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International Journal of Science and Research (IJSR), India Online ISSN: 2319-7064
Volume 2 Issue 9, September 2013
www.ijsr.net
Prediction for Pulmonary Disease Based on
Diagnostic Reciepes and Classification
1
Nidhi, 2
AP Nidhi
Department of Computer Science, Swami Vivekanand Institute of Engineering & Technology,
Punjab Technical University, Jalandhar, India
Abstract: In this research work we have developed a strategy in which the various parameters that influence the occurrence of
pulmonary disease have been gathered from survey of doctors who specialize in diagnoses of pulmonary disease and diagnostic recipes
involving if the else rules were built and given labels, which were used as target for machine learning algorithms [Logistic , SVM, RBF,
Naïve Bayes ] for identification of input dataset of symptoms of subjects . Multiple designs of these classifiers were implemented and
best possible machine algorithm was identified for implementing the complete methodology. Results shows that there was no absolute
answer for the design and selection of best possible machine algorithm as evident from the results based on multiple statistical tests,
therefore , distance from ideal values of statistical test to find best classifier with most optimized parameters was calculated and the
classifier which had closest to these ideal values was found and declared the best classifier for identification of pulmonary diseases
presence or absence .as per results naïve bayes classifier is performing best which is evident from the statistical test scores .
Keywords: SVM, RBF, Naïve Bayes, Logistic, pulmonary.
1. Introduction
Considerable population of the world does not have access to
even bare minimum healthcare facilities. Majority of these are
not able to avail these facilities because of lack of
resources/funds, resultantly they suffer. Irony however is that
most of the diseases are curable provided diagnosis and
treatment is initiated at right time. Information Technology in
general and predictive models in particular being used to
facilitate the physicians in diagnosis of diseases. Bayesian
networks have been extensively used in developing computer
based systems for diagnosis of various diseases. The purpose
of using these computer based systems in healthcare is to
reduce the chances of faulty diagnosis and prevent cost and
time over runs. However, the scope of the study in this
research work will be limited as we will be confined to the
information obtained. Doctors and dentists along with pilots,
police, miners and social workers are considered to be
members of high stress occupations [1]. This primarily is
because of the reason that in these professions scope for error
is minimal and in case a mistake happens there is a direct
impact on the human life and psyche. It is therefore of utmost
importance that people engaged in these professions exercise
extreme precaution in decision making and ensure minimal
error. In a country like India incorrect diagnosis may have
severe implications. The current annual per capita public
expenditure on health in the country is no more than Rupees
Two Hundred, which is among the five lowest in the world.
As per National Health Accounts [2], the total health
expenditure in India from all the sources was Rupees 1,
33,776 crores, consisting of 4.25 percent of the GDP. Of the
total health expenditure, the share of private sector was
highest at 78 percent (private individual households 71
percent and private firms 7 percent); public sector at 20
percent (Central Government 7 percent, State Government 12
percent and Local Government 1 percent) and external flows
contributed about 2 percent.
Figure 1: (Health Expenditure India – 2004) - Source:
National health accounts 2004-2005
It has been estimated that less than 20 percent of the
population, which seek OPD and less than 45 percent of that
which seek indoor treatment avail of such services in public
hospitals. These is despite the fact that most of these patients
do not have the means to make out – of – pocket payment for
private health services except at the cost of other essential
expenditure for items such as basic nutrition. Stated plainly
this means most of the people in India do not have the
capacity to pay for the expensive tests. As such, it is very
important for the doctors to make a correct diagnosis and if
possible with minimum reliance on laboratory tests and more
on their expertise based upon the presenting symptoms.
The present study is targeted to assist the doctors in making
correct diagnosis by using the advantages offered by
computer based systems. Computer based systems are expert
systems designed to process knowledge and reach diagnostic
decisions in the same way as human experts.
