This document provides guidelines for assessing the health of a newborn infant. It describes evaluating the infant's history including prenatal and delivery factors. Physical appearance is assessed including skin, tone, head size and overall appearance. Vital signs like temperature, heart rate, respiratory rate and status are examined. Laboratory tests including arterial and capillary blood samples are outlined. Gestational age assessment tools like the Dubowitz Scale and Ballard Scale are presented. Proper technique for obtaining capillary blood samples is also covered.
Basic examination of a newborn. A primer for postgraduate medical students to understand how to examine a just-born baby. Taken from a standard book, this presentation is a summary of the entire book.
This presentation is aimed at giving the basic information of a neonate classification on basis of gestational age and the birth weight. Prematurity has been discussed in details. I have also included the growth charts that can be used for growth monitoring in term as well as preterm babies.
** This presentation is available in a video lecture format at my youtube channel - NeonatoHub. Do watch it for further understanding of the topic & subscribe to the channel.
Hypothermia occurs when the newborn’s temperature drops below 36.3°C.
The smaller or more premature the newborn is, the greater the risk of heat loss. When heat loss exceeds the newborn’s ability to produce heat, its body temperature drops below the normal range and the newborn becomes hypothermic.
Early prevention measures are vital.
Health Assessment of the Newborn
The newborn requires thorough skilled observation to ensure a satisfactory adjustment to extra uterine life.
Health assessment of newborn after delivery can be divided into:
1. Initial Assessment
2. Transitional Assessment
3. Assessment of gestational age
4. Behavioural asessment
5. Systemic physical examination
Initial Assessment:
Initial assessment is done by using the APGAR scoring system.
APGAR score: It is method use to assess the newborn’s immediate adjustment to extra uterine life.
• The score based on five signs
1. Appearance (colour)
2. Pulse (Heart rate)
3. Grimace (Reflex irritability )
4. Activity (Muscle tone)
5. Respiratory rate
• Each item is given a score 0, 1, or 2
• 0-3 severe distress
• 4-6 moderate difficulty
• 7-10 no difficulty adjusting to life
• Evaluations of all five categories are made on 1-5 min after birth.
APGAR score:
Sign 0 1 2
Appearance (colour) Blue or pale Body pink, Extrimities Blue Completely Pink
Pulse (Heart rate) Absent Slow (<100 /> 100/m
Grimace (Reflex irritability ) No response Grimace Cough Or Sneeze
Activity(Muscle tone Limp Some flexion Active movement
Respiratory rate Absent Slow, Irregular Good, Crying
Other initial assessment are-
• Stabilization
• Measuring weight.
Transitional Assessment during the period of reactivity
First period of reactivity (6- 8 hours after birth):
During the first 30 minutes the newborn is very alert, cries vigorously, may suck a first greedily, and appears very interested in the environment. Physiologically the respiratory rate can be as high as 80 breaths/ min, crackles may be heard, heart rate may reach 180 beats/min, bowel sound are active, mucus secretions are increased and temperature may decrease slightly.
Second period of reactivity:
Began when the newborn awake from the deep sleep, it lasts about 2-5 hours. The newborn is alert and responsive, heart and respiratory rate are increased, gastric and respiratory secretions are increased, and passage of meconium commonly occurs.
Following this stage is a period of stabilization of physiologic systems & vacillating patern of sleep & activity.
Basic examination of a newborn. A primer for postgraduate medical students to understand how to examine a just-born baby. Taken from a standard book, this presentation is a summary of the entire book.
This presentation is aimed at giving the basic information of a neonate classification on basis of gestational age and the birth weight. Prematurity has been discussed in details. I have also included the growth charts that can be used for growth monitoring in term as well as preterm babies.
** This presentation is available in a video lecture format at my youtube channel - NeonatoHub. Do watch it for further understanding of the topic & subscribe to the channel.
Hypothermia occurs when the newborn’s temperature drops below 36.3°C.
The smaller or more premature the newborn is, the greater the risk of heat loss. When heat loss exceeds the newborn’s ability to produce heat, its body temperature drops below the normal range and the newborn becomes hypothermic.
Early prevention measures are vital.
Health Assessment of the Newborn
The newborn requires thorough skilled observation to ensure a satisfactory adjustment to extra uterine life.
