This document summarizes and comments on two scientific articles about recent research into noncoding RNA and developing vaccines for viruses. The first article discusses the discovery of a long noncoding RNA that regulates innate immunity and inflammation. The second describes work using a "genetic poison pill" to minimize mutations in a virus's RNA polymerase and reduce its ability to replicate when developing vaccines. The student observes that both studies could provide insights into treating inflammatory diseases and developing protections against lethal viruses.

1. Transcription,gene
regulation and operons
Mateo Torres Ceballos
Medicine Student

4. Introduction
Transcription is an
impor tant process
during the expression
of the DNA
Some studies try to
create a vaccine to
prevent from virus for
example from
coxsackievirus

5. Long noncoding RNA found to
quell inflammation
University of Massachusetts Medical
School
(2016, July 14).

6. Long noncoding RNA found to quell
inflammation
A long noncoding RNA is
responsible for regulating
the innate immunity and
i s v e r y c a r e f u l l y
regulated
Found in
Microphages

7. Long noncoding RNA found to quell
inflammation
Researches study this
RNA using a mouse
model lacking of
lincRNA-EPS

8. Long noncoding RNA found to quell
inflammation
This RNA can provide
information about Lupus
and inflammatory bowel
disease

9. Long noncoding
RNA found to
quell inflammation
Student`s
observation
I think this discovery is important
because it can led to the understanding
of a several pathologies related with
the immune system and inflammatory
processes, providing the best way to treat
them so they won`t be more a
difficulty like nowadays

10. Biochemists feed “poison pill” to
deadly virus
Colorado State University
(2016, July 15).

11. Biochemists feed “poison
pill” to deadly virus
The RNA polymerase is
the enzyme implicated
in making the copies
of the virus

12. Biochemists feed “poison pill” to
deadly virus
Researchers are creating
a vaccine with change of
an aminoacid in the RNA
polymerase (phe tyr) to
minimize the chances of
an infection produced by
the vaccine
The enzyme will make
l o w e r m u t a t i o n s ,
reducing the capacity
of the virus to
replicate and cause
illness that will cause a
self-destruction
“Genetic poison pill”

13. Biochemists feed “poison
pill” to deadly virus
This poison pill could also
be effective with those RNA
viruses linked with asthma
a n d f o o t - a n d - m o u t h
disease

14. Biochemists feed “poison
pill” to deadly virus
Student`s observation
I think this investigation
is important because it
can provide a mechanism
of protection to certain viruses
that produce deseases that in
some cases can be lethal

15. Medical Utility

16. Medical Utility
Both researches are trying
to find the way to prevent
diseases cause either
by a type of RNA or for
viruses

17. Medical Utility
Even though the investigations are looking
for something specific, they can also give
a lot of information about other diseases
that can be illustrated with further
investigations about it

18. Medical Utility
Through the understanding
of the process behind the
inflammatory diseases caused by
uncontrolled immune responses
like lupus the researchers can find
a better way to treat it

19. Bibliography
• Colorado State University. (2016, July 15). Biochemists
feed 'poison pill' to deadly virus. ScienceDaily.
R e t r i e v e d S e p t e m b e r 1 , 2 0 1 6 f r o m
w w w . s c i e n c e d a i l y . c o m / r e l e a s e s /
2016/07/160715130201.htm
• University of Massachusetts Medical School. (2016,
July 14). Long noncoding RNA found to quell
inflammation: Researchers implicate lincRNA in
immune system. ScienceDaily. Retrieved September 1,
2016 from www.sciencedaily.com/releases/
2016/07/160714120654.htm
• Martinez Sánchez, Lina Maria. Biologia Molecular. 2.
ed. Medellin: UPB. Fac. de Medicina, 2006. 208 p.

20. “The distance between your
dreams and reality is called
action”