels and altered dopamine signaling in both rodents and humans, which could underlie behavioral changes. Future research on the model is proposed to advance understanding of parasitic
Dr. Peter Davies - Emerging Issues in Antibiotic Resistance Linked to Use in ...John Blue
Emerging Issues in Antibiotic Resistance Linked to Use in Food Animals - Dr. Peter Davies, College of Veterinary Medicine, University of Minnesota, from the 2017 Allen D. Leman Swine Conference, September 16-19, 2017, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2017-leman-swine-conference-material
This document discusses ascariasis, a common helminth infection caused by the roundworm Ascaris lumbricoides. It infects over 25% of the world's population, predominantly children. Symptoms can include growth retardation, pneumonia, and intestinal obstruction. The life cycle and immunosuppressive effects of ascariasis are described, including its role in modulating the immune system and suppressing inflammatory responses through molecules like PAS-1. The hygiene hypothesis, which proposes that lack of early childhood exposure to pathogens like helminths may increase risk for allergic diseases, is also discussed.
Prof. Dr. Paolo Falagiani (1947 – 2011) was an Italian professor who published extensively on sublingual immunotherapy and allergen-specific immunotherapy. He authored or co-authored over 50 papers investigating the efficacy, safety, and immunological effects of sublingual and oral immunotherapy for allergies to various substances like pollens, mites, foods, and metals. Many of his studies were randomized controlled trials or retrospective analyses that demonstrated the clinical benefits and tolerability of immunotherapy approaches. He significantly contributed to the research and development of immunotherapy as an allergy treatment.
This document provides a bibliography of references related to Myriapoda (millipedes, centipedes, and others) of the world. The bibliography contains 103 references published between 1978 and 2002 on topics such as the taxonomy, biology, ecology, and behavior of various myriapod species around the world. Many of the references are studies conducted on myriapod populations found in locations like Brazil, India, Belgium, and other places. The references cover a range of research including karyological and meiotic studies, analyses of diets, habitat use, and phenology of different myriapod groups.
Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus fo...Trevor Kane
Staphylococcus aureus is a major bacterial pathogen capable of causing a range of infections from mild to life-threatening. The review discusses several major virulence factors produced by S. aureus including the agr quorum sensing system, α-toxin, phenol soluble modulins, protein A, Panton-Valentine leukocidin, and staphylococcal enterotoxins. Recent research into antivirulence approaches that target these factors are highlighted as a potential alternative to antibiotics for treating S. aureus infections.
estrategies infection, c. albicans and c. glabrataIPN
This document compares the infection strategies of two common pathogenic yeasts - Candida albicans and C. glabrata. While their strategies share some concepts, they differ significantly. C. albicans uses aggressive hyphal growth and host cell damage to obtain nutrients, triggering a strong inflammatory response. In contrast, C. glabrata relies on stealth, evasion and persistence without severe damage, interacting with macrophages inside non-acidified phagosomes. Both fungi are successful commensals and pathogens through independent evolutionary paths.
This document lists 27 publications by R. Meyer and various co-authors related to the detection of pathogens, genetically modified organisms, and food authenticity using polymerase chain reaction (PCR) techniques. The publications span from 1991 to 2014 and were published in international journals focused on food microbiology, chemistry, and hygiene. Many of the publications describe the development and validation of PCR-based methods for detecting specific bacteria, viruses, or genetically modified crops in foods.
Scientific publications list Armin ElbersArmin Elbers
This document provides a publication list of 41 papers authored by Armin R.W. Elbers. The publications span from 1989 to 1997 and cover topics related to pig and veterinary health including studies on pig nutrition, disease prevalence, blood profiles, and occupational health risks for veterinarians. Many of the publications involve epidemiological studies and were published in journals focused on veterinary medicine and livestock production.
This document discusses the relationships between human nutrition, the gut microbiome, and the immune system. It argues that understanding how diet influences the gut microbiome and immune system could help address global health problems like malnutrition. The marriage of metagenomic methods to study the gut microbiome and gnotobiotic methods using germ-free animals could provide insights into these relationships and help test hypotheses. Dietary patterns are changing worldwide due to various social and economic factors, and understanding how these changes impact the gut microbiome may provide clues about nutritional status and immune function.
This document discusses HIV-exposed seronegative individuals (HESNs) who remain uninfected despite repeated exposure to HIV-1. It explores both genetic and immunological factors that may contribute to their resistance. Genetically, variants of the CCR5 gene that prevent HIV from binding to immune cells, like CCR5-Δ32 in Caucasians and a G316A substitution in Southeast Asians, are common in HESNs. Immunologically, HESNs exhibit elevated expression of interferon-α which inhibits HIV replication, and their adaptive immune response is characterized by regulatory T cells and low inflammation, limiting HIV target cells. Studying these natural protection mechanisms could help develop new prevention strategies.
A pilot study on effects of vaccination on immunity of broiler chickensAlexander Decker
This document summarizes a pilot study that examined the effects of vaccination on the immunity of broiler chickens challenged with Newcastle disease virus (NDV). Twenty broiler chickens were divided into five groups, with four groups receiving different locally produced NDV vaccines and one unvaccinated control group. When challenged with NDV at five weeks old, the vaccinated groups showed no clinical signs of infection while the unvaccinated group had 100% mortality within 48 hours. This indicates that vaccination is important for preventing and controlling poultry diseases, as maternal immunity alone in young chicks is not sufficient to fight infections. Locally produced vaccines should be encouraged for small farmers to manage viral outbreaks.
The study investigated the transmission of Salmonella enterica, Cronobacter sakazakii, Escherichia coli O157:H7, and Listeria monocytogenes from adult house flies to their eggs and first filial (F1) generation adults. The researchers fed adult house flies food contaminated with low, medium, and high levels of each pathogen. They found that all pathogens were present in samples of pooled house fly eggs. Transmission was highest when adults consumed medium bacterial loads. Cronobacter sakazakii was most likely to be transmitted to eggs. S. enterica and C. sakazakii were transmitted to F1 adults and more likely to be found on their surfaces than in their guts
PTG-E Congress 2008 Microbe Hunters GI Lecturemarlicz
The document discusses the human gut microbiome and its relationship to health and disease. It references studies showing that the gut microbiome can influence obesity, metabolic disorders, and inflammatory diseases. Probiotics, prebiotics, and genetically engineered bacteria are mentioned as potential therapies for manipulating the gut microbiome to treat various conditions like inflammatory bowel disease.
Depopulation options as welfare indicator for layer systemsHarm Kiezebrink
Egg production systems have become subject to heightened levels of scrutiny. Multiple factors such as disease, skeletal and foot health, pest and parasite load, behavior, stress, affective states, nutrition, and genetics influence the level of welfare hens experience. Although the need to evaluate the influence of these factors on welfare is recognized, research is still in the early stages.
In this paper conventional cages are compared to furnished cages, non-cage systems, and outdoor systems. Specific attributes of each system are shown to affect welfare, and systems that have similar attributes are affected similarly.
Environments such as conventional cages, which limit movement, can lead to osteoporosis, but environments that have increased complexity, such as non-cage systems, expose hens to an increased incidence of bone fractures.
Less is understood about the stress that each system imposes on the hen, but it appears that each system has its unique challenges. Selective breeding for desired traits such as improved bone strength and decreased feather pecking and cannibalism may help to improve welfare.
It appears that no single housing system is ideal from a hen welfare perspective. Although environmental complexity increases behavioral opportunities, it also introduces difficulties in terms of disease and pest control.
One specific circumstance has not been taken into consideration in this paper: how to depopulate the hens in case of an outbreak situation. Emergency control is not an economic parameter to choose a specific production system, but comparing a production system with or without cages, it is clear that it is much easier to depopulate chickens in a system without cages. Without a proper technique to cull the animals in a animal welfare friendly way and to transport the carcasses out of the house mechanically, the chickens are killed and transported manually.
This is not only increasing the risks for humans to get infected, it also influences the risks that animals suffer unnecessary during depopulation. Handling animals during outbreak situations is mostly done by inexperienced responders who have little to no knowledge about animal welfare. Veterinary authorities in charge of the response activities have issues like effectiveness and efficiency to consider.