Health assessment of newborn after delivery can be divided into:
1. Initial Assessment
2. Transitional Assessment
3. Assessment of gestational age
4. Behavioural asessment
5. Systemic physical examination
Initial Assessment:
Initial assessment is done by using the APGAR scoring system.
APGAR score: It is method use to assess the newborn’s immediate adjustment to extra uterine life.
• The score based on five signs
1. Appearance (colour)
2. Pulse (Heart rate)
3. Grimace (Reflex irritability )
4. Activity (Muscle tone)
5. Respiratory rate
• Each item is given a score 0, 1, or 2
• 0-3 severe distress
• 4-6 moderate difficulty
• 7-10 no difficulty adjusting to life
• Evaluations of all five categories are made on 1-5 min after birth.
APGAR score:
Sign 0 1 2
Appearance (colour) Blue or pale Body pink, Extrimities Blue Completely Pink
Pulse (Heart rate) Absent Slow (<100 /> 100/m
Grimace (Reflex irritability ) No response Grimace Cough Or Sneeze
Activity(Muscle tone Limp Some flexion Active movement
Respiratory rate Absent Slow, Irregular Good, Crying
Other initial assessment are-
• Stabilization
• Measuring weight.
Transitional Assessment during the period of reactivity
First period of reactivity (6- 8 hours after birth):
During the first 30 minutes the newborn is very alert, cries vigorously, may suck a first greedily, and appears very interested in the environment. Physiologically the respiratory rate can be as high as 80 breaths/ min, crackles may be heard, heart rate may reach 180 beats/min, bowel sound are active, mucus secretions are increased and temperature may decrease slightly.
Second period of reactivity:
Began when the newborn awake from the deep sleep, it lasts about 2-5 hours. The newborn is alert and responsive, heart and respiratory rate are increased, gastric and respiratory secretions are increased, and passage of meconium commonly occurs.
Following this stage is a period of stabilization of physiologic systems & vacillating patern of sleep & activity.
Topic 03: Health Assessment of the Newborn
The newborn requires thorough skilled observation to ensure a satisfactory adjustment to extra uterine life.
Health assessment of newborn after delivery can be divided into:
1. Initial Assessment
2. Transitional Assessment
3. Assessment of gestational age
4. Behavioural asessment
5. Systemic physical examination
Initial Assessment:
Initial assessment is done by using the APGAR scoring system.
APGAR score: It is method use to assess the newborn’s immediate adjustment to extra uterine life.
• The score based on five signs
1. Appearance (colour)
2. Pulse (Heart rate)
3. Grimace (Reflex irritability )
4. Activity (Muscle tone)
5. Respiratory rate
• Each item is given a score 0, 1, or 2
• 0-3 severe distress
• 4-6 moderate difficulty
• 7-10 no difficulty adjusting to life
• Evaluations of all five categories are made on 1-5 min after birth.
APGAR score:
Sign 0 1 2
Appearance (colour) Blue or pale Body pink, Extrimities Blue Completely Pink
Pulse (Heart rate) Absent Slow (<100 /> 100/m
Grimace (Reflex irritability ) No response Grimace Cough Or Sneeze
Activity(Muscle tone Limp Some flexion Active movement
Respiratory rate Absent Slow, Irregular Good, Crying
Other initial assessment are-
• Stabilization
• Measuring weight.
Transitional Assessment during the period of reactivity
First period of reactivity (6- 8 hours after birth):
During the first 30 minutes the newborn is very alert, cries vigorously, may suck a first greedily, and appears very interested in the environment. Physiologically the respiratory rate can be as high as 80 breaths/ min, crackles may be heard, heart rate may reach 180 beats/min, bowel sound are active, mucus secretions are increased and temperature may decrease slightly.
Second period of reactivity:
Began when the newborn awake from the deep sleep, it lasts about 2-5 hours. The newborn is alert and responsive, heart and respiratory rate are increased, gastric and respiratory secretions are increased, and passage of meconium commonly occurs.
Following this stage is a period of stabilization of physiologic systems & vacillating patern of sleep & activity.
Gestational Age Assessment
An accurate assessment of age is important for 2 reasons
• Age and growth patterns appropriate to that age aid in identifying neonatal risks
• Help in developing management plans
Gestational age can measure by weight for gestational age chart.
