7. COMMON
SITES
OF
EXTRAPULMONARY
TUBERCULOSIS
SITE
Percentage
of
extrapulmonary
cases
Pleura
20-‐25
LymphaPcs
20-‐40
Genitourinary
5-‐18
Bone/joint
10
Central
nervous
system
5-‐7
Abdominal
4
Disseminated
7-‐11
8. FaMori
predisponenP
le
forme
di
TBC
extrapolmonare
• Razza
(neri,
indiani…….)
• Età
(bambini)
• Sesso
(femminile)
•
HIV/AIDS
• MicobaMeri
(ceppo
Beijing/w)
• ……………………………………………..
8
17. Correlation Between Extent of HIV-Induced Immuno-
Suppression and Clinical Manifestation of Tuberculosis
Duration of HIV infection
MedianCD4cellcount/mm3
0
100
200
300
400
500
De Cock KM, et al. J Am Med Assoc 1992;268:1581-7
Pulmonary tuberculosis
Lymphatic, serous tuberculosis
Tuberculous meningitis
Disseminated tuberculosis
29. HISTORY
of
Tuberculosis
Tuberculosis
Is
an
Ancient
Disease
Spinal
Tuberculosis
in
EgypLan
Mummies
History
dates
to
1550
–
1080
BC
IdenLfied
by
PCR
Dr.T.V.Rao MD 29
38. Genitourinary
Tuberculosis
• Direct
infecPon
or
amyloidosis
• Granulomas
in
glomeruli
heal
or
caseate
• Dysuria
and
hematuria
• IVP
helpful
• Upper
and
lower
GU
tract
60. Pott’s disease
• This
enPty
was
first
described
by
Percivall
PoM.
He
noted
this
as
a
painful
kyphoPc
deformity
of
the
spine
associated
with
paraplegia.
•
Tuberculosis
of
the
spine
is
one
of
the
oldest
diseases
afflicPng
humans.
Evidences
of
spinal
tuberculosis
have
been
found
in
EgypPan
mummies
daPng
back
to
3400
BC
61. MUMMY OF A TB SPINE AND CT SHOWING LESION T10/T11
82. 0
5
10
15
20
25
30
35
40
I Z R RIZE
%
< 70 anni
> 70 anni
EPATITE RASH INTOLLERANZA
GASTRICA
TUBERCOLOSI 2005: EFFETTI COLLATERALI
Istituto Malattie Infettive Università di Verona