How to depopulate the chickens in an outbreak situation is an important welfare indicator and the producer of these systems need to be kept responsible for the technical solution.
Harm Kiezebrink
Research Fellow Queensland University /
CEO AVT Europe AB
AVT Applied Veterinary Technologies Europe AB
Address details: c/o INTRED, Södra Hamnen 2,
45142 Uddevalla, Sweden
Phone: +44 7452 272 358
E-mail: harm.kie@gmail.com
Preparedness, Prediction and Prevention of Emerging Zoonotic Viruses with Pan...Global Risk Forum GRFDavos
Presentation at 3rd GRF One Health Summit 2015
The One Health Approach for Communicable Diseases
Sylvie VAN DER WERF, Institut Pasteur, France, on behalf of the PREDEMICS consortium
This document summarizes a study on the effect of Clostridium difficile experimental infection on the health of weaned rabbits. Thirty rabbits were divided into three groups, with two groups infected with C. difficile either subcutaneously or orally. The orally infected group showed signs of diarrhea and bloat, while no signs were seen in the subcutaneous group. No mortalities occurred. At the end of the study, the orally infected rabbits showed liver and kidney enlargement and congestion as well as mild enteritis. The C. difficile was re-isolated from infected rabbits. The study found that C. difficile can negatively impact the health of weaned rabbits.
This study investigated antibiotic resistance in urinary tract E. coli isolates from hospitalized patients in India. Urine samples were collected from 73 patients with urinary tract infections and E. coli was isolated from 35 samples (48%). The E. coli isolates showed high resistance to novobiocin, vancomycin, and co-trimaxazole. 80% of isolates were biofilm producers, with over 50% producing strong biofilms. 51% of isolates were beta-lactamase producers. The results indicate that biofilm-producing E. coli strains with beta-lactamase activity exhibited the highest antibiotic resistance.
Mold and cystic fibrosis : what can we learn from studying fungal microbiota ?Laurence Delhaes
This document discusses studying the fungal microbiota (mycobiota) in the lungs of cystic fibrosis (CF) patients. It begins by providing background on human microbial diversity and the emerging importance of studying the lung mycobiota. The authors aim to characterize the lung mycobiota in CF patients using deep sequencing techniques and analyze how the mycobiota relates to clinical status and bacterial composition. Preliminary results on 36 sputum samples from CF patients with and without pulmonary exacerbation show no association between common fungi like Aspergillus fumigatus and exacerbation. Principal component analysis of bacterial and fungal genera indicates some correlations and lack of correlation between certain microorganisms. Further statistical analysis is ongoing.
What can we learn from studying fungal microbiotaLaurence Delhaes
The document discusses analyzing the fungal microbiota (mycobiota) in the lungs of cystic fibrosis (CF) patients. It summarizes a study that used high-throughput sequencing to analyze sputum samples from CF patients. The study found greater fungal diversity than previous culture-based methods, identifying 24 fungal genera including Aspergillus. Preliminary results showed associations between decreased fungal diversity and poorer clinical outcomes in CF patients. Larger studies are still needed to better understand the role of the lung mycobiota in CF exacerbations and how it interacts with bacterial communities and clinical status.
This document discusses antimicrobial resistance mechanisms in Staphylococcus aureus, specifically methicillin-resistant S. aureus (MRSA). MRSA infections are now responsible for more deaths per year in the US than HIV and add billions to healthcare costs worldwide. MRSA strains have developed diverse genetic elements that confer resistance to multiple antimicrobials like methicillin, aminoglycosides, erythromycin, and tetracycline. Certain MRSA strains are also resistant to additional drugs including fluoroquinolones. Effective antimicrobial therapy is threatened as S. aureus continues developing resistance.
Increase your Understanding of the Pathogenesis of Gluten Spectrum DisordersCell Science Systems
Recently, researchers at Harvard University, Alessio Fasano et. al., and the National Institutes of Health (laboratories of immunology and cellular and molecular biology), reported real-time microscopic observations of gluten-induced neutrophil activation.
According to authors, " To what extent neutrophil function adds to, or protects against, gluten intolerance is currently under vigorous investigation."
This presentation will shed light on this question. It will also review the Fasano study and examine the role of neutrophil function in multiple disease conditions, as well as explore how neutrophil function may also play a dual role in protecting the body from the untoward effects of dietary and environmental agents.
This document reviews the role of the protozoan Toxoplasma gondii in manipulating host behavior. T. gondii can infect many warm-blooded animals and is able to alter host behavior in ways that may benefit transmission to feline hosts. The document introduces the concept of a "T. gondii-rat manipulation-schizophrenia model" to study how rodent behavior changes during infection could provide insights into behavioral changes in humans, including potential links to schizophrenia. It discusses evidence that T. gondii infection is associated with increased dopamine levels and altered dopamine signaling in both rodents and humans, which could underlie behavioral changes. Future research on the model is proposed to advance understanding of parasitic
Dr. Peter Davies - Emerging Issues in Antibiotic Resistance Linked to Use in ...John Blue
Emerging Issues in Antibiotic Resistance Linked to Use in Food Animals - Dr. Peter Davies, College of Veterinary Medicine, University of Minnesota, from the 2017 Allen D. Leman Swine Conference, September 16-19, 2017, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2017-leman-swine-conference-material
This document discusses ascariasis, a common helminth infection caused by the roundworm Ascaris lumbricoides. It infects over 25% of the world's population, predominantly children. Symptoms can include growth retardation, pneumonia, and intestinal obstruction. The life cycle and immunosuppressive effects of ascariasis are described, including its role in modulating the immune system and suppressing inflammatory responses through molecules like PAS-1. The hygiene hypothesis, which proposes that lack of early childhood exposure to pathogens like helminths may increase risk for allergic diseases, is also discussed.
Prof. Dr. Paolo Falagiani (1947 – 2011) was an Italian professor who published extensively on sublingual immunotherapy and allergen-specific immunotherapy. He authored or co-authored over 50 papers investigating the efficacy, safety, and immunological effects of sublingual and oral immunotherapy for allergies to various substances like pollens, mites, foods, and metals. Many of his studies were randomized controlled trials or retrospective analyses that demonstrated the clinical benefits and tolerability of immunotherapy approaches. He significantly contributed to the research and development of immunotherapy as an allergy treatment.
This study investigated using bacteriophage therapy to treat cholera. A single bacteriophage, Phi_1, was found to effectively control cholera in an infant rabbit model when given prophylactically or therapeutically, with phage-treated animals showing no clinical signs of disease. No phage-resistant bacterial mutants were found in the animals despite extensive searching. This provides the first evidence that a single phage could treat cholera without detectable resistance and suggests clinical trials in humans should be considered.
1. Gary Phillips has published 28 external publications related to in vitro models of lung disease, the effects of tobacco smoke and other toxins, and the role of oxidative stress and inflammation in smoking-related diseases and lung injury.
2. His publications include studies evaluating air-liquid interface cell culture models, the effects of diet on lung health, and vaccine candidates for ricin toxicity.
3. Many of his publications examine the role of oxidative stress, neutrophils, and inflammation in conditions like chronic obstructive lung disease and hyperoxic lung injury.
Genetic Resistance to Infectious Diseases in the Era of Personalized Medicine...CrimsonpublishersCJMI
Genetic Resistance to Infectious Diseases in the Era of Personalized Medicine by Andrei Alimov in Cohesive Journal of Microbiology & Infectious Disease
Polymicrobial colonisation of the nasopharynx in UK childrenRebeccagladstone
The three most common bacterial species found colonizing the nasopharynx of children in the study were Streptococcus pneumoniae (31%), Haemophilus influenzae (19%), and alpha-hemolytic streptococci (6%). Over 20% of samples showed co-colonization, most often S. pneumoniae and H. influenzae. Of S. pneumoniae-positive samples, 25% were co-colonized with H. influenzae, and 43% of H. influenzae-positive samples were co-colonized with S. pneumoniae, demonstrating significant co-occurrence of these species.