Gestational Age Number of weeks that have elapsed since the first day of the last menstrual period to the time of birth. This is usually retrieved from mother’s Antenatal History.
Gestational Age:
• SGA- small for gestational age-weight below 10th percentile •
• AGA-weight between 10 and 90th percentiles
• LGA-weight above 90th percentile
Behavioural Assessment
While babies may not speak their first word for a year, they are born
Newborn Examination
History taking
General Examination
Systemic Examination
Newborn reflexes
Reference : Paediatric clinical examination by Dr Santhosh Kumar
Prepared by Binisha Sebby,
Final year Medical Student,
Dr SMCSI Medical College,
Karakonam, Trivandrum, Kerala
baby born before 37 weeks of gestation calculating from the first day of last menstural period is defined as preterm baby/ premature baby.
These babies are known as preemies
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Defecation
Normal defecation begins with movement in the left colon, moving stool toward the anus. When stool reaches the rectum, the distention causes relaxation of the internal sphincter and an awareness of the need to defecate. At the time of defecation, the external sphincter relaxes, and abdominal muscles contract, increasing intrarectal pressure and forcing the stool out
The Valsalva maneuver exerts pressure to expel faeces through a voluntary contraction of the abdominal muscles while maintaining forced expiration against a closed airway. Patients with cardiovascular disease, glaucoma, increased intracranial pressure, or a new surgical wound are at greater risk for cardiac dysrhythmias and elevated blood pressure with the Valsalva maneuver and need to avoid straining to pass the stool.
Normal defecation is painless, resulting in passage of soft, formed stool
CONSTIPATION
Constipation is a symptom, not a disease. Improper diet, reduced fluid intake, lack of exercise, and certain medications can cause constipation. For example, patients receiving opiates for pain after surgery often require a stool softener or laxative to prevent constipation. The signs of constipation include infrequent bowel movements (less than every 3 days), difficulty passing stools, excessive straining, inability to defecate at will, and hard feaces
IMPACTION
Fecal impaction results from unrelieved constipation. It is a collection of hardened feces wedged in the rectum that a person cannot expel. In cases of severe impaction the mass extends up into the sigmoid colon.
DIARRHEA
Diarrhea is an increase in the number of stools and the passage of liquid, unformed feces. It is associated with disorders affecting digestion, absorption, and secretion in the GI tract. Intestinal contents pass through the small and large intestine too quickly to allow for the usual absorption of fluid and nutrients. Irritation within the colon results in increased mucus secretion. As a result, feces become watery, and the patient is unable to control the urge to defecate. Normally an anal bag is safe and effective in long-term treatment of patients with fecal incontinence at home, in hospice, or in the hospital. Fecal incontinence is expensive and a potentially dangerous condition in terms of contamination and risk of skin ulceration
HEMORRHOIDS
Hemorrhoids are dilated, engorged veins in the lining of the rectum. They are either external or internal.
FLATULENCE
As gas accumulates in the lumen of the intestines, the bowel wall stretches and distends (flatulence). It is a common cause of abdominal fullness, pain, and cramping. Normally intestinal gas escapes through the mouth (belching) or the anus (passing of flatus)
FECAL INCONTINENCE
Fecal incontinence is the inability to control passage of feces and gas from the anus. Incontinence harms a patient’s body image
PREPARATION AND GIVING OF LAXATIVESACCORDING TO POTTER AND PERRY,
An enema is the instillation of a solution into the rectum and sig
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3. History – Prenatal
• Problems during pregnancy
– Eclampsia
– History of drug abuse
– Maternal history of diabetes
– History of infections
4. History – Labor
• Length of labor
• Difficulties during labor
• Monitoring results
during labor
5. History – Delivery
• APGAR scores
• Presentation
• Interventions in
the delivery room
6. Physical Examination – Assessment of
Gestational Age
• Two primary evaluation tools used to
determine gestational age
– Dubowitz Scale
– Ballard Scale
7. Dubowitz Scale – External Superficial
Criteria
EXTERNAL
SIGN
SCORE RECORD
SCORE
0 1 2 3 4 HERE
EDEMA
Obvious
edema of
hands &
feet; pitting
over tibia
No obvious
edema of
hands &
feet; pitting
over tibia
No edema
SKIN TEXTURE
Very thin,
gelatinous
Thin &
smooth
Smooth,
medium
thickness.