2. Proposed Work
Since there is an urgent need to automate the process of
analysis of the datasets of symptoms in terms of taking
advantage of machine algorithms, so that availability of
large datasets of symptoms of patients suffering from
Paper ID: 12013160 72
International Journal of Science and Research (IJSR), India Online ISSN: 2319-7064
Volume 2 Issue 9, September 2013
www.ijsr.net
diseases can come aid to the current medical practitioner to
diagnose diseased that can be easily be identified by using
diagnostic recipes based on the experience of the doctors.
Therefore, we suggest method that can utilize in both the
alternative and mainstream medical field for easy and
accurate diagnostics of patients having pulmonary disease
or not.
3. Implementation Steps/Results
1) Literature survey and interaction with specialists for
collecting information pertaining to pulmonary diseases.
2) Collection of data pertaining to symptom matrix.
3) Data preprocessing to remove missing and superfluous
values.
4) Framing “If-then rules” to labeling and identification of
PD
5) Generating labeled dataset on the basis of these rules.
6) Running classifiers and selecting the most accurate
classifier.
Figure 3.1: Flow chart of the entire methodology
The data pertaining to parameters under study were
collected from the leading Bollywood websites.
 Data Normalization must be used to reduce the number
of samples and the complexity of the neural network and
the computation time of the neural network.
 For the classification schemes, it was found that training
the model with a large number of test data and with fast
training algorithm would greatly enhance the accuracy
and hence the reliability of the system.
 The design of our classifier was done by running the
neural network with different number of hidden layers
and it was apparent from the graphs that it affected the
accuracy [3]
 It was found that as we increase the number of hidden
layers there was also an increase in computation time
but high order of accuracy is also achieved until we have
reached the maximum of hidden layers, therefore, we
need an optimal combination of parameters to achieve
93.3% accuracy Figure 3.1 Methodology Flow Chart
Step 1: Identification of the symptoms
Preliminary data bank of symptoms - For this study initial
data bank of symptoms was collected on the basis of a
survey questionnaire to be administered to doctors seeking
their opinion and rating of symptoms based upon the
strength to correctly predict pulmonary disease. An initial
data bank was thus developed for further classification and
study. This was followed by prioritizing the symptoms for
accurate disease prediction and diagnosis.
Symptom Selection - Symptom selection was regarded as
the problem of feature selection. Symptoms are essential to
diagnose a disease. Therefore, a strong predicting model of
syndrome is based on key symptoms. In this phase, we
investigated which symptoms influence the predicted
syndromes most. [5]
Step 2 and 3 – Creation of symptom matrix
Based upon the above process a symptom matrix
representing the symptoms associated with pulmonary
diseases was created Table 4.1.
Table 4.1: Symptom Matrix
1 Symptoms 10 Swollen Ankles
2 Fever 11 Shivering
3 Wheezing 12 Blood in the cough
4 Shortness of breath 13 Morning Headaches
5 Cough Dry 14 Dizzy spells
6 Productive Cough 15 Restlessness
7 Difficulty in blowing out air 16 Slurring of speech
8 Weight Loss
9 Tiredness and Fatigue
Step 4 and 5 – Framing if then rules and Developing
Labeled Dataset
On the basis of the symptoms If-then-rules were framed in
consultation with the doctors. The labeled dataset so
obtained is represented in Table 4.2
Table 4.2: Labeled dataset so obtained
Symptoms Present Predicted Diagnosis
High Fever, Shivering, Fatigue,
Blood in sputum
Pulmonary disease
(Pneumonia)
Wheezing, Dry Cough, Pulmonary Disease (Asthma)
Productive Cough, Fever, Morning
Headache,
Pulmonary Disease (COPD)
Difficulty in blowing out air,
Tiredness, Weight loss
Pulmonary Emphysema
Swelling of ankles, Dizzy spells,
Restlessness, Slurring of speech
Advanced Pulmonary
Disease (Advanced COPD)
Summarization of the results of the study is shown in Table
4.3.