Immune Response The Key to BoneResorption in Periodontal Di.docxwilcockiris
Immune Response: The Key to Bone
Resorption in Periodontal Disease
Martin A. Taubman,* Paloma Valverde,† Xiaozhe Han,* and Toshihisa Kawai*
Periodontal disease infection with oral biofilm microorganisms initiates
host immune response and signs of periodontitis, including bone resorp-
tion. This review delineates some mechanisms underlying the host im-
mune response in periodontal infection and alveolar bone resorption.
Activated T lymphocytes have been historically implicated in experimen-
tal periodontal bone resorption. An experimental rat adoptive transfer/
gingival challenge periodontal disease model has been demonstrated to
require antigen-specific T lymphocytes and gingival instillation of antigen
and LPS for bone resorption. Interference with costimulatory interactions
between T cells and antigen-presenting cells abrogated bone resorption,
further emphasizing the significance of immune response in periodontal
disease. Receptor activator of nuclear factor kB ligand (RANKL), a critical
osteoclast differentiation factor, is expressed on T lymphocytes in human
periodontal disease as determined by immunohistochemical and confo-
cal microscopic analyses. Interference with RANKL by systemic adminis-
tration of osteoprotegerin (OPG), the decoy receptor for (and inhibitor of)
RANKL, resulted in abrogation of periodontal bone resorption in the rat
model. This finding indicated that T cell-mediated bone resorption is
RANKL-dependent. In additional experiments, treatment of T cell-trans-
ferred rats with kaliotoxin (a scorpion venom potassium channel inhibi-
tor) resulted in decreases in T-cell RANKL expression, diminished
induction of RANKL-dependent osteoclastogenesis, and abrogation of
bone resorption, implicating an important role of immune response/
RANKL expression in osteoclastogenesis/bone resorption. In other ex-
periments, adoptive transfer of antigen-specific, RANKL-expressing
B cells, and infection with the antigen-bearing Actinobaccillus actinomy-
cetemcomitans gave rise to periodontal bone resorption, indicating that B
cells also have the capacity to mediate bone resorption, probably via
RANKL expression. In humans, prominent T lymphocytes have been
identified in periodontal disease, and diseased tissues showed elevated
RANKL mRNA expression, as well as decreased OPG mRNA expression.
Mononuclear cells from periodontal lesions involving T cells and B cells of
patients induced osteoclastogenesis in vitro. In summary, a biofilm inter-
face initiates immune cell infiltration, stimulating osteoclastogenesis/
bone resorption in periodontal disease. This resorption can be amelio-
rated by inhibition of RANKL activity or by diminishing immune cell stim-
ulation. These two procedures, if localized, have the potential to lead to
the prevention or therapeutic management of periodontal disease and
therefore require further study. J Periodontol 2005;76:2033-2041.
KEY WORDS
B lymphocytes; osteoprotegerin; periodontal disease; T lymphocytes.
P
.
Pharma Gastro Intestinal Research, Outsourcing your R&DPaul Stoffels
This document provides a summary of 3 peer-reviewed publications on the topic of TIM systems:
1. A 2003 PhD thesis from the Swedish University of Agricultural Sciences on vitamin B12, folate, and folate binding proteins in dairy products.
2. A 2001 PhD thesis from Utrecht University on the mutagenic and antimutagenic activity of food compounds using an in vitro gastrointestinal model.
3. A 2010 PhD thesis from Maastricht University on bioactive compounds in whole grain wheat.
This document describes a microarray analysis comparing gene expression profiles in the large intestine, small intestine, liver, and spleen of mice with different gut microbiota colonization models: specific pathogen-free mice, germ-free mice colonized at birth, and germ-free mice colonized at 5 weeks of age. The analysis found hundreds of differentially expressed genes in each tissue and colonization model. Gene set enrichment analysis identified overrepresented gene ontology categories related to immune system development and antigen presentation in intestines of mice colonized at birth, and metabolic processes in intestines of specific pathogen-free mice. Analysis of signaling pathways found prominent changes in toll-like receptor and type 1 interferon signaling pathways in intestines of mice
Bordetella pertussis is a Gram-negative bacterium that causes whooping cough (pertussis) in humans. It colonizes the respiratory tract and is transmitted through respiratory droplets. The disease is characterized by paroxysmal coughing fits and was a major cause of childhood death before vaccination. While vaccination programs reduced cases, pertussis is reemerging, especially in adolescents and adults. This is likely due to antigenic divergence between vaccine strains and circulating strains, as well as waning vaccine-induced immunity over time. Improved vaccination strategies and vaccine development are needed to better control pertussis.
Bordetella pertussis is a Gram-negative bacterium that causes whooping cough (pertussis) in humans. It colonizes the respiratory tract and is transmitted through respiratory droplets. The disease was a major cause of childhood deaths before vaccination. While vaccination programs reduced cases, pertussis is reemerging, especially in adolescents and adults. This is likely due to waning vaccine-induced immunity and adaptation of B. pertussis strains to vaccines. Improved vaccines that protect for longer are needed to better control whooping cough.
This document lists 39 peer-reviewed research papers published by Dr. Kevin Gorman. The papers cover topics including field-evolved resistance to various insecticides in pests such as the brown planthopper and greenhouse whitefly, cross-resistance relationships between insecticides, identification of mutations associated with pyrethroid resistance, and characterization of resistance to neonicotinoid insecticides in species like Bemisia tabaci. Many of the papers involve characterizing the mechanisms and genetics of insecticide resistance.
This document summarizes immune evasion strategies used by flaviviruses. It discusses how flaviviruses evade innate immune responses such as type I interferon responses and complement system activation. It also describes adaptive immune evasion mechanisms, including antigenic variation, antibody-dependent enhancement of infection, and inhibition of antigen presentation. The document provides diagrams illustrating key concepts and cites related studies on flavivirus immune evasion and modulation of host inflammatory responses.
This document contains a curriculum vitae for Melissa Inman including her publications and research papers. It lists 28 publications from 1992 to 2015 related to her research on viruses that affect animals like African horse sickness virus, bovine herpesvirus 1, herpes simplex virus, Newcastle disease virus, swine influenza virus, and avian pathogenic Escherichia coli. The publications cover topics like viral infection mechanisms, detection methods, vaccine development, and viral latency and reactivation.
This document outlines a study on the identification and characterization of antimicrobial resistance and genetic traits of zoonotic Klebsiella pneumoniae isolates from a dairy farm in Laguna, Philippines. The study aims to determine the prevalence of K. pneumoniae in mastitic and bulk tank milk, and characterize the antibiotic resistance patterns and mechanisms. Isolates will be collected from cow milk and human workers from the dairy farm and tested for antibiotic susceptibility. Genes conferring antimicrobial resistance and virulence factors will be identified using molecular techniques. Results will provide data on antimicrobial resistance genes in K. pneumoniae from animals and humans to inform industry and policy.
This document provides a list of publications by Jan VAN LOO related to prebiotics and their effects. It includes 28 publications from 2001-2009 covering topics such as:
- Effects of prebiotic supplementation on stool metabolites and gut microbiota in senior cats.
- Prebiotics supporting the growth of probiotic bacteria in vitro.
- Prebiotics modulating markers of tumor progression in human colon tumor cells.
- Synbiotic consumption modulating cancer risk biomarkers in human subjects.
- Prebiotic treatment decreasing colon carcinogenesis in rats.
- Prebiotics having potential anticarcinogenic activities when evaluated in human volunteers.
The document discusses immunity to fungal infections. It notes that fungi can cause diseases through either a lack of immune recognition or overactivation of the inflammatory response. The immune system uses pattern recognition receptors and innate immune cells like phagocytes to recognize and respond to fungal pathogens. Both resistance mechanisms that limit fungal growth and tolerance mechanisms that limit host damage are important for maintaining immune homeostasis during fungal infections.