Rash or
superficial
peeling
Slight
thickening.
Superficial
cracking and
peeling, esp.
hands, feet
Thick and
parchment
like;
superficial or
deep cracking
SKIN COLOR
(Infant not crying)
Dark red
Uniformly
pink
Pale pink,
variable over
body
Pale. Only
pink over
ears, lips
palms, or
soles
SKIN CAPACITY
(Trunk)
Numerous
veins and
venules
clearly seen,
esp. over
abdomen
Veins and
tributaries
seen
A few large
vessels
clearly seen
over
abdomen
A few large
vessels seen
indistinctly
over
abdomen
No blood
vessels seen
8. Dubowitz Scale – External Superficial
Criteria – Cont
EXTERNAL
SIGN
SCORE RECORD
SCORE
0 1 2 3 4 HERE
LANUGO
(Over back)
No lanugo
Abundant;
long thick
over whole
back
Hair
thinning,
esp. over
lower back
Small
amount of
lanugo and
bald areas
At lest half of
back devoid
of lanugo
PLANTAR
CREASES
No skin
creases
Faint red
marks over
anterior half
of sole
Definite red
marks over
more than
anterior half;
indentations
over less
than anterior
third
Indentations
over more
than anterior
third
Definite deep
indentations
over more
than anterior
third
NIPPLE
FORMATION
Nipple
barely
visible; nor
areola
Nipple well-defined;
areola
smooth and
flat; diameter
< 0.75 cm
Areola
stippled,
edge not
raised;
diameter
< 0.75 cm
BREAST SIZE
No breast
tissue
palpable
Breast tissue
on one or
both side
<0.5 cm
diameter
Breast tissue
both sides,
one or both
0.5-1.0 cm
9. Dubowitz Scale – External Superficial
Criteria – Cont
EXTERNAL
SIGN
SCORE RECORD
SCORE
0 1 2 3 4 HERE
EAR FORM
Pinna flat
and
shapeless,
or no
incurving of
edge
Incurving of
part of edge
of pinna
Partial
incurving of
whole of
upper pinna
EAR FIRMNESS
Pinna soft,
easily
folded, no
recoil
Pinna, soft,
easily
folded, slow
recoil
Cartilage to
edge of
pinna, but
soft in
places,
ready recoil
Pinna firm,
cartilage to
edge, instant
recoil
GENITALIA
MALE/FEMALE (With
hips half abducted)
Neither testi
in scrotum
Labia majora
widely
separated,
labia minora
protruding
At lest one
testis high in
scrotum
Labia majora
almost cover
labia minora
At least one
testis fully
descended.
Labia majora
complete
cover labia
minora
10. Dubowitz Scale – Neurological Criteria
Neurological
Sign
Score Record
Score
Here
0 1 2 3 4 5
Posture
Square
Window
Ankle
Dorsiflexion
Arm Recoil
Leg Recoil
Popliteal Angel
Heel to Ear
Scarf Sign
Head lag
Ventral
Suspension
14. Physical Examination – Assessment of
Gestational Age
• Necessary to determine course of
infant and anticipate problems that
may occur
15. Physical Examination – Physical
Appearance
• Skin
– Generally pink
– During first 24 hours of life, may have
acrocyanosis, bluish tinge of the hands and feet
16. Physical Examination – Physical
Appearance
• Skin
– Yellowish tinge
• Indicates the presence of hyperbilirubinemia
with bilirubin level > 4 mg/dL
17. Physical Examination – Physical
Appearance
• Skin
– Yellowish Tinge
• Physiologic jaundice
– Present in many infants first few days after birth
– Caused by break down of fetal red blood cells
and inability of neonatal liver to conjugate the
bilirubin
18. Physical Examination – Physical
Appearance
• Skin
– Yellowish tinge
• Physiologic jaundice
– Normally does not require treatment or may
require exposure to phototherapy lights or
sunlight to aid in lowering the level of bilirubin
19. Physical Examination – Physical
Appearance
• Skin
– Yellowish Tinge
• Pathologic jaundice
– Appears within first 24 hours of life
– Indirect bilirubin levels > 13 mg/dL in term infants or >
15 mg/dL in premature infants
– Direct bilirubin levels > 1.5 mg/Dl
– Indirect levels rise greater than 5 mg/dL in 24 hour
period
20. Physical Examination – Physical
Appearance
• Skin
• Pathologic Jaundice
– Causes Kernicterus
» Bilirubin encephalopathy
Kernicterus
» May result in neurological deficits, including
locomotor dysfunction, cerebral palsy, and
hearing impairment
» In extreme cases, may be treated by exchange
transfusion
22. Physical Examination – Physical
Appearance
• Skin
– Pale
• Indicates severe anemia
• May result from Rh incompatibility
• May result from placental abruption