Paper ID: 12013160 73
International Journal of Science and Research (IJSR), India Online ISSN: 2319-7064
Volume 2 Issue 9, September 2013
www.ijsr.net
Table 4.3: Summary of the results
Algorithm Logistic Regression RBF SVM Naïve
MAE 0.1 0.2 0.006 0.0003
AUC 1 1 0.994 1
KS 0.9878 1 0.988 1
RMSE 0.0781 0.1 0.078 0.002
FP 0.1 0.1 0.006 0.2
TP 1 1 0.993 1
Precision 1 1 0.994 1
Recall 1 1 0.993 1
4. Conclusion
The study was intended to develop a framework for
pulmonary disease diagnosis using Bayesian Belief
networks, to evaluate its effectiveness with respect to actual
diagnosis made by the physicians and compare the results
obtained with other prediction models.
As a pre-requisite to the study a dictionary of symptoms
was created, these symptoms. A focus group discussion
with doctors was carried out to group these symptoms in a
manner that would assist in making correct diagnosis.
The results of the study indicate that naïve bayes classifier
are better at predicting pulmonary diseases least MAE
indicates that there is minimal deviation in predicted
diagnosis and actual diagnosis being carried out by the
doctors. AUC, Kappa value, TP, Precision and Recall all
these parameters have values equal to 1. This is highly
significant as already stated AUC describes effectiveness in
predicting true positive rates averaged over all false positive
rates. A value of 1 effectively means successful prediction
of true positive rates. Unity value of Kappa statistics, True
Positive (TP) and Precision (accuracy) further reinforces the
effectiveness of Naïve Bayes Algorithm. Recall value is an
indicator of the ability of the algorithm to reproduce the
same results over a period of time. Recall value of 1 for
naïve bayes classifier indicate that the algorithm when
subjected to same conditions over different period of times
gives the same results, indicating high reliability of the
algorithm.
5. Future Scope
In a developing country like India having considerable
population living below the poverty line, there is an urgent
need to use information technology in medicine. One such
area where IT can be used is, in assisting the physicians to
diagnose a disease without much reliance on expensive
laboratory tests. Further, in-order to make health care
accessible and affordable to entire population of the
country, this (using IT) may be the only alternative.
The focus of the present study has been to develop a Naïve
Bayes for diagnosing pulmonary diseases. As the results
indicate the suggested algorithm performs better on most of
the parameters under study, however, further improvements
are possible. Table 5.1 indicates that probably more
accurate results can be obtained by combining Naïve Bayes
and RBF algorithms, since on some parameters (RMSE and
FP) RBF performs better than Naïve Bayes [7].
The present study only focuses on absence or presence of
pulmonary disease. It does not further go into pin pointing
the type of pulmonary disease (whether it is pneumonia,
asthma, COPD etc.). A more in depth study may be
required to go into the detailed analysis.
6. Acknowledgement
I am thankful to A P Nidhi, Assistant Professor, Swami
Vivekanand Institute of Engineering & Technology, Banur,
for providing constant guidance and encouragement for this
research work.
References
[1] L.Zhang, J.Luo, S.Yang. “Forecasting Box Office
Revenues of Movies with BP Neural Networks”.
Expert Systems with Applications 2009, vol. 36 (3)
part 2, page 6580-6587.
[2] K.J.Lee, W. Chang. “Bayesian Belief Network for Box
Office Performance: A Case Study of Korean Movies”.
Expert Systems with Applications, 2009, vol. 36 (1),
page 280-291.
[3] Nidhi and AP Gurpinder Kaur, Pulmonary Disease
Diagnosis Using Bayesian Belief Networks: a
Conceptual Framework, International Journal of
Advanced Research in Computer Science and Software
Engineering, Volume 3, Issue 6, June 2013.
[4] T.Charitos, L.C.V.Gaag, S Visscher. “A Dynamic
Bayesian Network for Diagnosing Ventilator
Associated Pneumonia in ICU Patients”. Expert
Systems with Applications 2009, vol. 36 (2), page
1249-1258.
[5] J. C. Burges, “A tutorial on support vector machines
for pattern recognition,” Data Mining and Knowledge
Discovery, vol. 2, no. 2, pp. 121–167, 1998.
[6] Y. W. Chen and C. J. Lin, “Combining SVMs with
various feature selection strategies,” Taiwan
University, vol. 207, pp. 315–324, 2006.