This document provides an overview of the microbiology of periodontal disease. It discusses the various bacteria associated with periodontal diseases, including the "red complex" bacteria Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. It also examines the virulence factors of these pathogens and how they contribute to periodontal tissue destruction and bone loss. The document establishes the role of these microorganisms in periodontal diseases based on criteria such as their association with disease, elimination during treatment, ability to induce disease in animal models, and production of virulence factors that can damage host tissues.
Immunity against Helminths:role of InterleukinsIshfaq Maqbool
The document summarizes key aspects of the immune response against helminth parasites. It notes that helminths typically induce a type 2 immune response characterized by cytokines like IL-4, IL-5, and IL-13. This non-inflammatory response involves alternatively activated macrophages, eosinophils, and other effector cells that work to expel and kill parasites while repairing tissue damage. The response differs from bacterial and viral immunity, with Th1 responses only occurring during early larval migration stages.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...Donc Test
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler, Verified Chapters 1 - 33, Complete Newest Version Community Health Nursing A Canadian Perspective, 5th Edition by Stamler Community Health Nursing A Canadian Perspective, 5th Edition TEST BANK by Stamler Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Study Guide Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Stuvia Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Studocu Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Test Bank For Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Pdf Download Course Hero Community Health Nursing A Canadian Perspective, 5th Edition Answers Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Ebook Download Course hero Community Health Nursing A Canadian Perspective, 5th Edition Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Studocu Community Health Nursing A Canadian Perspective, 5th Edition Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Chapters Download Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Pdf Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Study Guide Questions and Answers Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Ebook Download Stuvia Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Questions Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Studocu Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Quizlet Community Health Nursing A Canadian Perspective, 5th Edition Test Bank Stuvia
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Novas diretrizes da OMS para os cuidados perinatais de mais qualidade
Publication list meurens_f
1. ARTICLES AND REVIEWS
H index (Scopus): 14
The “ranking” of the articles comes from “Journal of Citation report, 2012”.
59) DELGADO-ORTEGA M., OLIVIER M., SIZARET P.Y., SIMON G., MEURENS F.
Newborn pig trachea cell line cultured in air-liquid interface conditions allows a partial in vitro
representation of the porcine upper airway tissue. BMC Cell Biology, 2014, 15(1):14.
58) DELGADO-ORTEGA M., MELO S., PUNYADARSANIYA D., RAMÉ C., OLIVIER M.,
SOUBIEUX D., MARC D., SIMON G., HERRLER G., BERRI M., DUPONT J., MEURENS F.
Innate immune response to a H3N2 subtype swine influenza virus in newborn porcine
trachea cells, alveolar macrophages, and precision-cut lung slices. Veterinary Research,
2014, 45:42 (IF: 3.426; Q1 category Veterinary Sciences).
57) MAIR K.H., SEDLAK C., KÄSER T., PASTERNAK A., LEVAST B., GERNER W.,
SAALMÜLLER A., SUMMERFIELD A., GERDTS V., WILSON H.L., MEURENS F. The
porcine innate immune system: An update. Developmental and Comparative
Immunology, 2014, 45, 321-343 (IF: 3.238; Q1 category Zoology).
56) BERRI M., VIRLOGEUX-PAYANT I., CHEVALEYRE C., MELO S., ZANELLO G.,
SALMON H., MEURENS F. CCL28 involvement in mucosal tissues protection as a
chemokine and as an antibacterial peptide. Developmental and Comparative
Immunology, 2014, 44, 286-290 (IF: 3.238; Q1 category Zoology).
55) DOBRESCU I., LEVAST B., LAI K., DELGADO-ORTEGA M., WALKER S., BANMAN S.,
TOWNSEND H., SIMON G., ZHOU Y., GERDTS V., MEURENS F. In vitro and ex vivo
analyses of co-infections with swine influenza and porcine reproductive and respiratory
syndrome viruses. Veterinary Microbiology, 2014, 169, 18-32 (IF: 3.127; Q1 category
Veterinary Sciences).
54) LEVAST B., BERRI M., WILSON H.L., MEURENS F., SALMON H. Development of gut
immunoglobulin A production in piglet in response to innate and environmental factors.
Developmental and Comparative Immunology, 2014, 44, 235-244 (IF: 3.238; Q1 category
Zoology).
53) CANO P.M., SEEBOTH J., MEURENS F., COGNIE J., ABRAMI R., OSWALD I.P.
GUZYLACK L. Deoxynivalenol modulates the immune response towards a Th17-mediated
response: A new factor in the persistence of intestinal inflammatory diseases. PLoS One,
2013, 8(1): e53647 (IF: 3.730; Q1 category Biology).
52) DELGADO-ORTEGA M., DUPONT J., MARC D., TRAPP S., BERRI M., MEURENS F.
SOCS proteins in infectious diseases of mammals. Veterinary Immunology and
Immunopathology, 2013, 151, 1-19 (IF: 1.877; Q1 category Veterinary Sciences).
51) ZANELLO G., MEURENS F., SERREAU D., CHEVALEYRE C., MELO S., BERRI M.,
AUCLAIR E., SALMON H. Effects of dietary Saccharomyces cerevisiae yeast strains on
immunoglobulin levels in colostrum and milk of sows. Veterinary Immunology and
Immunopathology, 2013, 152, 20-27 (IF: 1.877; Q1 category Veterinary Sciences).
50) BREA D., MEURENS F., DUBOIS A.V., GAILLARD J., CHEVALEYRE C., JOURDAN
M.L., WINTER N., ARBEILLE B., SI-TAHAR M., GAUTHIER F., ATTUCCI S. Human-like
properties of pig neutrophils. Biochemical Journal, 2012, 447, 363-370 (IF: 4.654; Q1
category Biochemistry and Molecular Biology).
1
2. 49) BADIA R., ZANELLO G., CHEVALEYRE C., LIZARDO R., MEURENS F., MARTINEZ P.,
BRUFAU J., SALMON H. Effect of Saccharomyces cerevisiae var. Boulardii and beta-
galactomannan oligosaccharide on porcine intestinal epithelial and dendritic cells challenged
in vitro with Escherichia coli F4 (K88). Veterinary Research, 2012, 43:4 (IF: 3.426; Q1
category Veterinary Sciences).
48) GIRARD-MISGUICH F.*, DELGADO-ORTEGA M.*, BERTHON P., ROSSIGNOL C.,
LARCHER T., BRUEL T., GUIBON R., GUILLEN N., MEURENS F. Porcine colon explants in
the study of innate immune response to Entamoeba histolytica. Veterinary Immunology
and Immunopathology. *Contributed equally to this work, 2012, 145, 611-617 (IF: 1.877;
Q1 category Veterinary Sciences).
47) MEURENS F., SUMMERFIELD A., NAUWYNCK H., SAIF L., GERDTS V. The Pig: A
model for human infectious diseases. Trends in Microbiology, 2012, 20(1), 50-57 (IF:
8.434; Q1 category Microbiology).
46) GIRARD-MISGUICH F., COGNIE J., DELGADO M., BERTHON P., ROSSIGNOL C.,
LARCHER T., MELO S., BRUEL T., GUIBON R., CHEREL Y, SARRADIN P., SALMON H.,
GUILLEN N., MEURENS F. Towards the establishment of a porcine model to study human
amebiasis. PLoS One, 2011, 6(12): e28795. doi:10.1371/journal.pone.0028795 (IF: 3.730;
Q1 category Biology).
45) DELGADO-ORTEGA M., MELO S., MEURENS F. Expression of SOCS1-7 and CIS
mRNA in porcine tissues. Veterinary Immunology and Immunopathology, 2011, 144, 493-
498 (IF: 1.877; Q1 category Veterinary Sciences).
44) DEL MEDICO ZAJAC M.P., ROMERA S.A., LADELFA M.F., KOTSIAS F., DELGADO F.,
THIRY J., MEURENS F., KEIL G., THIRY E., MUYLKENS B. In vitro-generated interspecific
recombinants between bovine herpesviruses 1 and 5 show attenuated replication
characteristics and establish latency in the natural host. BMC Veterinary Research, 2011, 7,
19 (IF: 1.861; Q1 category Veterinary Sciences).