23. Physical Examination – Physical
Appearance
• Skin
– Vernix
• White, cream cheese-like
material covering
the fetus
• Indicative of prematurity
• Decreases at week 36 and disappears by week 41
24. Physical Examination – Physical
Appearance
• Lanugo
– Fine, downy hair covering the fetus
– Thins around week 28 and disappears by week
32
25. Physical Examination – Physical
Appearance
• General overall tone
– Asymmetry in movement
• Birth injury
• Paralysis
• Neurological impairment
26. Physical Examination – Physical
Appearance
• General overall tone
– Usually in fetal position
• Legs drawn to abdomen, arms flexed, tight to body
27. Physical Examination – Physical
Appearance
• Overall appearance
– Head in proportion to body
• Large head may indicate hydrocephaly
• Small head may indicate microcephaly or
anencephaly
31. Physical Examination – Physical
Appearance
• Overall appearance
– Abdomen
• Should move up as chest moves up
• Lag on inspiration indicates mild distress
• Opposing movement (see-saw movement) in
relation to chest indicates severe distress
32. Physical Examination – Physical
Appearance
• Overall appearance
– Scaphoid abdomen
• Concave abdomen
• May indicate diaphragmatic hernia or
agenesis of abdominal organs
– No obvious defects or abnormalities
33. Physical Examination – Vital Signs
• Temperature
– Normal value – 37⁰ C
– Axillary temperature
most common site
34. Physical Examination – Vital Signs
• Temperature
– Neutral thermal environment
• Environmental temperature at which infant’s metabolic
demands and oxygen consumption is minimized
– Chilling the infant causes increasing metabolic rate
and oxygen consumption; infants incapable of
shivering to respond to cold
– Overheating infant increases metabolism as infant
tries to cool; may cause apnea
35. Physical Examination – Vital Signs
• Temperature
– Neutral thermal environment
• Based upon weight and gestational age
• Ratio of body surface area to body mass is
greater in newborn, so heat loss is increased in
comparison to adult; in 1 kg infant, heat loss is
6 times greater
36. Physical Examination – Vital Signs
• Heart rate
– Normal Value – 120 to 160 beats per minute
– Measured either apically or at the brachial artery
37. Physical Examination – Vital Signs
• Respiratory rate
– May be observed, but most accurate if counted
via auscultation
– Normal value – 30 to 60 breaths per minute
38. Physical Examination – Vital Signs
• Respiratory rate
– Periodic breathing
• Periods of apnea lasting less than 20 seconds
• Common in pre-term infants
• No change in heart rate observed
39. Physical Examination – Vital Signs
• Respiratory rate
– True apnea
• Lasts at least 20 seconds
• Accompanied by bradycardia
40. Physical Examination – Vital Signs
• Respiratory rate
– True apnea
• Primary apnea
– Initial apnea after attempt at breathing
– Responds to stimulation
41. Physical Examination – Vital Signs
• Respiratory rate
– True apnea
• Secondary apnea
– Occurs after continuing oxygen deprivation
and attempts to gasp
– Does not respond to stimulation; assisted
ventilation required
42. Physical Examination – Vital Signs
• Respiratory status
– Retractions
• Inward movement of the skin of the chest during
inspiration
44. Physical Examination – Vital Signs
• Respiratory status
– Retractions
• Indicates respiratory distress, increased
inspiratory effort
• Intercostal retractions – occur between the ribs
• Xyphoid retractions – occur as the xyphoid is
drawn inward
45. Physical Examination – Vital Signs
• Respiratory status
– Nasal flaring
• Widening of the nares during inspiration and
returning to normal during expiration
• Attempt by the infant to get more volume into the
lungs
• Uses principle of Poiseuille’s Law
46. Physical Examination – Vital Signs
• Respiratory status
– Expiratory grunt
• Sound produced as infant exhales against a
partially closed glottis
• Analogous to pursed lip breathing in COPD
patients
• Used instinctively to generate positive pressure in
the airway to maintain integrity of the alveoli