[7] N. Friedman, D. Geiger, and M. Goldszmidt, “Bayesian
network classifiers,” Machine Learning, vol. 29, no. 2-
3, pp.131–163, 1997.
Paper ID: 12013160 74

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Prediction for Pulmonary Disease Based on Diagnostic Reciepes and Classification

  • 1. International Journal of Science and Research (IJSR), India Online ISSN: 2319-7064 Volume 2 Issue 9, September 2013 www.ijsr.net Prediction for Pulmonary Disease Based on Diagnostic Reciepes and Classification 1 Nidhi, 2 AP Nidhi Department of Computer Science, Swami Vivekanand Institute of Engineering & Technology, Punjab Technical University, Jalandhar, India Abstract: In this research work we have developed a strategy in which the various parameters that influence the occurrence of pulmonary disease have been gathered from survey of doctors who specialize in diagnoses of pulmonary disease and diagnostic recipes involving if the else rules were built and given labels, which were used as target for machine learning algorithms [Logistic , SVM, RBF, Naïve Bayes ] for identification of input dataset of symptoms of subjects . Multiple designs of these classifiers were implemented and best possible machine algorithm was identified for implementing the complete methodology. Results shows that there was no absolute answer for the design and selection of best possible machine algorithm as evident from the results based on multiple statistical tests, therefore , distance from ideal values of statistical test to find best classifier with most optimized parameters was calculated and the classifier which had closest to these ideal values was found and declared the best classifier for identification of pulmonary diseases presence or absence .as per results naïve bayes classifier is performing best which is evident from the statistical test scores . Keywords: SVM, RBF, Naïve Bayes, Logistic, pulmonary. 1. Introduction Considerable population of the world does not have access to even bare minimum healthcare facilities. Majority of these are not able to avail these facilities because of lack of resources/funds, resultantly they suffer. Irony however is that most of the diseases are curable provided diagnosis and treatment is initiated at right time. Information Technology in general and predictive models in particular being used to facilitate the physicians in diagnosis of diseases. Bayesian networks have been extensively used in developing computer based systems for diagnosis of various diseases. The purpose of using these computer based systems in healthcare is to reduce the chances of faulty diagnosis and prevent cost and time over runs. However, the scope of the study in this research work will be limited as we will be confined to the information obtained. Doctors and dentists along with pilots, police, miners and social workers are considered to be members of high stress occupations [1]. This primarily is because of the reason that in these professions scope for error is minimal and in case a mistake happens there is a direct impact on the human life and psyche. It is therefore of utmost importance that people engaged in these professions exercise extreme precaution in decision making and ensure minimal error. In a country like India incorrect diagnosis may have severe implications. The current annual per capita public expenditure on health in the country is no more than Rupees Two Hundred, which is among the five lowest in the world. As per National Health Accounts [2], the total health expenditure in India from all the sources was Rupees 1, 33,776 crores, consisting of 4.25 percent of the GDP. Of the total health expenditure, the share of private sector was highest at 78 percent (private individual households 71 percent and private firms 7 percent); public sector at 20 percent (Central Government 7 percent, State Government 12 percent and Local Government 1 percent) and external flows contributed about 2 percent. Figure 1: (Health Expenditure India – 2004) - Source: National health accounts 2004-2005 It has been estimated that less than 20 percent of the population, which seek OPD and less than 45 percent of that which seek indoor treatment avail of such services in public hospitals. These is despite the fact that most of these patients do not have the means to make out – of – pocket payment for private health services except at the cost of other essential expenditure for items such as basic nutrition. Stated plainly this means most of the people in India do not have the capacity to pay for the expensive tests. As such, it is very important for the doctors to make a correct diagnosis and if possible with minimum reliance on laboratory tests and more on their expertise based upon the presenting symptoms. The present study is targeted to assist the doctors in making correct diagnosis by using the advantages offered by computer based systems. Computer based systems are expert systems designed to process knowledge and reach diagnostic decisions in the same way as human experts. 