43) ZANELLO G., BERRI M., DUPONT J., SIZARET P.Y., D’INCA R., SALMON H.,
MEURENS F. Saccharomyces cerevisiae modulates immune gene expressions and inhibits
enterotoxigenic Escherichia coli-mediated ERK1/2 and p38 signaling pathways. PLoS One,
2011, 6(4): e18573. doi:10.1371/journal.pone.0018573 (IF: 3.730; Q1 category Biology).
42) ZANELLO G.*, MEURENS F.*, BERRI M., CHEVALEYRE C., MELO S., AUCLAIR E.,
SALMON H. Saccharomyces cerevisiae decreases inflammatory responses induced by F4+
enterotoxigenic Escherichia coli in porcine intestinal epithelial cells. Veterinary Immunology
and Immunopathology. *Contributed equally to this work, 2011, 141, 133-138 (IF: 1.877;
Q1 category Veterinary Sciences).
41) BOUGARN S., CUNHA P., GILBERT F., MEURENS F., RAINARD P. Validation of
candidate reference genes for RT-qPCR normalization in bovine mammary epithelial cells
responding to inflammatory stimuli. Journal of Dairy Sciences, 2011, 94, 2425-2430 (IF:
2.566; Q1 category Agriculture, Dairy and Animal Science).
40) FACCI M., AURAY G., MEURENS F., BUCHANAN R., VAN KESSEL J., GERDTS V.
Stability of expression of reference genes in porcine peripheral blood mononuclear and
dendritic cells. Veterinary Immunology and Immunopathology, 2011, 141, 11-15 (IF:
1.877; Q1 category Veterinary Sciences).
2
3. 39) LEVAST B., DE MONTE M., CHEVALEYRE C., MELO S., BERRI M., MANGIN F.,
ZANELLO G., LANTIER I., SALMON H., MEURENS F. Piglet ultra-early weaning and its
immune consequences: Seric IgA low concentrations and diversification of the IgA
mesenteric lymph node repertoire. Veterinary Immunology and Immunopathology, 2010,
137, 261-268 (IF: 1.877; Q1 category Veterinary Sciences).
38) BRUEL T., GUIBON R., MELO S., GUILLEN N., SALMON H., GIRARD-MISGUICH F.,
MEURENS F. Epithelial induction of suppressor of cytokine signaling 2 (SOCS2) gene
expression in response to Entamoeba histolytica. Developmental and Comparative
Immunology, 2010, 34, 562-571 (IF: 3.238; Q1 category Zoology).
37) SALMON H., BERRI M., MEURENS F. Immunité maternelle colostrale et lactée :
facteurs humoraux et cellulaires d’induction et de transmission au porcelet jusqu’au sevrage.
Journées Recherche Porcine, 2010, 42 (no IF).
36) LEVAST B., DE MONTE M., MELO S., CHEVALEYRE C., BERRI M., SALMON H.,
MEURENS F. Difference in transcriptomic profile and IgA repertoire between jejunal and ileal
Peyer’s patches. Developmental and Comparative Immunology, 2010, 34, 102-106 (IF:
3.238; Q1 category Zoology).
35) DEL MEDICO ZAJAC M.P., ROMERA S.A., LADELFA M.F., KOTSIAS F., THIRY J.,
ZIANT D., MEURENS F., KEIL G.M., THIRY E., MUYLKENS B. Characterization of
interspecific recombinants generated from closely related bovine herpesvirus 1 and 5
through multiple PCR sequencing assays. Journal of Virological Methods, 2009, 161, 75-
83 (IF: 1.900; Q3 category virology).
34) MUYLKENS B., FARNIR F., GRISART B., MEURENS F., SCHYNTS F.,
VANDERPLASSCHEN A., GEORGES M., THIRY E. Coinfection with two closely related
alphaherpesviruses results in a highly diversified recombination mosaic displaying negative
genetic interference. Journal of Virology, 2009, 83, 3127-3137 (IF: 5.076; Q1 category
Virology).
33) DE JESUS RODRIGUEZ B., CHEVALEYRE C., HENRI G., MOLLE D., VIRLOGEUX-
PAYANT I., BERRI M., BOULAY F., LEONIL J., MEURENS F., SALMON H. Identification in
milk of a serum amyloid A peptide chemoattractant for B lymphoblast. BMC Immunology,
2009, 10:4 (IF: 2.610; Q3 category Immunology).
32) PILON C., LEVAST B., MEURENS F., LE VERN Y., KERBOEUF D., SALMON H.,
VELGE-ROUSSEL F., LEBRANCHU Y., BARON C. CD40 engagement strongly induces
CD25 expression on porcine dendritic cells and polarizes the T cell immune response toward
Th1. Molecular Immunology, 2009, 46, 437-447 (IF: 2.645; Q3 category Immunology).
31) MEURENS F., BERRI M., AURAY G., MELO S., LEVAST B., VIRLOGEUX-PAYANT I.,
CHEVALEYRE C., GERDTS V., SALMON H. Early immune response following Salmonella
enterica subspecies enterica serovar Typhimurium infection in porcine jejunal gut loops.
Veterinary Research, 2009, 40:5 (IF: 3.426; Q1 category Veterinary Sciences).
30) MEURENS F.*, GIRARD-MISGUICH F.*, MELO S., GRAVE A., SALMON H., GUILLEN
N. Broad early immune response of porcine epithelial jejunal IPI-2I cells to Entamoeba
histolytica. *Contributed equally to this work. Molecular Immunology, 2009, 46, 927-936 (IF:
2.645; Q3 category Immunology).
29) ZANELLO G., MEURENS F., BERRI M., SALMON H. Saccharomyces boulardii effects
on gastrointestinal diseases. Current Issues in Molecular Biology, 2009, 11, 47-58 (IF:
3.650; Q2 category Biochemical Research Methods).
3
4. 28) SALMON H., BERRI M., GERDTS V., MEURENS F. Humoral and cellular factors of
maternal immunity in swine. Developmental and Comparative Immunology, 2009, 33,
383-394 (IF: 3.238; Q1 category Zoology).
27) PILON C., MEURENS F., DAUBA A., SALMON H., VELGE-ROUSSEL F., LEBRANCHU
Y., BARON C. Induction of porcine regulatory cells by mycophenolic acid-treated dendritic
cells. Transplantation Proceedings, 2009, 41, 700-702 (IF: 0.952; Q4 category
Immunology).
26) MAFUKO NSABIMANA J., MOUTSCHEN M., THIRY E, MEURENS F. Human infection
with simian herpes B virus in Africa. Santé, 2008, 18, 1-6 (no IF).
25) BOURGES D.*, MEURENS F.*, CHEVALEYRE C., ZANELLO G., LEVAST B., MELO S.,
GERDTS V., SALMON H. New insights into the dual recruitment of IgA+ B cells in the
developing mammary gland. Molecular Immunology, 2008, 45, 3354-3362. *Contributed
equally to this work (IF: 2.645; Q3 category Immunology).
24) BERRI M., MEURENS F., LEFEVRE F., CHEVALEYRE C., ZANELLO G., GERDTS V.,
SALMON H. Molecular cloning and functional characterization of porcine CCL28: possible
involvement in homing of IgA antibody secreting cells into the mammary gland. Molecular
Immunology, 2008, 45, 271-277 (IF: 2.645; Q3 category Immunology).
23) THIRY J., TEMPESTA M., CAMERO M., TARSITANO E., MUYLKENS B., MEURENS F.,
THIRY E., BUONAVOGLIA C. Clinical protection against caprine herpesvirus 1 genital
infection by intranasal administration of a live attenuated glycoprotein E negative bovine
herpesvirus 1 vaccine. BMC Veterinary Research, 2007, 3, 33 (IF: 1.861; Q1 category
Veterinary Sciences).
22) MEURENS F., BERRI M., SIGGERS R.H., WILLING B.P., SALMON H., VAN KESSEL
A.G., GERDTS V. Commensal bacteria and expression of two major intestinal chemokines,
TECK/CCL25 and MEC/CCL28, and their receptors. PLoS ONE, 2007, 2(7), e677.
doi:10.1371/journal.pone.0000677 (IF: 3.730; Q1 category Biology).