47. Physical Examination – Vital Signs
• Respiratory status
– Silverman-Anderson Index
• Used to evaluate respiratory status
48. Silverman-Anderson Index
Upper Chest
Lower
Chest
Xyphoid
Retractions
Nasal
Flaring
Expiratory
Grunt
0 Synchronized
No
Retractions
None None None
1
Lag on
Inspiration
Just Visible Just Visible Minimal
Audible on
Auscultation
Only
2 See-Saw Marked Marked Marked
Audible With
Naked Ear
• Significance of Silverman-Anderson Score – the Greater the
Number, the More Distress the Infant is in
49. Laboratory Data – Arterial Samples
• Umbilical artery
– Preferred site
– May not produce valid results in presence of
patent ductus arteriosus
– May cause infection or thromboembolism
50. Laboratory Data – Arterial Samples
• Radial artery
– More difficult to obtain
– May be inaccurate secondary to crying induced
by pain of
stick
51. Laboratory Data – Arterial Samples
• Radial artery
– Used to determine presence of patent ductus
arteriosus – compare samples from right radial
artery and umbilical artery (more common
method is echocardiogram)
52. Laboratory Data – Arterial Samples
• Normal values for neonatal arterial samples
– PaO2 – 50 to 70 mmHg
– PaCO2 – 35 to 45 mmHg
– pH – 7.35 to 7.45
– HCO3
- − 22 to 26 mEq/L
53. Laboratory Data – Capillary Samples
• Less hazardous and more easily obtained
than arterial sticks
• Useful in assessing pH and PCO2
– PCO2 and pH will approximate arterial values
– PO2 less than arterial value, but degree of
variation is unreliable for management
54. Laboratory Data – Capillary Samples
• Indications
– Arterial blood gas analysis is indicated but not
available
– Non-invasive monitor readings are abnormal
– Assessment of initiation, administration, or
change in therapeutic modalities is indicated
55. Laboratory Data – Capillary Samples
• Indications
– Change in patient status is detected by history
or physical assessment
– Monitoring of the severity and progression of a
documented disease process is desirable
56. Laboratory Data – Capillary Samples
• Contraindications
– Unsuitable sites are only sites available
• Posterior curvature of heel
• Finger of neonate
• Previous puncture site
• Inflamed, swollen, or edematous tissue
57. Laboratory Data – Capillary Samples
• Contraindications
– Unsuitable sites are only sites available
• Cyanotic or poorly perfused tissue
• Localized areas of infection
• Peripheral arteries
58. Laboratory Data – Capillary Samples
• Contraindications
– Patients less than 24 hours old
– Need for direct analysis of oxygenation
– Peripheral vasoconstriction
– Polycythemia
– Hypotension
59. Laboratory Data – Capillary Samples
• Hazards and complications
– Infection
– Burns
– Hematomas
– Bone calcification
60. Laboratory Data – Capillary Samples
• Hazards and complications
– Nerve damage
– Bruising
– Scarring
61. Laboratory Data – Capillary Samples
• Hazards and complications
– Laceration of tibial artery
– Pain
– Hemorrhage
62. Technique for Obtaining a Capillary
Sample
• Verify physician’s order and need for
procedure
• Ensure that the conditions of the patient have
not changed, e.g., no
change in FIO2
• Assemble the required
supplies
63. Technique for Obtaining a Capillary
Sample
• Wash hands and don gloves
• Warm the heel to approximately 42⁰ C
using a heat pack or other method
• Clean the area
with an antiseptic
solution
64. Technique for Obtaining a Capillary
Sample
• Puncture the skin with the lancet
• Wipe away the first
drop of blood and
observe flow
• Do not squeeze
65. Technique for Obtaining a Capillary
Sample
• Fill the sample tube
from the middle of the
drop of blood
• Place the metal flea in
the capillary tube and
seal both ends
66. Technique for Obtaining a Capillary
Sample
• Cover the site of the puncture with a
band-aid or sterile cotton
• Mix the sample by moving the flea back
and forth using the magnet
67. Technique for Obtaining a Capillary
Sample
• Place the sample in an icy slush for
transport
• Dispose of contaminated
materials properly
• Document the procedure