2. Proposed Work Since there is an urgent need to automate the process of analysis of the datasets of symptoms in terms of taking advantage of machine algorithms, so that availability of large datasets of symptoms of patients suffering from Paper ID: 12013160 72
  • 2. International Journal of Science and Research (IJSR), India Online ISSN: 2319-7064 Volume 2 Issue 9, September 2013 www.ijsr.net diseases can come aid to the current medical practitioner to diagnose diseased that can be easily be identified by using diagnostic recipes based on the experience of the doctors. Therefore, we suggest method that can utilize in both the alternative and mainstream medical field for easy and accurate diagnostics of patients having pulmonary disease or not. 3. Implementation Steps/Results 1) Literature survey and interaction with specialists for collecting information pertaining to pulmonary diseases. 2) Collection of data pertaining to symptom matrix. 3) Data preprocessing to remove missing and superfluous values. 4) Framing “If-then rules” to labeling and identification of PD 5) Generating labeled dataset on the basis of these rules. 6) Running classifiers and selecting the most accurate classifier. Figure 3.1: Flow chart of the entire methodology The data pertaining to parameters under study were collected from the leading Bollywood websites.  Data Normalization must be used to reduce the number of samples and the complexity of the neural network and the computation time of the neural network.  For the classification schemes, it was found that training the model with a large number of test data and with fast training algorithm would greatly enhance the accuracy and hence the reliability of the system.  The design of our classifier was done by running the neural network with different number of hidden layers and it was apparent from the graphs that it affected the accuracy [3]  It was found that as we increase the number of hidden layers there was also an increase in computation time but high order of accuracy is also achieved until we have reached the maximum of hidden layers, therefore, we need an optimal combination of parameters to achieve 93.3% accuracy Figure 3.1 Methodology Flow Chart Step 1: Identification of the symptoms Preliminary data bank of symptoms - For this study initial data bank of symptoms was collected on the basis of a survey questionnaire to be administered to doctors seeking their opinion and rating of symptoms based upon the strength to correctly predict pulmonary disease. An initial data bank was thus developed for further classification and study. This was followed by prioritizing the symptoms for accurate disease prediction and diagnosis. Symptom Selection - Symptom selection was regarded as the problem of feature selection. Symptoms are essential to diagnose a disease. Therefore, a strong predicting model of syndrome is based on key symptoms. In this phase, we investigated which symptoms influence the predicted syndromes most. [5] Step 2 and 3 – Creation of symptom matrix Based upon the above process a symptom matrix representing the symptoms associated with pulmonary diseases was created Table 4.1. Table 4.1: Symptom Matrix 1 Symptoms 10 Swollen Ankles 2 Fever 11 Shivering 3 Wheezing 12 Blood in the cough 4 Shortness of breath 13 Morning Headaches 5 Cough Dry 14 Dizzy spells 6 Productive Cough 15 Restlessness 7 Difficulty in blowing out air 16 Slurring of speech 8 Weight Loss 9 Tiredness and Fatigue Step 4 and 5 – Framing if then rules and Developing Labeled Dataset On the basis of the symptoms If-then-rules were framed in consultation with the doctors. The labeled dataset so obtained is represented in Table 4.2 Table 4.2: Labeled dataset so obtained Symptoms Present Predicted Diagnosis High Fever, Shivering, Fatigue, Blood in sputum Pulmonary disease (Pneumonia) Wheezing, Dry Cough, Pulmonary Disease (Asthma) Productive Cough, Fever, Morning Headache, Pulmonary Disease (COPD) Difficulty in blowing out air, Tiredness, Weight loss Pulmonary Emphysema Swelling of ankles, Dizzy spells, Restlessness, Slurring of speech Advanced Pulmonary Disease (Advanced COPD) Summarization of the results of the study is shown in Table 4.3. Paper ID: 12013160 73