21) MEURENS F., WHALE J., BROWNLIE R., DYBVIG T., THOMPSON D.R., GERDTS V.
Expression of mucosal chemokines TECK/CCL25 and MEC/CCL28 during fetal development
of the ovine mucosal immune system. Immunology, 2007, 120, 544-555 (IF: 3.705; Q2
category Immunology).
20) BOURGES D., CHEVALEYRE C., WANG C., BERRI M., ZHANG X., NICAISE L.,
MEURENS F., SALMON H. Differential expression of adhesion molecules and chemokines
between nasal and small intestinal mucosae: implications for T and sIgA+ B lymphocyte
recruitment. Immunology, 2007, 122, 551-561 (IF: 3.705; Q2 category Immunology).
19) MEURENS F., BERRI M., WHALE J., DYBVIG T., STROM S., THOMPSON D.,
BROWNLIE R., TOWNSEND H.G.G., SALMON H., GERDTS V. Expression of TECK/CCL25
and MEC/CCL28 chemokines and their respective receptors CCR9 and CCR10 in porcine
mucosal tissues. Veterinary Immunology and Immunopathology, 2006, 113, 313-327 (IF:
1.877; Q1 category Veterinary Sciences).
18) MUYLKENS B., MEURENS F., SCHYNTS F., FARNIR F., POURCHET A., BARDIAU M.,
GOGEV S., THIRY J., CUISENAIRE A., VANDERPLASSCHEN A., THIRY E. Intraspecific
bovine herpesvirus 1 recombinants carrying glycoprotein E deletion as a vaccine marker are
virulent in cattle. Journal of General Virology, 2006, 87, 2149-54 (IF: 3.127; Q2 category
Virology).
4
5. 17) MUYLKENS B., MEURENS F., SCHYNTS F., DE FAYS K., POURCHET A., THIRY J.,
VANDERPLASSCHEN A., ANTOINE N., THIRY E. Biological characterization of bovine
herpesvirus 1 recombinants possessing the vaccine glycoprotein E negative phenotype.
Veterinary Microbiology, 2006, 113, 283-291 (IF: 3.127; Q1 category Veterinary Sciences).
16) THIRY E., MUYLKENS B., MEURENS F., GOGEV S., THIRY J., VANDERPLASSCHEN
A., F. SCHYNTS. Recombination in the alphaherpesvirus bovine herpesvirus 1. Veterinary
Microbiology, 2006, 113, 171-177 (IF: 3.127; Q1 category Veterinary Sciences).
15) THIRY J., KEUSER V., MUYLKENS B., MEURENS F., GOGEV S.,
VANDERPLASSCHEN A., THIRY E. Ruminant alphaherpesviruses related to bovine
herpesvirus 1. Veterinary Research, 2006, 37, 1-22 (IF: 3.426; Q1 category Veterinary
Sciences).
14) THIRY E., MEURENS F., MUYLKENS B., McVOY M., GOGEV S., THIRY J.,
VANDERPLASSCHEN A., EPSTEIN A., KEIL G.M., SCHYNTS F. Recombination in
alphaherpesviruses. Reviews in Medical Virology, 2005, 15, 89-103 (IF: 7.615; Q1
category Virology).
13) MEURENS F. Influence of superinfection delay and genetic relatedness on bovine
herpesvirus 1 recombination. Annales de Médecine Vétérinaire, 2005, 149, 26-30 (IF:
0.033; Q4 category Veterinary Sciences).
12) MEURENS F., KEIL G., MUYLKENS B., GOGEV S., SCHYNTS F., NEGRO S.,
WIGGERS L., THIRY E. Interspecific recombination between two ruminant
alphaherpesviruses, bovine herpesviruses 1 and 5. Journal of Virology, 2004, 78, 9828-
9836 (IF: 5.076; Q1 category Virology).
11) MEURENS F., SCHYNTS F., KEIL G., MUYLKENS B., GALLEGO P., THIRY E.
Superinfection prevents recombination of the alphaherpesvirus bovine herpesvirus 1.
Journal of Virology, 2004, 78, 3872-3879 (IF: 5.076; Q1 category Virology).
10) THIRY E., GOGEV S., MEURENS F., MUYLKENS B., SCIPIONI A., THIRY J.
Vaccination contre l’infection par le virus de la BVD-MD : actualités et futures
développements. Le Point Vétérinaire, 2004, 35, 102-106 (no IF).
9) MEURENS F., MUYLKENS B., SCHYNTS F., BOURGOT I., THIRY E. L’interférence
virale chez les Alphaherpesvirinae, Virologie, 2003, 7, 319-328 (IF: 0.127 ; Q4 category
Virology).
8) GOGEV S., SCHYNTS F., MEURENS F., BOURGOT I., THIRY E. Biosafety of
herpesvirus vectors. Current Gene Therapy, 2003, 3, 597-611 (IF: 5.318; Q1 category
Genetic and Heredity).
7) MUYLKENS B., MEURENS F., SCHYNTS F., THIRY E. Les facteurs de virulence des
alphaherpèsvirus. Virologie, 2003, 7, 401-415 (IF: 0.127 ; Q4 category Virology).
6) SCHYNTS F., MEURENS F., DETRY B., VANDERPLASSCHEN A., THIRY E. Rise and
survival of bovine herpesvirus 1 recombinants after primary infection and reactivation from
latency, Journal of Virology, 2003, 77, 12535-12542 (IF: 5.076; Q1 category Virology).
5) SCHYNTS F., McVOY M.A., MEURENS F., DETRY B., EPSTEIN A.L., THIRY E. The
structures of bovine herpesvirus 1 virion and concatemeric DNA: Implications for cleavage
5
6. and packaging of herpesvirus genomes. Virology, 2003, 314, 326-335 (IF: 3.351; Q2
category Virology).
4) MEURENS F., GALLEGO P., BOURGOT I., THIRY E. L'herpèsvirus B du singe, un agent
d'anthropozoonose méconnu. Annales de Médecine Vétérinaire, 2002, 146, 1-8 (IF: 0.033;
Q4 category Veterinary Sciences).
3) SCHYNTS F., MEURENS F., MUYLKENS B., EPSTEIN A.L., McVOY M., THIRY E.
Réplication, clivage/encapsidation et recombinaison de l’ADN des herpèsvirus. Virologie,
2002, 6, 343-52 (IF: 0.127 ; Q4 category Virology).
2) MEURENS F., SCHYNTS F., THIRY E. La recombinaison chez les alphaherpèsvirus.
Annales de Médecine Vétérinaire, 2001, 145, 108-119 (IF: 0.033; Q4 category Veterinary
Sciences).
1) MEURENS F., DELAUNOIS A., BECKERS J.F., GUSTIN P. Les xéno-oestrogènes et leur
impact sur l'environnement. Annales de Médecine Vétérinaire, 2000, 145, 53-63 (IF: 0.033;
Q4 category Veterinary Sciences).
BOOK CHAPTER
1) FACCI M., AURAY G., MEURENS F., BABIUK L.A., GERDTS V. Recruitment and
activation of dendritic cells by innate immune stimulators. In: Recent development in
immunology. Ed.: Xiang J. Transworld Research Network, Kerala, India.
CONGRESS, ORAL COMMUNICATIONS
52) KÄSER T., CNUDDE T., LAI K., PASTERNAK A., MEURENS F. Isolation, culture and
monitoring of chlamydia and genital tract epithelial cells in the 21st
century. 6th
Prairie
Infectious Immunology Networking Conference, Hecla, Manitoba, Canada, 28-30th
May,
2014.
51) MEURENS F. Antiviral innate immune response of the porcine respiratory mucosa. 6th
Prairie Infectious Immunology Networking Conference, Hecla, Manitoba, Canada, 28-30th
May, 2014 (Oral communication).
50) MEURENS F. Beyond empiricism in vaccine development: utilisation of anatomical and
immunological knowledge to optimize parenteral vaccine application. Porcilis Symposium,
Nijmegen, The Netherlands, 27th
September, 2013 (Oral communication).