  • 3. International Journal of Science and Research (IJSR), India Online ISSN: 2319-7064 Volume 2 Issue 9, September 2013 www.ijsr.net Table 4.3: Summary of the results Algorithm Logistic Regression RBF SVM Naïve MAE 0.1 0.2 0.006 0.0003 AUC 1 1 0.994 1 KS 0.9878 1 0.988 1 RMSE 0.0781 0.1 0.078 0.002 FP 0.1 0.1 0.006 0.2 TP 1 1 0.993 1 Precision 1 1 0.994 1 Recall 1 1 0.993 1 4. Conclusion The study was intended to develop a framework for pulmonary disease diagnosis using Bayesian Belief networks, to evaluate its effectiveness with respect to actual diagnosis made by the physicians and compare the results obtained with other prediction models. As a pre-requisite to the study a dictionary of symptoms was created, these symptoms. A focus group discussion with doctors was carried out to group these symptoms in a manner that would assist in making correct diagnosis. The results of the study indicate that naïve bayes classifier are better at predicting pulmonary diseases least MAE indicates that there is minimal deviation in predicted diagnosis and actual diagnosis being carried out by the doctors. AUC, Kappa value, TP, Precision and Recall all these parameters have values equal to 1. This is highly significant as already stated AUC describes effectiveness in predicting true positive rates averaged over all false positive rates. A value of 1 effectively means successful prediction of true positive rates. Unity value of Kappa statistics, True Positive (TP) and Precision (accuracy) further reinforces the effectiveness of Naïve Bayes Algorithm. Recall value is an indicator of the ability of the algorithm to reproduce the same results over a period of time. Recall value of 1 for naïve bayes classifier indicate that the algorithm when subjected to same conditions over different period of times gives the same results, indicating high reliability of the algorithm. 5. Future Scope In a developing country like India having considerable population living below the poverty line, there is an urgent need to use information technology in medicine. One such area where IT can be used is, in assisting the physicians to diagnose a disease without much reliance on expensive laboratory tests. Further, in-order to make health care accessible and affordable to entire population of the country, this (using IT) may be the only alternative. The focus of the present study has been to develop a Naïve Bayes for diagnosing pulmonary diseases. As the results indicate the suggested algorithm performs better on most of the parameters under study, however, further improvements are possible. Table 5.1 indicates that probably more accurate results can be obtained by combining Naïve Bayes and RBF algorithms, since on some parameters (RMSE and FP) RBF performs better than Naïve Bayes [7]. The present study only focuses on absence or presence of pulmonary disease. It does not further go into pin pointing the type of pulmonary disease (whether it is pneumonia, asthma, COPD etc.). A more in depth study may be required to go into the detailed analysis. 6. Acknowledgement I am thankful to A P Nidhi, Assistant Professor, Swami Vivekanand Institute of Engineering & Technology, Banur, for providing constant guidance and encouragement for this research work. References [1] L.Zhang, J.Luo, S.Yang. “Forecasting Box Office Revenues of Movies with BP Neural Networks”. Expert Systems with Applications 2009, vol. 36 (3) part 2, page 6580-6587. [2] K.J.Lee, W. Chang. “Bayesian Belief Network for Box Office Performance: A Case Study of Korean Movies”. Expert Systems with Applications, 2009, vol. 36 (1), page 280-291. [3] Nidhi and AP Gurpinder Kaur, Pulmonary Disease Diagnosis Using Bayesian Belief Networks: a Conceptual Framework, International Journal of Advanced Research in Computer Science and Software Engineering, Volume 3, Issue 6, June 2013. [4] T.Charitos, L.C.V.Gaag, S Visscher. “A Dynamic Bayesian Network for Diagnosing Ventilator Associated Pneumonia in ICU Patients”. Expert Systems with Applications 2009, vol. 36 (2), page 1249-1258. [5] J. C. Burges, “A tutorial on support vector machines for pattern recognition,” Data Mining and Knowledge Discovery, vol. 2, no. 2, pp. 121–167, 1998. [6] Y. W. Chen and C. J. Lin, “Combining SVMs with various feature selection strategies,” Taiwan University, vol. 207, pp. 315–324, 2006. [7] N. Friedman, D. Geiger, and M. Goldszmidt, “Bayesian network classifiers,” Machine Learning, vol. 29, no. 2- 3, pp.131–163, 1997. Paper ID: 12013160 74