49) MEURENS F. Pig models in bacterial vaccine research. TransVac Symposium: Pig as a
model in human vaccine development, Lelystadt, The Netherlands, 20th
September, 2013
(Oral communication).
48) MEURENS F. Pig a model for the neonate. TransVac Symposium: Pig as a model in
human vaccine development, Lelystadt, The Netherlands, 20th
September, 2013 (Oral
communication).
47) DOBRESCU I., LAI K., LEVAST B., SIMON G., ZHOU Y., GERDTS V., MEURENS F. In
vitro and Ex vivo analyses of co-infections with swine influenza and porcine reproductive and
6
7. respiratory syndrome viruses. 10th
International Veterinary Immunology Symposium, Milan,
Italy, 28th
August to 1st
September, 2013.
46) DELGADO-ORTEGA M., MELO S., DUPONT J., DARSANIYA P., HERLLER G.,
SOUBIEUX D., MARC D., NAPPER S., SCRUTEN E., DOBRESCU I., LAI K., MEURENS F.
The porcine SOCS and their involvement in the response to two strains of influenza A virus.
10th
International Veterinary Immunology Symposium, Milan, Italy, 1st
September, 2013 (Oral
communication).
45) DELGADO-ORTEGA M., MELO S., DUPONT J., DARSANIYA P., HERRLER G.,
SOUBIEUX D., MARC D., MEURENS F. Expression of porcine SOCS in response to
influenza A virus H3N2. 5th
Prairie Infectious Immunology Networking Conference, Moose
Jaw, Canada, 19-21th
September, 2012.
44) MEURENS F. Towards a porcine model to study human amoebiasis. 5th
Prairie
Infectious Immunology Networking Conference, Moose Jaw, Canada, 19-21th September,
2012 (Oral communication).
43) DELGADO-ORTEGA M., MELO S., DUPONT J., DARSANIYA P., HERRLER G.,
SOUBIEUX D., MARC D., MEURENS F. Expression of porcine SOCS in response to
influenza A virus H3N2. 4th
European Veterinary Immunology Workshop, Edinburgh, UK, 2-
4th
September, 2012.
42) DELGADO-ORTEGA M., OLIVIER M., SIZARET P.Y., SIMON G., MEURENS F.
Differentiation of NPTr cells using air-liquid interface technique. 4th
European Veterinary
Immunology Workshop, Edinburgh, UK, 2-4th
September, 2012.
41) ZANELLO G., BERRI M., D’INCA R., SALMON H., MEURENS F. Saccharomyces
cerevisiae modulates immune gene expression and inhibits ETEC-induced ERK1/2 and p38
phosphorylation in porcine intestinal epithelial cell lines. 13th
International Congress on
Yeasts, Madison, USA, 26th
-30th
August, 2012 (Oral communication).
40) DELGADO-ORTEGA M., MELO S., DUPONT J., DARSANIYA P., HERRLER G.,
SOUBIEUX D., MARC D., MEURENS F. Expression des transcrits SOCS chez le porc, à
l’homéostasie et lors de la réponse innée à l’infection par un virus influenza H3N2. 14e
Journées francophones de virologie, Paris, France, 29-30 mars 2012.
39) MEURENS F. The pig: a model for human infectious diseases. EFOR meeting, farm
animal workshop, Paris, France, January 10th
2012 (Oral communication).
38) MEURENS F. Modèle porcin d’étude de l’amibiase humaine. Journées d’Animation
Scientifique de l’IFR 136 et du Cluster d’infectiologie, Tours, France, 22-23 mars 2010 (Oral
communication).
37) SALMON H., BERRI M., MEURENS F. Immunité maternelle colostrale et lactée :
facteurs humoraux et cellulaires d’induction et de transmission au porcelet jusqu’au sevrage.
Conférences et Journées Recherche Porcine, Paris, 2-3 février 2010, 42 (Oral
communication).
36) LEVAST B., CHEVALEYRE C., MELO S., BERRI M., SALMON H., MEURENS F.
Evaluation of the IgA intestine deficit due to early weaning of piglets. 3rd
EVIW European
Veterinary Immunology Workshop - Satellite meeting of the 2nd European Congress of
Immunology. Berlin, Germany, 10th
-13th
September 2009. Session CS5: Mucosal
Immunology (Oral communication).
7
8. 35) SALMON H., CHEVALEYRE C., ZANELLO G., MELO S., MEURENS F., BERRI M.
Vascular addressins and chemokines of broncho- and entero-mammary immune links in
sows. 3rd
EVIW European Veterinary Immunology Workshop - Satellite meeting of the 2nd
European Congress of Immunology. Berlin, Germany, 10th
-13th
September 2009. Session
CS5: Mucosal Immunology (Oral communication).
34) MEURENS F., GIRARD-MISGUICH F., BRUEL T., GUIBON R., MELO S., SALMON H.,
GUILLEN N. Amibiase humaine : établissement d’un modèle porcin. Journées d’animation
scientifique du Département Santé Animale de l’INRA, Port d’Albret, France, 25-28 mai 2009
(Oral communication).
33) LEVAST B., CHEVALEYRE C., MELO S., BERRI M., SALMON H., MEURENS F.
Evaluation of the IgA intestine deficit due to early weaning of piglets. Journées d’animation
scientifique du Département Santé Animale de l’INRA, Port d’Albret, France, 25-28 mai 2009
(Oral communication).
32) BERRI M., MEURENS F., CHEVALEYRE C., SALMON H. Expression des récepteurs
CCR10, CCR3 et CCR9 en relation avec celle des chemokines CCL28 et CCL25 dans
différents tissus muqueux et au cours du développement de la glande mammaire. Journées
d’animation scientifique du Département Santé Animale de l’INRA, Port d’Albret, France, 25-
28 mai 2009.
31) SALMON H., MEURENS F., BERRI M. Mécanisme de la prédominance des IgA dans le
lait des mammifères monogastriques. Journées d’animation scientifique du Département
Santé Animale de l’INRA, Port d’Albret, France, 25-28 mai 2009.
30) LEVAST B., DE MONTE M., MELO S., CHEVALEYRE C., SALMON H., MEURENS F.
Jejunal and ileal Peyer’s patches differ in cytokine, TLR expressions and in their
Immunoglobulin repertoire. 12ème
colloque cytokine du Croisic, Le Croisic, France, 18-20 mai
2009.
29) MEURENS F. Vers un modèle porcin d’étude de l’amibiase humaine. Première Journée
Recherche Porcine, « le porc, modèle pré-clinique » organisée conjointement par l’EA 4245
de Tours et l’unité INSERM 927 de Poitiers. Tours, 4 mai 2009 (Oral communication,
invited speaker).
28) MEURENS F. From bovine rhinotracheitis to porcine immunology. Institute of Virology
and Immunoprophylaxis (IVI) Seminar, Mittelhaeusern, Switzerland, December 4th
(Oral
communication, invited speaker).
27) MEURENS F. Réponse immune intestinale précoce à une infection à Salmonella
enterica subspecies enterica sérovar Typhimurium chez le porc. Immunologie des animaux
domestiques, INRA Tours, Nouzilly, France, 16 octobre 2008.
26) MEURENS F. The pig as an immunopathological model for human infectious diseases.
Séminaire du Département de Biologie Cellulaire et Infection. Institut Pasteur, Paris, France,
6 octobre 2008.
25) DEL MEDICO M.P., LADELFA M.F., KOTSIAS F., THIRY J., MEURENS F., KEIL G.,
ROMERA S.A., THIRY E., MUYLKENS B. Evaluation of two interspecific recombinant
viruses generated from two neurotropic bovine alphaherpesviruses : genomic
characterization and virulence properties in the natural host. Infectious diseases of the
nervous system: pathogenesis and worldwide impact, Paris, France, 10-13 septembre 2008.
8
9. 24) MEURENS F., , MIRAKHUR K., AURAY G., MELO S., LEVAST B., BERRI M., GERDTS
V., SALMON H. Cytokine expressions consecutive to Salmonella typhimurium jejunal
infection in the pig gut loops model. 11ème
colloque cytokine du Croisic, Le Croisic, France, 5-
7 mai 2008.
23) LEVAST B., CHEVALEYRE C., MELO S., BERRI M., SALMON H., MEURENS F.
Evaluation moléculaire du déficit immunitaire provoqué par le sevrage précoce du porcelet.
11ème
colloque cytokine du Croisic, Le Croisic, France, 5-7 mai 2008.
22) MEURENS F., BERRI M., WHALE J., DYBVIG T., STROM S., THOMPSON D.R.,
BROWNLIE R., SALMON H., GERDTS V. Implications des chimiokines épithéliales
TECK/CCL25 et MEC/CCL28 dans le développement du système immunitaire des
artiodactyles en relation avec la colonization bactérienne du tractus digestif. Journées
d’animation scientifique du Département Santé Animale de l’INRA, Tours, France, 25-27 juin
2007 (Oral communication).
21) MUYLKENS B., GRISART B., MEURENS F., SCHYNTS F., VANDERPLASSCHEN A.,
GEORGES M., THIRY E. Mise en évidence et évolution d’une mosaïque de virus
recombinants apparaissant in vitro entre deux souches sauvages de l’herpèsvirus bovin 1.
Journées d’animation scientifique du Département Santé Animale de l’INRA, Tours, France,
25-27 juin 2007 (Oral communication).
20) BERRI M., MEURENS F., LEFEVRE F., CHEVALEYRE C., ZANELLO G., GERDTS V.,
SALMON H. Clonage moléculaire et caractérisation fonctionnelle de la chimiokine
MEC/CCL28 porcine : Implication possible dans la domiciliation des plasmocytes à IgA dans
la glande mammaire. Journées d’animation scientifique du Département Santé Animale de
l’INRA, Tours, France, 25-27 juin 2007.
19) MUYLKENS B., GRISART B., MEURENS F., SCHYNTS F., GEORGES M., THIRY E.
Multiple recombination events in bovine herpesvirus 1 after coinfection in cell culture.
European Society for Veterinary Virology, 7th
International Congress of Veterinary Virology,
Lisbonne, Portugal, 24-27th
September 2006 (Oral communication).
18) MEURENS F., STROM S., BROWNLIE R., GERTS V. Identification of CCL25 and -28
and their respective receptors in pig and sheep. Immunology and Infectious Disease
Research Group Annual Retreat, Saskatoon, Canada, 3rd
December 2005.
17) MUYLKENS B., MEURENS F., SCHYNTS F., DE FAYS K., GOGEV S.,
VANDERPLASSCHEN A., THIRY E. Virulence of recombinant viruses between
glycoproteins-deleted and wild-type strains of the alphaherpesvirus bovine herpesvirus 1.
13th
International Congress of Virology, San Francisco, USA, July 25 2005 (Oral
communication).
16) MUYLKENS B., MEURENS F., SCHYNTS F., DE FAYS K., GOGEV S.,
VANDERPLASSCHEN A., THIRY E. Retained virulence in recombinant glycoprotein E gene
deleted bovine herpesvirus 1. European Society for Veterinary Virology, Veterinary
Herpesvirus Symposium, Gent, Belgique, March 3 2005 (Oral communication).
15) THIRY E., SCHYNTS F., MEURENS F., MUYLKENS B. Safety issues of recombination
between glycoprotein E deleted marker vaccine and wildtype strain of infectious bovine
rhinotracheitis virus. World Buiatrics Congress, Québec, Canada, July 15 2004.
14) MEURENS F., KEIL G., MUYLKENS B., GOGEV S., SCHYNTS F., NEGRO S.,
WIGGERS L., THIRY E. Recombinaison interspécifique entre deux alphaherpèsvirus de
ruminants. 6e
Journées francophones de virologie, Paris, France, 22-23 avril 2004.
9
10. 13) MEURENS F., KEIL G., MUYLKENS B., GOGEV S., NEGRO S., THIRY E. Interspecific
recombination between ruminant alphaherpesviruses in vitro. Microbial immune evasion
strategies, Belgian Society for Microbiology Symposium, 21 November 2003.
12) MEURENS F., KEIL G., MUYLKENS B., SCHYNTS F., VANDERPLASSCHEN A.,
THIRY E. Effect of superinfection delay on the production of bovine herpesvirus 1
recombinants. ESVV, 6th
International Congress of Veterinary Virology; Saint-Malo, France,
24-27 août 2003.
11) MEURENS F., MUYLKENS B., SCHYNTS F., KEIL G., THIRY E. Etude de l’exclusion à
la surinfection chez sept Alphaherpesvirinae apparentés. 5e
Journées francophones de
virologie, Paris, France, 10-11 avril 2003.
10) MUYLKENS B., MEURENS F., POURCHET A., SCHYNTS F., THIRY E. Virulence of
recombinant bovine herpes virus 1 deleted in the gene encoding glycoprotein E. Microbial
immune evasion strategies, Belgian Society for Microbiology Symposium, 21 November
2003.
9) MEURENS F., KEIL G., MUYLKENS B., SCHYNTS F., GALLEGO P., THIRY E. Effect of
superinfection delay on production of bovine herpesvirus 1 recombinants. Towards
understanding microbial interactions, Belgian Society for Microbiology Symposium, 22
November 2002.
8) MEURENS F., SCHYNTS F., VANDERPLASSCHEN A., THIRY E. Effet du délai de
surinfection sur la recombinaison intramoléculaire chez l’herpèsvirus bovin 1. Quatrièmes
Journées Francophones de Virologie, Paris, 25-26 avril 2002.
7) SCHYNTS F., MCVOY M.A., MEURENS F., DETRY B., EPSTEIN A.L., THIRY E.
Structure de l’ADN encapsidé et concatémérique de l’herpèsvirus bovin 1 : implications pour
le clivage et l’encapsidation de l’ADN des herpèsvirus. 5e
Journées francophones de
virologie, Paris, France, 10-11 avril 2003.
6) GONZALEZ F., CABRERA F., RODRIGUEZ E., REMY B., MEURENS F., BECKERS J.F.
Artificial insemination and embryo transfer as efficient tools to better control infectious
diseases transmission. 16th
International Symposium of the World Association of Veterinary
Microbiologists, Immunologists and Specialists in Infectious Diseases, Siena, Italy, May 18-
22, 2002 (Oral communication).
5) SCHYNTS F., McVOY M.A., MEURENS F., EPSTEIN A., THIRY E. Low levels of tail-to-
tail junction are present in concatemeric DNA of bovine herpesvirus 1. Belgian Society for
Microbiology Symposium, 9 November 2001.
4) SCHYNTS F., McVOY M.A., MEURENS F., EPSTEIN A., THIRY E. Low levels of tail-to-
tail junctions are present in concatemeric DNA of bovine herpesvirus 1. Twenty-Sixth
International Herpesvirus Workshop, Regensburg, 28 July-3 August 2001 (Oral
communication).
3) SCHYNTS F., MEURENS F., VANDERPLASSCHEN A., THIRY E. Dynamics of
recombination in cattle after inoculation of two bovine herpesvirus strains. First ESSV
Veterinary Herpesvirus Symposium, 22-23 March 2001, University of Zurich, Switzerland
(Oral communication).
10
11. 2) SCHYNTS F., MEURENS F., VANDERPLASSCHEN A., THIRY E. Dynamique de
recombinaison après inoculation du bovin par deux souches de l’herpèsvirus bovin de type 1.
Troisièmes Journées Francophones de Virologie, Paris, 19-20 avril 2001.
1) THIRY E., SCHYNTS F., MEURENS F. La latence chez les herpèsvirus animaux.
Troisièmes Journées Francophones de Virologie, Paris, 19-20 avril 2001 (Oral
communication).
+ One presentation power point about Arenavirus viruses (lesson of molecular virology).
+ Teaching at University François Rabelais (Tours, France) (around 25 hours/year).
Last update : 26/04/2014
11